Life Sciences Commons^™

Phytochemicals And Health, Heather Rebecca Stone

Undergraduate Honors Capstone Projects

Objectives: Define phytochemicals as currently recognized in the United States and discuss food sources. Identify aims and challenges of current research. Review touted health effects of phytochemicals in cancer, cardiovascular disease (CVD), immune function, and other benefits. Present dietary recommendations. Methods: A literature search was conducted through Medline to find peer-reviewed journal articles from the past five years. Articles were found that identified the compounds and highlighted recent research relating phytochemicals to disease. The review of literature focused on an introductory understanding of phytochemicals. Results: Studies show that phytochemicals are undefined under current U.S. food regulations. They are biologically …

Looking Back: Cyclamate, Allan Mazur, Kevin Jacobson

RISK: Health, Safety & Environment (1990-2002)

The second in a series re-evaluating hazards identified in the 1950s and 60s.

Health-Promoting Properties Of Common Herbs, Winston J. Craig

Faculty Publications

Herbs have been used as food and for medicinal purposes for centuries. Research interest has focused on various herbs that possess hypolipidemic, antiplatelet, antitumor, or immune-stimulating properties that may be useful adjuncts in helping reduce the risk of cardiovascular disease and cancer. In different herbs, a wide variety of active phytochemicals, including the flavonoids, terpenoids, lignans, sulfides, polyphenolics, carotenoids, coumarins, saponins, plant sterols, curcumins, and phthalides have been identified. Several of these phytochemicals either inhibit nitrosation or the formation of DNA adducts or stimulate the activity of protective enzymes such as the Phase II enzyme glutathione transferase (EC 2.5.1.18). Research …

Improved Culture Of Tumor-Infiltrating Lymphocytes, Roger A. Burger

Biology

Adoptive immunotherapy using in vitro expanded tumor-infiltrating lymphocytes (TIL) continues to be the subject of research and clinical trials for the treatment of cancer. However, the culture methods used to expand large numbers of TIL are limited and often ineffective. In this study using murine TIL, the level of in vitro expansion, expression of adhesion molecules and infiltration into tumors after infusion was evaluated. A comparison was made between lymphocyte culture fluid (LCF), a bovine plasma-based medium, and a bovine serum-based medium (SCM) as the culture media. Because plasma-based media lack the lymphocyte inhibitory factors associated with serum-based media, it …

Reaction-Diffusion Models Of Cancer Dispersion, Kim Yvette Ward

Mathematics & Statistics Theses & Dissertations

The phenomenological modeling of the spatial distribution and temporal evolution of one-dimensional models of cancer dispersion are studied. The models discussed pertain primarily to the transition of a tumor from an initial neoplasm to the dormant avascular state, i.e. just prior to the vascular state, whenever that may occur. Initiating the study is the mathematical analysis of a reaction-diffusion model describing the interaction between cancer cells, normal cells and growth inhibitor. The model leads to several predictions, some of which are supported by experimental data and clinical observations $\lbrack25\rbrack$. We will examine the effects of additional terms on these characteristics. …

Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer

Pharmaceutical Sciences ETDs

Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore, …

Cancer Genetic Susceptibility Testing: Ethical And Policy Implications For Future Research And Clinical Practice, Benjamin S. Wilfond, Karen H. Rothenberg, Elizabeth J. Thomson, Caryn Lerman

Faculty Scholarship

No abstract provided.

The Cellular And Molecular Dynamics Of The Queuosine Modification In Transfer Rna: Definition, Modulation, Deficiencies And Effect Of The Queuosine Modification System, Rana C. Morris

Theses and Dissertations in Biomedical Sciences

The presence of the queuosine modification in the wobble position of tRNA^asn, tRN^asp, tRNA^his, and tRNA^tyr is associated with a decrease in cellular growth rate, an increase in the ability to withstand environmental stress, and differentiation of pleuripotent cells into mature phenotypes. The loss of this normal modification is strongly correlated with neoplastic transformation and tumor progression of a wide variety of cancers.

The "normal" system for formation of the queuosine modification in tRNA was studied in human fibroblast cell cultures and in mouse, rat and human liver tissues. The queuosine modification system …

Nf97-325 Cancer Resources: Education, Risk Reduction, Treatment And Support, Linda S. Boeckner

University of Nebraska-Lincoln Extension: Historical Materials

This NebFact contains information about sources of cancer information that may be helpful to cancer patients, family members, support groups and health professionals.

Gynecomastia, ปารณีย์ มีแต้ม

The Thai Journal of Pharmaceutical Sciences

Gynecomastia เป็นภาวะปกติที่พบในทารก ชายวัยรุ่น และผู้สูงอายุ นอกจากนั้นยังเป็นพยาธิ สภาพเนื่องจ...

Fumonisins And Alternaria Alternata Lycopersici Toxins: Sphinganine Analog Mycotoxins Induce Apoptosis In Monkey Kidney Cells, Hong Wang, Clinton Jones, Janice Caiacci-Zanella, Todd Holt, David G. Gilchrist, Martin B. Dickman

Department of Plant Pathology: Faculty Publications

Fusarium moniliforme toxins (fumonisins) and Alternaria alternata lycopersici (AAL) toxins are members of a new class of sphinganine analog mycotoxins that occur widely in the food chain. These mycotoxins represent a serious threat to human and animal health, inducing both cell death and neoplastic events in mammals. The mechanisms by which this family of chemical congeners induce changes in cell homeostasis were investigated in African green monkey kidney cells (CV-1) by assessing the appearance of apoptosis, cell cycle regulation, and putative components of signal transduction pathways involved in apoptosis. Structurally, these mycotoxins resemble the sphingoid bases, sphingosine and sphinganine, that …

Development Of An In Vitro Assay To Predict Patient Response To Radiotheraphy, Mary Sheridan

Doctoral

At the present time, the treatment plan for a patient with cancer is usually based on parameters such as tumour site, histological type, and tumour stage and performance status. However, it is well know that the radiosensitivity of human cancers varies widely from one patient to another (Fertil et al., 1981), and that even within these broad categories some tumours will show greater response to radiotherapy than others. If those patients unlikely to be cured by radiotherapy could be identified prior to commencement of treatment, alternative or more aggressive therapies might be selected which may give a better chance of …

Identification And Characterization Of Genes Associated With V-Jun Induced Cell Transformation, Martin Toralballa Hadman

Biological Sciences Theses & Dissertations

The v-jun oncogene was initially identified as the causative agent for fibrosarcomas in chickens. Studies show that overexpression of v-Jun proteins transforms chicken embryo fibroblasts (CEF) in vitro, and forms tumors in chickens in vivo. The mechanisms for this are not clearly defined. Conceivably, overexpression of an unregulated transcription factor would cause cell transfonnation by illicit regulation of its target genes. In support of this, we show that in vivo v-Jun complexes exhibit differential binding to in vitro generated AP-1 and 'AP-1 like' target sequences, suggesting that the pattern of target gene expression is altered during cell transformation. …

Gold, Electron Microscopy, And Cancer Therapy, James F. Hainfeld

Scanning Microscopy

Radioactive gold has properties suitable for radiotherapy and can provide lethal irradiation to cells. If the gold is conjugated to a targeting molecule, such as an antibody, it may be possible to specifically deliver the dose to tumor cells. Various gold particles are possible candidates and include gold colloids with adsorption of antibodies or gold clusters with covalent attachment. Different sizes of gold particles are available and some may be preferred for certain situations. Problems with intravenous injection and in vivo delivery are numerous, and a more tractable application is the direct instillation into the urinary bladder of radiogold immunoconjugates …

Perceived Risks Of Emfs And Landowner Compensation, Linda J. Orel

RISK: Health, Safety & Environment (1990-2002)

Although public concerns about EMFs may eventually prove groundless, they can nevertheless depress the market value of residential property near powerlines. Ms. Orel argues that the scientific truth, as courts increasingly recognize, should play no role in determining whether or how much landowners should recover.

A Survey Of Residual Cancer Risks Permitted By Health, Safety And Environmental Policy, March Sadowitz, John D. Graham

RISK: Health, Safety & Environment (1990-2002)

The authors describe permitted U.S. residual cancer risks, focusing on numerical levels specifically and implicitly authorized by statute or regulation. They also discuss potential changes.

Outpatient Administration Of Paclitaxel, Siu Fun Wong

Pharmacy Faculty Articles and Research

Paclitaxel (Taxol®, Bristol-Meyers Squibb), anti neoplastic agent made from the bark of the Pacific yew tree, is undoubtedly one of the most exciting agents to be evaluated over the past decade. Paclitaxel has demonstrated significant promise against ovarian and metastatic breast cancer, and appears to be the most effective single agent to date for non-small-cell lung cancer in trials conducted by Eastern Cooperative Oncology Group (ECOG).

G93-1184 Bovine Ocular Neoplasia, L. J. Perino, D. D. Griffin, D. G. Rogers

University of Nebraska-Lincoln Extension: Historical Materials

This NebGuide will aid in the early identification and proper management of bovine ocular neoplasia, commonly known as cancer eye, including appropriate veterniary care. The common name for bovine ocular neoplasia, also known as ocular squamous cell tumors, is cancer eye. The term cancer eye is not entirely accurate and carries negative connotations. As we will explain in this NebGuide not all of these growths are cancerous. The scientific term for a cow is "bovine," the medical term for the eye is "ocular," and the medical term for these new and abnormal growths is "neoplasia." Thus, the term bovine ocular …

Old Remedies In The Biotechnology Age: Moore V. Regents, Michelle J. Burke, Victoria M. Schmidt

RISK: Health, Safety & Environment (1990-2002)

The California Supreme Court, by excluding a potential remedy, has eliminated many concerns generated by a lower court decision resolving rights to the cell line derived from John Moore's spleen. Yet, the Supreme Court gave little attention to remedies that remain. The authors argue that a constructive trust, a remedy of considerable vintage and great flexibility, could be applied to achieve a just result in such circumstances without affecting the biotechnology world at large.

Hla Typing For Breast Cancer Patients In Egypt, Maha Adly Guindi

Archived Theses and Dissertations

No abstract provided.

G90-975 Health Insurance For Older People (Revised February 1991), Kathleen Prochaska-Cue

University of Nebraska-Lincoln Extension: Historical Materials

This guide discusses basic Medicare benefits on private health insurance, commonly called Medigap insurance, available to supplement Medicare.

Medicare

What are the two parts of Medicare?

Medicare Part A -- Hospital Benefits. This pays for your care while you are in the hospital, and for related health services after you leave the hospital, including necessary care in a Medicare approved nursing home.

Medicare Part B -- Medical Insurance. This helps pay doctor bills and hospital out-patient expenses.

The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay

Theses and Dissertations in Biomedical Sciences

The targeting of proven anticancer drugs specifically to cancer cells would provide a unique opportunity to restrict neoplasms without damaging the cancer patient. The present research utilizes the phenomenon of illicit transport, i.e. the coupling of normally impermeant metabolites to permeant metabolites, in targeting the drug melphalan to mouse Ehrlich ascites tumor cells. The dipeptide beta-alanyl-melphalan was synthesized and tested in vitro for toxicity towards mouse Ehrlich ascites tumor cells, mouse liver cells, and mouse 3T3 embryonic cells. The parent compound, melphalan, was used as a control treatment. In addition, both melphalan and beta-alanyl-melphalan were utilized in in vivo chemotherapeutic …

An Electron Microscopic Study Of Hemopoietic Tissues In The Course Of Lewis Lung Carcinoma, Cheryl Hardy, Yuzhi Wang, Bettye Collier, Mehdi Tavassoli

Scanning Microscopy

Lewis lung carcinoma of C57Bl/6 mice causes a progressive anemia with reticulocytosis and splenomegaly, metastasizes to lungs, liver, and kidneys but does not invade hemopoietic tissues. The cause of this anemia is uncertain. We studied the structure of spleen and bone marrow in these tumor hosts by light and electron microscopy. Splenic congestion of the red pulp with numerous erythropoietic islands and marrow hyperplasia characterized the hemopoietic tissues of these mice, which, when coupled with other hematological parameters suggested a hemolytic condition. However, the erythropoietic response appeared to be in part ineffective as evidenced by phagocytosis of immature as well …

A Comparative Study On In Vitro Invasion Rates By Melanoma Cells In The Human Amniotic Basement Membrane Model Versus In Vivo Tumor Nodule Formation In C57bl6 Mice, B. Persky, G. W. Chmielewski

Scanning Microscopy

Invasion by murine B16-F10 melanoma cells was studied using the human amniotic basement membrane (HABM) assay. B16-F10 cells were collected after a single passage through the amnion and grown to near confluency. The cycle of plating, passaging, collecting, and culturing B16-F10 cells was repeated five times. The invasion rate for B16-F10 cells remained relatively unchanged after six passages through the amnion. Injection of first-passage B16-F10 cells into C57BL6 mice resulted in 29 lung tumors per animal whereas sixth-passage cells resulted in 300+ lung tumors. While there exists no correlation of the number of cells penetrating the amnion with colonization number, …

Studies Of N⁵, N¹⁰-Methylene Tetrahydrofolate Reductase From Porcine Kidney And Mouse L1210-Induced Tumor Tissues, Purification And Interaction With Antifolates, David W. Jayme

Theses and Dissertations

Methylene tetrahydrofolate reductase has been purified 1000-fold from porcine kidney and 400-fold from mouse L1210-induced tumor tissue by classical methods. The enzyme preparations have been demonstrated to be essentially free of contaminating methionine synthetase and serine transhydroxymethylase activity. Studies of the kinetic properties of the kidney and tumor enzymes, with respect to the reverse reaction using N5-methyl tetrahydrofolate as the variable substrate, have indicated Km values of 2.0 and 2.4 x 10-4 M, respectively. Inhibition of this key branch point enzyme in folate metabolism by a number of antimetabolites indicates that several of these antifolate compounds exhibit enzyme inhibition superior …

The External Morphology Of The First Zoeal Stages Of Cancer Magister (Dana), Cancer Antennarius (Stimpson), And Cancer Anthonyi (Rathbun), Robert Dotson Mir

University of the Pacific Theses and Dissertations

The literature dealing with the larva of Pacific Coast brachyuran crabs is slight. The prominent papers, those of Aikawa (1927, 1928, 1929, 1933, 1937), deal with a variety of genera and offer information useful in determin- ing family relationships. A single paper by Hart (1935) also deal with a number of brachyuran larvae found in the Pacific Ocean. None of these papers, however, identifies to species any member of the genus Cancer, although one member, C. magister (Dana) is of considerable economic importance on the pacific coast of North America. In the fall of 1958 an investigation was under taken …

Cancer Of The Lungs, H. James Hara

Medical Arts and Sciences: A Scientific Journal of the College of Medical Evangelists

No abstract provided.