Life Sciences Commons^™

An Analysis Of Moth Diversity In Garbhanga Reserve Forest, Basistha, Assam, India, Golphina Ahmed, Arup Nama Das, Lupamudra Borah, Rezina Ahmed

Journal of Bioresource Management

The Garbhanga Reserve Forest, located on the south-western side of Guwahati City, covers an area of about 117 km2 and borders the foothills of Meghalaya (26°05´36˝N and 91°44´57˝E). Despite the constant threat of exploitation due to its proximity to the rapidly developing city, this area hosts a diverse ecosystem of moths and butterflies. In a study conducted over one year from January 2022 to December 2022, a total of 140 moth species were documented, with the majority belonging to the Erebidae family (46 species) and 1090 individuals, followed by the Crambidae family (31 species) and 704 individuals. The dominance of …

Determination Of Manganese Concentration In Forages, Soil, Sewage Water Of Three Suburban Areas Of Sargodha, Pakistan, Iqra Anwar, Zafar Iqbal Khan, Kafeel Ahmad, Naila Riaz, Faiza Zubair, Asma Ashfaq, Muhammad Fahad Ullah, Farzana Siddique, Ijaz Rasool Noorka, Abid Ejaz, Maloofa Manzoor, Umbreen Bibi, Hafiza Memona Nazir, Saif Ullah

Journal of Bioresource Management

For irrigation of soil utilization of wastewater has risen significantly in the past few years. This wastewater often have large amount of trace elements and heavy metals, many of which are non-essential and harmful to living organisms such as plants, animals, and humans. In Pakistan, particularly around suburban areas, it is common to use this polluted water for growing vegetables. When such water is used for irrigation over an extended period of time, toxic substances can accumulate in the soil, potentially causing toxicity to plants and degrading soil quality. The samples analyzed in the study were prepared using the wet …

Green Synthesis Of Titanium Oxide Nanoparticles From Leaves Extract Of Cassia Fistula And Evaluation Of Their Antimicrobial Activities, Anum Sadiq, Muhammad Shahbaz, Ayesha Shahbaz, Badra Younis, Shmsa Manzoor, Syeda Sabahat Fiaz

Journal of Bioresource Management

The fields of biotechnology, pharmacy, agriculture, and health could all benefit greatly from advances in Nano science and nanotechnology. The synthesis, characterizations, and antibacterial qualities of titanium dioxide (TiO2) nanoparticles made using Cassia fistula leaves in a green synthesis procedure are the main objectives of this work which was carried out between September 2021 and June 2022. Four methods were used to analyse the structure of titanium dioxide nanoparticles: FTIR, XRD, and SEM. According to FTIR research, TiO2 exhibited stretching vibrations at 1500–1600 cm-1 and a UV absorption peak between 250 and 400 nm. Nanoparticle diameters ranged from 145.6 to …

Multi-Sensor Data Fusion And Gis-Drastic Integration For Groundwater Vulnerability Assessment With Rainfall Consideration, Wu Jiazhe, Dai Xinrui, Su Yangcheng, Zheng Xiangtian, Bushra Ghaffar, Rabiya Nasir, Ahsan Jamil, Zeeshan Zafar, Mohammad Suhail Meer, M. Abdullah-Al-Wadud, Rahila Naseer, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

In many areas of the world, particularly in arid and semi-arid regions, groundwater is the primary source of fresh water, and it supplies around one-third of the world's fresh water. Agriculture is the primary economic sector on the coast in the southern district (Nowshera). More food productivity is required due to the expanding population and diminishing agricultural lands, which increases the use of chemical pesticides and fertilizers in farming. The current study was conducted in northwestern parts of Pakistan to evaluate the impacts of the frequent use of pesticides and fertilizers in agricultural fields. Nine hydrogeological parameters were considered, and …

Predicting Kidney Graft Function And Failure Among Kidney Transplant Recipients, Yi Yao, Brad C Astor, Wei Yang, Tom Greene, Liang Li

Faculty, Staff and Student Publications

Background: Graft loss is a major health concern for kidney transplant (KTx) recipients. It is of clinical interest to develop a prognostic model for both graft function, quantified by estimated glomerular filtration rate (eGFR), and the risk of graft failure. Additionally, the model should be dynamic in the sense that it adapts to accumulating longitudinal information, including time-varying at-risk population, predictor-outcome association, and clinical history. Finally, the model should also properly account for the competing risk by death with a functioning graft. A model with the features above is not yet available in the literature and is the focus of …

Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu

Faculty, Staff and Student Publications

The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis. However, the role of the ciliary proteins responsible for initiating cilium assembly in skeletal development remains unknown. Here, we investigate the function of centrosomal protein of 164 kDa (CEP164), a key ciliogenesis regulator that localizes at the distal appendages of the mother centriole, during skeletal development in mice. Interestingly, the mesodermal cell-specific Cep164 deletion resulted in severe bone defects and osteoblast-specific deletion of Cep164 …

Cropsync: Ai-Powered Sustainable Crop Management, Ziad Doughan, Ibrahim Mneimneh, Zouheir Nakouzi, Noor Al Khaib, Samer Damaj, Jamal Chaaban, Hamza Mrad, Sari Itani

BAU Journal - Science and Technology

CropSync is a smart agriculture system that uses AI and IoT technologies to enable sustain- able crop management and precision farming. The system aims to address the challenges faced by the agriculture sector, such as increasing food production to meet global population demands while minimizing environmental impact. CropSync integrates sensors, cameras, and cloud-based analytics to provide farmers with real-time insights and recommendations for optimizing crop cul- tivation. The system upholds engineering professional and ethical standards, considering broader social, environmental, and economic implications. From a social perspective, CropSync improves food security and enhances farmers’ livelihoods through increased productivity and efficient re- …

Development Of An Injectable Chitosan-Based Bioink For Enhanced Bone Fracture Healing Via Msc-Derived Osteogenesis, Zeina H. Adel, Jana A. Hassan, Hala H. Muhammed, Haneen M. Elsaeid, Raghad M. Nasr, Ahmed M. Deghidy

BAU Journal - Science and Technology

Worldwide, bone fractures are a major public health concern and, there is an urgent requirement to create new treatments to accelerate the rate of the bone healing process. This research mainly relies on creating a hydrogel that satisfies the bone marrow mesenchymal stem cells (BM-MSCs) and makes it a suitable medium to differentiate into osteogenic cells. We combine the BM-MSCs with a chitosan polymer-based hydrogel, infused with PVA to enhance bone healing, this unique mixture forms " Bioink ". We induced a closed fracture model in the rat's right humerus, followed by injection of a single dosage of bioink. On …

What Is It Like To Be A Diplomat? Reflections On Donald Griffin And Emotion, Oliver H. Turnbull

Animal Sentience

This commentary addresses three aspects of Donald Griffin’s work: (1) his thoughts beyond cognition, on emotion; (2) his views on the earliest origins of mind, including primitive forms of consciousness; and (3) his diplomatic use of memorable phrases to facilitate change.

Food For Thought: A Qualitative Assessment Of Medical Trainee And Faculty Perceptions Of Nutrition Education, Olivia Kunitsky, Mahdi Taye, Karla Feeley, Hugh Johnson, Abigail Glynn, Avery Stivale, Matthew Hamers, Alexis Notarianni, Sireesha Mamillapalli, Gabi Waite, Sonia Lobo

Department of Neurology Faculty Papers

BACKGROUND: The American Society of Clinical Nutrition recommends 37 to 44 h of undergraduate medical nutrition education. The Total Health Curriculum at Geisinger Commonwealth School of Medicine (GCSOM) contains 14 h of objective-based nutritional instruction. This study aimed to examine the perceptions of key stakeholders regarding the role of nutrition in medicine and to identify barriers, opportunities for improvement, and roles/responsibilities for innovative implementation of nutrition education.

METHODS: This exploratory, qualitative study employed a phenomenological approach and inductive coding process. Purposive sampling recruited medical students, undergraduate medical education (UME) faculty, physicians, and other healthcare professionals at GCSOM and affiliated clinical …

Promotion Of Overall Health During The Adolescent Period For Adolescent Girls Through Teaching Program – A Quasi-Experimental Study, Anusuya V. Prabhu Mrs., Sangeetha Priyadarshini, Mamatha Shivananda Pai Dr., Yashoda Sathish Dr.

Manipal Journal of Nursing and Health Sciences

Background

Adolescence, characterized by physical, psychological, and behavioral transformations, often elicits varied responses from girls. Adequate data can aid them in navigating these changes effectively. The study aimed to assess adolescent girls' understanding of puberty, psychological transitions, reproductive health, and the importance of a balanced diet during this developmental stage.

Method:

In this quasi-experimental investigation, purposive sampling was utilized to gather data. The study comprised 184 teenage girls aged between 10 and 19, with 92 participants assigned to both the intervention and control groups. Data were collected using a pre-designed questionnaire consisting of thirty-one questions aimed at assessing knowledge of …

The Win Ratio Approach In Bayesian Monitoring For Two-Arm Phase Ii Clinical Trial Designs With Multiple Time-To-Event Endpoints, Xinran Huang, Jian Wang, Jing Ning

Faculty, Staff and Student Publications

To assess the preliminary therapeutic impact of a novel treatment, futility monitoring is commonly employed in Phase II clinical trials to facilitate informed decisions regarding the early termination of trials. Given the rapid evolution in cancer treatment development, particularly with new agents like immunotherapeutic agents, the focus has often shifted from objective response to time-to-event endpoints. In trials involving multiple time-to-event endpoints, existing monitoring designs typically select one as the primary endpoint or employ a composite endpoint as the time to the first occurrence of any event. However, relying on a single efficacy endpoint may not adequately evaluate an experimental …

Bayesian Nonparametric Model For Heterogeneous Treatment Effects With Zero-Inflated Data, Chanmin Kim, Yisheng Li, Ting Xu, Zhongxing Liao

Faculty, Staff and Student Publications

One goal of precision medicine is to develop effective treatments for patients by tailoring to their individual demographic, clinical, and/or genetic characteristics. To achieve this goal, statistical models must be developed that can identify and evaluate potentially heterogeneous treatment effects in a robust manner. The oft-cited existing methods for assessing treatment effect heterogeneity are based upon parametric models with interactions or conditioning on covariate values, the performance of which is sensitive to the omission of important covariates and/or the choice of their values. We propose a new Bayesian nonparametric (BNP) method for estimating heterogeneous causal effects in studies with zero-inflated …

Biphasic Models Improved S-Metolachlor Dissipation Endpoint Predictions, K. Badou-Jeremie Kouame, Mary Savin, Cammy Willett, Thomas R. Butts, Erin Grantz, Matthew Bertucci, Samantha E. Robinson, Rodrigo Werle, Nilda Roma-Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Accurate predictions of herbicide dissipation endpoints are essential for making environmental management decisions, estimating the duration of weed control, and deciding crop replant and rotation options. The performance of the single first-order (SFO), first-order multiple-compartment (FOMC), bi-exponential (BEXP), first-order double-exponential decay (FODED), and first-order two-compartment (FOTC) was evaluated to describe S-metolachlor dissipation. Results showed that the BEXP and FOTC were not appropriate. The FODED was ranked as the top model with the lowest Akaike's information criterion (AICc) value among the other three candidate models and was followed by the FOMC model. The SFO displayed the largest root mean square …

Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

Faculty, Staff and Student Publications

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH

What Is It Like To Be A Cognitive Ethologist?, Anne Wordsworth She/Her

Animal Sentience

Donald Griffin not only made the study of animal minds acceptable for scientific investigation but the work of the cognitive ethologists that he inspired made animals and their lives fascinating and accessible to the greater public. The scrupulously detailed examination of his life and work by Ristau ensures that this history will always be there to respect his work and his legacy

Chiropterophagy By The Siberian Weasel (Mustela Sibirica): The First Record In The Russian Far East, Valeriya E. Omelko, Mikhail P. Tiunov

International Journal of Speleology

Chiropterophagy is a widespread phenomenon, but only one case of bat consumption by sable has been documented in the Russian Far East. This study presents the first recorded instance of chiropterophagy by the Siberian weasel (Mustela sibirica) in the southern Russian Far East, based on excrement collected from the Solyanik Cave in the southern Sikhote-Alin Mountains in 2007. The excrement included bones from three bat species (Murina hilgendorfi, Myotis bombinus, Plecotus ognevi) and one vole species (Myodes rutilus). Our findings suggest that the Siberian weasel visits caves during the cold season, although …

Parp Inhibition Radiosensitizes Brca1 Wildtype And Mutated Breast Cancer To Proton Therapy, Mariam Ben Kacem, Scott J Bright, Emma Moran, David B Flint, David K J Martinus, Broderick X Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons. Protons (9.9 and 3.85 keV/µm) induced higher cell kill independent of BRCA1 status. PARP inhibition amplified the cell kill effect to both photons …

Cancer Organoids As Reliable Disease Models To Drive Clinical Development Of Novel Therapies, Giovanni Blandino, Ronit Satchi-Fainaro, Ingeborg Tinhofer, Giovanni Tonon, Sarah C Heilshorn, Yong-Jun Kwon, Ana Pestana, Carlotta Frascolla, Luca Pompili, Aurora Puce, Sara Iachettini, Annalisa Tocci, Sofia Karkampouna, Marianna Kruithof-De Julio, Piera Tocci, Nicla Porciello, Klizia Maccaroni, Daniela Rutigliano, Xiling Shen, Gennaro Ciliberto

Faculty, Staff and Student Publications

On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including organoids, explants, and engineered or bioprinted systems, have recently emerged as sophisticated tools capable of capturing the complexity and diversity of cancer cells …

Seasonal Occupancy Of The Thermal Plume Of A Spring Tributary To The South Fork Roanoke River, Virginia., Steven L. Powers, Michael M. Calvert, Charlotte M. Spaulding

Southeastern Fishes Council Proceedings

Detection of temperate stream fishes varies widely across seasons as streams teeming with life in summer often appear empty during winter sampling efforts. While much literature documents the disproportionate use of the thermal plumes of spring tributaries by cold water fishes during summer, few studies have investigated occupancy of those habitats by warm water fishes in winter. We conducted quantitative snorkeling observations within the near uniform temperatures (10-14^oC) of the thermal plume of a spring tributary to the South Fork Roanoke River across seasons and compared number of fishes observed and species richness to control observations made just …

Muramyl Peptide Blend Ameliorates Intestinal Inflammation And Barrier Integrity In Caco-2 Cells, Dmytro M. Masiuk, Victor S. Nedzvetsky, Giyasettin Baydas

Karbala International Journal of Modern Science

Intestinal barrier function depends on epithelial adhesion, which restricts permeability and microbial invasion from the internal environment. Impairment of barrier integrity and gut function is closely linked to pro-inflammatory changes. Inflammation is often the primary factor that provokes gut function disorders. The anti-inflammatory potential of postbiotics has been reported in recent years. Muramyl peptides (MPs) are small signaling molecules that stimulate intracellular pathogen receptors and can regulate cell responses. However, the molecular mechanisms of MPs' effects on intestinal cells remain unknown. The study of MPs treatment on lipopolysaccharide (LPS)-challenged Caco-2 intestinal cells aimed to investigate the postbiotic effects on intestinal …

Smokejumper Obituary: Harbine, Patrick E. “Pat” (Missoula 1951), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Potential Health Risks From Trace Elements In Four Commercially Important Fish Species From The Gulf Of Alaska And Bering Sea Excel Data Sheet, Miranda Brohman, Dimtirios Giarikos, Amy Hirons

SECLER Data

Alaskan waters support a diverse array of fish species that are critical to apex predators and substantial commercial fisheries. Archived white lateral muscle tissue for capelin, herring, walleye pollock, and Pacific cod, from 1993 to 1996 were analyzed for 15 trace elements using induced coupled plasma mass spectrometry. This analysis serves as a proxy for assessing trace element concentrations in the Gulf of Alaska and Bering Sea. The highest concentrations of eight of the 15 elements (cadmium, chromium, cobalt, iron, manganese, selenium, vanadium, and zinc) were found in fish from the central Gulf of Alaska, while capelin showed the …

Is Increased Mutation Driving Genetic Diversity In Dogs Within The Chornobyl Exclusion Zone?, Megan N. Dillon, Allison N. Dickey, Reade B. Roberts, Jennifer A. Betz, Timothy Mousseau, Norman J. Kleiman, Matthew Breen

Faculty Publications

Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically …

Is Increased Mutation Driving Genetic Diversity In Dogs Within The Chornobyl Exclusion Zone?, Megan N. Dillon, Allison N. Dickey, Reade B. Roberts, Jennifer A. Betz, Timothy Mousseau, Norman J. Kleiman, Matthew Breen

Faculty Publications

Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically …

Visualizing Parcel-Level Lead Risk Using An Exterior Housing-Based Index., Neal J. Wilson, Ryan Allenbrand, Elizabeth Friedman, Kevin Kennedy, Amy Roberts, Stephen Simon

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric lead poisoning remains a persistent public health problem. Children in the US spend the preponderance of their time at home; thus, housing is an important social determinant of health. Improving health outcomes derived from housing-based sources involves differentiating the risks posed by the existing housing stock. In this paper, we developed a parcel-level lead risk index (LRI) based on external housing conditions and the year of home construction. The purpose of this study was to introduce a housing-based lead risk index (LRI), developed using retrospective data, to estimate parcel-by-parcel variation in housing-based lead risk. We described how the LRI …

Enriched Microbial Consortia From Natural Environments Reveal Core Groups Of Microbial Taxa Able To Degrade Terephthalate And Terphthalamide, Laura G. Schaerer, Sulihat Aloba, Emily Wood, Allison Olson, Isabel B. A. Valencia, Rebecca Ong, Stephen Techtmann

Michigan Tech Publications

Millions of tons of polyethylene terephthalate (PET) are produced each year, however only ~30% of PET is currently recycled in the United States. Improvement of PET recycling and upcycling practices is an area of ongoing research. One method for PET upcycling is chemical depolymerization (through hydrolysis or aminolysis) into aromatic monomers and subsequent biodegradation. Hydrolysis depolymerizes PET into terephthalate, while aminolysis yields terephthalamide. Aminolysis, which is catalyzed with strong bases, yields products with high osmolality, which is inhibitory to optimal microbial growth. Additionally, terephthalamide, may be antimicrobial and its biodegradability is presently unknown. In this study, microbial communities were enriched …

Degradation Of Cyanobacteria And Microalgae Using Ultraviolet Radiation At 222 Nm And Its Application In The Bleaching Of Lampenflora On Cave Rock Surfaces, Keisuke Naito, Shuji Watanabe, Masuo Komukai, Takehiro Kazama, Masayuki Itoh, Masahiro Kawasaki

International Journal of Speleology

Cyanobacterial and microalgae blooms negatively affect ecological environments. One of the emerging problems of these blooms occurs in calcareous caves, where visible lighting systems in tourist caves induce the formation of photosynthetic biofilms known as lampenflora on rock surfaces. In this study, we evaluated the inactivation effect of ultraviolet (UV) light irradiation at 222 nm (rare gas halide lamp) and 254 nm (mercury lamp) on cyanobacteria and microalgae in a laboratory and on lampenflora in Ryusenshindo Cave in Japan. Based on the laboratory experiments, irradiation at 222-nm was more effective than that at 254-nm for degrading plants. The photosensitivity of …

Proactive Use Of Perturbation Training On Balance And Posture Control In Geriatric Rehabilitation- An Experimental Study, Reema Joshi, Kinjal Shah

Chulalongkorn Medical Journal

Background:

Ageing is a complex process involving a range of variables that interact to cause deterioration of various physiological functions.

Objectives:

Study attempts to find effect of Perturbation training on postural control upon Centre of Gravity (COG) sway velocity in older individuals using modified-Clinical Test of Sensory Integration on Balance (mCTSIB) component on NeuroCom Balance master® and Timed up and go(TUG) test.

Methods:

An experimental study, employing a pre-post intervention model, involved 30 individuals aged 65-85 years with mild to moderate fall risk was conducted at Tertiary Hospital, Pune from August 2022 to January 2023. Perturbation Training was given …

Immune Checkpoint Inhibitor-Associated Cutaneous Adverse Events: Mechanisms Of Occurrence, Abdulaziz M. Eshaq, Thomas W. Flanagan, Abdulqader A. Ba Abbad, Zain Alabden A. Makarem, Mohammed S. Bokir, Ahmed K. Alasheq, Sara A. Al Asheikh, Abdullah M. Almashhor, Faroq Binyamani, Waleed A. Al-Amoudi, Abdulaziz S. Bawzir, Youssef Haikel, Mossad Megahed, Mohamed Hassan

School of Medicine Faculty Publications

Immunotherapy, particularly that based on blocking checkpoint proteins in many tumors, including melanoma, Merkel cell carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast (TNB cancer), renal cancer, and gastrointestinal and endometrial neoplasms, is a therapeutic alternative to chemotherapy. Immune checkpoint inhibitor (ICI)-based therapies have the potential to target different pathways leading to the destruction of cancer cells. Although ICIs are an effective treatment strategy for patients with highly immune-infiltrated cancers, the development of different adverse effects including cutaneous adverse effects during and after the treatment with ICIs is common. ICI-associated cutaneous adverse effects include mostly inflammatory and bullous dermatoses, as …