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2014

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Articles 301 - 330 of 1049

Full-Text Articles in Animal Sciences

American Bison Ecology And Bison-Cattle Interactions In An Isolated Montane Environment, Dustin H. Ranglack May 2014

American Bison Ecology And Bison-Cattle Interactions In An Isolated Montane Environment, Dustin H. Ranglack

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

As bison are considered to be ecologically extinct, and negative interactions between bison and cattle are perceived to limit bison restoration and cattle production, I designed a series of studies to test for potential competition between bison (Bison bison) and cattle (Bos taurus) for forage on the Henry Mountains in southern Utah. These studies provide insight into key information gaps previously identified by the Utah Division of Wildlife Resources (UDWR), Bureau of Land Management, and the local grazing association. The results indicate that bison and cattle are not strong competitors for forage on the Henry Mountains. …


Effects Of Condensed Tannins On The Toxicity Of Fireweed (Senecio Madagascariensis) To Cattle, Carolyn L. Wong May 2014

Effects Of Condensed Tannins On The Toxicity Of Fireweed (Senecio Madagascariensis) To Cattle, Carolyn L. Wong

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Fireweed (Senecio madagascariensis) is a noxious and invasive weed affecting pastures in Hawaii, Australia, and South America. Fireweed contains compounds called pyrrolizidine alkaloids that are toxic to most grazing mammals. Toxic effects to cattle include irreversible damage to liver cells, hardening of the liver, and loss of liver function, which may lead to jaundice, swelling, and the accumulation of fluids in the stomach and other physiological malfunctions. External effects include rough appearance, diarrhea, low energy and dullness, photosensitization, and abnormal behavior, many of which can lead to death. Fireweed also can reduce pasture productivity by as much as …


Assessing The Impact Of Supplements, Food Aversions, And Silica On Medusahead Use By Sheep, Tyler Hamilton May 2014

Assessing The Impact Of Supplements, Food Aversions, And Silica On Medusahead Use By Sheep, Tyler Hamilton

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Ranchers, farmers, land managers, and resource management agencies have been plagued with various types of invasive weeds for decades, ultimately affecting millions of acres of viable wildlife habitat, grazing, and recreational opportunities. Invasive weeds often have nutritional contexts that negatively affect animals in some way, increasing the incentive to avoid consuming it by various animal species and domestic livestock. With the current amount of land infested with this weed, and the limited knowledge of the reason for avoidance, the underlying causes of livestock avoidance require in-depth and fundamental understanding.

In my MS program, I sought to explore the relationship of …


A Male Spider’S Ornamentation Polymorphism Maintained By Opposing Selection With Two Niches, Bo Deng, Alex Estes, Brett Grieb, Douglas Richard, Brittney Hinds, Eileen Hebets May 2014

A Male Spider’S Ornamentation Polymorphism Maintained By Opposing Selection With Two Niches, Bo Deng, Alex Estes, Brett Grieb, Douglas Richard, Brittney Hinds, Eileen Hebets

Eileen Hebets Publications

The Levene mechanism to maintain genotypic polymorphism by opposing selection on genotypes in multiple niches was proposed 60 years ago, and yet no systems were found to satisfy the mechanisms rather restrictive conditions. Reported here is such an example that a wolf spider population lives in a habitat of mixed rocks and leafy litter for which the females are phenotypically indistinguishable and the males have two distinct phenotypes subject to opposing selection with respect to the substrates. Census data is best-fitted to a population genetics model of the Levene type. A majority of the best fit support polymorphism, with many …


Tactical Adjustment Of Signaling Leads To Increased Mating Success And Survival, Laura Sullivan-Beckers, Eileen A. Hebets May 2014

Tactical Adjustment Of Signaling Leads To Increased Mating Success And Survival, Laura Sullivan-Beckers, Eileen A. Hebets

Eileen Hebets Publications

Most sexually reproducing animals overcome the challenge of searching for and attracting mates by utilizing signals that are broadcast through a spatially and temporally varying environment. A diverse suite of behavioral solutions exist for overcoming such environmental variability, including the adjustment of signaling behavior based upon receiver feedback. Few studies have directly examined the relationship between such tactical signaling adjustments and proxies of male fitness; the few that have, failed to find a relationship. Using the wolf spider, Schizocosa rovneri, we set out to first quantify among-male variation in the form and degree of responsiveness to female feedback. Following …


Effects Of Distillers Grains Plus Solubles And Monensin Supplementation On Yearlings Grazing Smooth Bromegrass, Tyler L. Hasenauer May 2014

Effects Of Distillers Grains Plus Solubles And Monensin Supplementation On Yearlings Grazing Smooth Bromegrass, Tyler L. Hasenauer

Department of Animal Science: Dissertations, Theses, and Student Research

Supplementing cattle on grass is an effective way of increasing animal efficiency and grass utilization. Distiller grains plus solubles (DGS) supplementation has been repeatedly proven as an effective supplement by providing ruminally undegradable protein (RUP), fat, and highly digestible fiber. The effects of monensin supplementation on grazing cattle are variable. Although some research has shown a decrease in forage organic matter intake (FOMI), the popular belief is monensin increases ADG while maintaining DMI in a grazing situation. Two experiments were designed to observe the effects of DGS and monensin supplementation on cattle grazing smooth bromegrass. In the first study, ADG …


Effects Of Conventional And Alternative Curing Methods On Processed Turkey Quality Traits, Amy Lynn Redfield May 2014

Effects Of Conventional And Alternative Curing Methods On Processed Turkey Quality Traits, Amy Lynn Redfield

Department of Animal Science: Dissertations, Theses, and Student Research

This study compared physicochemical and sensory qualities of deli-style turkey breast produced pre-converted celery juice powder (CP; for alternative curing) or sodium nitrite (SN; for conventional curing). Formulas were designed to include 0, 50, 100, 150, and 200 ppm ingoing sodium nitrite or the equivalent from CP or SN, and 3 replicates of products were manufactured. Turkey and curing brines were tumbled, stuffed, and cooked to an internal temperature of 73.9oC. Products were stabilized and sliced into 12 mm slices (physicochemical trait analysis) and 2 mm slices (sensory trait analysis). Physicochemical traits measured only on d 0 were …


Genomic Predictions For Age At Puberty And Reproductive Longevity In Sows Using Bayesian Methods, Katherine Lindsay Lucot May 2014

Genomic Predictions For Age At Puberty And Reproductive Longevity In Sows Using Bayesian Methods, Katherine Lindsay Lucot

Department of Animal Science: Dissertations, Theses, and Student Research

Including marker-assisted selection in breeding programs is potentially more efficient than traditional selection for improving traits that are expensive or difficult to measure. One of the challenges of genomics is the lack of robustness of marker effects across populations and over time (generations) and the cost to commercial producers of high-density arrays. The objective of this study was to analyze differences in the proportion of phenotypic variation explained by different fractions of major 1 Mb windows and SNPs. Using a population of Nebraska Index Line and commercial Large White x Landrace females (n = 1,234) generated in 11 batches, …


Alteration Of Host Cell Ubiquitination By The Intracellular Bacterial Pathogen Coxiella Burnetii, Lindsey Elizabeth Pritchett May 2014

Alteration Of Host Cell Ubiquitination By The Intracellular Bacterial Pathogen Coxiella Burnetii, Lindsey Elizabeth Pritchett

Poultry Science Undergraduate Honors Theses

The intracellular bacterial agent of Q fever, Coxiella burnetii, replicates within a phagolysosome-like parasitophorous vacuole (PV) in human macrophages and delivers effector proteins to the host cytosol via a Dot/Icm type IV secretion system (T4SS). T4SS effectors are critical for PV formation and prevention of host cell death that allows sufficient time for bacterial replication. Recruitment of ubiquitin-related components to the C. burnetii PV is also predicted to be involved in PV formation and bacterial replication and is likely controlled by effector proteins. In this study, we assessed the role of the Dot/Icm T4SS in regulating ubiquitination by comparing subcellular …


Genome-Wide Analysis Of The Variation In Host Genetics In Response To Experimental Challenges With Porcine Circovirus 2b, Taylor B. Engle May 2014

Genome-Wide Analysis Of The Variation In Host Genetics In Response To Experimental Challenges With Porcine Circovirus 2b, Taylor B. Engle

Department of Animal Science: Dissertations, Theses, and Student Research

Porcine circovirus is the primary causative agent responsible for inducing a group of associated diseases known as porcine circovirus associated diseases (PCVAD), which can have detrimental effects on production efficiency as well as lead to mortality. The variation in host genetics plays a role in the ability to initiate an effective immune response. The objective of this research was to identify major genetic variants and genes that influence immune response and PCVAD susceptibility. Commercial crossbred pigs (n=974) were experimentally infected with a PCV2b strain to analyze genetic sources of variation in PCVAD susceptibility. The strain used for experimental infection was …


Reproduction And Nesting In Teleost Fish, With A Focus On Reproduction In Centrarchids And Specific Analysis Of Nesting In Lepomis Megalotis, Rebecca Irene Allee May 2014

Reproduction And Nesting In Teleost Fish, With A Focus On Reproduction In Centrarchids And Specific Analysis Of Nesting In Lepomis Megalotis, Rebecca Irene Allee

Undergraduate Honors Thesis Collection

Fish represent the most diverse and oldest living class of vertebrates, making up approximately 48% of all known members of the subphylum Vertebrata (Bolis, et al. 2001). They are able to live in a wide variety of habitats, from salt water to fresh water and from cold polar seas to areas of intense pressure in the depths of the ocean (Moyle and Cech 1996). Because of this overwhelming diversity, the evolution and ecology of fishes has been a dynamic field of study (Moyle and Cech 1996). Researchers have generally divided fish into three distinct groups: jawless fishes (Class Agnatha), …


Lifecycle Efficiency Of Mice Divergently Selected For Heat Loss, Adrienne Bhatnagar May 2014

Lifecycle Efficiency Of Mice Divergently Selected For Heat Loss, Adrienne Bhatnagar

Department of Animal Science: Dissertations, Theses, and Student Research

Divergent selection for heat loss as an indication of maintenance energy requirements in mice resulted in a low (ML) and high maintenance line (MH), and an intermediate control line (MC). Improved feed efficiency has been observed in ML mice, which would be economically beneficial in livestock species. However, previous work showed evidence of unfavorable correlated responses to selection in ML mice compared to MH mice. Therefore, the objective of this study was to model a lifecycle similar to a livestock production system using these lines and determine if these correlated responses diminish the benefit of improved feed efficiency by calculating …


Use Of Distiller Grains In Alternative Beef Heifer Systems, Jared M. Mracek May 2014

Use Of Distiller Grains In Alternative Beef Heifer Systems, Jared M. Mracek

Department of Animal Science: Dissertations, Theses, and Student Research

Every year, producers select replacement heifers with the intention that these heifers are the future of their cow herd. Producers normally select replacement heifers at weaning based on weight and structure. When selecting heifers at weaning, producers risk not selecting heifers that would be productive cows based on their criteria. By delaying the selection of replacements, it will allow producers to increase the opportunity to thoroughly evaluate replacement prospects. The corn dry-milling industry produces byproducts that can be economical supplements to growing cattle on forage. An experiment evaluated an alternative heifer system utilizing distiller grains as an energy source to …


The Effects Of Feed Additives, Housing Systems, And Stress On Salmonella Shedding In Single Comb White And Brown Laying Hens, Dana L. Hahn May 2014

The Effects Of Feed Additives, Housing Systems, And Stress On Salmonella Shedding In Single Comb White And Brown Laying Hens, Dana L. Hahn

Department of Animal Science: Dissertations, Theses, and Student Research

A series of studies were conducted examining feed additives, housing systems and stress on Salmonella shedding. Alternative feed additives such as prebiotics, probiotics and essential oils have been shown to reduce pathogenic bacteria colonization. Furthermore, stressors such as movement have been shown to increase Salmonella shedding. The goal of the studies was to examine if alternative ingredients reduce Salmonella shedding in alternative housing systems and through movement stress. Study 1 examined cage and cage-free housing with mannan oligosaccharide (MOS) supplementation. Treatments were arranged in a 2x2 factorial design: cage or cage free; MOS (0% or 0.08%). There was no effect …


Social Learning And The Development Of Social Foraging Behavior In Golden Lion Tamarins (Leontopithecus Rosalia), Carly Slack May 2014

Social Learning And The Development Of Social Foraging Behavior In Golden Lion Tamarins (Leontopithecus Rosalia), Carly Slack

All Theses

Golden lion tamarins are highly social, group-living primates and are cooperative breeders. As such they are an ideal species in which to study social learning. Observations of six groups of wild golden lion tamarins were used to examine the development of social foraging and related behaviors in juveniles. Rates at which juveniles approached adults that were foraging for plant foods tended to decline with age (F=3.34, p=.0531), and the rates at which they begged (F=4.71, p=.0193), and foraged at the same site (i.e., co-foraged; F=3.44, p=.0495) decreased significantly. For prey foraging, rates at which adults vacated a site to allow …


Balking Incidence And Behavioral Responses During Handling In Fed Cattle With Genetic And Carcass Implications, Michelle Lynn Thomas May 2014

Balking Incidence And Behavioral Responses During Handling In Fed Cattle With Genetic And Carcass Implications, Michelle Lynn Thomas

Graduate Theses and Dissertations

Temperament in cattle is often defined as the reactivity to human handling or novel environments. Temperament differences have been shown among breed-type categories, within breed types, among crossbreds, and between sexes. Temperament tests are typically completed at weaning time on beef cattle, and rarely on fed Holstein steers for beef production. Balking behavior, or cease in forward motion, in the cattle working facility can pose welfare issues as the electric prod use to coerce movement is implemented. Three observational field projects were designed to evaluate balking behavior incidence in unknown breed-types at the processing plant, Holstein steers in the feedlot …


Poultry Performance And Food Safety Impacts Of Selected Organic Acids And Probiotics, Anita Menconi May 2014

Poultry Performance And Food Safety Impacts Of Selected Organic Acids And Probiotics, Anita Menconi

Graduate Theses and Dissertations

Improving production parameters and controlling foodborne pathogens have been challenges to the poultry industry. Salmonella has been the most common bacterial pathogen in laboratory confirmed foodborne illness cases, and contaminated poultry and poultry products have been identified as the most important source of transmission of Salmonella to humans. Therefore, research on effective interventions to reduce Salmonella transmission at the poultry production level has gained attention. Initially, a series of studies was conducted to evaluate the use of selected organic acids in controlling foodborne pathogens and improving poultry performance. Then, the characterization and application of lactic acid bacteria and Bacillus spp. …


Taxonomic And Seasonal Variation Among Extant Hyracoids Based On Dental Microwear Texture Analysis, Ann Marie Walcutt May 2014

Taxonomic And Seasonal Variation Among Extant Hyracoids Based On Dental Microwear Texture Analysis, Ann Marie Walcutt

Graduate Theses and Dissertations

A number of works have been published on habitats and diets of living hyraxes but much remains to be learned about the paleoenvironment contexts of the much larger, more dominant but now extinct forms of the order. Here, I analyze the dental microwear of modern hyraxes to assess dietary and ecological relationships among the four extant species of Procaviidae: Heterohyrax brucei, Procavia capensis, Dendrohyrax arboreus, and Dendrohyrax dorsalis. The purpose of this study was to establish an extant baseline series for the interpretation of microwear texture patterns, and inference of diets, of extinct members of the …


The Cova Des Pas De Vallgornera (Llucmajor, Mallorca): A Singular Deposit Bearing An Exceptional Well Preserved Early Pleistocene Vertebrate Fauna, Pere Bover, Alex Valenzuela, Carmen Guerra, Juan Rofes, Josep A. Alcover, Joaquin Gines, Joan J. Fornos, Gloria Cuenca-Bescós, Antoni Merino May 2014

The Cova Des Pas De Vallgornera (Llucmajor, Mallorca): A Singular Deposit Bearing An Exceptional Well Preserved Early Pleistocene Vertebrate Fauna, Pere Bover, Alex Valenzuela, Carmen Guerra, Juan Rofes, Josep A. Alcover, Joaquin Gines, Joan J. Fornos, Gloria Cuenca-Bescós, Antoni Merino

International Journal of Speleology

The Cova des Pas de Vallgornera is the longest cave of Mallorca (Balearic Islands, Western Mediterranean) and one of the 30 longest caves in the world. The exploration of one of the galleries allowed the discovery of a fossiliferous deposit of vertebrate remains in a remarkable preservation state. The fossil faunal complex found in this gallery is composed of up to 5 mammalian species (Myotragus aff. kopperi, Hypnomys onicensis, Nesiotites aff. ponsi, Rhinolophus aff. mehelyi and Pipistrellus sp.), at least 14 bird species (among them two Mallorcan endemic taxa: Pica mourerae and Athene vallgornerensis), one …


Response Of Large River Fishes To A Prolonged High Water Event In The Missouri River, Nebraska, Nicholas Paul Hogberg May 2014

Response Of Large River Fishes To A Prolonged High Water Event In The Missouri River, Nebraska, Nicholas Paul Hogberg

School of Natural Resources: Dissertations, Theses, and Student Research

Regulation and modification of large rivers to accommodate human uses have been a root cause of freshwater biodiversity declines. The Missouri River is among the most drastically-altered large river systems in North America, with a series of mainstem impoundments in the upper watershed altering flow characteristics downstream, and channelization throughout the lower river homogenizing instream habitat and reducing off-channel habitat. Precipitation events during the winter and spring 2010-2011 caused flooding of the greatest magnitude and duration since reservoir completion. The large magnitude and long duration of this flood made it unlike any flood in recent history and provided a unique …


Accuracy Or Precision: Implications Of Sample Design And Methodology On Abundance Estimation, Lucas K. Kowalewski May 2014

Accuracy Or Precision: Implications Of Sample Design And Methodology On Abundance Estimation, Lucas K. Kowalewski

School of Natural Resources: Dissertations, Theses, and Student Research

Estimation of population size by spatially replicated counts (point-count method) has been used for many large-scale animal-monitoring programs, yet its application in aquatic environments has been limited. Multiple site-specific estimates of abundance can be averaged and combined with covariate data to predict total abundance across an area of interest. Covariate data also provide an understanding of the relationship between abundance and habitat use, which is a fundamental interest of many animal-population investigations. Design of sampling scenarios for point-count population-estimate surveys can influence the accuracy and precision of the population estimate. The first objective of this study was to examine how …


Influence Of Non-Native Trout On Native Non-Game Fish In Nebraska Headwater Streams, Kelly C. Turek May 2014

Influence Of Non-Native Trout On Native Non-Game Fish In Nebraska Headwater Streams, Kelly C. Turek

School of Natural Resources: Dissertations, Theses, and Student Research

Introduced, non-native trout may have detrimental competitive or predatory interactions with native fishes. However, few studies have experimentally examined interactions between introduced trout and native non-game species. Therefore, the objectives of this study were to determine 1) if non-native rainbow trout Oncorhynchus mykiss influence survival, behavior, movement, or distribution of native longnose dace Rhinichthys cataractae under laboratory conditions, 2) if non-native rainbow trout influence survival of native longnose dace under in-situ conditions using in-stream enclosures, and 3) if native fish populations or communities differ in the presence and absence of non-native trout under natural conditions.

Rainbow trout preyed on longnose …


Zutrition: Analyzing And Evaluating Diets Fed To Captive Mammals At Capron Park Zoo, Briell M. Dzierga May 2014

Zutrition: Analyzing And Evaluating Diets Fed To Captive Mammals At Capron Park Zoo, Briell M. Dzierga

Senior Honors Projects

Zoos provide both experiential and educational opportunities for the general public to learn about animals found in a variety of habitats around the world. A successful zoo must provide a safe and enjoyable environment for the visitors, in addition to the species living within the enclosures. Animal husbandry and welfare are crucial aspects to which close attention must be paid, and zoos have a responsibility to attempt to approximate the captive species’ natural habitats and life histories. An essential part of maintaining a captive zoo animal’s health and wellbeing is providing the animal with an appropriate diet. In addition to …


The Integration Of Google Maps Into American Kestrel, Falco Sparvarius, Nest Trail Programs, Dylan M. Harper May 2014

The Integration Of Google Maps Into American Kestrel, Falco Sparvarius, Nest Trail Programs, Dylan M. Harper

Undergraduate Honors Theses

American Kestrel Nest Box Programs have been established since the mid 1960’s. The population of American Kestrels (Falco sparverius) along nest box trails has decreased by 47 percent since their original implementation. There are existing technologies that can help in the location of prime kestrel habitat (open fields with conspicuous perching locations) along highways, which reduces the amount of labor in searching for new box locations. These technologies can also help increase the efficiency of monitoring and maintaining kestrel nest trail programs. This study provides an example of how Google Maps can be implemented into a kestrel trail …


Developing An In-Season Predictor Of Commercial Landings For Quota Monitoring In The U.S. Virgin Islands, Mary Janine Vara May 2014

Developing An In-Season Predictor Of Commercial Landings For Quota Monitoring In The U.S. Virgin Islands, Mary Janine Vara

USF Tampa Graduate Theses and Dissertations

The lack of timely reporting of commercial fisheries landings interferes with effective management of fisheries in United States Virgin Islands (USVI). Federal law requires that landings be limited to prevent annual catch limits (ACLs) from being exceeded. Previous attempts to predict total landings have used historic data from prior fishing seasons to predict future landings rather than leveraging available in-season data to provide a more real-time prediction of landings. This study presents an in-season model that predicts total landings using partial reports from the current fishing year. This estimate of total landings, including error bounds around that estimate, can then …


Choice And Control Of Enrichment For A Rescued And Rehabilitated Atlantic Bottlenose Dolphin (Tursiops Trunactus), Hannah Bahe May 2014

Choice And Control Of Enrichment For A Rescued And Rehabilitated Atlantic Bottlenose Dolphin (Tursiops Trunactus), Hannah Bahe

Honors Theses

Animals living under human care experience stress related to a lack of control over t environment. One way to remedy this is through the use of cognitive enrichment, su choice and control of enrichment. This type of enrichment has been shown to have benefits for animals under human care including increased activity and social interactions. To determine if choice and control was more beneficial than enrichmen alone, a three year old male Atlantic bottlenose dolphin (Tursiops truncatus) was ex to novel enrichment items in two experimental conditions. For the first condition, th animal was given a novel object. During the …


Diet Analysis Of Burbot From Eastern Lake Michigan: 1999-2012, Casey J. Hares May 2014

Diet Analysis Of Burbot From Eastern Lake Michigan: 1999-2012, Casey J. Hares

All NMU Master's Theses

The Lake Michigan fish community has undergone many changes due to introduction of non-native species, climate shifts, and management actions. Managers need to understand the time course of these alterations, including the time-frame of impact on the food web in the lake. I used a collection (1999-2012) of diet samples from burbot from eastern Lake Michigan to evaluate temporal alterations in burbot diet with particular attention to non-native vs. native forage. Catch per unit effort (burbot/net · day) decreased from a high of 5.82 burbot/net · day (± 2.19) in 2001 to a low of 0.750 burbot/net · day (± …


Effects Of Climate Change On The Potential Distribution Of 12 Endemic Lizards Of The Genus Plestiodon Of Mexico, Mayra Oyervides May 2014

Effects Of Climate Change On The Potential Distribution Of 12 Endemic Lizards Of The Genus Plestiodon Of Mexico, Mayra Oyervides

Theses and Dissertations - UTB/UTPA

Anthropogenic global climate change is a large scale threat to biodiversity. Species distribution models (SDMs) were created to assess the possible effects of climate change on the distribution of 12 Plestiodon lizards of Mexico. Species presence data was obtained from online databases, literature, and field data. Occurrences were correlated with 19 climatic variables from www.worldclim.org to model species' current suitable habitat. These models were then projected to future (2050) conditions for which bioclimatic information was downloaded from the CCAFS website. Forecasts were made using 4 General Circulatory Models, 2 IPCC scenarios, and the software MaxEnt. Models were replicated 10 times …


Snow Monkeys In South Texas, A Thirty Year Study Of Behavioral Adaptation, Lou E. Griffin May 2014

Snow Monkeys In South Texas, A Thirty Year Study Of Behavioral Adaptation, Lou E. Griffin

Theses and Dissertations - UTB/UTPA

A thirty year study of a transplanted species of primate, Macaca fuscata, Japanese snow monkey, documents the environmental influences on an intact troop relocated from Arashiyama, Japan to south Texas. These influences include novel disease, toxins, and predation. The effects of the environment on the social structure, hierarchy, and population of the primates are presented. The study begins in 1972 and is completed in 2002.


Producing An Ovine Model Of Cystic Fibrosis, Kira Perry Morgado May 2014

Producing An Ovine Model Of Cystic Fibrosis, Kira Perry Morgado

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cystic Fibrosis (CF) is an autosomal recessive disease that significantly affects quality of life and lifespan. There are currently no effective animal models of CF that mimic the human disease state. This prevents the development of pharmaceutical treatments for patients. Sheep have been considered for a useful animal model because of their size, life expectancy, and similarities in their anatomy and physiology. In order to generate a sheep transgenic model to study CF we have produced two Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene targeting DNA vectors containing large regions of homology to the CFTR gene in sheep. One of …