Life Sciences Commons^™

Examining Factors Of Variance In Energy Metabolism Of Dairy Cattle, Addison L. Carroll

Department of Animal Science: Dissertations, Theses, and Student Research

Variation is thought to occur in the use of dietary energy for production in dairy cattle. First, variance can be observed when new methane mitigation strategies are fed resulting in increased H₂ output potentially resulting in downstream effects on estimates of heat production via the Brouwer (1965) equation. Therefore, in chapter 3 a review was created to systematically describe the mathematics and theory behind the Brouwer equation, and rederive a heat production equation to integrate H₂ production. Results indicate heat production using the classical Brouwer equation (1965) relative to the rederived equation resulted in an overestimation of heat …

Impacts Of Annual Forage Management On Grazing Cattle Performance And Carrying Capacity, Shelby Davies Jenkins

Department of Animal Science: Dissertations, Theses, and Student Research

Rapid conversion of historical grasslands to cropland in recent history has led to limited perennial pasture availability and an increase in cost of pasture rent. Annual forages are an alternative grazing source. Many annual forages can grow and accumulate stockpile following summer harvest of wheat. Strip grazing is often suggested to increase grazing efficiency of stockpiled forages. To evaluate this, a stockpiled mixture of annual forages were either strip grazed or grazed continuously in the fall and winter. The mixture contained oats and rapeseed in the first year and a diverse warm season annual mixture in the second. Strip grazing …

This Year In Space: The Astounding Astronomical Events Of 2024, Celeste Wicks

The Synapse: Intercollegiate science magazine

No abstract provided.

Issue 41

The Synapse: Intercollegiate science magazine

No abstract provided.

The Care Crisis: The Neurology Of Dementia And International Solutions, Sophie Paton

The Synapse: Intercollegiate science magazine

No abstract provided.

Will My Celsius Addiction Kill Me?: The Thermogenic Drink And Its Impact On Nutrition And Metabolism, Katie Johnstone

The Synapse: Intercollegiate science magazine

No abstract provided.

Genes And Zzz's: The Genetic Variations Of Sleep Disorders, Ananya Sivasubramaniam

The Synapse: Intercollegiate science magazine

No abstract provided.

Call For Contributors

The Synapse: Intercollegiate science magazine

No abstract provided.

Puzzle Corner

The Synapse: Intercollegiate science magazine

No abstract provided.

Invisible Intruders: The Growing Presence Of Microplastics And Its Effects On The Brain, Megan Carlson

The Synapse: Intercollegiate science magazine

No abstract provided.

Digging Up A New Era In Fertilizer: Investigating The Potential Of Electron Bifurcation In Ammonia Synthesiss, Ella Wurtzbacher

The Synapse: Intercollegiate science magazine

No abstract provided.

Peeling Back Allergies: Punica Granatum And Its Various Bene.Its, Mina Stalhamer, Haimanot Assefa

The Synapse: Intercollegiate science magazine

No abstract provided.

On A Color Wheel: Adhd Under The Social Model's Scope, Ben Tran

The Synapse: Intercollegiate science magazine

No abstract provided.

This Land Is Your Land, This Land Is My Land, Alexia Liu

The Synapse: Intercollegiate science magazine

No abstract provided.

Wired For Love: The Neuroscience Behind Romantic Attraction, Jacqueline Rogers

The Synapse: Intercollegiate science magazine

No abstract provided.

Bioinformatics Analysis Of The Microsporidia Sp. Mb Genome: A Malaria Transmission-Blocking Symbiont Of The Anopheles Arabiensis Mosquito, Lilian Mbaisi Ang’Ang’O, Jeremy Keith Herren, Özlem Tastan Bishop

All Peer-Reviewed Publications

Background: The use of microsporidia as a disease-transmission-blocking tool has garnered significant attention. Microsporidia sp. MB, known for its ability to block malaria development in mosquitoes, is an optimal candidate for supplementing malaria vector control methods. This symbiont, found in Anopheles mosquitoes, can be transmitted both vertically and horizontally with minimal effects on its mosquito host. Its genome, recently sequenced from An. arabiensis, comprises a compact 5.9 Mbp. Results: Here, we analyze the Microsporidia sp. MB genome, highlighting its major genomic features, gene content, and protein function. The genome contains 2247 genes, predominantly encoding enzymes. Unlike other members of the …

Shaping The Microbial Landscape: Parasitoid-Driven Modifications Of Bactrocera Dorsalis Microbiota, Rehemah Gwokyalya, Jeremy K. Herren, Christopher W. Weldon, Shepard Ndlela, Joseph Gichuhi, Nehemiah Ongeso, Anne W. Wairimu, Sunday Ekesi, Samira A. Mohamed

All Peer-Reviewed Publications

Koinobiont endoparasitoids regulate the physiology of their hosts through altering host immuno-metabolic responses, processes which function in tandem to shape the composition of the microbiota of these hosts. Here, we employed 16S rRNA and ITS amplicon sequencing to investigate whether parasitization by the parasitoid wasps, Diachasmimorpha longicaudata (Ashmaed) (Hymenoptera: Braconidae) and Psyttalia cosyrae (Wilkinson) (Hymenoptera: Braconidae), induces gut dysbiosis and differentially alter the gut microbial (bacteria and fungi) communities of an important horticultural pest, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). We further investigated the composition of bacterial communities of adult D. longicaudata and P. cosyrae to ascertain whether the adult parasitoids …

Blend Matters: Interactions Of Rice Cultivars On Milling, Physico-Chemical & End Use Traits, Bindu Regonda

Graduate Theses and Dissertations

Rice blending or mixing of different rice cultivars, a common practice in the industry, significantly impacts processing efficiency and end-product quality, yet its effects on end products remain understudied. This research investigated the implications of blending contemporary Arkansas rice cultivars through two comprehensive studies focusing on milling yields and physicochemical properties, instantization, and parboiling processes. Five long-grain cultivars, including hybrids (RT 7521 FP, RT 7321 FP, XP 753) and purelines (Ozark, CLL 16), were blended in various combinations and different drying.

The first study revealed that blending significantly affected milling yields and physicochemical attributes. Pre-drying blending yielded better results compared …

Proteolytic Manipulation Of Neutrophil Responses And The Efferocytic Synapse By Porphyromonas Gingivalis., Kelley N. Cooper

Electronic Theses and Dissertations

Porphyromonas gingivalis (Pg) is etiologically associated with chronic periodontitis, a highly prevalent chronic inflammatory disease characterized by the destruction of hard and soft tissues of the periodontium. Pg is adapted to live in the human oral subgingival niche, a hostile environment dominated by excessive numbers of activated neutrophils and antimicrobial mediators. Its survival is contingent upon prompt and effective inactivation of neutrophil effector functions. In this dissertation, I uncover a novel pathogenic mechanism employed by Pg that disarms the antimicrobial capacity of live neutrophils and simultaneously sequesters them within macrophages. Mechanistically, RgpB, a cysteine protease produced by Pg …

The Impact Of Wild Pigs (Sus Scrofa) On Avian Occupancy And Vegetation Structure, Kenneth Wilson

Graduate Theses and Dissertations

Invasive species, particularly wild pigs (Sus scrofa), pose a significant threat to native ecosystems through both direct and indirect impacts. Wild pigs are large-bodied omnivorous species that can consume a wide variety of plants and animals and are known for destructive foraging behaviors, which likely threatens avian communities through habitat alteration and can impact the long term structure of ecosystems where they are present.

In chapter 1, we used a combination of avian point count surveys, vegetation assessments, and camera trap surveillance to quantify how the occupancy of breeding birds in bottomland hardwood forests changed in relation to …

Utilization Of Prosur Phr As A Novel Phosphate Alternative In Tumble, Inject, And Tumble Injection Marinated Chicken Breast, Sarah E. Johnson

Graduate Theses and Dissertations

Poultry is the most widely consumed meat protein worldwide for its health consideration, affordability, and versatility. Historically, the poultry industry has utilized numerous methods to improve meat quality most significantly, marination. Marination is practice commonly used in the industry by imparting various chemical functional ingredients that are known to enhance sensory characteristics such as tenderness, juiciness, and flavor. Various marination methods used in the industry including tumble, injection, and soaking. Ingredients, such as sodium chloride and phosphates are commonly used in the marination process. In recent years the industry has witnessed a shift in consumer preferences to “clean-label”. This trend …

Nuclear Expression Of Dynamin 2 Is Associated With Tumor Aggressiveness In Bladder Cancer Patients: A Bioinformatics And Experimental Approach, Mahdieh Razmi, Leili Saeednejad Zanjani, Mandana Rahimi, Roya Sajed, Sadegh Safaei, Zahra Madjd, Roya Ghods

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Dynamin 2 (DNM2) is aberrantly expressed in different malignancies and exerts a function in tumor progression.

AIMS: This study, for the first time, aimed to evaluate the clinical and prognostic value of DNM2 in the pathophysiology of bladder cancer using bioinformatics analysis and experimental evaluation.

METHODS AND RESULTS: We analyzed gene expression of DNM2 in bladder tumor by GEPIA2 and GENT2 platforms. Cluster subnetworks were recognized from the protein-protein interaction (PPI) network using the MCODE plugin to screen the key genes. Subsequently, the pathway enrichment analysis was evaluated. Then, the immunohistochemical examination was conducted on 209 paraffin-embedded bladder cancer …

Delineating Genetic Influences On Neurodegenerative Disorders And Infectious Diseases Through Advanced Computational Methods, Xiaowei Zhuang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Genetics plays a critical role in understanding the molecular mechanisms underlying neurodegenerative disorders and pathogen evolution in infectious diseases. For example, identifying genetic variants associated with a disease phenotype uncovers functional pathways that could lead to potential drug targets and therapeutic interventions. In addition, tracking the genetic evolution of pathogens enables early detection and warning of infectious disease outbreaks. In both applications, given the large amount of genetic data, advanced computational methods, including longitudinal and multivariate models, could significantly boost the statistical power and capture interrelationships among traits, environmental factors and genetic influences. This dissertation focuses on four applications of …

The Bacterial Cell Wall Components Lipopolysaccharide And Peptidoglycan Initiate Divergent Local Tissue And Systemic Inflammatory Response Profiles In The Chicken Model, Kristen A. Byrne, Gisela F. Erf

Poultry Science Faculty Publications and Presentations

The innate immune system plays an important role in the early defense against pathogens. To better understand the chicken’s innate inflammatory responses, we concurrently examined the cellular responses at the injection site and in the blood following intradermal (i.d.) injections of lipopolysaccharide (LPS) or peptidoglycan (PGN) into the pulp of growing feathers (GFs). Both LPS from Gram-negative bacteria and PGN from Gram-positive bacteria are potent stimulators of innate inflammatory responses. The time-course study conducted revealed similarly elevated levels of heterophils and macrophages in injected GF-pulps during the first 24 h for both LPS and PGN. However, PGN also stimulated rapid …

Characterization Of An Acetogenin-Carrying Nanosuspension And Its Effect On Bacteria Of Interest In The Poultry Industry, Brandon A. Lopez-Romero, Gabriela Aguilar-Hernandez, Billy M. Hargis, Maria De Lourdes Garcia-Magana, Ulises M. Lopez-Garcia, Rosa I. Ortiz-Basurto, Adalberto Zamudio-Ojeda, Juan D. Latorre, Efigenia Montalvo-Gonzalez

Poultry Science Faculty Publications and Presentations

This work aimed to develop a nanosuspension (NSps) as an acetogenin (ACGs) carrier, using soy lecithin (SL) and hydroxypropyl-β-cyclodextrin (βCD) named NSps-βCDSL-ACGs. It was characterized by various spectroscopic techniques (DLS, FTIR, UV-vis diffuse reflectance). Moreover, the NSps morphology was observed by transmission electron microscopy (TEM). Also, the antibacterial activity of NSps-βCDSL-ACGs was evaluated against strains of interest in the poultry sector. NSps-βCDSL-ACGs presented nanometric size (207–239 nm), acceptable polydispersity index (PDI) values (0.13–0.17) and a high Z potential value (−47.17–50.36 mV), demonstrating high stability. The presence of ACGs in NSps-βCDSL-ACGs was confirmed by FTIR analysis. The nanoparticles had a spherical …

Socio-Ecological Drivers Of Anthropogenic Marine Debris Effects On Coral Reef Communities In The Florida Keys, Usa, Tokea Payton

All Dissertations

The Florida Keys reef tract has rapidly shifted from a structurally complex, hard coral-dominated reef to a less rugose, soft coral-dominated reef. Persistent anthropogenic stressors facilitate ecological transitions by including recreational and commercial fishing and increased anthropogenic marine debris. These artificial structures are becoming habitats for small marine taxa known as cryptofauna. Cryptofauna are among the most essential yet understudied reef taxa where little is known about their fate considering degrading coral reefs and increasing anthropogenic disturbance. With increased anthropogenic stressors on the marine environment, the SCUBA diving community has initiated extensive marine debris removal efforts to assist in cleaning …

Gc-Ms Analysis And Evaluation Of Antioxidant, Anticancer, Cytotoxicity, And Hypoglycemic Properties Of The Libyan Moringa Oleifera Leaf Extract On Alloxan-Induced Diabetes In Mice, Osama Abdel-Hafeez Mohammed Al-Bedak, Ahlam Rashed, Seham T.M. Oskandali, Nouri Kushlaf, Amal Eishebani, Samira A. Alacrouk, Fadia T.M. Oshkandale, Manal Eisheli, Zahur R. Almesai, Ameerah Shaeroun, Steven L. Stephenson, Fuad Ameen

Biological Sciences Faculty Publications and Presentations

Libyan Moringa oleifera leaves were extracted using methanol, and the bioactive components' antibacterial, antioxidant, anti-inflammatory, and anticancer characteristics were assessed using gas chromatography mass spectrometry analysis (GC-MS). Moringa oleifera exhibited antioxidant activity, with an IC50 of 11.53 µg/mL. Wi38 cell line's viability decreased with increasing M. oleifera extract concentration, while its cytotoxicity increased with an IC50 of 393.41±7.77 μg/mL. Alloxan-induced diabetes model in Swiss albino mice was implemented. Three different doses (100, 200, or 300 mg/kg of mice body weight) of M. oleifera’s extract were evaluated for their effects on blood sugar concentration and the histology of the pancreatic islets. …

Morphological Changes Of Liver Among Post-Fontan Surgery Patients, Varatharajan Nainamalai, Håvard Bjørke Jenssen, Khadiza Tun Suha, Mostafa Rezaeitaleshmahalleh, Min Wang, Sarah Khan, Marcus Haw, Jingfeng Jiang, Joseph Vettukattil

Michigan Tech Publications

Purpose: Liver screening and longitudinal study of Fontan Associated Liver Diseases (FALD) is essential to identifying hepatomegaly and how hepatomegaly relates to various stages of liver fibrosis. In this study, we investigated longitudinal liver shape changes and liver stiffness in a cohort of patients with Fontan Associated Liver Disease. Methods: We used 170 image volumes of 40 Fontan stage 3 completion patients. We also used 65 computed tomography images of healthy individuals from three datasets for comparison. Thirteen radiomic shape features of Fontan patients and individuals with a healthy liver were extracted and analyzed longitudinally. We studied correlations among features, …

Overcoming The Barrier To The Clinical Application Of Naloxone: Application Of Drug Delivery Technologies, Akeemat O. Tijani

Electronic Theses and Dissertations

Opioid overdose crisis continues to demand innovative solutions for rapid and effective drug administration. Naloxone (NAL), a critical opioid antagonist, has been the primary treatment for reversing opioid-induced respiratory depression. However, its current delivery methods, such as intravenous and intranasal formulations, are limited by their invasive nature, short half-life, and the need for repeated dosing. This dissertation investigates advanced drug delivery technologies aimed at overcoming these challenges and enhancing the clinical utility of NAL.

This research focused on improving the transdermal and transnasal delivery of NAL using minimally invasive techniques. Various approaches were evaluated, including sonophoresis, microneedles, laser ablation, dermaplaning …

Evaluation Of Industrial Hemp Cultivar And Biochar Rate To Remediate Heavy-Metal-Contaminated Soil From The Tar Creek Superfund Site, Usa, Dietrich V. Thurston, Kristofor R. Brye, David M. Miller, Philip A. Moore Jr., Donald M. Johnson, Mike Richardson

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Soil contamination by cadmium (Cd), lead (Pb), and zinc (Zn) at the Tar Creek superfund site in northeast Oklahoma, United States, remains a threat to the environment and local ecosystem. Phytoremediation with industrial hemp (Cannabis sativa L.) and the use of biochar (BC) have been independently shown to be effective methods to remediate heavy-metal-contaminated soils. The objective of this greenhouse study was to evaluate the effects of industrial hemp cultivar (‘Carmagnola’ and ‘Jinma’), biochar rate (0, 2, 5, and 10% by volume), soil contamination level (low, medium, and high), and their interactions on above- (AG) and belowground dry matter …