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Articles 391 - 420 of 1256
Full-Text Articles in Animal Sciences
Selective Harvest Methods And Chemical Treatment Of Baled Corn Residue For Utilization In Growing Calf And Dry Cow Diets, Ashley C. Conway
Selective Harvest Methods And Chemical Treatment Of Baled Corn Residue For Utilization In Growing Calf And Dry Cow Diets, Ashley C. Conway
Department of Animal Science: Dissertations, Theses, and Student Research
Three studies were conducted to evaluate baled corn residue using selective harvest method and anhydrous ammonia treatments to assess utility in growing calf and dry cow diets. Baled corn residue was harvested using conventional rake-and-bale (CONV) method, or harvested using the New Holland Cornrower in which either eight rows (8ROW), or two rows (2ROW) of corn stalks were chopped into the windrow with tailings. Bales were either not treated or ammoniated at 5.5% DM. When fed to wether lambs in a mixed ration (65% residue, 30% wet corn gluten feed) to determine digestibility, the 2ROW residue had greater apparent DM, …
Condition-Dependent Begging Elicits Increased Parental Investment In A Wild Bird Population, E. Keith Bowers, Jonathan B. Jenkins, Alexander J. Mueller, Kelly D. Miller, Charles F. Thomspon, Scott K. Sakaluk
Condition-Dependent Begging Elicits Increased Parental Investment In A Wild Bird Population, E. Keith Bowers, Jonathan B. Jenkins, Alexander J. Mueller, Kelly D. Miller, Charles F. Thomspon, Scott K. Sakaluk
Faculty Publications – Biological Sciences
The coevolution of parental supply and offspring demand has long been thought to involve offspring need driving begging and parental care, leaving other hypotheses underexplored. In a population of wild birds, we experimentally tested whether begging serves as a negatively condition-dependent signal of need or a positively condition-dependent signal of quality. Across multiple years, we supplemented nestling house wrens with food shortly after hatching and simultaneously manipulated corticosterone levels to simulate the hunger-induced increase in glucocorticoids thought to mediate begging. This allowed us to also test whether begging is simply a proximate signal of hunger. Days after supplementation ended, food-supplemented …
Hormone Signaling, Gene Expression, And Mitochondrial Hormone Receptor Expression In Avian Muscle (Cells), Kentu Rushadd Lassiter
Hormone Signaling, Gene Expression, And Mitochondrial Hormone Receptor Expression In Avian Muscle (Cells), Kentu Rushadd Lassiter
Graduate Theses and Dissertations
Mitochondria are vital to the proper growth and function of muscle cells since they’re responsible for the majority of ATP production used for cellular energy. Previous studies have investigated how differences in mitochondrial function affects feed efficiency (FE) in broilers phenotyped for High and Low FE. Low FE broilers have been shown to have increased levels of reactive oxygen species (ROS), thus contributing to higher levels of oxidative stress and damage seen in these birds. Global gene and protein expression studies conducted on breast muscle of the High FE and Low FE phenotypes have suggested that differences in mitochondrial function …
Stabilizing Forces In Acoustic Cultural Evolution: Comparing Humans And Birds, Daniel C. Mann
Stabilizing Forces In Acoustic Cultural Evolution: Comparing Humans And Birds, Daniel C. Mann
Dissertations, Theses, and Capstone Projects
Learned acoustic communication systems, like birdsong and spoken human language, can be described from two seemingly contradictory perspectives. On one hand, learned acoustic communication systems can be remarkably consistent. Substantive and descriptive generalizations can be made which hold for a majority of populations within a species. On the other hand, learned acoustic communication systems are often highly variable. The degree of variation is often so great that few, if any, substantive generalizations hold for all populations in a species.
Within my dissertation, I explore the interplay of variation and uniformity in three vocal learning species: budgerigars (Melopsittacus undulatus), …
Development Of Mouse Models For Respiratory And Neurological Disease Caused By Enterovirus D68 And Evaluation Of Antiviral Therapies, Brett L. Hurst
Development Of Mouse Models For Respiratory And Neurological Disease Caused By Enterovirus D68 And Evaluation Of Antiviral Therapies, Brett L. Hurst
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Enterovirus D68 (EV-D68) is a virus that normally causes disease in children. While this virus typically causes a respiratory infection, in 2014, a large outbreak of the virus was associated with patients that had paralysis of the arms or legs. Even though the virus was discovered in 1962, little was known about the life cycle of the virus or its ability to cause disease. An animal model of disease was needed to understand how the virus causes disease and to develop antiviral compounds to target the virus life cycle.
We adapted the virus by serial-passage in lung tissues from mice …
Ruminal Protection And Intestinal Availability Of Rumen-Protected Methionine And Lysine In Lactating Dairy Cows, Sara Menchu
Ruminal Protection And Intestinal Availability Of Rumen-Protected Methionine And Lysine In Lactating Dairy Cows, Sara Menchu
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Rumen protected Methionine (MET) and Lysine (LYS) are critical for milk protein synthesis in dairy cows. N-acetyl-L-methionine (NALM) is a MET derivative that consists of L-Met protected with an acetyl group that is attached to the α-amino group.N-acetyl-L-lysine (NALL) is a LYS derivative that is similarly protected. The objectives of these studies were to quantify the gastrointestinal availability of NALM and NALL. Three experiments were run as 3 × 3 Latin square using 3 second lactation Holstein cows that have been fitted with cannulas in the rumen and duodenum. The cows …
Evaluation Of Casein Hydrolysate As An Alternative Dry-Off Treatment And Milk Quality Management Tool In Dairy Cows, Justine Elena Britten
Evaluation Of Casein Hydrolysate As An Alternative Dry-Off Treatment And Milk Quality Management Tool In Dairy Cows, Justine Elena Britten
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Mastitis, an infection of the mammary gland, is the most common and expensive animal health problem for the dairy industry and affects every dairy farm to some degree. This disease complex is painful for dairy cows, increases the on-farm use of antibiotics, presents a threat to milk quality and is a waste of time, money and milk production. Each year, the dairy industry loses as much as a billion dollars to mastitis.
Many cows will experience mastitis at least once during a lactation cycle and some animals will develop recurring mastitis episodes in a single mammary quarter. These mastitic quarters …
Male Reproductive Infection And Sexual Transmission Of Zika Virus In An Immunocompromised Mouse Model, Chad S. Clancy
Male Reproductive Infection And Sexual Transmission Of Zika Virus In An Immunocompromised Mouse Model, Chad S. Clancy
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Zika virus (ZIKV) is a sexually transmitted viral infection most frequently transmitted by mosquitoes. The source of infectious virions in the male reproductive tract has yet to be elucidated. The goals of the studies included developing and characterizing two mouse models for reproductive transmission studies and demonstration of sexual transmission of virus via artificial insemination. The mouse strains used in the study lacked receptors to interferon molecules, key signaling proteins of the host immune response. Inflammation severity was assessed during acute disease, 5-11 days after infection using a novel histopathology grading system. ZIKV proteins and genome were initially detected in …
From Deviant Symbol To Cultural Icon? Understanding Pit Bull Stigma, Genevieve Minter
From Deviant Symbol To Cultural Icon? Understanding Pit Bull Stigma, Genevieve Minter
UNLV Theses, Dissertations, Professional Papers, and Capstones
This research draws from twelve months of ethnographic data using Las Vegas as a case study to understand how pit bull owners experience and negotiate stigma in various social settings. The human-dog relationship, long rooted in utility, transformed in the modern era as animals were promoted from worker to companion. The world’s first dog register, The American Kennel Club, created breed standards and encouraged selective breeding, which influenced the idea of certain dogs being more physically “dangerous” than others. Though the pit bull is not the first dog “breed” to be the object of discrimination, it is the first dog …
Effects Of Elevated Temperature On Gonadal Functions, Cellular Apoptosis, And Oxidative Stress In Atlantic Sea Urchin (Arbacia Punctulata), Jackson B. Johnstone
Effects Of Elevated Temperature On Gonadal Functions, Cellular Apoptosis, And Oxidative Stress In Atlantic Sea Urchin (Arbacia Punctulata), Jackson B. Johnstone
Theses and Dissertations
Increasing surface sea water temperatures effect on growth, reproduction and development in marine organisms. Sea urchins are excellent indicator species and ideal model organisms to focus on. In this study, I tested the effect of higher temperatures on reproductive functions, heat shock protein (HSP, a chaperone protein produced by cells in response to heat stress) and nitrotyrosine protein (NTP, an indicator of reactive nitrogen species, RNS) expressions, cellular apoptosis, and ceolomic fluid (CF, a body fluid which regulates important physiological processes) conditions in Atlantic sea urchin at three different temperatures. Ten sea urchins were placed in each of six aquariums …
A Snapshot Of The Age, Growth, And Reproductive Status Of Gray Triggerfish (Balistes Capriscus, Gmelin 1789) On Three Artificial Reefs In The Northwest Gulf Of Mexico, Adam M. Lee
Theses and Dissertations
Age, growth, and reproductive status of gray triggerfish (Balistes capriscus) were identified from 2015-2016 on artificial reefs in the northwest Gulf of Mexico. Individuals ranged from 232-432 mm fork length with and a mean fork length of 319 mm. Individuals from age 0.2 to 5.2 yrs were observed with a weight to length relationship of Wg = 1.1 x -104 x FL2.7 (r2 = 0.94, n = 112), where FL = fork length (mm) and Wg = weight (g). A von Bertalanffy growth equation of Lt = 326(1 - e - 0.9 (t + 1.71)) was calculated irrespective …
Cognitive Models Of Defense Behaviors In Hosts Of Brood Parasites, Thomas J. Manna
Cognitive Models Of Defense Behaviors In Hosts Of Brood Parasites, Thomas J. Manna
Dissertations, Theses, and Capstone Projects
Social parasites exploit the behavioral repertoire of their hosts for their own benefit, thereby reducing host reproductive success. Whether and how hosts respond to prevent, reduce, or eliminate the costs of parasitism requires the characterization of host cognitive algorithms in response to parasites. In this dissertation, I review the suite of the defense behaviors and decision rules of hosts targeted by avian and insect brood parasites, and present new experimental data on the detection of parasitism through the visual system of focal host species. In Chapter 1, I review extensive data already accumulated to isolate the cognitive mechanisms used by …
Optimization Of The Light Environment For Broiler Chickens, Douglas J. Aldridge
Optimization Of The Light Environment For Broiler Chickens, Douglas J. Aldridge
Graduate Theses and Dissertations
The use of artificial light sources has been necessitated by the use of fully enclosed rearing facilities for improved environmental control. Light Emitting Diodes (LED) have been developed as a light source that reduce the utilities required to provide equal light to that of incandescent sources. The following reports were carried out to investigate the effects of two light color temperatures, light intensity and light intensity gradients on broiler chicken production and behavior. The first investigation consisting of two consecutive trials investigated the effect of two light color temperatures (2700 K and 5000 K) in addition to the preference for …
Broiler Breeder Amino Acid Levels And Progeny Nutritional Status, Leasea Butler
Broiler Breeder Amino Acid Levels And Progeny Nutritional Status, Leasea Butler
Graduate Theses and Dissertations
Crude protein needs of chickens have changed due to genetic line differences and selection of those lines for differing broiler traits. Standard commercial broiler strains have been selected to be used to meet multiple processing categories typically at live body weights less than 3.5 kg. In the last two decades high-yielding broiler strains were introduced into the commercial market. These breeds are known as the Cobb 700 and Ross 708. The works included within are focused on the Cobb 700 high-yielding broiler strain, and its response to crude protein, with emphasis on digestible lysine.
The Impacts Of Administering Metabolites Of Saccharomyces Cerevisiae On Broiler Performance, Yields And Salmonella Content Of Component Portions, Bill Douglas Potter
The Impacts Of Administering Metabolites Of Saccharomyces Cerevisiae On Broiler Performance, Yields And Salmonella Content Of Component Portions, Bill Douglas Potter
Graduate Theses and Dissertations
The impacts of using health-promoting Saccharomyces cerevisiae fermentation metabolites in poultry production and processing can be measured in respect to multiple measures of success. Traditionally this yeast-based compound has been administered to poultry, livestock, poultry, and other species to improve animal performance and production volume output. In addition, Saccharomyces cerevisiae fermentation metabolites have also been shown in more recent research to reduce colonization of pathogenic bacteria in the host organism’s gastro-intestinal tract. In this dissertation, the impacts of administering a functional ingredient containing Saccharomyces cerevisiae metabolites on broiler performance measures and pathogen reduction were measured. One of the studies in …
Development And Evaluation Of Selected Chemoprophylaxis Candidates And A Candidate Live-Attenuated Vaccine For Prevention Of Histomoniasis In Turkeys, Lesleigh Beer
Graduate Theses and Dissertations
Histomoniasis, commonly known as blackhead disease, has increased in prevalence due to the regulatory ban of prophylactics and therapeutics within the past 30 years. The objective of this thesis was to evaluate the efficacy of selected dietary chemoprophylaxis candidates as well as an in vitro live-attenuated vaccine candidate Histomonas meleagridis for prevention of histomoniasis. Chapter one addresses deoxycholic acid and a biliogenic diet intended to endogenously increase production of this secondary bile acid. Deoxycholic acid was effective in vitro but failed to prevent histomoniasis when evaluated during the in vivo experimental disease trial with turkeys. The biliogenic diet did not …
Animal Experimentation: Working Towards A Paradigm Change, Kathrin Herrmann (Ed.), Kimberley Jayne (Ed.)
Animal Experimentation: Working Towards A Paradigm Change, Kathrin Herrmann (Ed.), Kimberley Jayne (Ed.)
eBooks
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific …
Altered Gene Response To Aflatoxin B1 In The Spleens Of Susceptible And Resistant Turkeys, Kent M. Reed, Kristelle M. Mendoza, Roger A. Coulombe Jr.
Altered Gene Response To Aflatoxin B1 In The Spleens Of Susceptible And Resistant Turkeys, Kent M. Reed, Kristelle M. Mendoza, Roger A. Coulombe Jr.
Animal, Dairy, and Veterinary Science Faculty Publications
Susceptibility and/or resistance to aflatoxin B1 (AFB1) is a threshold trait governed principally by glutathione S transferase (GST)-mediated detoxification. In poultry, domesticated turkeys are highly sensitive to AFB1, most likely due to dysfunction in hepatic GSTs. In contrast, wild turkeys are comparatively resistant to aflatoxicosis due to the presence of functional hepatic GSTAs and other possible physiological and immunological interactions. The underlying genetic basis for the disparate GST function in turkeys is unknown as are the broader molecular interactions that control the systemic response. This study quantifies the effects of dietary AFB1 on gene …
California Sea Lion (Zalophus Californianus) Ethogram & Handedness Study, Tricia A. Flesner
California Sea Lion (Zalophus Californianus) Ethogram & Handedness Study, Tricia A. Flesner
Undergraduate Research Symposium
Studying the behaviors of captive animals provides caretakers, ecologists, and conservationists with vital information on how better to care for them. I chose captive male California sea lions (Zalophus californianus) for my ethogram as little is known about their behavioral activities. I wanted to determine if they present an asymmetrical swimming preference and whether they display agonistic behaviors when there are no females present. I also aimed to examine the sea lions time budget, how they utilized their time in the pool. I used many observational sampling methods to gather data. My findings suggested there is a possibility that captive …
Shirley Family Letters (Sc 3403), Manuscripts & Folklife Archives
Shirley Family Letters (Sc 3403), Manuscripts & Folklife Archives
Manuscript Collection Finding Aids
Finding aid and scans (Click on "Additional Files" below) for Manuscripts Small Collection 3403. Letters received by the Shirley family of Eagle Station, Carroll County, Kentucky. A nephew writes of his new job with a Fort Wayne, Indiana newspaper, a specialist with the Dixie Poultry Journal gives advice on treating worms in poultry, and Albert Shirley writes his wife Lydia from their daughter Kathleen’s home. Includes a doctor’s notes on the health of Kathleen’s young son Robert.
Evaluation Of A Proprietary Slow-Release Oxytocin Formulation On Corpus Luteum Function In Mares, Brendan Sarnecky
Evaluation Of A Proprietary Slow-Release Oxytocin Formulation On Corpus Luteum Function In Mares, Brendan Sarnecky
Student Research Symposium
Prolonging function of the corpus luteum (CL) is a method of suppressing estrus that relies on continued secretion of endogenous progesterone to keep mares out of heat naturally. The use of oxytocin treatment to prolong CL function is gaining increasing use, and the most common treatment protocol involves administration of 60 units of oxytocin intramuscularly (IM) once daily on days 7 to 14 after ovulation (8 daily treatments). Although that protocol induces prolonged CL function in â 70% of treated mares, the need for daily administration is a drawback to its use. Therefore, the objective of this study was to …
Employing Recombinant Adeno-Associated Viral Vectors For Delivery Of A Therapeutic Timp-3 Transgene To The Equine Distal Extremity, Anisa Rose Samhouri
Employing Recombinant Adeno-Associated Viral Vectors For Delivery Of A Therapeutic Timp-3 Transgene To The Equine Distal Extremity, Anisa Rose Samhouri
Student Research Symposium
Equine laminitis is a condition that results in lameness, extreme pain, and in many cases, concludes in euthanasia. The epidermal and dermal layers of the hoof's lamina are stabilized by connective tissues. Homeostatic metabolic factors allow for healthy remodeling of the lamina. When laminitis occurs, the enzymes that degrade lamellar connective tissue are upregulated while the concentration of degradative inhibitors (TIMP-3) is not changed. The unbalanced state of the metabolic factors compromises the structural integrity of the lamina and allows for movement of the coffin bone within the hoof capsule. Gene therapy has manifested promising results for preventing laminitis. The …
Vaquita Face Extinction From Bycatch. Comment On Manjarrez-Bringas, N. Et Al., Lessons For Sustainable Development: Marine Mammal Conservation Policies And Its Social And Economic Effects., Karl W. Flessa, Luis Calderon-Aguilera, Carlos E. Cintra-Buenrostro, David L. Dettman, Gregory P. Dietl, David H. Goodwin, David K. Jacobs, Michal Kowalewski, Steven M. Nelson, Kirsten Rowell, Bernard R. Schone, Jansen A. Smith, Francisco Zamora-Arroyo
Vaquita Face Extinction From Bycatch. Comment On Manjarrez-Bringas, N. Et Al., Lessons For Sustainable Development: Marine Mammal Conservation Policies And Its Social And Economic Effects., Karl W. Flessa, Luis Calderon-Aguilera, Carlos E. Cintra-Buenrostro, David L. Dettman, Gregory P. Dietl, David H. Goodwin, David K. Jacobs, Michal Kowalewski, Steven M. Nelson, Kirsten Rowell, Bernard R. Schone, Jansen A. Smith, Francisco Zamora-Arroyo
School of Earth, Environmental, & Marine Sciences Faculty Publications
We are among the scientists who have documented the environmental and ecological changes to the Upper Gulf of California following the reduction in the Colorado River’s flow. We object to any suggestion that our research supports Manjarrez-Bringas et al.’s conclusion that the decline in the Colorado River’s flow is the reason for the decline in the population of the endangered vaquita porpoise (Phocoena sinus). Manjarrez-Bringas et al.’s conclusions are incongruent with their own data, their logic is untenable, their analyses fail to consider current illegal fishing practices, and their recommendations are unjustified and misdirected. Vaquita face extinction because of bycatch, …
Impact Of The Introduction Of Black Raspberries In A Standard Western-Style Diet On Colitis And Colorectal Cancer Risk In Mice, Daphne Rodriguez, Korry Hintze
Impact Of The Introduction Of Black Raspberries In A Standard Western-Style Diet On Colitis And Colorectal Cancer Risk In Mice, Daphne Rodriguez, Korry Hintze
Student Research Symposium
Approximately 1.4 million people suffer from inflammatory bowel disease, which is major risk factor for developing colitis associated colorectal cancer (CAC). Dietary interventions with the goal to reduce colon inflammation and encourage gut microbiome homeostasis may be a strategy to reduce the risk of CAC. The antioxidants and antiinflammatory compounds present in black raspberries (BRB) have demonstrated protective effects in the colon epithelium and may alter the composition of the gut microbiome. Previously, we showed that dietary supplementation with black raspberries significantly suppressed coliti and colon tumorigenesis promoted by the consumption of a Western type diet in mice. The goal …
Wilson, Alexander Gordon, 1888-1970 (Sc 3384), Manuscripts & Folklife Archives
Wilson, Alexander Gordon, 1888-1970 (Sc 3384), Manuscripts & Folklife Archives
Manuscript Collection Finding Aids
Finding aid only for Manuscripts Small Collection 3384. Letters of WKU English faculty member Gordon Wilson to fellow faculty member Frances Richards and her sister Mary Ellen Richards, Franklin, Kentucky. The folklorist and accomplished amateur ornithologist writes effusively about his life and post-retirement work, including his autobiography and his linguistic and bird studies in the Mammoth Cave region. He reports various bird sightings and counts to Mary Ellen, discusses upcoming speeches and publications, shares news of his family, friends and health, and thanks Frances for gifts of phonograph records. Includes notes from his wife written after his death.
Livestock At Marala Head, Zahid Bhatti, Fakhra Nazir, Jibran Haider
Livestock At Marala Head, Zahid Bhatti, Fakhra Nazir, Jibran Haider
Journal of Bioresource Management
Pakistan possesses the most varied and widely distributed network of wetlands. The study area spanned across Kikar post to head Marala at river Jammu Tawi from Kalyal to head Marala at river Chenab and from Rangpur Kuri to head Marala at river Manawar Tawi. Total count of the livestock (resting grazing) population was taken during each calendar month of the year, i.e., from October, 2000 to September 2001. The results of the survey confirmed the presence of 6 common species of livestock i.e. sheep, goat, buffaloes, cows, donkeys and horses in the study area in different sizes of populations.
Prevalence Of Flying Squirrels Recorded From Selected Areas Of Ajk, Jibran Haider, Madeeha Manzoor, Inayatullah Malik
Prevalence Of Flying Squirrels Recorded From Selected Areas Of Ajk, Jibran Haider, Madeeha Manzoor, Inayatullah Malik
Journal of Bioresource Management
Squirrels belong to the Sciuridae family. This family comprises of small and medium-sized rodents. They are native in regions of US, Eurasia, and Africa. Different nature parks were selected for survey. Dhirkot Nature Reserve (DNR) was observed in February, 2008, Banjosa Nature Reserve (BNR) in May to June, 2009), Tolipir National Park (TNP) in April to May, 2008, Pir Chanasi National Park (PCNP) in April to May, 2010 and Pir Lasura National Park (PLNP) in June to July, 2009. Only two species from the family Sciuridae were found in the study area; Hylopetes fimbriatus (Small Kashmir flying squirrel) and …
The Physico-Chemical Environment And Aquatic Biodiversity Of Head Marala Wetland During 2000-2001, Zahid Bhatti, Muhammad Asif Gondal, Andleeb Batool
The Physico-Chemical Environment And Aquatic Biodiversity Of Head Marala Wetland During 2000-2001, Zahid Bhatti, Muhammad Asif Gondal, Andleeb Batool
Journal of Bioresource Management
An ecological study on Head Marala Wetland was undertaken. The study will help in providing sound basis for the future conservation activities and its management, on sounder footing. The Marala wetlands in Bajwat area included river Jammu Tawi, river Chanab and river Manawar Tawi were studied for a period of one year, i.e. from October, 2000 to September, 2001. In this study, 36 Phytoplanktons belonging to six families were observed. The other aquatic fauna observed included 14 species of fish, 2 turtles, one leech, one prawn, one shrimp and one bullfrog. The results showed that physico-chemical parameters had an impact …
Board Invited Review: Prospects For Improving Management Of Animal Disease Introductions Using Disease-Dynamic Models, Ryan S. Miller, Kim M. Pepin
Board Invited Review: Prospects For Improving Management Of Animal Disease Introductions Using Disease-Dynamic Models, Ryan S. Miller, Kim M. Pepin
United States Department of Agriculture Wildlife Services: Staff Publications
Management and policy decisions are continually made to mitigate disease introductions in animal populations despite often limited surveillance data or knowledge of disease transmission processes. Science-based management is broadly recognized as leading to more effective decisions yet application of models to actively guide disease surveillance and mitigate risks remains limited. Disease-dynamic models are an efficient method of providing information for management decisions because of their ability to integrate and evaluate multiple, complex processes simultaneously while accounting for uncertainty common in animal diseases. Here we review disease introduction pathways and transmission processes crucial for informing disease management and models at the …
Efficacy Of A Ml336 Derivative Against Venezuelan And Eastern Equine Encephalitis Viruses, Colleen B. Jonsson, Xufeng Cao, Jasper Lee, Jon D. Gabbard, Yong-Kyu Chu, Elizabeth A. Fitzpatrick, Justin G. Julander, Dong-Hoon Chung, Jennifer Stabenow, Jennifer E. Golden
Efficacy Of A Ml336 Derivative Against Venezuelan And Eastern Equine Encephalitis Viruses, Colleen B. Jonsson, Xufeng Cao, Jasper Lee, Jon D. Gabbard, Yong-Kyu Chu, Elizabeth A. Fitzpatrick, Justin G. Julander, Dong-Hoon Chung, Jennifer Stabenow, Jennifer E. Golden
Animal, Dairy, and Veterinary Science Faculty Publications
Currently, there are no licensed human vaccines or antivirals for treatment of or prevention from infection with encephalitic alphaviruses. Because epidemics are sporadic and unpredictable, and endemic disease is common but rarely diagnosed, it is difficult to identify all populations requiring vaccination; thus, an effective post-exposure treatment method is needed to interrupt ongoing outbreaks. To address this public health need, we have continued development of ML336 to deliver a molecule with prophylactic and therapeutic potential that could be relevant for use in natural epidemics or deliberate release scenario for Venezuelan equine encephalitis virus (VEEV). We report findings from in vitro …