Life Sciences Commons^™

Empowering Women: Understanding Neurological Changes In The Aging Brain, Joy Mckenzie

InnovateHER Meeting 2026

Women tend to have more neurological changes than men as they age starting in their mid-30s (Mosconi, 2024). While aging is a natural process, the neurological changes can impact a woman’s personal and professional quality of life (Faubion et al., 2023; Gravini, 2023). For years, women’s neurological symptoms have been ignored by being told that their experiences are normal and just a part of life (Haver, 2025). That narrative is starting to shift with the increased awareness of changes specific to women. There are resources to assess cognitive changes such as memory, processing speed, and word finding and strategies to …

Unearthing Misconceptions And Opinions In An Established Pollinator Project, Stella Holstrom

InnovateHER Meeting 2026

The Sartell High School has 13 acres of pollinator fields that were cultivated within the last 3 years. While the main part of the garden has signage, it is far from the more visible parts of the gardens. Over the last three years, there has been some negative feedback about the gardens, much of which seems to come from a place of ignorance by the public. A literature review about pollinator project and their benefits establishes that most research has surround bees or plants, but not usually both or the public reaction to pollinator gardens. My hypothesis was that most …

Designing For The Brain: Neuroarchitecture, Isabella Schutte

Hospitality Design Graduate Student Capstones

This capstone explores how principles from neuroscience can inform the design of micro-scale architectural environments to support emotional well-being and cognitive clarity. Through research, sensory analysis, immersive VR testing, and physiological and perceptual data collection, the project investigates how elements such as light, materiality, form, and atmosphere influence human experience. By comparing existing, aesthetic, and neuroscience-informed environments, the study suggests that intentional sensory design may better support restoration, stress regulation, and overall well-being within everyday spaces.

Cell Cycle Inhibition: Illudin S And Its Effects On Cdk2 In Ewing Sarcoma, Stephanie Diez, Natalie Flores, Alexandria Hernandez, Viviana Palacios, Terry Jo Shackleford

Cell and Molecular Methods

Ewing Sarcomas are aggressive round cell mesenchymal neoplasmas that have a high occurrence in children and young adults. CDK2 is a protein that is involved in the G1 phase of the cell cycle, which promotes the transition to the S phase. CDK2 kinase activation is mainly observed in the G1/S-phase transition.3 CDK2 binds to Cyclin proteins is responsible for entry and progression, thereby leading to maximal apoptosis activity in the S-phase. Illudin S is a drug that has been known to target cancer-specific cells, such as leukemia. Illudin S, in general are a cytotoxic metabolite that comes from plants, specifically …

Yap1 Knockdown And Panobinostat Treatment Increase Apoptotic Response And Decrease Gene Expression In Ewing Sarcoma Cells, Luna Collazo-Garcia, Alejandra Favela Santos, Madeline Torres-Salazar, Isabella Toscano, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma (EWS) is considered to be one of the most aggressive pediatric malignancies, often characterized by its dysregulated gene expression driven by oncogenic fusion proteins. The Hippo signaling effector Yes-associated protein 1 (YAP1) has been known in promoting cell proliferation, survival, and therapeutic resistance in multiple cancers. However, its role in Ewing sarcoma response to treatment remains unclear. This study investigated whether YAP1 knockdown enhances the sensitivity of Ewing sarcoma cells to the histone deacetylase inhibitor Panobinostat. Ewing sarcoma, ES8, cells were transfected with a YAP1-targeting siRNA (siYAP1) or a non-targeting control (siControl) and treated with DMSO, 0.1 μM, …

Everolimus Treatment Combined With Akt1 Knockdown Increased Apoptosis And Decreased Cell Proliferation In Ewing Sarcoma Cells, Arisha Arif, Alfie Barcenez, Sophia Ruter, Nicole Vanegas-Riddick, Terry Jo Shackleford

Cell and Molecular Methods

The purpose of this study is to use the gene AKT1, due to the interest in AKT1’s role in cancer cell proliferation, and the drug Everolimus, to determine if combined targeted therapy works as a more efficient therapeutic approach. Ewing Sarcoma has been connected to chromosomal translocations and is most common in pediatric patients. It is most often treated with chemotherapy and local treatments. It may be connected to the gene AKT1 due to how it regulates cell metabolism, growth, and proliferation. The gene mTOR is similarly connected to cell metabolism and proliferation, and is inhibited by the drug Everolimus. …

Sirna Knockdown Of Rptor Reduces Rptor Expression, Increases Brd4 Expression, And Alters Proliferation And Apoptosis In Ewing's Sarcoma Cells, Sergio Cipriano, David Leavitt, Michael Olivia, Liam Valdez, Terry Jo Shackleford

Cell and Molecular Methods

Ewing sarcoma is a highly aggressive cancer that primarily affects children and young adults. Although treatment options exist, many patients do not respond effectively, showing the need for improved targeted therapies. RPTOR is a key in mTORC1 complex which regulates cell growth, proliferation, and survival. LY2874455 is a selective pan-FGFR inhibitor that targets growth factor signaling pathways involved in tumor progression, and FGFR signaling interacts with pathways such as mTOR, making it a potential target for combination therapies. We hypothesized that silencing RPTOR in Ewing sarcoma cells would disrupt mTOR signaling and alter expression of genes linked to cell survival …

Everolimus And Sirna-Mediated Mtor Inhibition Reduces Proliferation And Promotes Apoptosis In Ewing Sarcoma Cells, Dylan Calvert, Malorie Martinez, Alexa Miner, Ellis Quiroga, Terry Jo Shackleford

Cell and Molecular Methods

Ewing Sarcoma (ES) is an aggressive pediatric bone cancer characterized by rapid cell proliferation and poor prognosis, making the identification of therapeutic targets critical. One of  the mechanistic targets is rapamycin (mTOR) signaling pathway, which is critical for regulating cell growth, proliferation, and survival. Abnormal activation of the mTOR signaling pathway has been linked to the progression of ES, as it drives uncontrolled cell growth and apoptosis resistance. Because mTOR represents a promising therapeutic target for ES treatment, we hypothesized that inhibiting mTOR activity through an siRNA-mediated knockdown or through Everolimus drug treatment, would reduce cell proliferation and promote ES …

From Sunshine To Sight Lost: Amd In North Dakota, Sidney J. Leciejewski, Diane Darland

Arts & Sciences Undergraduate Showcase

Age-related macular degeneration (AMD) is a progressive eye disease that directly harms the macula, which could eventually cause vision loss. The macula is an area on the back of the eye that contains cone cells, which allow for our color vision. Its location also allows us to have our central vision. There are two kinds: the dry and wet form, where the wet form is more extreme. The disease, itself, is highly prevalent in North Dakota, which is why it is important to note its causes and prevention methods. Some causes of AMD include genetic risks,  health risks, and metabolic …

Skeletal Muscle Characteristics Long-Living Dwarf Mice In Response To High Fat Diet, Landon Schumacher, Matthew Johnston, Jaspreet Osan, Holly Brown-Borg

Arts & Sciences Undergraduate Showcase

Introduction: The effects of high fat diet (HFD; 60% kcal: fat) on skeletal muscle in mice with postnatal growth hormone deficiency is relatively unknown. We compared the tibialis anterior (TA) muscle from middle aged female Ames Dwarf and Wildtype mice fed HFD for 16 weeks and standard diet (STD; 10%: fat) to see the impacts of a HFD on inflammation and fibrotic formation in the musculature.   Methodology: Mice were euthanized after diet duration (age 10-12 months), and TAs were collected and frozen in OCT for cross-sectional cryosection. Ten um thick muscle was fixed to slides and stained with Oil Red-O …

Ai×Life 2026: Advances In Computational Biology Across Scales For Life & Health Sciences, Suma Mohan S., Devika N. T., Pranavathiyani G.

Conference Proceedings

Book of Abstracts of the International Conference, AIxLife 2026: Advances in Computational Biology Across Scales for Life & Health Sciences, held on 17–18 April 2026, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, INDIA 

About the Conference

Conventional computational biology laid the foundation for biological data analysis through statistical models, algorithms, and curated databases, enabling insights into genes, proteins, and pathways. Today, the integration of artificial intelligence, spanning machine learning, deep learning, and large language models (LLMs) is driving a transformative shift across biological scales, from atomic and molecular interactions to pathways, cellular systems, organisms, and populations.

AI-powered approaches …

Maternal Toxicity: A Meta-Narrative Review Of Pfas And Epigenetic Regulation In Embryonic Development, Catherine Duong, Hayden J. Fisher, Shannon Mccauley, Danny M. Nguyen

Research Methods Poster Session 2026

No abstract provided.

The Beat Behind The Bark: Investigating The Effects Of Music Tempo On Canine Physiological And Psychological States, Marley Lanier

Poster Presentations

Music is a universal component of human culture that has been demonstrated influencing emotional, cognitive, and physiological responses, specifically heart rate and hormonal responses (Mehr et al., 2019; Trappe, 2012). Recently, this research has expended to explore how music may affect non-human animals, particularly dogs, due to their roles as therapy animals, service animals, and human companions (Lindig et al., 2020; Gee et al., 2021). Being able to understand how music influences canine stress and relaxation hold important applications in environments such as shelters, veterinary clinics, and at home. One important feature of music is tempo, or beats per minute …

College Of Natural Sciences Spring Newsletter, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

[Page 1] Dean's Message
[Page] 2 Awards & Recognitions // Student Spotlights
[Page] 3 Zhang Named to Landsat Science Team // The Power of Teaching
[Page] 4 “Science as Art” Competition Welcomes High School Artists
[Page] 5 Testing for “Forever Chemicals” in Surface Water // New Faculty Spotlight
[Page] 6 Ambassador Initiated Outreach
[Page] 7 57th Annual Geography Convention
[Page] 8 Twice the Impact on On Call with the Prairie Doc
[Page] 9 Making Staple Foods Healthier // Halaweish & Cole-Dai Retire
[Page] 10 Drone Day 2026
[Page] 11 Student Research, Scholarship, and Creative Activity Day (SRSCAD)
[Page] 12 Ceremony …

Emotional Intelligence Documentary - The Journey, Not The Destination: A Spain Reflection, Elise I. Palacios

Cultivating Emotional Intelligence through the Humanities in Spain

The Journey, Not the Destination follows my study abroad experience in Madrid and Toledo, Spain through a Medical Humanities course. Through art, history, culture, and personal reflection, I explore how travel broadened my understanding of the human experience and shaped my perspective as a future physician. More than a story about a place, this documentary is about growth, empathy, and the lessons we learn along the journey.

2026 - The Thirtieth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the 30th Annual Symposium of Student Scholars, held on April 22-24, 2026. Includes abstracts from the presentations and posters.

Environmental Racism, Rawan Abass

Undergraduate Research Symposium Podium Presentations

Environmental racism is defined as the disproportionate exposure of racialized communities to environmental hazards, toxic waste, and climate related impacts as a result of historical injustices. This system of inequality is believed to have lasting effects that continue into the present. This study examines the direct relationship between environmental racism and rising asthma rates in low-income communities in Los Angeles including the potential policy reforms that could address these disparities. Using historical redlining maps, GIS analysis, and pollution data, this study analyzes the spatial patterns between historically marginalized neighborhoods and current environmental conditions. The findings indicate that historically redlined areas …

Relationship Between Supplement Use And Eating Disorder Symptoms, Hannah Segura, Lisa Menegatos, Danielle Morabita, Maegan Nation

Undergraduate Research Symposium Posters

Background: Eating disorders encompass a spectrum of cognitive, behavioral, and physical symptoms related to eating and compensatory weight management behaviors. Supplement usage is becoming increasingly common, especially among younger populations. Using supplements has been shown to put adolescents at an increased risk for body dysmorphia, disordered eating behaviors, as well as other potentially harmful health effects, like electrolyte complications, heart issues, or even death. However, there is less research done on supplement usage in the college student population, especially in men. Across the past 10 years, supplement use in college students has increased 19.5%. Overall, there is a lack of …

False Halos: A Case Of Digoxin Poisoning, Usman Nazeer, Sarita Thanedar, Jacob Sanderson, Gongkai Liu, Hitesh Gidwani

Central & West Texas and San Antonio GME Research Day 2026

No abstract provided.

Play For All: Promoting Inclusivity And Providing Modifications For Kids With Disabilities Within An Indoor Play Space, Yasmeen Ikbal, Mary Jan Greer

Spring 2026 OTD Capstone Symposium

Children’s environments need to be enhanced to match their developmental levels (Winter & Dempsey, 1994). There is a lack of tools, play equipment, and structures specifically targeted to children with disabilities (Therrien et al., 2022). Lack of opportunities for these children can hinder their development (Mullick, 2013). This capstone intends to educate staff and parents on how to promote inclusivity by increasing their understanding of disabilities, creating accessible environments, adapting activities, and building confidence in supporting children with disabilities to participate in their occupations.

Cognition And Mental Health: Addressing The Impact Of Traumatic Brain Injuries (Tbi) On Adults, Hannah E. Smith, Lesley Khan-Farooqi, Anne Mcdonnell, Mpa, Otr/L, Cbist

Spring 2026 OTD Capstone Symposium

This project addresses cognitive and mental health challenges in adults with traumatic brain injuries (TBI). It developed evidence-based resources, including a clinician handbook and user-friendly survivor guidebook - using research, interviews, and observations. The materials were refined with expert feedback and support improved interventions, education, and quality of life for individuals with TBIs, and their caregivers.

Burnout Sentinel: An Early Warning System For Student Burnout Using Workload And Recovery Indicators, Minh Duy Do

Expo Student Presentations

2026 Spring Expo Video Essay Presentation

• Biological & Life Sciences
• Health Sciences & Health Professions
• Physical & Applied Sciences
• Service-Learning
• Social & Behavioral Sciences

Effect Of Missense Mutation In Pah Gene At Position 46: Glycine To Arginine, Lily Hammond, Tiffany Tran

Expo Student Presentations

2026 Spring Expo Online Poster Presentation

• Biological & Life Sciences

Hif1Α-Driven Glycolysis Controls Ifn-Γ Production And Immune Checkpoint Blockade Response In Hypoxic T Cells, Zach Lewis, Hongxing Shen, Oluwagbemiga A. Ojo, Vivian Y. Shi, Haitao Ding, Abdelrahman Yassin, James A. Bonner, Lewis Zhichang Shi

Expo Student Presentations

2026 Spring Expo Poster Presentation

• Biological & Life Sciences

Sex Specific Effects Of Early Life Stress On Blood Pressure Regulation Is Independent Of Arterial Stiffness In Rats, Vanvy Ly, Hiruni M. Aponso, David M. Pollack

Expo Student Presentations

2026 Spring Expo Poster Presentation

• Biological & Life Sciences

Effects Of Kiwifruit Extract On Apoptosis And Cytokine Production In Inflamed Thp-1-Derived Macrophages, Adrian Cruz, Isbella Brigman

Posters - 2026

White blood cells are essential components of the immune system involved in helping defend the body against infections. Macrophages are a type of white blood cell that play a major role in stimulating and regulating the inflammatory response. Inflammation is a natural response of the immune system to infection, injury, or harmful stimuli. Scientific research commonly studies inflammation by exposing immune cells to lipopolysaccharide (LPS). Macrophages stimulated with LPS undergo changes in cell processes such as apoptosis which is programmed cell death. Apoptosis is crucial for the immune system that helps eliminate infected or damaged cells to prevent the spread …

The Effects Of Mycoplasma Pneumoniae Cards Toxin On M2 Macrophage Polarization And Formation, Ria Modi

Posters - 2026

Macrophages are key cells of the innate immune system, playing essential roles in host defense, tissue homeostasis, and inflammation. Depending on stimuli, macrophages can polarize into distinct functional phenotypes, characterized as classically activated (M1) or alternatively activated (M2) macrophages. M2 macrophages are associated specifically with anti-inflammatory responses, tissue repair, and immune regulation. They contribute to wound healing and can regulate host responses during infection. Community-acquired respiratory distress syndrome (CARDS) toxin, a key virulence factor of Mycoplasma pneumoniae, plays a role in altering host immune responses, but its impact on M2 macrophage function and polarization remains unclear.

Contrast Therapy Is Associated With Higher Thermal Comfort For A Similar Acute Inflammatory Response Compared With Sauna Therapy, Rene Barbier, Benjamin Enslow, Jace Nicolet, Louis Hein, Kelvin Wu, Sven Hoekstra

Posters - 2026

Passive heat therapy, through sauna or hot water immersion, can improve cardiometabolic health outcomes. An increasingly popular thermal modality is contrast therapy, during which sauna therapy is interspersed with cold exposure. However, the acute physiological and perceptual responses to contras therapy in  comparison with traditional sauna remains unknown. This study compared the acute inflammatory, physiological, and perceptual responses to contras against heat therapy in predominantly young, healthy individuals

Comparing Head Shape Of Polymorphic Subterranean E. Latitans And Subterranean E. Sp. 4, Brandon Chapa, Jordan Cosgrove, Lizzeth Holguin

Posters - 2026

Eurycea latitans (E. latitans) from Honey Creek Cave and unnamed Eurycea species from New Braunfels, Texas (E. sp. 4) are two paedomorphic subterranean species. E. latitans is polymorphic, meaning it also exists as a surface species. Similarities in morphology of subterranean salamander species may be due to convergent evolution as a result of living in similar environments. These similarities include having flatter, wider heads, and wider mouths than surface species (Tovar et al. 2025). Variation may also exist among different subterranean salamander species. Texas Eurycea salamanders display “complex patterns of morphological divergence”, suggesting that isolation and local environmental pressures can …

Impact Of Liver-Secreted Small Extracellular Vesicles On Myotube Funcation, Tatiana Barrantes, Ioannis Tsialtas, Qing Zhang, Kevin Koronowski

Posters - 2026

Extracellular vesicles (EVs) mediate intercellular communication by transferring molecular signals between tissues. Liver-derived EVs contribute to metabolic regulation and have been implicated in tissue cross-talk during health and disease. Skeletal muscle is a highly metabolic tissue that depends on mitochondrial respiration for energy production. However, whether liver-secreted EVs influence myotube mitochondrial function remains unclear. Here, we investigate the impact of liver-derived EVs on myotube mitochondrial respiration.