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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Manganese Distribution Across The Blood-Brain Barrier. Iv. Evidence For Brain Influx Through Store-Operated Calcium Channels, Janelle S. Crossgrove, Robert A. Yokel
Pharmaceutical Sciences Faculty Publications
Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Previous studies showed Mn influx into brain is carrier-mediated, though the putative carrier(s) were not established. Studies conducted with cultured bovine brain microvascular endothelial cells (bBMECs), which comprise the blood–brain barrier, revealed 54Mn (II) uptake positively correlated with pH, was temperature-dependent, and was sodium- and energy-independent. Brain 54Mn uptake correlated inversely with calcium (Ca) concentration, but 45Ca uptake was unaltered by high Mn concentration. Lanthanum (La), a non-selective inhibitor of several Ca channel types, as well as …
Modulation Of L-Type (Cav1.3) Calcium Channels, Brian Thomas
Modulation Of L-Type (Cav1.3) Calcium Channels, Brian Thomas
Undergraduate Honors Capstone Projects
L-type CaV1.3 calcium channels perform critical functions in auditory hair cells, cardiac pacemaker cells, and pancreatic β-cells, but little is currently known about how these channels are modulated by cell signaling mechanisms. To begin to address this issue, we have tested the ability of various G protein-coupled receptors (GPCRs) to modulate CaV1.3 expressed in a mammalian cell line. Expression plasmids encoding CaV1.3 and auxiliary calcium channel subunits α2-δb and β3 were transiently coexpressed in HEK293 cells along with plasmids encoding a single type of GPCR. As a control for functional expression of the GPCR, …
Influence Of Calcium Metabolism On Meat Tenderness In Heiferettes, Kelly W. Bruns, Robbi H. Pritchard
Influence Of Calcium Metabolism On Meat Tenderness In Heiferettes, Kelly W. Bruns, Robbi H. Pritchard
South Dakota Beef Report, 2005
Forty beef-type heiferettes (initial BW=1016 ± 93 lb) were used to evaluate the influence of dietary calcium depletion followed by dietary repletion prior to slaughter on carcass and meat quality traits. Treatments were 1.) control - feed calcium diet for duration of trial (13 hd); 2.) calcium depleted 14 days followed by one feeding of replete diet 20 h prior to slaughter (13 hd); 3.) calcium depleted 14 days followed by two feedings of repleted diet 20 h and 44 h before harvest (14 hd). Heifers were sorted on condition and weight from a larger population of 280 head. Heiferettes …
Calmodulin-Dependent Kinase Kinase/Calmodulin Kinase I Activity Gates Extracellular-Regulated Kinase-Dependent Long-Term Potentiation, John M. Schmitt, Eric S. Guire, Takeo Saneyoshi, Thomas R. Soderling
Calmodulin-Dependent Kinase Kinase/Calmodulin Kinase I Activity Gates Extracellular-Regulated Kinase-Dependent Long-Term Potentiation, John M. Schmitt, Eric S. Guire, Takeo Saneyoshi, Thomas R. Soderling
Faculty Publications - Department of Biological & Molecular Science
No abstract provided.
Effects Of Deboning Methods On Chemical Composition And Some Properties Of Beef And Turkey Meat, Meltem Serdaroğlu, Gülen Turp Yildiz, Neri̇man Bağdatlioğlu
Effects Of Deboning Methods On Chemical Composition And Some Properties Of Beef And Turkey Meat, Meltem Serdaroğlu, Gülen Turp Yildiz, Neri̇man Bağdatlioğlu
Turkish Journal of Veterinary & Animal Sciences
The objective of this research was to compare some chemical and physical characteristics of mechanically deboned and hand deboned turkey meat and beef. Samples were analyzed for proximate composition, cholesterol, TBA, calcium and iron contents, hunter colour parameters and fatty acid composition. Deboning method affected chemical composition of beef and turkey meat. Mechanical deboning resulted higher cholesterol values and calcium and iron content. In hand deboned turkey meat the most abundant fatty acids were C16:0, C18:1 and C18:2. Mechanical deboning process was increased the percent of C18:1, C18:2 and C18:3 in turkey meat. C16:0, C18:0 and C18:1 were the major …
3,4-Methylenedioxymethamphetamine Activates Nuclear Factor- Κb, Increases Intracellular Calcium, And Modulates Gene Transcription In Rat Heart Cells, David A. Tiangco, Frank A. Lattanzio Jr., Christopher J. Osgood, Stephen J. Beebe, Julie A. Kerry, Barbara Y. Hargrave
3,4-Methylenedioxymethamphetamine Activates Nuclear Factor- Κb, Increases Intracellular Calcium, And Modulates Gene Transcription In Rat Heart Cells, David A. Tiangco, Frank A. Lattanzio Jr., Christopher J. Osgood, Stephen J. Beebe, Julie A. Kerry, Barbara Y. Hargrave
Biological Sciences Faculty Publications
3,4-Methylenedioxymethamphetamine (MDMA) is an illicit psychoactive drug that has gained immense popularity among teenagers and young adults. The cardiovascular toxicological consequences of abusing this compound have not been fully characterized. The present study utilized a transient transfection/dual luciferase genetic reporter assay, fluorescence confocal microscopy, and gene expression macroarray technology to determine nuclear factor-κB (NF-κB) activity, intracellular calcium balance, mitochondrial depolarization, and gene transcription profiles, respectively, in cultured rat striated cardiac myocytes (H9c2) exposed to MDMA. At concentrations of 1×10−3 M and 1×10−2 M, MDMA significantly enhanced NF-κB reporter activity compared with 0 M (medium only) control. This …