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2025

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Articles 11851 - 11880 of 12458

Full-Text Articles in Life Sciences

The Role Of Floodplain Complexity In Wood Turtle Habitat Use, Laura S. Deming Jan 2025

The Role Of Floodplain Complexity In Wood Turtle Habitat Use, Laura S. Deming

Antioch University Dissertations & Theses

Wood turtles occupy cold, low-gradient riverine habitat throughout the northeastern United State and southeastern Canada. Stream alterations, such as dams, channel straightening, and floodplain development have diminished the natural hydrologic and sedimentation regimes that result in complex channel and floodplain geomorphology. Studies throughout the species’ range have quantified many aspects of their habitat, but none have quantified components of geomorphology of wood turtle sites. The goal of this study was to explore the role of stream channel and floodplain geomorphology in wood turtle habitat use, with specific objectives to (1) quantify components of stream channel and floodplain geomorphic complexity, (2) …


Pick Up A Frog, Or Pet A Dog; Animals Are Our First Teachers, Allison Ratner Jan 2025

Pick Up A Frog, Or Pet A Dog; Animals Are Our First Teachers, Allison Ratner

Antioch University Dissertations & Theses

This dissertation’s goal was an attempt to answer the question: What are the emotional, cognitive, and/or spiritual effects of children’s relationships/interactions with animals that potentially impact their development? By utilizing autoethnography, I analyzed instances from my own life where interacting with animals changed me permanently; my thinking, my knowing, my feeling, my judgement, my empathy, my attitude, and my ethics. With a standpoint rooted in the research of experts from the fields of psychology and education, I combined my personal knowledge gained over a lifetime, to grant merit to the profundity of children’s relationships with animals. With the analyzed data, …


Behavioral Response Of Wild Greater Caribbean Manatees (Trichechus Manatus Manatus) To Playbacks Of Conspecifics In Maya Beach, Belize, Phoebe Sonia Hodson Jan 2025

Behavioral Response Of Wild Greater Caribbean Manatees (Trichechus Manatus Manatus) To Playbacks Of Conspecifics In Maya Beach, Belize, Phoebe Sonia Hodson

Antioch University Dissertations & Theses

The behavioral response of the wild Greater Caribbean manatee (Trichechus manatus manatus) to the acoustic vocalizations of their closely related subspecies, the Florida manatee (Trichechus manatus latirostris), was examined for the first time in Placencia Lagoon, Maya Beach, Belize. The main goal of this study was to determine how vocalizations from conspecifics influence the behavior of the wild Greater Caribbean manatee and how this behavioral change may give insight into the functionality of manatee vocalizations. Three call types (squeak, squeal and high squeak) and chewing sounds were played to varying size aggregations of manatees. Broad behavioral …


Distribution And Ecology Of The Cedar Keys Mole Skink (Plestiodon Egregius Insularis), Kevin M. Enge, Louis A. Somma, Paul E. Moler, Travis M. Thomas, Matthew T. Fedler, John M. Matter, Dennis C. Haney Jan 2025

Distribution And Ecology Of The Cedar Keys Mole Skink (Plestiodon Egregius Insularis), Kevin M. Enge, Louis A. Somma, Paul E. Moler, Travis M. Thomas, Matthew T. Fedler, John M. Matter, Dennis C. Haney

Papers in Herpetology

We conducted surveys for the Cedar Keys Mole Skink, Plestiodon egregius insularis (Mount), during 1989– 1999 and 2015–2024, examined museum vouchers, and compiled personal observations from others to determine the status and distribution of this subspecies, which has the smallest geographic distribution of the five subspecies and is being considered for federal listing. We observed Cedar Keys Mole Skinks on Airstrip Island, Atsena Otie, Cedar Point, Deer Island, North Key, Scale Key, Seahorse Key, Snake Key, and possibly Dog Island. We have anecdotal reports of Mole Skinks on Way Key, which contains the most potential habitat and is the main …


Environmental And Climate Change Dictionary: Part Ii, Fozia Parveen Jan 2025

Environmental And Climate Change Dictionary: Part Ii, Fozia Parveen

Books

When we published our first environment and climate change dictionary in 2023 at IED (https://ecommons.aku.edu/books/117/), I was surprised by the response we received. Many people reached out to us to tell us how they hear these terms in their workplaces and how our dictionary helps them understand the words better. I wanted to make sure that we continue to add words to the dictionary in order to increase the understanding of others but also our own understanding of many terms we hear on a day-to-day basis. This year with the participants of “Introduction to Climate Change” course at FAS we …


Summer Research Fellowship Project Descriptions 2025, Clark Science Center's Summer Research Fellows Program Jan 2025

Summer Research Fellowship Project Descriptions 2025, Clark Science Center's Summer Research Fellows Program

SURF Abstracts (Women in Science)

A summary of research done by Smith College’s 2025 Summer Research Fellowship (SURF) Program participants. Ever since its 1967 start, SURF has been a cornerstone of Smith’s science education. Supervised by faculty mentor-advisors drawn from the Clark Science Center and connected to its eighteen science, mathematics, and engineering departments and programs and associated centers and units. At summer’s end, SURF participants were asked to summarize their research experiences for this publication.


Neuroinflammatory Signaling And Immune Cell Infiltration Differ In Brains Of Rats Exposed To Space Radiation And Social Isolation, Austin M. Adkins, Zachary N. M. Luyo, Alea F. Boden, Riley S. Heerbrandt, Richard A. Britten, Laurie L. Wellman, Larry D. Sanford Jan 2025

Neuroinflammatory Signaling And Immune Cell Infiltration Differ In Brains Of Rats Exposed To Space Radiation And Social Isolation, Austin M. Adkins, Zachary N. M. Luyo, Alea F. Boden, Riley S. Heerbrandt, Richard A. Britten, Laurie L. Wellman, Larry D. Sanford

Center for Integrative Neuroscience and Inflammatory Diseases (CINID) Faculty Publications

Astronauts on the proposed Mars missions will be exposed to extended periods of social isolation (SI) and space radiation (SR). SI and SR-induced immune dysregulation can result in persistent neuroinflammation and neuronal damage which could negatively impact an astronaut’s health and ability to maintain adequate levels of performance. The synergistic effects of combined SI and SR on immune system functionality and the brain remain unknown. Determining how single and combined inflight stressors modulate the immune system is crucial for fully understanding pathways impacting astronaut health and performance. We used ground-based analogs of SI and SR in rodent models to investigate …


Loneliness Associates With Endothelial Dysfunction In A Community-Based Cohort: A Pilot Study And Translational Approach, Yvonne Baumer, Brian A. Tirado, Lola R. Ortiz-Whittingham, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Laurel G. Mendelsohn, Abhinav Saurabh, Joshua A. Jacobs, Marcus R. Andrews, Valerie M. Mitchell, Billy S. Collins, Antwan Jones, Danielle M. Schwartz, Anca D. Dobrian, Michael V. Stanton, Tiffany M. Powell-Wiley Jan 2025

Loneliness Associates With Endothelial Dysfunction In A Community-Based Cohort: A Pilot Study And Translational Approach, Yvonne Baumer, Brian A. Tirado, Lola R. Ortiz-Whittingham, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Laurel G. Mendelsohn, Abhinav Saurabh, Joshua A. Jacobs, Marcus R. Andrews, Valerie M. Mitchell, Billy S. Collins, Antwan Jones, Danielle M. Schwartz, Anca D. Dobrian, Michael V. Stanton, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Loneliness is known to be an important contributor to cardiovascular disease (CVD). However, little is known about the impact of loneliness on endothelial barrier integrity, a crucial hallmark of CVD development and progression. In this study, we aimed to investigate how loneliness might impact the endothelium. We found greater perceived loneliness associated with the product of circulating epinephrine and TNFα (E/T), which, in turn, associated with lower VE-cadherin on endothelial cells in an ex vivo experiment. Additionally, circulating plasma levels of soluble VE-cadherin were associated significantly with subclinical CVD. To explore the mechanistic aspects of these associations, we measured the …


Green Chelation Strategy For Deashing Of Algal Biomass, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar Jan 2025

Green Chelation Strategy For Deashing Of Algal Biomass, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

This study investigated a green chelation strategy for deashing algal biomass using nitrilotriacetic acid (NTA) and deionized water (DI) to enhance its suitability for biofuel and bioproduct applications. Solid-state algal turf scrubber (SS ATS), green algal turf scrubber (ATS), and Scenedesmus were analyzed, with Scenedesmus selected for detailed evaluation due to its high ash removal efficiency. The objective was to optimize a purification process that minimizes ash and heavy metal content while preserving biochemical integrity. Algal biomass underwent sequential washing with DI, NTA, and NTA+DI under varying temperatures (90-130 °C). Analytical techniques including Fourier Transform Infrared (FTIR) spectroscopy, Inductively Coupled …


Organic Carbon Decay Mediated By A Mesopelagic Microbial Community: The Relevance Of Carbon Pools And Broad Biochemical Composition, Noah J. Craft, Alexander B. Bochdansky Jan 2025

Organic Carbon Decay Mediated By A Mesopelagic Microbial Community: The Relevance Of Carbon Pools And Broad Biochemical Composition, Noah J. Craft, Alexander B. Bochdansky

OES Faculty Publications

The mesopelagic zone is a site of strong microbially driven particle attenuation with depth and thus plays a crucial role in controlling the transfer efficiency of the ocean's biological pump. However, little quantitative information exists on the dependency of decay processes on the source material. Here we followed the decay of ¹⁴C-labeled dead particulate organic carbon (POC) and dissolved organic carbon (DOC) from three different phytoplankton species, and two incubations of live diatoms, in mesopelagic water over 3 months. Commonly used first-order kinetics failed to adequately describe the decay of organic material as rate constants varied from day to day. …


Characterization Of Microbial Biofilms On Marine Plastics: Community Development And Density Implications For Vertical Transport Dynamics, Gregory M. Joern, Rut Pedrosa-Pàmies, Xiangtao Jiang, Zhanfei Liu, Alexander B. Bochdansky Jan 2025

Characterization Of Microbial Biofilms On Marine Plastics: Community Development And Density Implications For Vertical Transport Dynamics, Gregory M. Joern, Rut Pedrosa-Pàmies, Xiangtao Jiang, Zhanfei Liu, Alexander B. Bochdansky

OES Faculty Publications

Marine plastic pollution poses a significant and escalating threat to ocean ecosystems, with microbial colonization on plastics playing a critical role in determining their environmental fate. Despite the recognized importance of microbial biofilms, their composition, dynamics, and functional contributions on buoyant plastics remain poorly understood. In this study, we leveraged a novel integrative approach by simultaneously employing 16S, 18S, and ITS sequencing alongside microscopy, lipidomics, pigment analysis, adenosine triphosphate and biogenic silica quantification. This comprehensive methodology allowed for a thorough characterization of microbial growth and community dynamics on plastic debris in a mid-latitude, tidal sub-estuary. Our analyses consistently identified diatoms, …


The Effect Of Temperature And Salinity On Margalefidinium Polykrikoides Group Iii Va, Usa Strain Growth, Eduardo Pérez-Vega, Margaret R. Mulholland, Katherine E. Crider, Kimberly E. Powell, P. Dreux Chappell, Alexander Bochdansky Jan 2025

The Effect Of Temperature And Salinity On Margalefidinium Polykrikoides Group Iii Va, Usa Strain Growth, Eduardo Pérez-Vega, Margaret R. Mulholland, Katherine E. Crider, Kimberly E. Powell, P. Dreux Chappell, Alexander Bochdansky

OES Faculty Publications

Margalefidinium polykrikoides is a cosmopolitan dinoflagellate that blooms in coastal waters. Despite genomic evidence that it belongs to Group III and so closely related to isolates from Puerto Rico, Malaysia, North America, and Central America, M. polykrikoides blooms in the Chesapeake Bay at warmer temperatures and lower salinities than in coastal ecosystems occupied by its closest relatives. In this study, the effect of temperature and salinity on the growth rate and total cell yield of an M. polykrikoides VA culture isolate were examined and compared with environmental observations made during M. polykrikoides blooms in the Chesapeake Bay. M. polykrikoides group …


Optimizing An Image Analysis Protocol For Ocean Particles In Focused Shadowgraph Imaging Systems, Huanqing Huang, Alexander B. Bochdansky Jan 2025

Optimizing An Image Analysis Protocol For Ocean Particles In Focused Shadowgraph Imaging Systems, Huanqing Huang, Alexander B. Bochdansky

OES Faculty Publications

A variety of imaging systems are in use in oceanographic surveys, and the opto-mechanical configurations have become highly sophisticated. However, much less consideration has been given to the accurate reconstruction of imaging data. To improve reconstruction of particles captured by Focused Shadowgraph Imaging (FoSI)—a system that excels at visualizing low-optical-density objects, we developed a novel object detection algorithm to process images with a resolution of ~ 12 μm per pixel. Suggested improvements to conventional edge-detection methods are relatively simple and time-efficient, and more accurately render the sizes and shapes of small particles ranging from 24 to 500 μm. In addition, …


Microbial Mats In Dinosaur Ichnocoenoses, Nora Noffke, Paul C. Murphey, Roger C. Buntin, Martin G. Lockley Jan 2025

Microbial Mats In Dinosaur Ichnocoenoses, Nora Noffke, Paul C. Murphey, Roger C. Buntin, Martin G. Lockley

OES Faculty Publications

Until now, the significance of microbial mats in preservation of dinosaur tracks and in reconstructing the palaeoenvironment in which dinosaurs roamed was rarely studied. Dinosaur tracks are commonly found close to ancient aquatic bodies where moist sediment had once allowed footstep registration. At such sites, epibenthic or endobenthic microbial mats may have developed as well and may have led to exquisite track preservation. Microbial mats in coastal, lacustrine or flood plain environments cause ‘microbially induced sedimentary structures—MISS’, which are micobialites found in sandy or evaporitic settings. The microbial structures record environmental parameters including meteorological conditions that existed at the time …


A Century Of Sediment Metal Contamination Of Mar Menor, Europe's Largest Saltwater Lagoon, Irene Alorda-Montiel, Valentí Rodellas, Ariane Arias-Ortiz, Albert Palanques, Andrea G. Bravo, Júlia Rodriguez-Puig, Aaron Alorda-Kleinglass, Carlos Green-Ruiz, Marc Diego-Feliu, Pere Masqué, Javier Gilabert, Jordi Garcia-Orellana Jan 2025

A Century Of Sediment Metal Contamination Of Mar Menor, Europe's Largest Saltwater Lagoon, Irene Alorda-Montiel, Valentí Rodellas, Ariane Arias-Ortiz, Albert Palanques, Andrea G. Bravo, Júlia Rodriguez-Puig, Aaron Alorda-Kleinglass, Carlos Green-Ruiz, Marc Diego-Feliu, Pere Masqué, Javier Gilabert, Jordi Garcia-Orellana

OES Faculty Publications

Coastal enclosed ecosystems, such as lagoons, are vulnerable to anthropogenic impacts because they favor the accumulation of contaminants from the surrounding watersheds, particularly in their sediments. Europe's largest saltwater lagoon, the Mar Menor (SE, Iberian Peninsula), is a highly impacted ecosystem and the first in the continent to be granted personhood rights. Based on a high-resolution spatial and temporal dataset, we present the historical reconstruction of metal contamination in this ecosystem during the last century. Our results highlight that sediment metal contamination has been mainly driven by the development of the mining industry in the nearby Sierra Minera de Cartagena-La …


Successful Eastern Oyster (Crassostrea Virginica) Recruitment On Intertidal Artificial Substrates In Virginia, Usa, Rochelle D. Seitz, Kathleen E. Knick, Emily Suchonic, Amanda Pysher Jan 2025

Successful Eastern Oyster (Crassostrea Virginica) Recruitment On Intertidal Artificial Substrates In Virginia, Usa, Rochelle D. Seitz, Kathleen E. Knick, Emily Suchonic, Amanda Pysher

OES Faculty Publications

Declines of eastern oyster (Crassostrea virginica) populations and scarcity of natural oyster shell necessitate quantifying the effectiveness of artificial oyster reef substrates over varying environmental conditions. Oyster castles are often used in intertidal areas with moderate wave energy; however, new concrete, natural-looking substrates, GROW Reef Tiles, are now available. Eastern oyster recruitment and size on oyster castles (OC) and GROW Reef Tiles (GT), with 27% higher surface area on OC, were assessed three times over 25 months in locations with varying salinity. Four sites in the Chesapeake Bay region were examined: Cherrystone Inlet, Mockhorn Bay, Elizabeth River, and …


Organic Geochemical Evidence For Life In Archean Rocks Identified By Pyrolysis-Gc-Ms And Supervised Machine Learning, Michael L. Wong, Anirudh Prabhu, Conel O'D. Alexander, H. James Cleaves Ii, George D. Cody, Grethe Hystad, Marko Bermanec, Wouter Bleeker, C. Kevin Boyce, Andrea Corpolongo, Andrew D. Czaja, Souvik Das, Robert R. Gaines, Daniel D. Gregory, John A. Jaszczak, Emmanuelle J. Javaux, Jaganmoy Jodder, Andrew H. Knoll, Martin Van Kranendonk, Katie M. Maloney, Nora Noffke, Robert Rainbird, Emersyn Slaughter, Eva E. Stüeken, Roger E. Summons, Frances Westall, Jasmina Wiemann, Shuhai Xiao, Robert M. Hazen Jan 2025

Organic Geochemical Evidence For Life In Archean Rocks Identified By Pyrolysis-Gc-Ms And Supervised Machine Learning, Michael L. Wong, Anirudh Prabhu, Conel O'D. Alexander, H. James Cleaves Ii, George D. Cody, Grethe Hystad, Marko Bermanec, Wouter Bleeker, C. Kevin Boyce, Andrea Corpolongo, Andrew D. Czaja, Souvik Das, Robert R. Gaines, Daniel D. Gregory, John A. Jaszczak, Emmanuelle J. Javaux, Jaganmoy Jodder, Andrew H. Knoll, Martin Van Kranendonk, Katie M. Maloney, Nora Noffke, Robert Rainbird, Emersyn Slaughter, Eva E. Stüeken, Roger E. Summons, Frances Westall, Jasmina Wiemann, Shuhai Xiao, Robert M. Hazen

OES Faculty Publications

Throughout Earth’s history, organic molecules from both abiogenic and biogenic sources have been buried in sedimentary rocks. Most of these organic molecules have been significantly altered by geologic processes through deep time. Nonetheless, the nature and distribution of those ancient fragmentary organic remains have the potential to reveal diagnostic biomolecular information after billions of years of burial. Here, we analyzed 406 fossil, modern biological, meteoritic, and synthetic samples using pyrolysis gas chromatography and mass spectrometry. We explored these analytical data via supervised machine-learning methods to discriminate samples of biogenic vs. abiogenic origin, plant vs. animal phylogenetic affinity, and photosynthetic vs. …


Association Of Prenatal Exposure To Phthalates And Phenols With Adverse Pregnancy Outcomes, Misa Hayasaka, Diana Aboukhater, George Saade, Tetsuya Kawakita Jan 2025

Association Of Prenatal Exposure To Phthalates And Phenols With Adverse Pregnancy Outcomes, Misa Hayasaka, Diana Aboukhater, George Saade, Tetsuya Kawakita

Department of Obstetrics & Gynecology Faculty Publications

OBJECTIVE:

To evaluate the association between prenatal exposures to phthalates and phenols and adverse pregnancy outcomes, including preterm birth (PTB), small-for-gestational-age (SGA) birth weight, and gestational diabetes mellitus (GDM).

METHODS:

This study analyzed data from the Environmental Influences on Child Health Outcomes consortium, which harmonized longitudinal data on more than 30,000 pregnancies and 57,000 children from 69 cohorts across the United States and Puerto Rico. Pregnancy outcomes included PTB, SGA, and GDM, identified from medical records or self-reports. Generalized estimating equations models with Poisson distribution and robust variance were used to estimate relative risks (RRs) and 95% CIs per interquartile …


Association Between The Intensity Of Exercise In The First Trimester And Early Second Trimester And The Risk Of Gestational Diabetes, Takaki Tanamoto, Misa Hayasaka, Tetsuya Kawakita Jan 2025

Association Between The Intensity Of Exercise In The First Trimester And Early Second Trimester And The Risk Of Gestational Diabetes, Takaki Tanamoto, Misa Hayasaka, Tetsuya Kawakita

Department of Obstetrics & Gynecology Faculty Publications

Objective

Although some studies show that exercise decreases the incidence of gestational diabetes mellitus (GDM), the optimal exercise intensity during pregnancy remains unclear. We examined GDM risk according to exercise intensity in pregnant individuals.

Methods

We analyzed data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers‐to‐Be (nuMoM2b), a prospective study enrolling nulliparous individuals in the first trimester. Participants with pregestational diabetes or delivery before 20 weeks were excluded. Exercise intensity during the first (6–13 weeks’ gestation) and early second (16–21 weeks’ gestation) trimesters was categorized by metabolic equivalent of task hours per week (MET‐hr/week) as none, low intensity (< 7.5), moderate intensity (7.5–14.9), or high intensity (≥ 15). The primary outcome was GDM; secondary outcomes included preeclampsia, gestational hypertension, preterm birth, small‐for‐gestational‐age birth, and stillbirth. Adjusted relative risks (aRRs) with 95% confidence intervals (CIs) were calculated using a generalized linear mixed‐effects model with a Poisson distribution and robust error variance, controlling for the random effects of individuals and potential confounders.

Results …


Husbandry Of Jellyfish And Ctenophores: Why Gelatinous Forms Thrive In Their Natural Habitat And Yet Often Struggle To Survive In Aquaria, Regina Garza Ramirez Jan 2025

Husbandry Of Jellyfish And Ctenophores: Why Gelatinous Forms Thrive In Their Natural Habitat And Yet Often Struggle To Survive In Aquaria, Regina Garza Ramirez

Undergraduate Theses and Capstone Projects

Recent observations in the behaviors of several gelatinous forms in the wild have demonstrated that human impacts to their environment have likely accelerated growth of their populations tremendously. Interestingly enough, population growth of jellyfish and ctenophores in aquariums and artificial habitats is less often observed under controlled conditions, while they often bloom in rapidly changing environments of nature. Seeking the knowledge of aquarists and researchers that have worked directly with gelatinous animals through interviews, and documenting the experiences of each individual, allowed acquisition of data that can be used to compare the reproductive success of these animals in captivity and …


Topss: Tolerability Of Transcranial Direct Current Stimulation In Pediatric Stroke Survivors, Stuart Fraser, Anna Clearman, Melika Abrahams, Bernadette Gillick, Tia Lal, Sean Savitz, Nuray Yozbatiran Jan 2025

Topss: Tolerability Of Transcranial Direct Current Stimulation In Pediatric Stroke Survivors, Stuart Fraser, Anna Clearman, Melika Abrahams, Bernadette Gillick, Tia Lal, Sean Savitz, Nuray Yozbatiran

Faculty, Staff and Student Publications

Background: Transcranial direct current stimulation is a non-invasive neuromodulation technique with emerging therapeutic potential in neurodevelopmental conditions. While childhood-onset stroke survivors frequently experience long-term motor impairment, there are very few studies examining the safety and feasibility of transcranial direct current stimulation in this population.

Objective: To evaluate the safety, feasibility, and tolerability of bihemispheric transcranial direct current stimulation paired with occupational therapy in children and adolescents with chronic hemiparesis following childhood-onset arterial ischemic stroke or intracranial hemorrhage.

Methods: In this single-arm, open-label pilot study, five participants aged 6-19 years of age received five daily sessions of transcranial direct current stimulation …


Racial Differences In Systemic Immune Parameters In Individuals With Lung Cancer, Mitchell S Von Itzstein, Jialiang Liu, Hong Mu-Mosley, Farjana Fattah, Jason Y Park, Jeffrey A Sorelle, J David Farrar, Mary E Gwin, David Hsiehchen, Yvonne Gloria-Mccutchen, Edward K Wakeland, Suzanne Cole, Sheena Bhalla, Radhika Kainthla, Igor Puzanov, Benjamin Switzer, Gregory A Daniels, Yousef Zakharia, Montaser Shaheen, Jianjun Zhang, Yang Xie, David E Gerber Jan 2025

Racial Differences In Systemic Immune Parameters In Individuals With Lung Cancer, Mitchell S Von Itzstein, Jialiang Liu, Hong Mu-Mosley, Farjana Fattah, Jason Y Park, Jeffrey A Sorelle, J David Farrar, Mary E Gwin, David Hsiehchen, Yvonne Gloria-Mccutchen, Edward K Wakeland, Suzanne Cole, Sheena Bhalla, Radhika Kainthla, Igor Puzanov, Benjamin Switzer, Gregory A Daniels, Yousef Zakharia, Montaser Shaheen, Jianjun Zhang, Yang Xie, David E Gerber

Faculty, Staff and Student Publications

Introduction: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer.

Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. Clinical and demographic information were obtained from electronic medical records. Pretreatment peripheral blood samples were collected and analyzed for cytokines using a multiplex panel and for immune cell populations using mass cytometry. Differences between Black and White patients were determined and corrected for multiple comparisons.

Results: A …


Treatment Of Myocardial Infiltration Of Hodgkins Lymphoma: A Catch-22, Jennifer Priessnitz, Erin Biringen, Fadi Khoury, Christina Bergin Jan 2025

Treatment Of Myocardial Infiltration Of Hodgkins Lymphoma: A Catch-22, Jennifer Priessnitz, Erin Biringen, Fadi Khoury, Christina Bergin

Department of Medicine Faculty Publications

Background: Cardiac sequelae in Hodgkin Lymphoma (HL) can manifest as involvement of the heart and pericardium. Direct cardiac involvement is rare, and myocardial infiltration is distinctly unusual.¹ When it does occur, it is often a late manifestation of lymphoma, with a median onset of 20 months after initial diagnosis, and it is usually associated with advanced-stage disease.²

Case: A 34-year-old male was diagnosed with classic HL by lymph node biopsy. During his hospitalization, the patient remained in sinus tachycardia with heart rate up to 150 with no dysrhythmias. Transthoracic echocardiogram (TTE) revealed a reduced ejection fraction (EF) of 36% concerning …


Drug-Induced Leukocytoclastic Vasculitis From An Unreported Source: Daptomycin, Jennifer K. Priessnitz, Timothy Kuzel, Lindsay Ackerman, Nelson Nicolasora Jan 2025

Drug-Induced Leukocytoclastic Vasculitis From An Unreported Source: Daptomycin, Jennifer K. Priessnitz, Timothy Kuzel, Lindsay Ackerman, Nelson Nicolasora

Department of Medicine Faculty Publications

Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis caused by immune-complex-mediated deposition on endothelial cells of dermal capillaries. Common triggers include medications, infections, autoimmune disorders, and malignancies. We present a case of a 58-year-old male who developed daptomycin-induced LCV after being treated for Methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. The patient experienced painful palpable purpura on his lower extremities, which was diagnosed as LCV by skin biopsy. At the time of the biopsy, warfarin and daptomycin were discontinued, and the patient was transitioned to heparin and ceftaroline. MRSA-induced LCV was ruled out, due to negative blood cultures and adequate source control …


Late Diagnosis Of Klinefelter Syndrome: Overcoming Phenotypic Variability And Diagnostic Oversights, Amna Kamran, Chinelo Okigbo Jan 2025

Late Diagnosis Of Klinefelter Syndrome: Overcoming Phenotypic Variability And Diagnostic Oversights, Amna Kamran, Chinelo Okigbo

Department of Medicine Faculty Publications

We report a case of Klinefelter syndrome (KS) diagnosed in adulthood, emphasizing the impact of phenotypic variability and the declining reliance on physical examination in delayed recognition. A 27-year-old male with obesity, low libido, and biochemical and clinical primary hypogonadism was found to have 47, XXY karyotype, consistent with KS. His hypogonadism was initially attributed to obesity and overlooked, despite classic signs of a micropenis and small testes. The case highlights the importance of physical examination, comprehensive history, and clinician awareness in diagnosing KS, particularly in atypical presentations. KS is associated with increased risks of osteoporosis, cardiovascular disease, and psychosocial …


Consumption Of The Food Groups With The Revised Benefits In The New Wic Food Package: A Scoping Review, Qi Zhang, Priyanka T. Patel, Bidusha Neupane, Caitlin M. Lowery, Futun Alkhalifah, Faezeh Mahdavi, Esther May Sarino Jan 2025

Consumption Of The Food Groups With The Revised Benefits In The New Wic Food Package: A Scoping Review, Qi Zhang, Priyanka T. Patel, Bidusha Neupane, Caitlin M. Lowery, Futun Alkhalifah, Faezeh Mahdavi, Esther May Sarino

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Background: On 18 April 2024, the United States Department of Agriculture (USDA) published the first food package changes to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in over a decade, which reduced some food benefits (juice, milk, canned fish, and infant fruits and vegetables) and offered substitutes (cash-value vouchers (CVVs) or cash-value benefits (CVBs) to redeem for fruits and vegetables, cheese, soymilk, or other dairy products). Methods: To assess the impact of the changes on the consumption and redemption of these food groups, a systematic search was conducted, identifying 23 peer-reviewed publications between 2010 and 2024. …


Diversifying Ecology Education For Everyone Through More Inclusive, Interdisciplinary, And Accessible Teaching, Loren B. Byrne, Emily S. J. Rauschert, Vikki L. Rodgers, Gillian Bowser, Et Al. Jan 2025

Diversifying Ecology Education For Everyone Through More Inclusive, Interdisciplinary, And Accessible Teaching, Loren B. Byrne, Emily S. J. Rauschert, Vikki L. Rodgers, Gillian Bowser, Et Al.

Arts & Sciences Faculty Publications

Educating more students about ecology and its beneficial applications to societal issues is urgent yet challenging. To address this challenge, diversifying ecology education is a key way to make ecology more inclusive, accessible, and interdisciplinary for more people than ever. Advancing this goal requires ecology educators to develop a more expansive view of (1) how to engage more diverse undergraduate students in ecology courses, especially those from historically underrepresented groups and non-majors, (2) the interdisciplinarity of content in those courses, and (3) the learner-centered pedagogies used to engage students. We suggest ways that ecologists can advance “ecology education for everyone” …


Assessment Of Bifidobacterium Longum Itt 13 As A Probiotic Candidate, Eleana Keatley Jan 2025

Assessment Of Bifidobacterium Longum Itt 13 As A Probiotic Candidate, Eleana Keatley

Masters

Probiotics are live microorganisms that when administered in adequate amounts confer a health benefit on the host. Beneficial microbes are found in several sites throughout the body such as the oral cavity, skin, respiratory tract, vagina, urinary tract, breast tissue and the gut. In this research, the culture Bifidobacterium longum ITT 13, which was previously isolated from a neonatal faecal sample, was examined for its potential as a probiotic candidate. Probiotics can have numerous desirable characteristics. The pertinent ones to this research are being of human or animal origin, not prone to antibiotic resistance, demonstration of antagonistic activity towards pathogens, …


Synthesis And Assessment Of Biobased Acrylated Epoxidized Soybean Oil Resins For Stereolithography 3d Printing Of Microfluidic Devices, Natalie S. Romero Figueroa Jan 2025

Synthesis And Assessment Of Biobased Acrylated Epoxidized Soybean Oil Resins For Stereolithography 3d Printing Of Microfluidic Devices, Natalie S. Romero Figueroa

College of Graduate Studies: Theses & Dissertations

This research focuses on the development and characterization of a biobased photocurable resin synthesized from soybean oil for use in stereolithography (SLA) 3D printing of microfluidic devices. The study explores a sustainable alternative to petroleum-based resins by performing an acrylation reaction on epoxidized soybean oil (ESO) to produce acrylated epoxidized soybean oil (AESO), which was then formulated into a photocurable resin with the addition of a photo initiator. The fabrication process involved designing microfluidic molds in SolidWorks and printing them using an Elegoo Mars 4 SLA printer under various exposure and layer thickness parameters. The printed samples consisted of microchannels …


Enhancing The Mechanical Properties Of Sla 3d-Printed Bio-Resin From Linseed Oil Using Cellulose And Lignin Biopolymers, Chukwunonso A. Ikedionu Jan 2025

Enhancing The Mechanical Properties Of Sla 3d-Printed Bio-Resin From Linseed Oil Using Cellulose And Lignin Biopolymers, Chukwunonso A. Ikedionu

College of Graduate Studies: Theses & Dissertations


Abstract

This research explores the development of bio resin from linseed oil by the process of epoxidation and acrylation to produce acrylated epoxidized linseed oil (AELO). Lignin and cellulose biopolymers were added as reinforcement at varying weight fractions of 1 wt.%, 2.5 wt.%, and 5 wt.%, and their mechanical performance was compared against pure AELO. The formulations were printed using an Elegoo SLA 3D printer to create standardized test specimens like tensile bars, compression cylinders, and hardness blocks, which were all prepared according to the ASTM testing standard.

The results indicate that reinforcement effects depend on both filler type and …