Life Sciences Commons^™

Patenting Ai Discoveries In Life Sciences: Overcoming Eligibility, Disclosure, And Inventorship Challenges, Dhohyung Kim, Ryan P. Hiler

IP Theory

The pharmaceutical and biotechnology industries face transformative opportunities through artificial intelligence and machine learning integration. However, these technological advances create distinct patent law complications that traditional drug development does not encounter. This article analyzes three interconnected obstacles: establishing eligible subject matter under 35 U.S.C. § 101, meeting disclosure standards under § 112(a), and determining proper inventorship when AI systems contribute substantially to claimed inventions. Drawing from recent USPTO guidance and Federal Circuit precedent, this analysis offers evidence-based strategies for patent practitioners, research scientists, and business leaders seeking robust intellectual property protection for AI-integrated pharmaceutical innovations.

53rd Annual Food Science And Technology Conference, Leonard Koolman, Elena-Alexandra Alexa, Jesus Maria Frias

Books/Book Chapters/ Proceedings

53rd IFSTI Annual Food Science and Technology Conference on 22nd and 23rd of January 2026. Theme is 'Global Food Resilience, its challenges and strategic approaches'.

A Conserved Ethylene-Triggered Cell Death Mechanism May Underlie Hollow Stem Formation Across Plant Species, Mengxiao Yan, Weijuan Fan, Yinghui Meng, Jiamin Zhao, Wei Yang, Ziyin Xu, Yusen Gao, Haiyan Zhuang, Wuyu Zhou, Yuqin Wang, Qingjun Huang, Ling Yuan, Hongxia Wang, Jun Yang

Plant and Soil Sciences Faculty Publications

Hollow stems have independently evolved multiple times across the plant kingdom and play crucial roles in plant development and various environmental adaptations. However, the mechanisms underlying stem hollowness remain poorly understood. Water spinach (Ipomoea aquatica) is one of the few hollow-stemmed plants in the Convolvulaceae family (eudicot: asterid), and its hollow stems are essential for thriving in aquatic environments. Using histochemical staining and transcriptome analysis, we found that programmed cell death (PCD) is involved in cavity formation at water spinach shoot tips. Single-cell and spatial transcriptome analyses further revealed that ethylene and reactive oxygen species (ROS) likely drive …

Supplemental Bibliographic Details. From 2001 Mars Odyssey To Earth’S Climate Crisis: Integrating Gamma Spectroscopy, Martian Soil Simulants, And Plant Genomes For Agroecology, Anchored In Sri Lanka’S Mars-Context Serpentinites, Suniti Karunatillake, Maheshi Dassanayake, Carlos Gary Bicas

Planetary Science Lab

Bibliographic details follow to supplement hyperlinked citations in the multinational GANGOTRI-supporting project conceived by Karunatillake, Dassanayake, and Gary-Bicas

Detection And Characterization Of Cancer Using Cfdna Fragmentomic Analysis, Guneet Bhogal

Master's Projects

Cell-free DNA (cfDNA) fragmentomics has emerged as a promising non-invasive approach for detecting and characterizing cancer by analyzing DNA fragmentation patterns. These fragment patterns are unique and can be used to distinguish between tumor and healthy DNA. This paper uses machine learning models to detect cancer by evaluating Shannon entropy of fragment lengths at the first coding exon 1 regions and correlating them to targeted cancer genes. This approach was applied to two datasets consisting of samples with prostate, breast, and lung cancers. Our results indicated that exon 1 fragmentation entropy captures biologically relevant differences in cancer-specific chromatin organization and …

Combining Crispr And Nanoasv To Uncover The Rare Bacterial Communities Of The Human Oral Microbiome, Gilma Ruth Sevilla Alvarez

Master's Projects

Studying the oral microbiome is vital because its health implications are not contained to the mouth. Cariogenic bacteria cause tooth demineralization and oral microbes that translocate to extra-oral organ systems are linked to conditions like Alzheimer’s disease, heart disease, diabetes, and cancer. Some of these pathogens belong to the most abundant phyla in the oral cavity: Bacillota, Pseudomonadota, Bacteroidota, Actinomycetota, Spirochaetota, and Fusobacteriota, which together comprise 94% of the oral microbiome. This project uses CRISPR-Cas9 to deplete sequences from highly abundant phyla and the Eubacteria domain, enriching the remaining 6% of rarer taxa. Paired with NanoASV for single-nucleotide resolution, this …

Midwestern Farmers' Willingness To Engage With Precision Agriculture Technologies And On-Farm Precision Experimentation, Reagen G. Tibbs, Nicholas J. Heller, David S. Bullock, Maria A. Boerngen

Faculty Publications - Agriculture

Precision agriculture technologies (PATs) have revolutionized the agriculture industry and provide many benefits to farmers. Among these benefits is the ability to conduct experiments in a process known as on-farm precision experimentation (OFPE). By conducting these experiments and through collaboration with researchers, crop consultants, and extension agents, farmers can learn site-specific management practices to better address challenges in their operations. However, adoption rates of these technologies have remained below 50% in the United States. Furthermore, very few studies have explored the factors that influence a farmer's decision to conduct experiments, or their willingness to collaborate with external stakeholders such as …

A Preliminary Study On Producing Volatile Fatty Acids From Winter Cover Crops, Tuba Yasmin Lubna, Robert L. Rhykerd, David E. Kopsell, Nicholas J. Heller, Md. Mahadi Hasan, Kathryn Stahl, Liangcheng Yang

Faculty Publications - Agriculture

Winter cover crops provide many ecological benefits, though their economic impacts have been shown to be mixed. While cover crop biomass is typically terminated or used as livestock feed, it can also serve as a feedstock for bioenergy production, offering opportunities for additional revenue. This study evaluated the potential of wild pennycress, CoverCress™, annual ryegrass, cereal rye, and field pea biomass for volatile fatty acids (VFAs) production through arrested anaerobic digestion (AAD). Specifically, the effects of harvest timing on cover crop biomass composition and VFAs yield were examined, given the need for effective utilization and storage of early-harvested biomass. The …

Native Seed Scoop, 2026 New Year's Edition, University Of Northern Iowa. Tallgrass Prairie Center.

Native Seed Scoop

Contents:

--- Message from Laura Walter
--- Upcoming Events
--- TPC Plant Materials 2025 Wrap

Rna-Sequence-Driven Identification Of Differentially Expressed Genes In Α-Crystallin-Deficient Zebrafish, Kehlie Hopper

SPARK Symposium Presentations

Fetal Alcohol Syndrome (FAS) is a condition that develops in infants when exposed to alcohol in utero, leading to physical impairments such as reduced eye size and disrupted retinal function. Alpha-crystallin A is a key structural protein required for proper lens development and maintenance of transparency, while Alpha-crystallin B plays a protective role against cellular stress during eye development. In this study, I compared AB wild-type (ABWT), αA-crystallin knockout (cryaa), and αB-crystallin knockout (cryaba) zebrafish to investigate how the loss of these proteins influences eye development under ethanol exposure. The cryaa mutants exhibited reduced eye size even under control conditions, …

A Sweet Spot For Chemotherapy: The Influence Of Insulin And Glucagon On Oxaliplatin Sensitivity In Colorectal Cancer Cells, Daniella Cohen, Andrea Florian

SPARK Symposium Presentations

There is a well-established relationship between cellular metabolism, cancer progression, and treatment response. Metabolic hormones such as insulin and glucagon regulate pathways involved in cell growth, survival, and stress responses and have been linked to tumor development and chemotherapy sensitivity. Understanding how metabolic signaling influences cancer treatment may provide insight into factors that affect therapeutic outcomes. This study aims to investigate how insulin and glucagon affect the susceptibility of colorectal cancer cells (CRC) to the chemotherapeutic agent oxaliplatin. CRC cells were treated with insulin or glucagon and exposed to varying concentrations of oxaliplatin. Cell viability was measured to evaluate treatment …

Murder On The Menu, Andrea Florian, Leslie Deleon, Angela Simpkins, Anamika Chhetri

SPARK Symposium Presentations

You're invited to a birthday party in Maryland! There will be many guests and even...seafood cuisine at a fancy restaurant! All is well until one of our guests comes down with a peculiar sickness. Do you think you can figure out what happened?

Honeymoon Horror Story, Andrea Florian, Aunalise Terreri, Kiley St. John, Sienna White

SPARK Symposium Presentations

On what was supposed to be a romantic honeymoon getaway, a newly married couple’s paradise quickly turns dark. The wife, Julia Harper, is found dead under mysterious circumstances, and suspicion falls on her neuroscientist husband. As lies unravel, investigators discover that this honeymoon was never about love, but revenge. In the end, all that’s left is betrayal and secrets…Can you solve this murder mystery?

The Last Ball, Andrea Florian, Lili M. Wrenne, Mehrael Adly, Jia Howell

SPARK Symposium Presentations

Sixty-year old, billionaire, Walter Spencer has been found dead at his annual birthday celebration. Guests reported odd behavior before he passed with wild mood swings, speaking gibberish, and experiencing hallucinations. Close friends of Walter say his young 25-year-old wife was the last to see him. Are you able to solve his mystery?

A Sweet Deception, Andrea Florian, Ellis Stafford, Bridget Mcloud, Awi Siam

SPARK Symposium Presentations

Have you ever wanted to be a detective and solve a murder? Well, here is your chance! Bradley Thompson, an investment banker at JP Morgan, was murdered in his home, and we are relying on you to piece together the toxicological clues and find his killer! This murder-mystery activity will involve selecting different toxicological tests and evaluating evidence to determine who committed this heinous crime.

Potential Environmental Triggers Of Goodpasture's Disease And The Role Of The Sulfimine Crosslink, Colton S. Miller, Andrea Florian, Elena Pokidysheva

SPARK Symposium Presentations

Goodpasture’s syndrome (GP) is an autoimmune disorder that primarily affects kidneys and lungs. The main issue for patients with Goodpasture's syndrome is the binding of autoantibodies to the glomerular basement membrane (GBM), which hinders the filtration of blood. A key characteristic of Goodpasture's syndrome is the presence of autoantibodies that target the NC1 domain of the α345 isoform of type IV collagen, a crucial component of the GBM that provides structural support and is critical for filtration function. Sulfilimine bonds crosslink the collagen IV NC1 hexamers, contributing to the stabilization of these structures. A recent clinical case of recurring Goodpasture's …

Data For Forthcoming Article: "Employing Zebrafish To Understand Genetic Drivers Of Epilepsy-Related Comorbid Behaviors", Colleen Carpenter-Swanson

Biology Faculty Data

Forthcoming from Frontiers in Pharmacology:

"Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contribute more significantly to overall disease burden than the seizures themselves. To improve quality-of-life (QOL) for these children, treatment options should be selected that control seizures and ameliorate comorbidities. Unfortunately, such therapeutics remain largely elusive. Addressing this issue requires suitable preclinical models. Here we used CRISPR-generated zebrafish with single-gene mutations linked to pediatric epilepsy and applied clinically-relevant behavioral assays to study the effects of these mutations. Using high-throughput locomotion-based …

Characterization Of A Coastwide Sheepshead (Archosargus Probatocephalus) Fishery Reveals Increased Fishing Pressure During Spawning Activity In Texas, Ethan T. Getz, Catherine M. Eckert, Charles Downey Iii

Gulf and Caribbean Research

Sheepshead (Archosargus probatocephalus) have been characterized as one of the most vulnerable species to overfishing in the Gulf of Mexico (GOM) based on their reproductive strategy of spawning in aggregations. Here, we analyzed fishery—independent and dependent data (1983—2023) collected by the Texas Parks and Wildlife Department to assess Sheepshead populations and describe the fishery in Texas. Gill net sampling was used to describe Sheepshead abundance and distribution, while creel survey data and commercial landings were used to determine spatial and temporal characteristics of the fishery and evaluate targeted fishing activity during the spawning season. Sheepshead encountered in gill …

Effect Of Endophytic Fungi On Thrips Tabaci Development And Population Dynamics, Ngoc Anh Vu, Sevgan Subramanian, Rainer Meyhöfer

All Peer-Reviewed Publications

Endophytic fungi are promising biocontrol agents because they colonise healthy plant tissues asymptomatically while inducing systemic resistance that negatively affects herbivorous insects. We investigated whether treatments with the endophytes Trichoderma harzianum and Beauveria bassiana in two onion cultivars (Allium cepa L.; Sturon and Red Baron) induce plant responses that alter Thrips tabaci behaviour and population development. Under controlled conditions, seeds were treated with conidial suspensions and plants subsequently received foliar applications; plants were then exposed to T. tabaci for 72 h, 4 weeks, or 8 weeks in no-choice assays. Both endophytes reduced thrips host-plant preference: at 72 h post-exposure, inoculated …

Characterization Of The Genetic Diversity Of Curlyleaf Pondweed (Potamogeton Crispus L.) In The Contiguous United States And Canada And Analysis Of Possible Hybrid Potamogeton Crispus Lineages, Mallory M. Kaiser

All Graduate Theses, Dissertations, and Other Capstone Projects

Curlyleaf Pondweed (Potamogeton crispus L.) is a prolific invasive species that has spread across the United States and into parts of Canada since its introduction to North America in the 1840s. It causes extensive economic and environmental damage across its invasive range, and its control and eradication are of utmost importance to agricultural, ecological, recreational, and transportational stakeholders. Developments in molecular ecology and invasive management have found that genetic diversity and hybridization of aquatic macrophytes may affect their susceptibility to herbicide treatments, and genotype or lineage identification are important control variables that must be considered in field and …

Psr Impacts Chromatin Condensation During Spermatogenesis In Nasonia Vitripennis, Jacqueline R. Solomon

CMC Senior Theses

Paternal Sex Ratio (PSR) is a supernumerary, selfish B chromosome found in the jewel wasp (Nasonia vitripennis). PSR is transmitted strictly paternally to progeny, and when present, it causes paternal genome elimination (PGE) just after fertilization. Due to the haplo-diploid reproduction of N. vitripennis, this PGE event results in all-male broods of progeny, ~90% of which carry and transmit PSR. Thus, PGE is beneficial for PSR’s transmission.  A previous study showed that PSR induces PGE by expressing a gene called haploidizer during spermatogenesis. Although how haploidizer functions in PGE is unknown, this finding suggests two basic models: that (i) the …

Exploration Of The Use Of Radiocarbon Time-Series Records As Indicators Of Upwelling Areas, Rena Reshmi Mukherjee

CMC Senior Theses

The Earth’s oceans buffer climate change, regulate weather patterns, sustain global food security, and support biomedical research. Ocean currents redistribute heat and nutrients while promoting genetic diversity, which can serve as a source of novel compounds for biomedical research. Understanding ocean circulation is essential for maintaining these ecosystem services as the climate continues to change. Upwelling, a form of vertical water movement that transports nutrient-rich deep water to the surface, plays a key role in marine productivity and carbon cycling. However, global upwelling patterns remain incompletely mapped. Radiocarbon (14C), a radioactive isotope of carbon, provides a useful tracer of ocean …

Modulating Oran Nitrate-Reducing Bacteria To Enhance Nitric Oxide Bioavailability As A Therapeutic Target For Atherosclerosis, Donovan C. Davidson

CMC Senior Theses

Atherosclerosis remains the primary driver of global cardiovascular disease, yet clinical interventions are largely restricted to high-cost, invasive procedures only after it has reached a critical stage. Recent research has identified a connection between the oral microbiome and vascular health via the enterosalivary nitrate-nitrite-nitic oxide (NO) pathway. Oral nitrate-reducing bacteria (ONRB) drive the synthesization of NO by reducing dietary nitrate into nitrite, which is then converted into bioavailable NO. NO is a potent vasodilator that maintains endothelial health by suppressing inflammation through inhibiting the expression of adhesion molecules VCAM-1 and ICAM-1. However, this pathway is easily compromised by dysbiotic oral …

Not Biological, But Built: Structural And Metabolic Pathways Driving Black Maternal Health Disparities In The United States, Alexandra I. Umegboh

CMC Senior Theses

Black infants in the United States are more than twice as likely to die before their first birthday than white infants, a disparity often attributed to genetics, behavior, or individual health choices. However, this idea is challenged by a key contradiction: African immigrant women consistently experience better birth outcomes than U.S.-born Black women despite being similarly racialized. This thesis investigates the origins of this reproductive advantage and the factors contributing to its decline over time. By drawing on epidemiological data, metabolic health research, and literature on African diasporic healing traditions, it argues that the “healthy immigrant effect” is not biological, …

The Evolution Of California Wildfire Governance Through State Bills, Regulations, And Executive Actions, Cassandra Dawn Blevins

History and Political Science | Senior Theses

California faces an escalating wildfire crisis, driven by climate change, drought, and development in fire-prone areas. Despite decades of scientific research on wildfire behavior and risk reduction, catastrophic fires since 2017 raise a critical question: to what extent have California state laws and policies kept up with the intensifying wildfire crisis? Existing scholarship provides extensive insight into wildfire ecology, land-use planning, fuel management, and community resilience, yet it lacks a comprehensive evaluation of whether California’s legislative, regulatory, and executive actions have adapted in a coordinated and evidence-informed manner. In particular, the literature offers limited analysis of how state laws integrate …

The Impacts Of Wing-Flashing By Northern Mockingbirds On Foraging, Parental Care, And Reproductive Success, Anna R. Starman

Undergraduate Honors Theses

Foraging efficiency may be enhanced by flashing patches of white wing and tail feathers and has been documented in several avian species. Northern Mockingbirds (Mimus polyglottos, NOMO) exhibit this “wing-flashing” (WF) behavior while foraging, during displays, and in response to predators. In NOMOs, WF has been hypothesized to increase foraging success, but previous findings are inconclusive. To further investigate the biological role(s) of WF behavior in NOMOs, the ventral surface of white primary feathers of male NOMOs were artificially darkened, and the foraging and provisioning rates of undarkened (control) males and their mates were compared. While foraging, undarkened …

Radial And Carotid Arterial Pulse Signals For Assessing Cardiovascular Function At Rest And During Post-Exercise Recovery In A Heart Transplant Patient: A Case Study, Md Mahfuzur Rahman, Mamun Hasan, Jennifer F. May, John M. Herre, Leryn Reynolds, Zhili Hao

Mechanical & Aerospace Engineering Faculty Publications

Aim: This study investigates the feasibility of using radial and carotid arterial pulse signals to assess cardiovascular (CV) function at rest and during post-exercise recovery in a heart transplant (HTx) patient. Method: Two micro-fabricated tactile sensors were used to simultaneously acquire arterial pulse signals at the radial artery (RA) and carotid artery (CA). Measurements were taken at rest and at multiple time points post-exercise on three subjects: an HTx patient, a percutaneous coronary intervention (PCI; coronary stent) patient and a healthy control. An SDOF-TF-based time-frequency analysis algorithm was applied to extract a comprehensive set of CV parameters, including heart rate …

Tick Lipocalin Triggers Mammalian Igfbp-3-Mediated Apoptosis In Macrophages And Keratinocytes, Krittika Nandy, P. P. Mahesh, Lichao Liu, Daniel E. Sonenshine, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

Ticks secrete several molecules, including lipocalins, in their saliva during blood feeding on a vertebrate host. In this study, we provide novel evidence on the role of Ornithodoros turicata americanus tick lipocalin (Otlip) in modulating cytokine expression and in triggering apoptosis in mammalian macrophages and keratinocytes. The cytokine array analysis revealed significantly increased secretion of insulin-like growth factor-binding protein 3 (IGFBP3) from murine macrophage cell line upon treatment with recombinant Otlip protein (rGST-Otlip) when compared to the secretion noted from cells treated with a control protein (rGST). Similar observation with cytokine protein array analysis was noted when murine macrophages were …

Differential Growth Dynamics Of Common Salt Marsh Species Spartina Alterniflora And Juncus Roemerianus Under Varied Sediment Amendments, Caitlin Hemphill, Richard P. Hale, Erik S. Yando

Biological Sciences Faculty Publications

Introduction

Many coastal wetlands are at high risk of degradation or loss due to sea‐level rise. Restoration techniques for maintaining coastal marshes are paramount, with thin‐layer placement (TLP) emerging as one feasible solution. Despite TLP's utilization, additional research is needed on species‐ and sediment‐specific responses.

Objectives

Our research combines greenhouse and field experimentation to test species and sediment composition responses aimed at maximizing vegetation while maintaining increased elevation.

Methods

The greenhouse experiment used two common marsh plants, Spartina alterniflora and Juncus roemarianus. Five centimeters of sediment (mud, sand, and sand/mud mix) was added, and subsequent sediment and vegetation metrics …

Using Genetic Analysis To Infer Familial Relationships Of Westslope Cutthroat Trout In The Lower Priest River, Idaho, Kolby Emtman

EWU Masters Thesis Collection

The Westslope Cutthroat Trout (Oncorhynchus lewisi) is a native species of salmonid that holds both cultural and ecological significance in the Idaho Panhandle region of the United States. Within this region, the Priest River is a major contributor of migrant Westslope Cutthroat Trout to the Clark Fork Pend Oreille basin. This study aimed to estimate the proportion of juveniles that have at least one migrant parent, illustrate gene flow using juvenile half sibling relationships, and showcase varying levels of spawning success using juvenile full sibling relationships. Sampling of juvenile individuals occurred in 11 tributaries of the Priest River over …