Life Sciences Commons^™

12.02.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Email Address Matters

All of Us Researcher Symposium

Welcome Anya Goldman

Exploration In Cell Growth: Rac3 And Its Effect On Ewing Sarcomas Tumorigenic Properties, Allie Woods, Samuel De La Cruz, Catherine Garcia, Terry Jo Shackleford

Cell and Molecular Methods

Multiple experiments were conducted to measure the effectiveness of certain genes on cell growth. In the exploration of this process, RAC3 acted as the target gene and was applied to both SOX18 overexpressing and normal expressing cells (control). RAC3 is a gene that typically controls the intercellular signaling pathway of a cell. This means it helps with the movement of cells and allows for migration.The purpose of these experiments were to determine how the gene RAC3 would work when introduced to carcinogenic cells, specifically Ewing Sarcoma. Typically, RAC3 acts as a messenger for the cell, but when in conjunction with …

The Effect Of Knockdown Of Gene Kit On Sox18 Gene Expression Through The Jak2/Stat3 Signaling Pathway Within An Ewing Sarcoma Cell, Samantha Aragon, Cristina Herrera, Felicity Rodriguez, Riley Smith, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma is an aggressive cancer that affects children & adolescents. Common treatments include surgery, radiation, and chemotherapy, yet individuals have a poor survival rate and often develop side effects from treatment, including fertility issues, secondary cancer, heart problems, and growth abnormalities.1SOX18 is a gene identified to aid in cell proliferation and cell differentiation, leading to the development of several cancers, such as gastric, bladder, and lung cancer.2,3 SOX18 resides in the JAK2/STAT3 pathway as a regulator, along with another gene named KIT that instigates the formation of the cell signaling pathway.4KIT is a transmembrane tyrosine kinase, which instigates cell …

The Effects Of Ewing Sarcoma Through The Overexpression And Knockdown Of Transcription Factors Sox18 And Stat1, Victoria Castillo, Melany Cervantes, Nicole Robles, Terry Jo Shackleford

Cell and Molecular Methods

SOX18, a transcription factor with a DNA-binding HMG domain, plays a critical role in regulatory processes linked to cancer progression. Exhibiting oncogenic properties, SOX18 has been linked to various cancers, where it promotes tumor growth by enhancing cell invasion, uncontrolled proliferation, and resistance to apoptosis through dysregulated signaling pathways. STAT1, a protein crucial for immune system regulation, is prominently expressed in immune-associated tissues like the lymph nodes, and bone marrow, suggesting it could play a role in tumor growth. Ewing Sarcoma (EWS), an aggressive cancer that targets bone and soft tissue, carries a high mortality rate of 90% without treatment …

12.09.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Employee Profiles

In Person Account Reconciliation and Tableau Training

NSF Proposals with Consultant or Professional Services

Use Of Creative Outlets To Impact Quality Of Life For Individuals With Amyotrophic Lateral Sclerosis, Andria Burden, Helen Carey, Zeida Gutierrez

Fall 2024 OTD Capstone Symposium

Amyotrophic Lateral Sclerosis (ALS) profoundly impacts quality of life by limiting participation in meaningful activities. This mixed-methods study explored the role of creative outlets in enhancing quality of life for individuals with ALS. Quantitative data from the ALS-Specific Quality of Life Questionnaire-Short Form (ALSSQOL-SF) and qualitative insights from semi-structured interviews revealed key themes of adaptation, purpose, community, and quality of life. Findings indicate that creative outlets foster self-expression, social connection, and cognitive engagement while reducing isolation. Recommendations include integrating tailored creative activities into occupational therapy (OT), emphasizing group settings and early introduction to promote adaptability and community-building. This study underscores …

Smokejumper Obituary: Rossheim, John David (Missoula 1949), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Smokejumper Obituary: Cook, James Edward "Jim" (North Cascades 1960), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

The Power Of Plate & Knowledge: Nutrition’S Role In Pcos Management For Asian American Women, Cassandra Camille Diego Curameng

Nursing | Student Research Posters

Polycystic ovarian syndrome (PCOS) is a metabolic endocrine disorder affecting 8–11% of women worldwide, with 70% remaining undiagnosed (WHO, 2023). It presents with symptoms such as irregular menstrual cycles, insulin resistance, high testosterone levels, anxiety, depression, and infertility, significantly impacting quality of life and health (OASH, 2021). The symptoms of PCOS can severely impact women’s quality of life, mental health, and long-term well-being. Insulin resistance contributes to symptom severity and a 50% likelihood of developing diabetes or prediabetes by age 40 (Wang et al., 2011). Women with PCOS face a threefold increased risk of endometrial, ovarian, and breast cancers (Barry …

Dairy & Food Science News, December 2024, Department Of Dairy And Food Science News

Dairy & Food Science News

Message from the Department Head
Faculty & Staff Updates
New Faculty Joining Our Department
Current Team of Faculty & Staff
Recruitment Updates & Opportunities
Extension Updates
Student Updates
Events & Calendar

Northern Great Plains Native Seed Strategy, Lora Perkins, Amy Symstad, Jennifer Zavaleta-Cheek, Emily Rohrer, Krista Ehlert

Native Plant Initiative Newsletters and Reports

Developed by the Northern Great Plains Native Seed Partnership

Advocating For Occupational Therapy Intervention With In-House Athletics, Jatia Littles, Cynthia Haynes

Fall 2024 OTD Capstone Symposium

Occupational therapists (OT) have the opportunity to work with athletes by outsourcing through orthopedic centers with professional leagues such as the National Football League (NFL) (Jobs in Sports, 2022) but rarely do you see OTs within the sports complex working in-house. Although many studies go into great detail on the benefits of occupational therapy during the rehabilitation process, there are only a limited number of studies that explore occupational therapy intervention in athletics (Andreas et al., 2021). This project designed and implemented an occupational therapy-focused advocacy project that involves informing interprofessional sports faculty on the benefits of OTs being a …

73 | ‘Akko Iii: The 1991–1998 Excavations: The Late Periods Part 2: The Knights’ Hotel Site, The Messika Plot And Miscellaneous Studies, Danny Syon, Ayelet Tatcher

IAA Reports—Monograph Series of the Israel Antiquities Authority

Akko III: The Late Periods comprises two parts (IAA Reports 72 and 73), the third and fourth volumes in a series publishing the results of four excavations that took place within and just outside of the Old City of ‘Akko between 1991 and 1998. These two volumes present the archaeological finds from the Early Islamic to Ottoman periods, concentrating on the architecture and small finds from the Crusader period.

The present volume (Part 2; IAA Reports 73) presents the excavations in the Knights’ Hotel Site, which yielded a wealth of small items of daily use, including glass finds, lead ampullae, …

Cuisine As A Compass: Exploring The Therapeutic Benefits Of Community, Cooking, And More Within The Lgbtqia+ Population, Sera Shevchenko, Karen Park Otd, Otr/L, Bcp, Susan Macdermott Otd, Otr/L

Fall 2024 OTD Capstone Symposium

Background: The LGBTQIA+ population experiences unique barriers to occupation and well being. Anti-LGBTQ legislation encroaches on inclusive and affirming care affecting occupational access. Limited occupational participation and additional exhaustive adaptive strategies to engage in occupations safely have an emotional cost. This research study explores how food or mealtime occupations such as cooking, eating, and hosting can support LGBTQIA+ well-being. This research was made possible by LGBTQIA+ participants that are experts of their lived experience.

Methods: This mixed methods research used both qualitative and quantitative methods to gather data on the significance of food-based occupations, culture, mental health, and identity in …

Native Seed Scoop, 2024 Post Harvest Edition, University Of Northern Iowa. Tallgrass Prairie Center.

Native Seed Scoop

Contents:

--- Upcoming Events
--- TPC Highlights
--- What's Your Scoop
--- A New Toolkit for Finding CRP Plant Materials
--- Native Seed Plant Stakeholder Meeting
--- News from the Plots
--- New Collections
--- A Scoop of Science
--- In Other News . . .

Smokejumper Obituary: Smith, Gerald Paul “Jerry” (Missoula 1962), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

The Utilization Of String Pulling To Determine Female Rats' Dual Cognitive Motor Task Performance Following Space Flight Stressor Exposure, Doc-Haden Rodgers, Nicole M. Atttallah, Teresa L. Garcia, Nuhamine A. Moges, N. A. Moges, K. D. Omengan, J. F. Cortez, K. S. Dhede, A. A. Blackwell

Undergraduate Research Symposium Posters

During deep space exploration, astronauts depend on mission-essential performance in Dual Cognitive Motor Tasks (DCMT), such as receiving information from ground control to assemble and configure wires during a spacewalk. DCMT relies upon processing cognitive and motor information simultaneously. Previous research on rodent models has shown various impairments in cognition and motor function in separate tasks after exposure to deep space radiation and sleep fragmentation (SF). However, an assessment of DCMT performance in rodents has not been established. Rats and humans use similar hand-over-hand movements to pull a string, and task demands may be varied to assess cognition and motor …

Examining Emotion And Ease Of Recall For Life Story Memories In Young Adults, Roxanna E. Chavez, Erin L. Murphy, David E. Copeland

Undergraduate Research Symposium Posters

Life stories are narratives that use autobiographical memories to shape personal identity. This study investigated how emotional valence and ease of recall may change over time. Participants were asked to recall ten life story memories in two interviews held three weeks apart. Participants provided ratings of emotional valence and ease of recall for each memory. A significant difference was found in emotional valence between Session 1 (M = 3.159, SD = .772) and Session 2 (M = 2.905, SD = .788), t(68) = 2.734, p < .01, with Session 1 memories rated as significantly more negative (M = 1.812, SD = 1.427) than those in Session 2 (M = 1.275, SD = 1.316), t(68) = 3.232, p < .01. Furthermore, negative memories were more frequent in the last five Session 1 memories (M = 0.986, SD = 0.866) than in all of Session 2 memories (First Five: M = 0.652, SD = .783; Last Five: M = 0.623, SD = .892), F(3, 204) = 3.663, p < .05. For ease of recall, the first five memories in both sessions (Session 1: M = 5.684, SD = 0.806; Session 2: M = 5.612, SD = 0.963) were significantly easier to recall than the last five in both sessions (Session 1: M = .214, SD = 1.128; Session 2: M = 5.136, SD = 1.080), F(2.498, 169.864) = 7.369, p < .001. Overall, these findings suggest participants recalled more accessible memories first, with negative memories being harder to retrieve as sessions progressed.

Investigating The Impact Of Psychological Interventions On Autoimmune Disease Progression In Women, Nicole Datastanyan

Undergraduate Research Symposium Posters

Autoimmune disease arises when an individual's immune system mistakenly attacks and damages the body’s tissues. Autoimmune disease disproportionately affects women, with eighty percent of diagnosed patients being female. This research proposal aims to explore the relationship between psychological factors (e.g., stress, anxiety, depression) and the progression of autoimmune diseases. This poster will propose a detailed study to assess whether reducing psychological distress through cognitive behavioral therapy (CBT) can slow disease progression. Cognitive behavioral therapy is a form of talk therapy to relieve symptoms of mental health conditions such as depression, anxiety, stress, or grief. Two hundred female patients diagnosed with …

Pathway-Based Polygenic Risk Score Analysis Of Brain Glial Indicates Cell-Type-Specific Roles In Alzheimer's Disease, Tyrell Pratt, Alice Lee, Jennifer Zheng, Faria Tavacoli, Hayley Ho, Tingwei Liu, Jingchun Chen

Undergraduate Research Symposium Posters

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline and extensive brain pathology, including amyloid plaques, neurofibrillary tangles, and neuroinflammation. This study aims to identify any glial cell type-specific pathways associated with AD.

Methods: We first investigated the correlation between AD and the genetic risk of glia-specific pathways using pathway-based polygenic risk score (PRS) with PRSet software in the discovery data (ADc1234ADA) adjusted by the top two principal components (PC1, PC2) (Model 1), followed by additional adjustment with sex, age, and APOE ε4 count in Model 2. Further PRSet analyses were replicated in independent data …

Inter-Rater Reliablility Of Sharp Wave Ripple Detection In Recently Trained Experts, Orlando Montiel, Gage Pompa, Yader Gomez, Talha Soluoko

Undergraduate Research Symposium Posters

Sharp wave ripples (SWR) are a brain phenomenon that originate in the hippocampus, a region crucial for memory and learning. These events occur during periods of rest or slow-wave sleep and are characterized by fast oscillatory bursts (150-250Hz) and are thought to be important for the brain to consolidate memory. SWR are believed to facilitate the transfer of information from the hippocampus to the cortex, strengthening synaptic connections & enabling long-term memory storage. Accurate detection & assessment of SWRs is essential for advancing how the brain processes and stores information.

This study examines the accuracy/consistency of SWR image selection and …

The Effects Of Divides Attention On Long-Term Memory For Natualistic Stimuli, Gaia Steinberg, Jackson S. Pelzner, Rhiannon N. Soriano Smith, Colleen M. Parks

Undergraduate Research Symposium Posters

The ability to identify previously experienced events is a fundamental aspect of memory. This study investigates recognition memory using naturalistic stimuli, specifically news headlines, to explore both controlled (recollection) and automatic (familiarity) memory processes. Most recognition memory experiments rely on simplistic stimuli like words or pictures, but we aim to extend these theories by using more complex, naturalistic materials (news headlines). Participants completed recognition tasks with both headlines and pictures to establish baseline differences between these stimuli types. The order of presentation between stimulus types was randomized between pictures or headlines first. They were assigned to either full or divided …

Glial-Specific Genes Are Strongly Associated With Alzheimer's Disease By Gene-Based Polygenic Risk Score Analysis, Jennifer Zheng, Faria Tavacoli, Tyrell Pratt, Alice Lee, Tingwei Liu, Jingchun Chen

Undergraduate Research Symposium Posters

Methods: Gene-based PRSs were constructed in AD cases and controls within each gene of the glial cells, according to the GWAS summary statistics of European ancestry. In detail, gene-based PRSs were first calculated for each glial cell type-specific gene for AD cases and controls in the discovery dataset (ADc1234ADA) using PRSet software. A meta-analysis with a fixed model was performed when the signal in both datasets was in the same direction. Bonferroni corrections for multiple testing (at α = .05) were used to determine significance within each of the three glial groups. Forest plots were used to visualize the results …

Exploring Modality Differences In Recognition Memory: Repetition Effects On Recollection And Familiarity, Ivanesa Velikova, Kevin Mohawk, Colleen Parks

Undergraduate Research Symposium Posters

Research has shown that memory for visual objects tends to be superior compared to memory for auditory objects. The present study aimed to investigate the underlying mechanisms of why recognition memory tends to be better for visual information. Recognition memory relies on two processes, recollection and familiarity. Recollection involves retrieving contextual details of a memory while familiarity is simply a feeling that something has been encountered before. We investigated recollection and familiarity in the two modalities by having participants lean a list of auditory objects (e.g., dog barking) and visual objects (e.g., picture of a lion) under full attention (FA) …

The Effect Of Encoding Strategies On Recognition Memory, Camila Schettini, Cole Kaneshiro, Kevin Mohawk, Colleen Parks

Undergraduate Research Symposium Posters

Successful memory decisions require distinguishing between true and false memories. VariouS strategies can be used to avoid false memories such as the Recall-To-Reject (R-R) strategy and the Distinctiveness Heuristic (DH). R-R involves rejecting false information by recalling correct information (I know this person is not Bob, because Bob has brown hair); while DH involves the rejection of false information due to failure to recollect expected information (I know I never met this person because I would remember if I had). The purpose of this study is to examine how these strategies affect recognition memory. In the present study participants were …

Comparing Forgetting Rates Between Item And Relational Memories, Lex De Asis, Rhiannon N. Soriano Smith, Colleen M. Parks

Undergraduate Research Symposium Posters

Forgetting is an everyday occurrence where an idea that could be recalled successfully is no longer able to be retrieved (Tulving, 1974). Multiple theories suggest how forgetting occurs, such as the decay theory, which suggests that memories are gradually forgotten over time, and the interference theory, in which forgetting occurs because of competing information. Additionally, there are two newer theories which both predict that item representations should be forgotten because of interference and mnemonic discrimination should be forgotten due to decay: the memory system-dependent forgetting hypothesis (Hardt, Nader, & Nadel, 2013), and the representation theory of forgetting (Sadeh et al., …

The Characterization Of Cooperative String-Pullung Behavior In Rats After Exposure To Space Flight Stressors, Teresa L. Garcia, Nuhamine A. Moges, Sierra Ordonez, Nicole M. Attallah, D. H. Rodgers, A. Adhikari, K. D. Omengan, D. Lloyd, S. L. Gleed, A. A. Blackwell

Undergraduate Research Symposium Posters

Astronauts work cooperatively to complete tasks on missions through deep space where they will experience stressors, including radiation and sleep fragmentation, that may impair performance. Animals work together to achieve a common goal during cooperative tasks using string-pulling behaviors. While string-pulling behavior has revealed deficits in rat sensorimotor function after exposure to space flight stressors, it has yet to be determined if rats will engage in cooperative string-pulling or if these stressors will influence cooperation. Thus, to explore how space flight stressors impact cooperative behavior, female Wistar rats were exposed to either sham (n = 8) or 10 centi-grays of …

Assessing Ectomycorrhizal Advantage On Tree Species Within Differing Soil Materials In Spring Mountains, Nevada, Kirsten Soriano, Riley Jones, Daniel Thompson

Undergraduate Research Symposium Posters

Ectomycorrhizal fungi (ECM) form symbiotic relationships with their partner plant, creating root systems which allow for the exchange of nutrients among connected plants. The Spring Mountains National Recreation Area (NRA) in Southern Nevada is the study site for examining ECMs due to its diverse ecosystem with numerous inhabiting species. To assess the effects of ECMs on the tree composition, literature review was conducted to outline previous methods. Through data analysis and observations of the sample sites, it is concluded that ECMs are highly likely to have an effect on tree composition of the Spring Mountains NRA. The purpose of this …

Effect Of Macronutrients On A Rat Model Of Clostridioides Difficile Infection, Stephanie Yang, Maria Niamba, Rose Jiang, Ashton Wippel, Efren Heredia, Liliko Watanabe, Katrina Valadez, Erica Bacab, Ernesto Abel-Santos

Undergraduate Research Symposium Posters

Clostridioides difficile (C. diff) is an anaerobic, spore forming, gram-positive bacteria. C. diff is the causative agent of C. difficile infections (CDIs) and is recognized as the leading cause of nosocomial infective diarrhea worldwide. CDI is associated with the use of antibiotics that alter the gut microbiome and C. diff resides in the large intestine where onset of the disease then occurs. Having observed the impacts of CDI on mice models, the Abel-Santos lab now shifts to observing this infectious disease in rat models. Establishing the infectious dosage at 109 spores, this study aims to identify the correlation between diet …

Effects Of Fire Temperatures On Mojave Desert Native And Nonnative Seeds, Sophia Lorenzana, Lindsay Chiquoine

Undergraduate Research Symposium Posters

Large-scale wildfires have been historically rare in hot deserts like the Mojave, largely due to the scarcity or uneven distribution of native plant biomass as fuel. Thus, native plants in these regions are ill-adapted to withstand spreading wildfire, resulting in slow post-fire recovery. Here, I test the hypothesis that nonnative grasses respond better to heat cues than native plant species. Seeds from 3 invasive and 13 native plant species were collected from research sites located in the eastern Mojave Desert, near surrounding Clark County Flood Control District weather stations. Seeds were buried in an artificial substrate mimicking field soil conditions …