Life Sciences Commons^™

Immune System (Spanish), Your Very Favorite, Children's Health

Spanish

single-page, Spanish

Synthesis Of Drug-Like Molecules And Investigation Of Their Biological Activity, Duyen Nguyen '25, Sunny Nguyen '26, Jeffery A. Hansen

Annual Student Research Poster Session

This study examines the products derived from the ring-opening reactions of two novel epoxides—chlorobenzene epoxide and furan epoxide—highlighting their notable biological activity, particularly in the context of potential anticancer agents. One key finding: a synthesized stereoisomer of a hexylamine-derived β-amino alcohol exhibited a remarkably low LC50 value of 6.6 ppm in the Brine Shrimp Lethality Assay, significantly outperforming the other isomer compound’s LC50 value, at 13 ppm. This discovery underscores the critical role of stereochemistry in enhancing bioactivity, as evidenced by the distinct physical and chemical properties of the two hexylamine-derived isomers, including differences in appearance and solubility. Building on …

Inhibition Of Integrin Binding: Exploring Its Impact On Epidermal Cell Attachment, Erin R. Johnson '25, Colleen L. Doçi

Annual Student Research Poster Session

I worked with HaCaT cells, human epidermal cells that are sticky and like to attach to their surroundings in the skin. They have a surface protein called integrin, which interacts directly with collagen to induce cell attachment. I was particularly interested in interrupting this connection between integrin and collagen. I achieved this by using an inhibitory peptide that bound to the active site of integrin. This would allow me to calculate the cell attachment of HaCaT cells while in the presence of collagen. If we were able to target this treatment to tumor cells, we could help to stop them …

Investigating Neurite Outgrowth Influenced By Breast Cancer Progression Using In Vitro Models Of Collagen I Hydrogels, Emma Waskom '27, Nikolas Ala-Kokko, Younghye Song

Annual Student Research Poster Session

Through the use of vitro modeling of tumor progression, using collagen I hydrogels and progressing cell lines, a demonstration of the interactions between breast cancer cells and nerve cells can be investigated. With these models, our goal is to compare the measurement of outgrowth of nerve cells through the use of supplemented NGF and co cultures of breast cancer cells. Human MCF-CA1a.cl1, -AneoT, and -10A, adipose-derived stem cells (ASCs), and rat PC-12 cells, were all passaged from 2D cultures and cultured in a collagen I hydrogen at a cell density of 250,000 cells/ml of media. Collagen hydrogels were then made …

Investigating The Impact Of Nmdar Loss On The Maturation Of Somatostatin Interneurons In Mpfc Of The Mouse Brain, Muhammed Shalan, Zoya Fazal, Gülcan Akgül, Natalia De Marco Garcia

Expo Student Presentations

2024 Fall Expo Online Poster Presentation

• Biological & Life Sciences

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Bacteriostatic Effects Of Hydroxyl Radical-Generating Device On Klebsiella And Pseudomonas, Caroline Le '26, Philips Akinwole, Nipun Chopra

Annual Student Research Poster Session

Healthcare-associated infections (HAIs) serve as one of the most pressing problems in the medical field. On any given day, one in 31 hospital patients has at least one HAIs and even though the average duration of inpatient admissions has decreased, the frequency of HAIs has increased. The most popular treatment for HAIs is antimicrobial medications such as antibiotics, however, bacteria have been documented to develop resistance to several antibiotics. Hydroxyl radical is being explored as an alternative preventative treatment to HAIs as it has microbicidal effects on planktonic bacteria and fungi over short treatment time, but few studies have looked …

Designing An Attachment Assay For Keratinocytes Stimulated By Fibroblast Conditioned Media, Linh "Kas" Do '26, Colleen L. Doçi

Annual Student Research Poster Session

Cell attachment involves the interaction between an individual cell with its neighbors and the extracellular matrix. These interactions are often regulated by the signaling molecules, including a variety of proteins, cytokines and growth factors. It is found in several studies that keratinocytes in the epidermis communicate with dermal fibroblasts in a bilateral paracrine model, in which they were simultaneously stimulated by the byproduct of the others. We developed this protocol with a simple, low-cost, and effective model to examine keratinocyte attachment that could be applied to examine the effects of fibroblasts on cell adhesion. For this method, we collected the …

A Quantitative Survey Of Goldenrods And Their Galls In Greencastle, Indiana., Chiamaka Ndubuokwu '27, Danielle Sommerman '25, Rose Keith

Annual Student Research Poster Session

During the spring to summer months, galls—an abnormal growth of plant tissue—are commonly found on goldenrod plants. Some of the most common galls that plague goldenrods are the rosette, ball, and elongated galls caused by different flies and midges. This study set out to quantitatively survey goldenrod galls of those three types in Greencastle, Indiana and their potential fitness effects. The literature currently available focuses heavily on the relationships between ball galls and goldenrods, while the other gall types are understudied. This finding was especially surprising considering that the results of our data analysis suggests that the rosette galls were …

Avoidance Behavior Of Oppia Nitens (Oribatid Mites) To Herbicide: Glyphosate Compared To Microplastics In Standard Artificial Soil., Thi Doan '27, Philips Akinwole

Annual Student Research Poster Session

Despite growing public interest in environmental issues, awareness of contaminants affecting soil organisms remains broadly lacking, despite decades of research. This study investigated the impacts of a common herbicide; glyphosate, (Roundup), on the avoidance behavior of Oppia nitens - a soil mite species used as an indicator of soil health, and soil moisture content. The study involved exposing O.nitens to standard artificial soil treated with glyphosate concentrations ranging from 47.8 to 501.6 mg/kg. Avoidance behavior was assessed by observing mite distribution between treated and untreated soil over a 48-hour period. Results demonstrated clear avoidance behavior at higher glyphosate concentrations (501.6 …

Metabolic Adaptation Of Soil Microbial Communities To Metal Contamination: Assessment Of Cadmium Stress, Nina Shaffer '25, Emma Jacobs '25, Philips Akinwole

Annual Student Research Poster Session

Anthropogenic contamination of soil with heavy metals such as Cadmium (Cd2+) alters the metabolic activities and structure of soil microbial communities and has profound impacts on the soil ecosystem. In this study, we examined the effects of Cd2+ exposure on soil microbial communities by amending soil solutions with different concentrations of Cadmium nitrate tetrahydrate Cd(NO3)2 ● 4H2O (0, 0.5, 1.0, 1.5, and 2.5 mM). 150 µL of the Cd2+ amended and control soil solutions were added to BIOLOG 96-well ecoplates and incubated (26 ±1oC) over a 7-day period for metabolic analysis of 31 selected carbon substrates. Average well-color development (AWCD) …

Phenotypic Variations In T. Repens (White Clover) Leaf Pigmentation, Danielle Sommerman '25, Chiamaka Nbubuokwu '27, Rose Keith

Annual Student Research Poster Session

There is a known variation in patterning amongst the leaves of variegated plants. The reasons as to why this polymorphism occurs has long been debated by botanists and biologists, but some hypotheses include thermoregulation, ultraviolet protection, and pollinator attraction among others (Kuo et al., 2024). We hypothesized that physical location may play a role in the leaf variegation of Trifolium repens (white clover). Starting mid July of 2024, we collected sample leaflets from multiple local populations from three distinct sites in Greencastle, IN. After collecting, we looked at the frequency of chevron presence as well as the size of the …

Development And Quantification Of An Attachment Assay For Epidermal Cells To Varying Extracellular Matrix Dilutions, Julian Vargas '26, Colleen L. Doçi

Annual Student Research Poster Session

The concept of cellular attachment is cells interacting with the extracellular matrices surrounding it. Extracellular matrices are made of various components, and it has been shown that the interactions differ between different classes of extracellular matrices. The basement membrane plays a critical role in the structure and function of the epidermis, the outermost layer of the skin. It is composed of key extracellular matrix components, which are crucial for structural stability of the skin and for maintaining the integrity of the epidermis. Through components like collagen, laminin, and proteoglycans, the BM facilitates communication between the epidermal cells and the connective …

A Comparative Analysis Of Urea Vs. Acetamide In Aot Reverse Micelles, Kate Walsh '26, Bridget Gourley, Nancy E. Levinger

Annual Student Research Poster Session

In our exploration of the interactions between water and amide osmolytes, we focused on the effects of urea and acetamide on the stability of reverse micelles (RMs) formed with Sodium Bis(2-ethylhexyl)sulfosuccinate (AOT) in isooctane. Water, with its unique polarity and its ability to facilitate hydrogen and proton transfer, played a crucial role in our study, as we aimed to uncover how these amides would influence micellar behaviour. Our results revealed a compelling contrast between urea and acetamide. Acetamide, with its lower polarity due to a methyl group substitution, demonstrated superior solubility and significantly reduced precipitate formation compared to urea. This …

Designing An Attachment Assay For Epidermal Cell-To-Cell Attachment, Tiala Ortega '26, Colleen L. Doçi

Annual Student Research Poster Session

Cell adhesion includes various processes and is essential in cell communication and regulation. The mechanical interactions between a cell and its extracellular matrix control the behavior and function of a cell. In this project, we are studying cell attachment in different ways. The epidermal monostrato layer is a vertical and horizontal interaction and is not accounted for in usual assay protocols so I wanted to investigate this by creating an assay including multiple cell layers, a monolayer and an attached layer, to further develop a protocol for optimal cell-to-cell attachment. I hypothesized that the number of cell attachments to the …

Comparison Of S100Β Expression In Sk-Mel-25 And A-375, Nev Hommel '26, Ayusha Pokharel '27, Nipun Chopra

Annual Student Research Poster Session

Traumatic brain injury (TBI) affects more than 2 million Americans each year. S100β protein acts as a biomarker for TBI– studies have shown that micromolar levels of S100β are dangerous to neuronal health. Our plan for the summer was to experiment with whether miRNA-4705 could inhibit the production of S100β or not. To get started on the transfection, we had two hurdles to overcome. One of them was to find an efficient s100B primary antibody and the second was to ensure our s100B siRNA worked. By analyzing various research papers and their western blot, we identified and selected two s100B …

Comparison Of Two Disaccharides And Their Saccharide Components In Aot Reverse Micelles: Impacts Of D-Trehalose And D-Sucrose, Delaney Collier '25, Bridget L. Gourley, Nancy E. Levinger

Annual Student Research Poster Session

Reverse micelles, featuring an AOT surfactant with a polar head group and nonpolar tail, encapsulate a polar phase at the nanoscale. With water as the polar phase, the nanoconfined water pool interactions and water-interface interactions mimic biological nanoconfinement. Thus, we investigated the impact of osmolytes on AOT reverse micelles to explore the role they play in biological systems. We investigated two disaccharides, D-trehalose and D-sucrose, and their monosaccharide components, glucose+glucose and glucose+fructose. We chose these molecules for their biological significance and to allow us to investigate whether subtle structural changes in the osmolyte impacts the intermolecular interactions in confinement as …

Lingnan Gardeners Newsletter (No. 72) = 彩園通訊 (第72期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University

Lingnan Gardeners Newsletter 嶺南彩園通訊

No abstract provided.

University Of Nebraska At Omaha Division Of Biomechanics And Research Development Annual Report 2022-2023, Uno Biomechanics

Biomechanics Annual Report

This report contains:

A letter from the Director: Dr. Nick Stergiou

Highlights articles

Our ne Cobre: the Center for Cardiovascular Research in Biomechanics (CRiB) articles

The Center for Research in Human Movement Variability (MOVCENTR) articles

People of UNO Biomechanics

Student Centered articles

Faculty Success articles

Education Initiative articles

Health Matters! Coloring And Activity Book (80-Pages), Your Very Favorite, Children's Health, Lorraine Sheldon, May Bressler

English

Health Matters! is a English-language health literacy resource designed for pediatric patients and their families. Written at an approximately 6th-grade reading level, it supports patient education through engaging coloring and activity pages.

The content covers a wide range of health and wellness topics, including body systems, nutrition, mental wellness, patient safety, and social-emotional skills such as building friendships and navigating conversations when returning to school. Developed for use in both hospital settings and the broader community, the resource promotes learning through interactive, age-appropriate activities.

This printable PDF version contains the complete collection of activities and comprises 80 pages. The resource …

10.01.2024 Orsp Connect, Liz Williamson

ORED Newsletter

NIH Podcast on simplified review framework

LINC lunch External Review

NIDA Diversity Supplements Webinar

La Salud Es Importante: Libro De Actividades (80-Pages), Your Very Favorite, Children's Health, Lorraine Sheldon, May Bressler

Spanish

Health Matters! is a Spanish-language health literacy resource designed for pediatric patients and their families. Written at an approximately 6th-grade reading level, it supports patient education through engaging coloring and activity pages.

The content covers a wide range of health and wellness topics, including body systems, nutrition, mental wellness, patient safety, and social-emotional skills such as building friendships and navigating conversations when returning to school. Developed for use in both hospital settings and the broader community, the resource promotes learning through interactive, age-appropriate activities.

This printable PDF version contains the complete collection of activities and comprises 80 pages. The resource …

E-Textbook For Better Learning In Chemistry 120, Anh Vu '27, Jeffery A. Hansen

Annual Student Research Poster Session

Organic chemistry is a highly visual subject since organic compounds are 3D objects. For this reason, in order to fully understand the composition, properties, and chemistry of these compounds, it is essential to understand and visualize their 3D structures. Nevertheless, there is a frequent necessity to depict organic substances on 2D surfaces, such as paper, a computer screen, or a whiteboard. As a result, one of the biggest obstacles we will face is learning these molecules in a 2D format while maintaining an accurate understanding of 3D nature. The purpose of this e-textbook is to fully utilize the digital medium …

Chacahoula 2024, Vol 91, Alayna Pellegrin

Chacahoula

MERGING REALITIES:

The 2023 issue of Chacahoula includes December 2023 and May 2024 graduating classes, as well as stunning photography of Week of Welcome, Homecoming, Mardi Gras, and Spring Fever. With features covering notable students, faculty, and staff, this year's time capsule beautifully preserves an academic year in the life of the University of Louisiana at Monroe.

Smokejumper Obituary: Congleton, Walter Sheldon (Cave Junction 1968), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

09.16.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Human Research with AI workshop

External Funding Opportunities for Students

Editorial: Centering Humanism In Stem Education, Desirée Forsythe, Sheila S. Jaswal, Bryan Dewsbury, Susannah Mcgowan

Biology, Chemistry, and Environmental Sciences Faculty Books and Book Chapters

"To understand why this Research Topic exists, it is important to recall the original goal from our call for proposals: to reorient STEM researchers and practitioners to reconsider the actual purpose of the practice of teaching and learning. Bryan Dewsbury often invokes us in his writing and talks to understand our why. As educators, we wish to provide insights, practices, and proposed theories to reflect on our WHY in STEM education—from one instructor’s empathetic approach to understanding the undergraduate student experience in gateway courses to the cultural initiation ceremonies at the disciplinary level. These components of humanism and the lens …

Smokejumper Obituary: Krout, Robert D. (Missoula 1955), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

09.09.2024 Orsp Connect, Liz Williamson

ORED Newsletter

New training course available: Sponsored Travel Guidance

OpenScholar Overview

Learn about Nature Masterclasses On-Demand Training

NSF Sessions on Phase 1 ISBIR/STTR Proposals

Smokejumper Obituary: Nicholas, Victor W. (Fairbanks 1969), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Parry, D. Ross (Missoula 1958), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.