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Other Immunology and Infectious Disease

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Full-Text Articles in Animal Sciences

Comparison Of The Humoral Immune Response Following Both Bacterial Challenge And Rnai Of Major Factors On Proliferation Of Bartonella Quintana In The Human Louse, Jake Zina Oct 2022

Comparison Of The Humoral Immune Response Following Both Bacterial Challenge And Rnai Of Major Factors On Proliferation Of Bartonella Quintana In The Human Louse, Jake Zina

Masters Theses

Human body lice, Pediculus humanus humanus, and head lice, Pediculus humanus capitis, have been hematophagous ectoparasites of humans for thousands of years. Despite being ecotypes, only body lice are known to transmit bacterial diseases to humans, and it appears that lower humoral and cellular immune responses allow body lice to possess a higher vector competence. We previously observed that the transcription level of the defensin 1 gene was up-regulated only in head lice following oral challenge of Bartonella quintana, a causative agent of trench fever, and also that body lice excreted more viable B. quintana in their …


The Effect Of Infection Risk On Female Blood Transcriptomics, Brenna M. G. Gormally, Patricia C. Lopes Oct 2022

The Effect Of Infection Risk On Female Blood Transcriptomics, Brenna M. G. Gormally, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Defenses against pathogens can take on many forms. For instance, behavioral avoidance of diseased conspecifics is widely documented. Interactions with these infectious conspecifics can also, however, lead to physiological changes in uninfected animals, an effect that is much less well understood. These changes in behavior and physiology are particularly important to study in a reproductive context, where they can impact reproductive decisions and offspring quality. Here, we studied how an acute (3 h) exposure to an immune-challenged male affected female blood transcriptomics and behavior. We predicted that females paired with immune-challenged males would reduce eating and drinking behaviors (as avoidance …


Maternal Responses In The Face Of Infection Risk, Patricia C. Lopes, Brenna M. G. Gormally, Aubrey Emmi, Delilah Schuerman, Chathuni Liyanage, Ursula K. Beattie, L. Michael Romero Jun 2022

Maternal Responses In The Face Of Infection Risk, Patricia C. Lopes, Brenna M. G. Gormally, Aubrey Emmi, Delilah Schuerman, Chathuni Liyanage, Ursula K. Beattie, L. Michael Romero

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When animals are sick, their physiology and behavior change in ways that can impact their offspring. Research is emerging showing that infection risk alone can also modify the physiology and behavior of healthy animals. If physiological responses to environments with high infection risk take place during reproduction, it is possible that they lead to maternal effects. Understanding whether and how high infection risk triggers maternal effects is important to elucidate how the impacts of infectious agents extend beyond infected individuals and how, in this way, they are even stronger evolutionary forces than already considered. Here, to evaluate the effects of …


Female Presence Does Not Increase Testosterone But Still Ameliorates Sickness Behaviours In Male Japanese Quail, Brenna M. G. Gormally, Kaelyn Bridgette, Aubrey Emmi, Delilah Schuerman, Patricia C. Lopes May 2022

Female Presence Does Not Increase Testosterone But Still Ameliorates Sickness Behaviours In Male Japanese Quail, Brenna M. G. Gormally, Kaelyn Bridgette, Aubrey Emmi, Delilah Schuerman, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Infections can dramatically modify animal behaviour. The extent of these changes depends on an animal's environment. It has been proposed that testosterone modulates the suppression of behavioural symptoms of sickness under certain reproductive contexts. To further understand the role played by testosterone in modulating sickness behaviours under reproductive contexts, we studied a species, the Japanese quail, in which female exposure rapidly decreases circulating testosterone in males. Males received either an immune challenge (lipopolysaccharide – LPS) or a control injection and their behaviours, mass change and testosterone levels were quantified in the presence or absence of a female. Both the presence …


Microplastics Exposure In At-Risk Myotis Lucifugus Bats Of The Northeastern United States, Leah Crowley May 2022

Microplastics Exposure In At-Risk Myotis Lucifugus Bats Of The Northeastern United States, Leah Crowley

Chancellor’s Honors Program Projects

No abstract provided.


Genomic Analysis Of Metabolic Differences Found In Clostridium Perfringens That Cause Necrotic Enteritis In Poultry, Connor Aylor Apr 2022

Genomic Analysis Of Metabolic Differences Found In Clostridium Perfringens That Cause Necrotic Enteritis In Poultry, Connor Aylor

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Clostridium perfringens is a common member of gut microbiota in healthy animals, but can also be an important pathogen in human and veterinary medicine. It produces several protein toxins that contribute to both histotoxic and enteric diseases in animals. Necrotic enteritis in poultry has been associated with the NetB toxin of C. perfringens; however, this toxin alone is insufficient to cause disease in infected chickens. While considerable research has focused on the presence of toxins and virulence factors, little has been done to assess the function of metabolic factors on the ability of the bacteria to cause disease. In …


Wc1 And Tcr Interactions For Γδ T Cell Activation, Alexandria Gillespie Mar 2022

Wc1 And Tcr Interactions For Γδ T Cell Activation, Alexandria Gillespie

Doctoral Dissertations

Major subpopulations of gamma delta T cells within ruminant and pigs are defined by expression of WC1, a hybrid pattern recognition receptor/co-receptor to the T cell receptor (TCR). It is known that when WC1 is knocked down cells fail to respond. Showing that WC1 plays an active role in the stimulation of bovine gamma delta T cells. Here we explored the spatio-temporal dynamics of WC1 and TCR interaction using imaging flow cytometry and stochastic optical reconstruction microscopy. We found that in quiescent gamma delta T cells both WC1 and TCR existed in separate protein domains (protein islands) but after activation …


Escherichia Coli And Salmonella Sp. In Domestic Cattle And Wild Roosevelt Elk: Fecal Pathogens At The Wildlife-Domestic Interface, Emily A. Buck Jan 2022

Escherichia Coli And Salmonella Sp. In Domestic Cattle And Wild Roosevelt Elk: Fecal Pathogens At The Wildlife-Domestic Interface, Emily A. Buck

Cal Poly Humboldt theses and projects

Direct or indirect contact between domestic populations of animals and wildlife carries an inherent risk for transmission of pathogens that cause infectious disease. In Humboldt and Del Norte counties of northern California, ongoing conflict between ranchers and Roosevelt elk groups results from elk use of ranching pastures and pastures on private land. Fecal samples from elk in association with cattle, cattle, and from elk not in known association with cattle were assessed for the presence of bacteria Salmonella enterica and pathogenic Escherichia coli to assess whether association with cattle increases risk of infection for elk. Group identity (one of the …


Prevalence Of Snake Fungal Disease Caused By Ophidiomyces Ophiodiicola In East Texas, Alan Lizarraga Dec 2020

Prevalence Of Snake Fungal Disease Caused By Ophidiomyces Ophiodiicola In East Texas, Alan Lizarraga

Biology Theses

Fungal pathogens and resultant disease are credited with the decline of many species across all branches of the tree of life. Fungal diseases such as Snake Fungal Disease (SFD), primarily caused by the fungus Ophidiomyces ophiodiicola (Oo), have been strongly associated with the cause of the decrease/disappearance of many snake populations in North America. To date SFD in the wild has been described as far southwest as central Louisiana. Due to similar conditions and the proximity of East Texas to central Louisiana, a survey of local snake populations provided crucial information about the spread and presence of this emerging pathogen. …


White-Nose Syndrome And Immune Responses In A Resistant Bat Species (Eptesicus Fuscus), Keslie Skye Naffa Jan 2019

White-Nose Syndrome And Immune Responses In A Resistant Bat Species (Eptesicus Fuscus), Keslie Skye Naffa

MSU Graduate Theses

White-nose syndrome (WNS) has had a large negative impact on bat populations across eastern North America since its arrival in 2006. Bats affected by WNS appear to die of starvation, possibly due to the increased arousals during hibernation when there is no food present to replace the energy used to arouse. During hibernation, the bat’s immune system should be suppressed. However, once a bat of a susceptible species is exposed to the fungus that causes WNS, Psuedogymnoascus destructans (Pd), the immune system seems to respond, potentially causing an elevation in metabolic rate, which may cause the bat to …


Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy Jun 2016

Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Plants, Prions And Possibilities: Current Understanding And Significance Of Prion Uptake Into Plants, Tracy A. Nichols May 2016

Plants, Prions And Possibilities: Current Understanding And Significance Of Prion Uptake Into Plants, Tracy A. Nichols

USDA Wildlife Services: Staff Publications

Chronic wasting disease (CWD) is an infectious, neurodegenerative disease of deer (white-tailed and mule), elk, moose, sika deer and muntjac caused by a misfolded version of a normally occurring protein. The notion that CWD could be spread indirectly via the environment has been documented and accepted in the scientific community for quite some time. Deer and elk consume soil, inhale dust and lick objects that have infectious material on them, resulting in chronic, low dose exposure. Surface contamination of plants with urine or feces is likely an additional source of exposure via ingestion and has been modeled in the laboratory …


A Novel Population Of Natural Killer Cells Plays A Critical Role In The Depletion Of Splenic B2 B Cells During Experimental African Trypanosomiasis, Deborah Frenkel Mar 2015

A Novel Population Of Natural Killer Cells Plays A Critical Role In The Depletion Of Splenic B2 B Cells During Experimental African Trypanosomiasis, Deborah Frenkel

Doctoral Dissertations

Loss of humoral immune competence in T. brucei-infected mice is associated with the apoptotic depletion of splenic transitional, marginal zone and follicular B cells as well as a depletion of CD8+ T cells. This occurs rapidly after infection and impairs responses to vaccine antigens in addition to responses to newly arising VSG antigenic variants, leading to uncontrolled parasite growth and death of the infected mice. Infection-induced B2 B cell and CD8+ T cell loss requires the presence of a novel population of natural killer (NK) cells and is mediated by a perforin-dependent process consistent with perforin- and …


The Effects That Liquid And Solid Cattle Manure Have On The Water Quality Of Drainage Ditches In Putnam County, Ohio, Janelle Horstman Jan 2014

The Effects That Liquid And Solid Cattle Manure Have On The Water Quality Of Drainage Ditches In Putnam County, Ohio, Janelle Horstman

Honors Projects

Lake Erie has experienced harmful algal blooms with increased frequency since the mid-1990s due to excess nutrients from Rivers, such as the Maumee River, and largely agricultural watersheds. Nonpoint source pollution from agriculture contributes to eutrophication, algal blooms, and the degradation of water quality. This creates stress on aquatic fauna, reduced aesthetic quality, odor, and limits of the water for usage of drinking, recreation, and industry. This research paper asks what the contributions of having access to manure application records, soil records, and information about antibiotics have on what is known about manure management and antibiotic resistance, which has been …


Equine Serum Antibody Responses To Streptococcus Equi And Streptococcus Zooepidemicus, Rafaela De Negri Jan 2013

Equine Serum Antibody Responses To Streptococcus Equi And Streptococcus Zooepidemicus, Rafaela De Negri

Theses and Dissertations--Veterinary Science

Streptococcus zooepidemicus (Sz) and Streptococcus equi (Se) share 98% DNA sequence homology, but display different pathogenic properties. Infection by one organism does not cross-protect against the other. To better understand pathogenic differences between these organisms and gain information about which proteins are expressed in horses infected experimentally with Se, intrauterine Sz or naturally with respiratory Sz we compared antibody specificities of convalescent sera using ELISA. These comparisons were based on sets of 8 and 14 immunoreactive recombinant proteins of Se strain CF32 and Sz strain NC78, respectively. Sera from donkeys that were previously naturally affected with strangles and later developed …


Molecular Surveillance Of Low Pathogenic Avianinfluenza Viruses In Wild Birds Across The United States:Inferences From The Hemagglutinin Gene, Antoinette J. Piaggio, Susan A. Shriner, Kaci Van Dalen, Alan B. Franklin, Theodore D. Anderson, Sergios-Orestis Kolokotronis Dec 2012

Molecular Surveillance Of Low Pathogenic Avianinfluenza Viruses In Wild Birds Across The United States:Inferences From The Hemagglutinin Gene, Antoinette J. Piaggio, Susan A. Shriner, Kaci Van Dalen, Alan B. Franklin, Theodore D. Anderson, Sergios-Orestis Kolokotronis

Alan B Franklin

A United States interagency avian influenza surveillance plan was initiated in 2006 for early detection of highly pathogenic avian influenza viruses (HPAIV) in wild birds. The plan included a variety of wild bird sampling strategies including the testing of fecal samples from aquatic areas throughout the United States from April 2006 through December 2007. Although HPAIV was not detected through this surveillance effort we were able to obtain 759 fecal samples that were positive for low pathogenic avian influenza virus (LPAIV). We used 136 DNA sequences obtained from these samples along with samples from a public influenza sequence database for …


Clam (Corbicula Fluminea) As A Potential Sentinel Of Human Norovirus Contamination In Freshwater, Xunyan Ye May 2012

Clam (Corbicula Fluminea) As A Potential Sentinel Of Human Norovirus Contamination In Freshwater, Xunyan Ye

Dissertations

The purpose of this study was to evaluate and validate the use of the clam Corbicula fluminea as a sentinel of human noroviruses (HuNoV) contamination in freshwater. The first specific aim was to develop a new method to extract HuNoV RNA from contaminated bivalves (e.g. oysters, clams) that would be much faster than existing methods. The procedure developed includes an initial total RNA extraction using TRI Reagent, followed by HuNoV RNA concentration and purification using biotinylated probe-capture technology. HuNoV RNA is finally detected by real-time RT-PCR. Using bivalve homogenates spiked with HuNoV, 100 PCR detection units of the virus was …


Status Of The Major Oyster Diseases In Virginia 2006-2008 A Summary Of The Annual Oyster Disease Monitoring Program, Ryan Carnegie, Eugene M. Burreson Dec 2009

Status Of The Major Oyster Diseases In Virginia 2006-2008 A Summary Of The Annual Oyster Disease Monitoring Program, Ryan Carnegie, Eugene M. Burreson

Reports

Fall Survey sampling revealed P. marinus levels to be generally normal to high in Virginia tributaries. By 2007 P. marinus was present on every oyster reef sampled, and by the end of the 2006-2008 period the parasite was probably causing some mortality throughout Virginia waters. Data for H. nelsoni are still incomplete for 2006/7 because of funding limitations, but in 2008 H. nelsoni was observed at 17 of 31 sampled reefs, a marked expansion in distribution since 2003/4. A significant MSX disease outbreak occurred in the Great Wicomico River in 2008, as a mild winter and a long period of …


Status Of The Major Oyster Diseases In Virginia 2005 A Summary Of The Annual Monitoring Program, Ryan Carnegie, Eugene M. Burreson Jul 2006

Status Of The Major Oyster Diseases In Virginia 2005 A Summary Of The Annual Monitoring Program, Ryan Carnegie, Eugene M. Burreson

Reports

More normal riverflows and salinities returned in 2005 after two very wet years. Temperatures were somewhat colder than normal during the winter, and warmer during the summer. The physical environment was generally more favorable for parasite activity, and thus brought a slight increase in prevalence and intensity of the oyster diseases caused by Perkinsus marinus (Dermo) and Haplosporidium nelsoni (MSX). Among quarterly James River Survey sites, maximum annual P. marinus prevalences returned to levels typical of the mid- 1990s, before the years of drought. P. marinus prevalence reached 92% at Wreck Shoal, 56% at Point of Shoal, 68% at Horsehead …


Differential Expression Of Immune Response Genes In Steller Sea Lions (Eumetopias Jubatus): An Indicator Of Ecosystem Health?, Lizabeth Bowen, Brian Aldridge, Kimberlee Beckmen, Tom Gelatt, Lorrie Rea, Kathy Burek, Ken Pitcher, Jeffrey L. Stott Jan 2006

Differential Expression Of Immune Response Genes In Steller Sea Lions (Eumetopias Jubatus): An Indicator Of Ecosystem Health?, Lizabeth Bowen, Brian Aldridge, Kimberlee Beckmen, Tom Gelatt, Lorrie Rea, Kathy Burek, Ken Pitcher, Jeffrey L. Stott

United States Department of Commerce: Staff Publications

Characterization of the polygenic and polymorphic features of the Steller sea lion major histocompatibility complex (MHC) provides an ideal window for evaluating immunologic vigor of the population and identifying emergence of new genotypes that reflect ecosystem pressures. MHC genotyping can be used to measure the potential immunologic vigor of a population. However, since ecosystem-induced changes to MHC genotype can be slow to emerge, measurement of differential expression of these genes can potentially provide real-time evidence of immunologic perturbations. MHC DRB genes were cloned and sequenced using peripheral blood mononuclear leukocytes derived from 10 Steller sea lions from southeast Alaska, Prince …


Status Of The Major Oyster Diseases In Virginia 2004 A Summary Of The Annual Monitoring Program, Ryan Carnegie, Eugene M. Burreson Mar 2005

Status Of The Major Oyster Diseases In Virginia 2004 A Summary Of The Annual Monitoring Program, Ryan Carnegie, Eugene M. Burreson

Reports

2004 was the second very wet year in a row. While rainfall and streamflows were normal in winter and early spring, and just slightly above average during the summer, the fall of 2004 was nearly as wet as the year before. Salinities were again depressed throughout the lower Bay. Water temperatures were below normal during the winter, but typical otherwise. Low salinities and, in the winter, temperatures brought continued abatement in the oyster diseases caused by Perkinsus marinus (Dermo) and Haplosporidium nelsoni (MSX). Among quarterly James River Survey sites, maximum annual P. marinus prevalences were the lowest they had been …


Status Of The Major Oyster Diseases In Virginia 2003 A Summary Of The Annual Monitoring Program, Ryan Carnegie, Lisa M. Ragone Calvo, Eugene M. Burreson Jun 2004

Status Of The Major Oyster Diseases In Virginia 2003 A Summary Of The Annual Monitoring Program, Ryan Carnegie, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

Low temperatures and salinities brought abatement in the oyster diseases caused by Perkinsus marinus (Dermo) and Haplosporidium nelsoni (MSX) for the first time since 1998. In the James River, P. marinus prevalences were the lowest they had been since 1998. In summer and fall, when P. marinus is normally most prevalent, it was found in a maximum of 72% of oysters at Wreck Shoal and in less than half the oysters at Horsehead Rock and Point of Shoals. Advanced infections were very rare. Haplosporidium nelsoni had disappeared completely from quarterly James River samples by July


Status Of The Major Oyster Diseases In Virginia 2002 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Mar 2003

Status Of The Major Oyster Diseases In Virginia 2002 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

Samples collected monthly from the upper James River sites from January through May showed a decline in P. marinus prevalence during the 4 winter and spring following a typical annual pattern; however, annual minimums were atypically high, particularly at Point of Shoals and Wreck Shoal (12-44%). Unusually high salinity conditions and warm winter temperatures promoted high overwintering survival of the pathogen and an early onset of the disease in the summer months. Perkinsus marinus prevalence increased to 100% at all four of the upper river stations and record high infection intensities were observed at Deepwater Shoal and Horsehead Rock. It …


Status Of The Major Oyster Diseases In Virginia 2001 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Feb 2002

Status Of The Major Oyster Diseases In Virginia 2001 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

Thirty-nine oyster populations were surveyed for disease in fall 2001. Perkinsus marinus was found in all areas sampled and prevalence exceeded 90% at all but 5 sample locations. In the James River P. marinus prevalence ranged from 88-100% at Deepwater Shoal, Horsehead Rock, Point of Shoals, Wreck Shoal, Mulberry Point, Swash, Long Shoal, and Dry Shoal. A lower prevalence was observed down river at Thomas Rock, 72%, and at Nansemond Ridge, 12%. The extremely low prevalence at Nansemond Ridge is likely age and density related; the oyster population was primarily comprised of spat; few small to market oysters were present …


Status Of The Major Oyster Diseases In Virginia 2000 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson May 2001

Status Of The Major Oyster Diseases In Virginia 2000 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

As a consequence of the relatively warm temperatures, high salinities, and high oyster parasite abundances in the fall of 1999, both P. marinus and H. nelsoni were widely distributed throughout oyster populations in Virginia in 2000. Fortunately, however, we did not see severe epizootics of the diseases as observed in some areas in 1999.


Status Of The Major Oyster Diseases In Virginia 1999 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Feb 2000

Status Of The Major Oyster Diseases In Virginia 1999 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

As a consequence of the relatively warm temperatures and high salinities severe epizootics of both H. nelsoni and P. marinus occurred in most tributaries in VA. In the upper James River, VA prevalences and intensities of P. marinus were the highest on record. The proportion of advanced infections (moderate and heavy intensity) in October was 60% at Wreck Shoal and 48% at Horsehead Rock suggesting that significant oyster mortalities occurred in these areas. 1 Record high levels of P. marinus were also observed in Virginia's other major tributaries. Of the 39 bay oyster populations surveyed in the fall, P. marinus …


Status Of The Major Oyster Diseases In Virginia 1998 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Mar 1999

Status Of The Major Oyster Diseases In Virginia 1998 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

No abstract provided.


Status Of The Major Oyster Diseases In Virginia 1997 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Mar 1998

Status Of The Major Oyster Diseases In Virginia 1997 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

No abstract provided.


Status Of The Major Oyster Diseases In Virginia 1996 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Mar 1997

Status Of The Major Oyster Diseases In Virginia 1996 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

No abstract provided.


Status Of The Major Oyster Diseases In Virginia 1995 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson Jan 1996

Status Of The Major Oyster Diseases In Virginia 1995 A Summary Of The Annual Monitoring Program, Lisa M. Ragone Calvo, Eugene M. Burreson

Reports

No abstract provided.