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Articles 181 - 210 of 472

Full-Text Articles in Animal Sciences

Putting The Pieces Together: Using Cattle To Build Soil For Crops, John Bell Jan 2018

Putting The Pieces Together: Using Cattle To Build Soil For Crops, John Bell

Forage Symposium at the Kentucky Cattlemen’s Convention

Raising livestock AND crops is an important topic to me and perhaps one of the most significant keys to the success of Elmwood Stock Farm.

In some parts of the country either you ride a horse following livestock and are called a rancher or you ride steel, grow crops and are a farmer. Not both. Fortunately, I grew up in central Kentucky where, due to topography and climate, we did some of both. Few people had enough land to run enough cattle alone to make a living. Likewise, few farms laid in a manner that allowed someone to raise only …


Building Strong Nutrient Cycles In Kentucky's Pastures, Christopher D. Teutsch Jan 2018

Building Strong Nutrient Cycles In Kentucky's Pastures, Christopher D. Teutsch

Forage Symposium at the Kentucky Cattlemen’s Convention

Well managed grassland ecosystems are one of the most sustainable forms of agricultural production. Few nutrients are removed from properly managed grazing systems. Instead these nutrients are cycled within the grazing system. In addition, proper grazing management maintains a healthy and vigorous sod that protects the soil from erosion and increases rainfall infiltration. This article will discuss how to build and maintain strong nutrient cycles in Kentucky's pastures.


The Soil Is Alive!, Mark S. Coyne Jan 2018

The Soil Is Alive!, Mark S. Coyne

Forage Symposium at the Kentucky Cattlemen’s Convention

Grab a handful of soil. . . . . What does it look like? What does it feel like? It may seem rather ordinary; but look closer. What are you holding in your hand? A mixture of minerals and air with some water and organic matter? Is that all? No. There's so much more to soil than that. For a soil scientist in general and a soil microbiologist in particular the soil is a living thing, a mixture of living and dead organisms in an organic/mineral matrix. Not every organism is identical, or as abundant, or does the same things, …


2017 Long-Term Summary Of Kentucky Forage Variety Trials, Gene L. Olson, S. Ray Smith, Christopher D. Teutsch Jan 2018

2017 Long-Term Summary Of Kentucky Forage Variety Trials, Gene L. Olson, S. Ray Smith, Christopher D. Teutsch

Forage Symposium at the Kentucky Cattlemen’s Convention

Forage crops occupy approximately 7 million acres in Kentucky. Forages provide a majority of the nutrition for beef, dairy, horse, goat, sheep, and wildlife in the state. In addition, forage crops play an environmentally friendly role in soil conservation, water quality, and air quality. There are over 60 forage species adapted to the climate and soil conditions of Kentucky. Only 10 to 12 of these species occupy the majority of the acreage, but within these species there is a tremendous variation in varieties. This publication was developed to provide a user-friendly guide to choosing the best variety for producers based …


Forages At Kca Foreword [2018], Christopher D. Teutsch, Christi L. Forsythe Jan 2018

Forages At Kca Foreword [2018], Christopher D. Teutsch, Christi L. Forsythe

Forage Symposium at the Kentucky Cattlemen’s Convention

No abstract provided.


Conservation Limnogeology And Benthic Habitat Mapping In Central Lake Tanganyika (Tanzania), Joseph S. Lucas Jan 2018

Conservation Limnogeology And Benthic Habitat Mapping In Central Lake Tanganyika (Tanzania), Joseph S. Lucas

Theses and Dissertations--Earth and Environmental Sciences

Small scale protected zones are valuable for helping the health and productivity of fisheries at Lake Tanganyika (East Africa). Spatial placement of protected areas relies on accurate maps of benthic habitats, consisting of detailed bathymetry data and information on lake-floor substrates. This information is unknown for most of Lake Tanganyika. Fish diversity is known to correlate with rocky substrates in ≤ 30 m water depth, which provide spawning grounds for littoral and pelagic species. These benthic habitats form important targets for protected areas, if they can be precisely located.

At the NMVA, echosounding defined the position of the 30-m isobath …


The Impact Of Insulin Dysregulation On Protein Metabolism In Horses, Caroline Margot Marcelle Loos Jan 2018

The Impact Of Insulin Dysregulation On Protein Metabolism In Horses, Caroline Margot Marcelle Loos

Theses and Dissertations--Animal and Food Sciences

Insulin plays a vital role in whole-body metabolism and provides a major anabolic stimulus for cellular signaling pathways, including those involved in the metabolism of glucose and protein. Consequently, insulin dysregulation (ID) is known to alter molecular signal transduction in insulin-sensitive tissues such as skeletal muscle, thereby disrupting glucose metabolism and compromising protein synthetic capacity. Our first objective was to induce ID in healthy horses by administering dexamethasone (DEX), a potent glucocorticoid, for 21 days. We evaluated the effects on insulin-stimulated muscle protein signaling components involved in the mammalian target of rapamycin (mTOR) pathway. DEX-induced ID reduced insulin-stimulated activation of …


Factors Influencing Phosphorus Excretion By Horses, Ashley Lauren Fowler Jan 2018

Factors Influencing Phosphorus Excretion By Horses, Ashley Lauren Fowler

Theses and Dissertations--Animal and Food Sciences

Excessive phosphorus (P) excreted by animals can affect water quality and cause eutrophication. Better understanding of factors that influence P utilization and excretion in horses may reduce the environmental impact of P. Two animal experiments were conducted that examined P excretion by horses. The efficacy of titanium dioxide as an external marker to calculate digestibility was studied concurrently with both animal experiments. Additionally, pasture P concentrations were evaluated over the growing season using near-infrared spectroscopy (NIRS). Experiment 1 examined P excretion by post-lactational mares fed a low P diet immediately prior to weaning compared to non-lactating controls fed an adequate …


On-Farm Utilization Of Precision Dairy Monitoring: Usefulness, Accuracy, And Affordability, Elizabeth A. Eckelkamp Jan 2018

On-Farm Utilization Of Precision Dairy Monitoring: Usefulness, Accuracy, And Affordability, Elizabeth A. Eckelkamp

Theses and Dissertations--Animal and Food Sciences

Precision dairy monitoring is used to supplement or replace human observation of dairy cattle. This study examined the value dairy producers placed on disease alerts generated from a precision dairy monitoring technology. A secondary objective was calculating the accuracy of technology-generated disease alerts compared against observed disease events. A final objective was determining the economic viability of investing in a precision dairy monitoring technology for detecting estrus and diseases.

A year-long observational study was conducted on four Kentucky dairy farms. All lactating dairy cows were equipped with a neck and leg tri-axial accelerometer. Technologies measured eating time, lying time, standing …


Dairy Cattle Hoof Disease Costs And Considerations For Prevention, Karmella A. Dolecheck Jan 2018

Dairy Cattle Hoof Disease Costs And Considerations For Prevention, Karmella A. Dolecheck

Theses and Dissertations--Animal and Food Sciences

Lameness is considered one of the most important health and welfare issues in the dairy industry. Understanding the total cost per case of disease-specific lameness can help producers select better treatment, prevention, and control strategies for their herds. The first objective of our research was to calculate the costs associated with 3 lameness causing hoof diseases: digital dermatitis, sole ulcer, and white line disease. To accomplish this, a survey of hoof health professionals (hoof trimmers and veterinarians) was conducted to identify treatment related expenditures per case. Data from the hoof trimmer responses to the survey and previously published research were …


An Evaluation Of Physiological And Behavioral Indicators Of Postpartum Diseases And Heat Stress In Dairy Cows, Amanda Renee Lee Jan 2018

An Evaluation Of Physiological And Behavioral Indicators Of Postpartum Diseases And Heat Stress In Dairy Cows, Amanda Renee Lee

Theses and Dissertations--Animal and Food Sciences

Precision dairy monitoring technologies can be used to monitor changes in physiology and behavior associated with transition period postpartum diseases and heat stress. Research Objective One was to evaluate how traditional visual examination, body condition, and locomotion with and without blood, milk, and urine variables and precision dairy monitoring technologies determine variable association with hyperketonemia, metritis, mastitis, hypocalcemia and retained placenta,. This was accomplished by monitoring cows 2 weeks before calving to 3 weeks after calving for any postpartum diseases using daily visual examination and automatically detected variables including activity, milk yield, milk components, lying behavior, feeding behavior, rumination time, …


The Effects Of Housing On Dairy Cow Comfort, Immune Function, Stress, Productivity, And Milk Quality, Matthew Richard Borchers Jan 2018

The Effects Of Housing On Dairy Cow Comfort, Immune Function, Stress, Productivity, And Milk Quality, Matthew Richard Borchers

Theses and Dissertations--Animal and Food Sciences

Mastitis and milk quality affect every dairy farmer across the globe. Sand bedded freestalls are the industry standard for cow comfort, welfare, and the control of environmental mastitis. Compost bedded packs may be a viable alternative to the sand bedded freestall.

Compost bedded packs are maintained at a consistent level of moisture, nutrients, and aeration to favor compost microorganisms. Greater bacteria counts in bedding have traditionally been associated with increased mastitis rates and mastitis pathogens can be found in the pack and on the teats of cattle housed in even well managed compost bedded pack barns. In spite of this, …


Assessment Of The Serum Amyloid A Assay For Diagnosing Disease In Neonatal Foals, Samantha W. Strouss Jan 2018

Assessment Of The Serum Amyloid A Assay For Diagnosing Disease In Neonatal Foals, Samantha W. Strouss

Theses and Dissertations--Animal and Food Sciences

Diagnosing disease in equine neonates poses a challenge for the equine industry because of the nonspecific manifestations of many diseases and the rapid deterioration that occurs. The differential diagnostic procedure requires many laboratory tests, whose results take days to receive. Serum amyloid A (SAA) is the only major acute phase protein identified in the horse; it exists in low levels in the healthy horse and increases over 100 fold in response to inflammatory stimulus 6-8 hours post stimulus. A point of care test allows veterinarians to obtain a SAA concentration within minutes that indicates the existence of infection. Being able …


Whole-Body Protein Metabolism In Mature And Growing Horses Receiving Predominantly Forage Diets, Sophie A. Stratton Jan 2018

Whole-Body Protein Metabolism In Mature And Growing Horses Receiving Predominantly Forage Diets, Sophie A. Stratton

Theses and Dissertations--Animal and Food Sciences

There has been limited investigation as to whether a predominantly forage-based diet can provide adequate amounts of limiting amino acids (AA) to horses. The first objective was to determine if AA supplementation of AA believed to be limiting to protein synthesis in forage-based diets would affect measures of whole-body protein metabolism in sedentary mature horses. The effect of forage type (timothy or alfalfa) and AA supplementation (lysine, threonine or histidine) on plasma urea nitrogen (PUN) and AA concentrations and measures of whole-body phenylalanine kinetics were evaluated. There was no effect of either forage type or AA supplement on rates of …


Influence Of Dietary Ractopamine And Supranutritional Supplementation Of Vitamin E On Proteome Profile Of Postmortem Beef Longissimus Lumborum Muscle, Hyun Mok Kim Jan 2018

Influence Of Dietary Ractopamine And Supranutritional Supplementation Of Vitamin E On Proteome Profile Of Postmortem Beef Longissimus Lumborum Muscle, Hyun Mok Kim

Theses and Dissertations--Animal and Food Sciences

The effects of dietary ingredients on the proteome profile of postmortem beef longissimus lumborum (LL) muscle were evaluated. In the first experiment, the influence of dietary ractopamine on the whole-muscle proteome of beef LL was examined. Five proteins were differentially abundant between ractopamine-fed (RAC) and non-ractopamine fed (CON) groups. The differentially abundant proteins were over-abundant in RAC and were related to muscle structure development (F-actin-capping protein subunit beta-2 and PDZ and LIM domain protein-3), chaperone (heat shock protein beta-1), oxygen transportation (myoglobin), and glycolysis (L-lactate dehydrogenase A chain). These findings indicated that ractopamine influences the abundance of proteins associated with …


Comparing Dairy Farm Performance And Heat Stress Abatment Strategies In The United States Using Summer To Winter Ratios, Jenna M. Guinn Jan 2018

Comparing Dairy Farm Performance And Heat Stress Abatment Strategies In The United States Using Summer To Winter Ratios, Jenna M. Guinn

Theses and Dissertations--Animal and Food Sciences

Heat stress abatement is a challenge for producers in the United States, especially in the southern states. Dairy producers could benefit by having a simply metric to measure heat stress abatement strategies with the goal of motivating improvement in heat stress management. Managing heat stress is key to ameliorating the effects on dairy cow performance. A study was performed to explore the use of a heat stress metric called the Summer to Winter performance ratio (S:W ratio), to quantify and compare farm performance variables among regions of the United States. Summer to Winter ratios were closest to 1.0 in the …


Long-Term Effects Of Dietary Copper Source And Level On Performance And Health Of Sows And Piglets, Ning Lu Jan 2018

Long-Term Effects Of Dietary Copper Source And Level On Performance And Health Of Sows And Piglets, Ning Lu

Theses and Dissertations--Animal and Food Sciences

The objectives of this study were to investigate the long-term effects of feeding increasing supplemental levels (20, 120, or 220 mg/kg) of dietary copper (Cu) as tribasic copper chloride (TBCC) or copper sulfate (CuSO4) on performance, antioxidant status, nutrient digestibility, and trace mineral deposition of sows and piglets; as well as to assess nursery dietary Cu levels on growth performance and response to immunological challenge in nursery pigs from sows fed either high or low Cu diets. In the long-term sow experiment, sows fed TBCC diets had greater adjusted weaning weight for litter and piglet (P < 0.10), as well as adjusted litter and piglet weight gain (P …


Applications In Utilization Of Forage Chemical Composition And Predicting Equine Digestibility, Veronica Taylor Bill Jan 2018

Applications In Utilization Of Forage Chemical Composition And Predicting Equine Digestibility, Veronica Taylor Bill

Theses and Dissertations--Animal and Food Sciences

Most forage quality models were developed for ruminant nutrition, and may not apply to the horse. This two-part study evaluated the relationship between forage chemical composition and dry matter digestibility (DMD) using an in vitro method with equine feces as the inoculums. The first experiment determined that compared to 48 h of incubation, 72 h of incubation resulted in higher DMD for some forages. As a result of experiment 1, incubations in experiment 2 were conducted using 48 and 72 h incubation periods at 38 degrees C. The second experiment evaluated the effect of chemical composition on DMD. Thirty-one hay …


Effect Of Exogenous Enzymes On Apparent Metabolizable Energy Value Of Barley In Swine And Broiler Chickens, Brian L. Bryson Jan 2018

Effect Of Exogenous Enzymes On Apparent Metabolizable Energy Value Of Barley In Swine And Broiler Chickens, Brian L. Bryson

Theses and Dissertations--Animal and Food Sciences

The objective of this thesis was to evaluate the effect of exogenous enzyme supplementation, phytase and xylanase-glucanase, on AME value of barley in poultry and swine. In the first study, 280 broilers were assigned 1 of 8 treatments. Barley inclusion in the diet resulted in decreased (P < 0.05) performance. There was a treatment × phytase × xylanase-glucanase interaction for dry matter retention with birds fed the corn-SBM-barley diet supplemented with phytase and xylanase-glucanase having higher (P < 0.05) DM retention compared to birds fed corn-SBM-based diet with only xylanase-glucanase supplementation. AME and AMEn of corn-SBM-based diets were greater (P < 0.05) than the corn-SBM-barley-based diets. Energy metabolizability and AMEn of barley significantly increased with xylanase-glucanase supplementation. In the second study, 24 pigs (12 pigs/phase) were assigned to 1 of 4 treatments with xylanase-glucanase and phytase. After a 7-d adaption period, urine and feces were quantitatively collected for 5 d. DE of the barley-based diet supplemented with xylanase-glucanase (3,578 kcal/kg) and phytase and xylanase-glucanase in combination (3,617 kcal/kg) were significantly different. Compared to control diets, exogenous enzymes either significantly improved or had a tendency to improve AME and AMEn value of barley in broilers, but not in growing pigs.


Characterization And Evaluation Of Androgen-Binding Protein, Sex Hormone-Binding Globulin, And Thyroxine-Binding Globulin In The Horse, Blaire O'Neil Fleming Jan 2018

Characterization And Evaluation Of Androgen-Binding Protein, Sex Hormone-Binding Globulin, And Thyroxine-Binding Globulin In The Horse, Blaire O'Neil Fleming

Theses and Dissertations--Veterinary Science

The objectives of this study are to characterize two carrier proteins in the horse that significantly decrease in humans following anabolic androgenic steroid administration: sex hormone-binding globulin (SHBG) and thyroxine-binding globulin (TBG). For SHBG characterization, qPCR, RNA sequencing, and immunohistochemistry were performed on testes and equine livers. Free and total testosterone immunoassays were utilized to confirm the presence of a carrier protein in equine circulation. SHBG was detected in the testes using qPCR, RNA sequencing, and IHC, indicating the presence of the isoform androgen-binding protein (ABP). SHBG was not detected in any liver samples. Evidence of a carrier protein was …


Effects Of Endophyte-Infected Tall Fescue Seed And Bromocriptine On Endocrine And Immune Function In Horses, Jessica Marie Hanneman Jan 2018

Effects Of Endophyte-Infected Tall Fescue Seed And Bromocriptine On Endocrine And Immune Function In Horses, Jessica Marie Hanneman

Theses and Dissertations--Veterinary Science

Consumption of endophyte-infected (E+) grasses has long been associated with health problems in animals. In cattle E+ tall fescue consumption leads to fescue toxicosis, and in horses it leads reproductive problems. The health-related issues associated with endophyte consumption have been attributed to the effects caused by the ergot alkaloids produced by the fungus. These ergot alkaloids are considered D2-like receptor agonists, and 5-HT2 serotonin and α-adrenergic receptor partial agonists. Many studies in humans, swine, cattle, and horses have identified that ergopeptines cause a decrease in prolactin production due to their dopaminergic activities. Additionally, these molecules have been found to cause …


Diet Composition Explains Reductions In Stream Salamander Occupancy And Abundance Along A Conductivity Gradient, Jacob Matthew Hutton Jan 2018

Diet Composition Explains Reductions In Stream Salamander Occupancy And Abundance Along A Conductivity Gradient, Jacob Matthew Hutton

Theses and Dissertations--Forestry and Natural Resources

Changes in land use such as mountaintop removal mining with valley fills (MTR/VF) affect chemical, physical, and hydrological properties of headwater streams. Although numerous stream taxa have experienced significant declines from MTR/VF, stream salamanders appear to be particularly sensitive. Yet, the specific mechanism(s) responsible for the population declines has eluded researchers. We sampled salamander assemblages across a continuous specific conductivity (SC) gradient in southeastern Kentucky and estimated occupancy rates and abundance estimates along this gradient. We also examined the diet of larval and adult salamanders to determine if autochthony (A/T prey), total prey volume, and body condition is influenced by …


Diet And Space Use Of The Martial Eagle (Polemaetus Bellicosus) In The Maasai Mara Region Of Kenya, Richard Stratton Hatfield Jan 2018

Diet And Space Use Of The Martial Eagle (Polemaetus Bellicosus) In The Maasai Mara Region Of Kenya, Richard Stratton Hatfield

Theses and Dissertations--Forestry and Natural Resources

The martial eagle (Polemaetus bellicosus) is a vulnerable species that is declining throughout large portions of its range. There is an urgent need to improve understanding of this species’ ecology to inform its conservation. I equipped 20 adult martial eagles with global positioning system backpack transmitters to characterize diet and space use of the species in the Maasai Mara region of Kenya. The resulting high-resolution transmitter data sets allowed for the rapid location of kills and provided a means to estimate home range size. From November 2016 to April 2018, 191 kills were identified from 206 kill location …


The Effect Of Early Life Photoperiod Manipulation On Cocaine-Induced Behavioral Sensitization In Male And Female Japanese Quail, Shannon Elizabeth Eaton Jan 2018

The Effect Of Early Life Photoperiod Manipulation On Cocaine-Induced Behavioral Sensitization In Male And Female Japanese Quail, Shannon Elizabeth Eaton

Theses and Dissertations--Psychology

Estrogens seem to play a role in the locomotor activating effects of cocaine. Japanese quail provide a good model for hormonal manipulation as alterations of their photoperiod controls hormone levels. The current study aims to examine the role of early life photoperiod manipulation in cocaine-induced behavioral sensitization in quail. It was expected that if quail were raised on a short photoperiod, they would have a reduction in gonadal hormones and this reduction in hormones would affect the acquisition of cocaine-induced behavioral sensitization. Quail were raised on an 8L:16D or a 16L:8D light cycle. Following 2 days of habituation, quail were …


Inhibition Of Growth And Ammonia Production Of Ruminal Hyper Ammonia-Producing Bacteria By Chinook Or Galena Hops After Long-Term Storage, Michael D. Flythe, Brittany E. Harlow, Glen E. Aiken, Gloria L. Gellin, Isabelle A. Kagan, Jesse Pappas Dec 2017

Inhibition Of Growth And Ammonia Production Of Ruminal Hyper Ammonia-Producing Bacteria By Chinook Or Galena Hops After Long-Term Storage, Michael D. Flythe, Brittany E. Harlow, Glen E. Aiken, Gloria L. Gellin, Isabelle A. Kagan, Jesse Pappas

Animal and Food Sciences Faculty Publications

Surplus hops (Humulus lupulus L.) that are not needed by the brewing industry could be used as a feed supplement for cattle and other ruminants. Previous research indicates that antimicrobial hops plant secondary metabolites (i.e., α- and β-acids) inhibit methane and ammonia production and promote the growth of ruminant animals. The goal was to determine that hop pellets produced for brewing still possessed the requisite antimicrobial activity after 5-year storage. HPLC (high performance liquid chromatography) analysis indicated that the α- and β-acid concentrations in two varieties of hops were relatively stable after 5 years of storage under N2 …


Integrating Herbivore Population Dynamics Into A Global Land Biosphere Model: Plugging Animals Into The Earth System, Shree R. S. Dangal, Hanqin Tian, Chaoqun Lu, Wei Ren, Shufen Pan, Jia Yang, Nicola Di Cosmo, Amy Hessl Dec 2017

Integrating Herbivore Population Dynamics Into A Global Land Biosphere Model: Plugging Animals Into The Earth System, Shree R. S. Dangal, Hanqin Tian, Chaoqun Lu, Wei Ren, Shufen Pan, Jia Yang, Nicola Di Cosmo, Amy Hessl

Plant and Soil Sciences Faculty Publications

Mammalian herbivores are an essential component of grassland and savanna ecosystems, and with feedbacks to the climate system. To date, the response and feedbacks of mammalian herbivores to changes in both abiotic and biotic factors are poorly quantified and not adequately represented in the current global land surface modeling framework. In this study, we coupled herbivore population dynamics in a global land model (the Dynamic Land Ecosystem Model, DLEM 3.0) to simulate populations of horses, cattle, sheep, and goats, and their responses to changes in multiple environmental factors at the site level across different continents during 1980–2010. Simulated results show …


Pituitary Genomic Expression Profiles Of Steers Are Altered By Grazing Of High Vs. Low Endophyte-Infected Tall Fescue Forages, Qing Li, Raquel Hegge, Phillip J. Bridges, James C. Matthews Sep 2017

Pituitary Genomic Expression Profiles Of Steers Are Altered By Grazing Of High Vs. Low Endophyte-Infected Tall Fescue Forages, Qing Li, Raquel Hegge, Phillip J. Bridges, James C. Matthews

Animal and Food Sciences Faculty Publications

Consumption of ergot alkaloid-containing tall fescue grass impairs several metabolic, vascular, growth, and reproductive processes in cattle, collectively producing a clinical condition known as “fescue toxicosis.” Despite the apparent association between pituitary function and these physiological parameters, including depressed serum prolactin; no reports describe the effect of fescue toxicosis on pituitary genomic expression profiles. To identify candidate regulatory mechanisms, we compared the global and selected targeted mRNA expression patterns of pituitaries collected from beef steers that had been randomly assigned to undergo summer-long grazing (89 to 105 d) of a high-toxic endophyte-infected tall fescue pasture (HE; 0.746 μg/g ergot alkaloids; …


Preventing Horse-Related Injuries By Watching Out For Other Humans, William R. Gombeski Jr., Fernanda C. Camargo, Holly Wiemers, Connie Jehlik, Polly Haselton Barger, James Mead Sep 2017

Preventing Horse-Related Injuries By Watching Out For Other Humans, William R. Gombeski Jr., Fernanda C. Camargo, Holly Wiemers, Connie Jehlik, Polly Haselton Barger, James Mead

Animal and Food Sciences Faculty Publications

The more one rides or handles horses, the more likely one is to have a horse-related injury. These injuries are caused by many factors, including those generated by other riders, handlers or spectators. An analysis of 266 cases of injured equestrians showed that 16% of those injuries were caused by other humans. A panel of horse riding safety experts felt 63% were preventable, and the injured individuals themselves felt 51% were preventable. The study findings suggest that increased awareness of the role others play in causing horse-related injuries and increased education about common people-caused injuries could reduce the number of …


Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review, Wesley C. Van Voorhis, J. Stone Doggett, Marilyn Parsons, Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold, Michael W. Riggs, Andrew Hemphill, Daniel K. Howe, Robert H. Mealey, Audrey O. T. Lau, Ethan A. Merritt, Dustin J. Maly, Erkang Fan, Kayode K. Ojo Sep 2017

Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review, Wesley C. Van Voorhis, J. Stone Doggett, Marilyn Parsons, Matthew A. Hulverson, Ryan Choi, Samuel L. M. Arnold, Michael W. Riggs, Andrew Hemphill, Daniel K. Howe, Robert H. Mealey, Audrey O. T. Lau, Ethan A. Merritt, Dustin J. Maly, Erkang Fan, Kayode K. Ojo

Veterinary Science Faculty Publications

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites’ survival and proliferation. In this review, we review efficacy against the kinase target, the parasite growth in vitro, and in animal infection models, as well …


Hops (Humulus Lupulus L.) Bitter Acids: Modulation Of Rumen Fermentation And Potential As An Alternative Growth Promoter, Michael D. Flythe, Isabelle A. Kagan, Yuxi Wang, Nelmy Narvaez Aug 2017

Hops (Humulus Lupulus L.) Bitter Acids: Modulation Of Rumen Fermentation And Potential As An Alternative Growth Promoter, Michael D. Flythe, Isabelle A. Kagan, Yuxi Wang, Nelmy Narvaez

Animal and Food Sciences Faculty Publications

Antibiotics can improve ruminant growth and efficiency by altering rumen fermentation via selective inhibition of microorganisms. However, antibiotic use is increasingly restricted due to concerns about the spread of antibiotic-resistance. Plant-based antimicrobials are alternatives to antibiotics in animal production. The hops plant (Humulus lupulus L.) produces a range of bioactive secondary metabolites, including antimicrobial prenylated phloroglucinols, which are commonly called alpha- and beta-acids. These latter compounds can be considered phyto-ionophores, phytochemicals with a similar antimicrobial mechanism of action to ionophore antibiotics (e.g., monensin, lasalocid). Like ionophores, the hop beta-acids inhibit rumen bacteria possessing a classical Gram-positive cell envelope. This …