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The Thai Journal of Pharmaceutical Sciences

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Full-Text Articles in Life Sciences

Risk Assessment For Ingestion Of Off-Season Longan Stimulated By Potassium Chlorate, Theerayut Baubhom, Kannikar Chatsantiprapa Jan 2019

Risk Assessment For Ingestion Of Off-Season Longan Stimulated By Potassium Chlorate, Theerayut Baubhom, Kannikar Chatsantiprapa

The Thai Journal of Pharmaceutical Sciences

Off-season longans in Thailand were stimulated by potassium chlorate (KClO3). KClO3 is hazardous chemical and prohibited in food since it might cause harm to human health. This research aimed to observe for chemical effects on longan trees, and analyze t.


In Silico Analysis Of Phytochemical Compound Found In Snake Fruit (Salacca Zalacca) Peel As Anti-Aging Agent, Ermi Girsang, Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Wahyu Widowati, Satrio Haryo Benowo Wibowo, Fajar Sukma Perdana, Rizal Rizal Jan 2019

In Silico Analysis Of Phytochemical Compound Found In Snake Fruit (Salacca Zalacca) Peel As Anti-Aging Agent, Ermi Girsang, Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Wahyu Widowati, Satrio Haryo Benowo Wibowo, Fajar Sukma Perdana, Rizal Rizal

The Thai Journal of Pharmaceutical Sciences

Skin aging is a complicated natural phenomenon characterized by progressive loss of structural integrity and physiological function of the skin. Snake fruit (Salacca zalacca) is an important fruit crop native from Indonesia. Its waste is a potential sour.


Various Nmdar Antagonists Decrease Interferon-Alpha Induced Depression Behavior In Mice Model Of Despair, Azadeh Mesripour, Ahmad Purhasani, Valiollah Hajhashemi Jan 2019

Various Nmdar Antagonists Decrease Interferon-Alpha Induced Depression Behavior In Mice Model Of Despair, Azadeh Mesripour, Ahmad Purhasani, Valiollah Hajhashemi

The Thai Journal of Pharmaceutical Sciences

Introduction: Treatment with interferon-alpha (IFNa) can induce depression that is likely the result of its effect on the tryptophan–kynurenine pathway. Kynurenine passes through the blood-brain barrier and breaks to neurotoxic metabolites, such as qui...


Hepatoprotective And Choleretic Activity Of Tanacetum Vulgare Flowers Extract, Oksana Ya. Mishchenko, Kateryna O. Kalko, Marharyta Yu. Zolotaikina, Tatyana M. Gontova, Victoria V. Mashtaler, Catherine Yu. Yurchenko, Lyudmyla V. Derymedvid, Anastasia Yu. Pozdniakova Jan 2019

Hepatoprotective And Choleretic Activity Of Tanacetum Vulgare Flowers Extract, Oksana Ya. Mishchenko, Kateryna O. Kalko, Marharyta Yu. Zolotaikina, Tatyana M. Gontova, Victoria V. Mashtaler, Catherine Yu. Yurchenko, Lyudmyla V. Derymedvid, Anastasia Yu. Pozdniakova

The Thai Journal of Pharmaceutical Sciences

Objectives: The article presents the study of hepatoprotective and choleretic properties of Tanacetum vulgare flores dry extract (TVFDE) in vivo. Materials and Methods: The research was carried out using model of subchronic toxi? hepatitis in rats, caus..


Characterization And Potention Phytoestrogen Of Pigeon Pea (Cajanus Cajan L. Mill Sp.) On Rat Ovary, Cicilia Primiani, Pujiati Pujiati, Sutiman Sumitro Jan 2019

Characterization And Potention Phytoestrogen Of Pigeon Pea (Cajanus Cajan L. Mill Sp.) On Rat Ovary, Cicilia Primiani, Pujiati Pujiati, Sutiman Sumitro

The Thai Journal of Pharmaceutical Sciences

Objectives: The objective of this study to analyze the estrogenic compounds in pigeon pea seeds and the effect of the plant seeds on the development of rat ovaries. Materials and method: Liquid chromatography-mass spectrometry (MS) and gas chromatography.


Screening Of Acetylcholinesterase Inhibitory Activity In Essential Oil From Myrtaceae, Vipaporn Sareedenchai Jan 2019

Screening Of Acetylcholinesterase Inhibitory Activity In Essential Oil From Myrtaceae, Vipaporn Sareedenchai

The Thai Journal of Pharmaceutical Sciences

Objective: This research was to investigate acetylcholinesterase inhibitory activity of the essential oil from Myrtaceae and its components. Methods: The essential oils were extracted from fresh leave of Myrtaceae plants: Eucalyptus globulus Labill (Euca.


Physicochemical Characters And Fatty Acid Composition Of Payena Lucida Seed Oils, Penpun Wetwitayaklung Jan 2019

Physicochemical Characters And Fatty Acid Composition Of Payena Lucida Seed Oils, Penpun Wetwitayaklung

The Thai Journal of Pharmaceutical Sciences

Introduction: Payena lucida A.DC. seed oil has long been used as edible oil and treating various kinds of diseases as oral and topical applications in some local areas of Myanmar. Objectives: This research aimed to identify and qualify the physicochemi...


Microwave-Assisted Synthesis, In Silico Studies And In Vivo Evaluation For Antidiabetic Activity Of New Brominated Pyrazoline Analogues, Neni Frimayanti, Jasril Jasril, Ihsan Ikhtiarudin, Syilfia Hasti, Anisa Indah Reza Jan 2019

Microwave-Assisted Synthesis, In Silico Studies And In Vivo Evaluation For Antidiabetic Activity Of New Brominated Pyrazoline Analogues, Neni Frimayanti, Jasril Jasril, Ihsan Ikhtiarudin, Syilfia Hasti, Anisa Indah Reza

The Thai Journal of Pharmaceutical Sciences

Introduction: Pyrazolines have played crucial role in the drug discovery researches and have been used widely as an important pharmacophores or intermediet for synthesis of bioactive compounds. Objective: The aim of this work is to explore the potentia...


Association Between The Appropriate Antimicrobial Therapy And Clinical Outcomes In Patients With Sepsis, Ploylarp Lertvipapath, Chankit Puttilerpong, Peerawong Werarak, Tipa Chakorn, Nasikarn Angkasekwinai, Napakadol Noppakusomboon, Apichaya Monsomboon Jan 2019

Association Between The Appropriate Antimicrobial Therapy And Clinical Outcomes In Patients With Sepsis, Ploylarp Lertvipapath, Chankit Puttilerpong, Peerawong Werarak, Tipa Chakorn, Nasikarn Angkasekwinai, Napakadol Noppakusomboon, Apichaya Monsomboon

The Thai Journal of Pharmaceutical Sciences

Sepsis is leading cause of death in hospitals, but appropriate antimicrobial therapy canreduce the mortality rate and improve the clinical outcome. This prospective studyanalyzed the association between appropriate antimicrobial therapy and clinical outc.


The Effect Of Glucose, Adenosine-5’-Triphosphate, And Adenosine On Glucose Transporter 9 Expression In Mdck Cells, Jamras Kanchanapiboon, Thitima Pengsuparp Jan 2019

The Effect Of Glucose, Adenosine-5’-Triphosphate, And Adenosine On Glucose Transporter 9 Expression In Mdck Cells, Jamras Kanchanapiboon, Thitima Pengsuparp

The Thai Journal of Pharmaceutical Sciences

This study aimed to investigate the effect of glucose, adenosine triphosphate (ATP) and adenosine and their concentration dependence on GLUT9 expression in hyperglycemic conditions. These compounds have been reported to be associated with hyperglycemia i.


Mitragynine Reduced Morphine-Induced Conditioned Place Preference And Withdrawal In Rodents, Rittinarong Meepong, Thongchai Sooksawate Jan 2019

Mitragynine Reduced Morphine-Induced Conditioned Place Preference And Withdrawal In Rodents, Rittinarong Meepong, Thongchai Sooksawate

The Thai Journal of Pharmaceutical Sciences

Introduction: Kratom (Mitragyna speciosa Korth) has been long used in folklore medicine in Southeast Asian countries for its analgesic effects and the treatment of opioid withdrawal. Mitragynine is a major alkaloid found in the leaves of kratom plant th.


A Novel Assay For Evaluation Of The Total Antioxidant Capacity (Tac) Using A Nontoxic Probe, Sirirat Panich Jan 2018

A Novel Assay For Evaluation Of The Total Antioxidant Capacity (Tac) Using A Nontoxic Probe, Sirirat Panich

The Thai Journal of Pharmaceutical Sciences

A novel and simple method for measuring total antioxidant capacity (TAC) was established. Herein, the new assay is based on generating the deep blue Imipramine (IMI) free radical by oxidising IMI with ammonium tetra vanadate (NH4VO3) in acid medium. Once.


In Silico Evaluation Of Molecular Interactions Between Known ?-Glucosidase Inhibitors And Homologous ?-Glucosidase Enzymes From Saccharomyces Cerevisiae, Rattus Norvegicus, And Ganc-Human, Teni Ernawati Jan 2018

In Silico Evaluation Of Molecular Interactions Between Known ?-Glucosidase Inhibitors And Homologous ?-Glucosidase Enzymes From Saccharomyces Cerevisiae, Rattus Norvegicus, And Ganc-Human, Teni Ernawati

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to observe molecular interactions between alpha glucosidase inhibitor waith alpha glucosidase enzyme derived from Saccharomyces cereviseae, Rattus norvegicus and GANC-human. Therefore, they were used against four of the well-kno.


Intended High-Performance Liquid Chromatography Procedure For The Quantification Of Norfloxacin And Its Potential Impurities In Active Pharmaceutical Ingredient And Tablet Dosage Forms, Bikshal Babu Kasimala, Venkateswara Rao Anna, Useni Reddy Mallu, L. Maheshwara Reddy Jan 2018

Intended High-Performance Liquid Chromatography Procedure For The Quantification Of Norfloxacin And Its Potential Impurities In Active Pharmaceutical Ingredient And Tablet Dosage Forms, Bikshal Babu Kasimala, Venkateswara Rao Anna, Useni Reddy Mallu, L. Maheshwara Reddy

The Thai Journal of Pharmaceutical Sciences

Norfloxacin [NFXC] is an active pharmaceutical ingredient belongs to 4-quinolone antibacterial agent used for the prophylaxis of gram +ve and gram-ve bacterial infections. A reliable stability-indicating RP-HPLC method was developed for the separation an.


Development And Validation Of Novel Stability-Indicating High-Performance Liquid Chromatography Method For The Determination Of Miglitol In Pharmaceuticals, Kanakapura Basavaiah, Nagaraju Rajendraprasad Jan 2018

Development And Validation Of Novel Stability-Indicating High-Performance Liquid Chromatography Method For The Determination Of Miglitol In Pharmaceuticals, Kanakapura Basavaiah, Nagaraju Rajendraprasad

The Thai Journal of Pharmaceutical Sciences

A reversed phase high performance liquid chromatographic (RP-HPLC) method for the determination of miglitol (MGL) in pharmaceuticals is presented. The assay was performed on a Phenomenex Luna C18 (150 × 4.6 mm; 5µm particle size) column using phosphate...


Quantitative Structure–Activity Relationship Modeling Of S-Triazines And 2-Arylpyrimidines As Selective Pde4b Inhibitors, Anand Gaurav, Gabriel Akyirem Akowuah, Choo Shiuan Por Jan 2018

Quantitative Structure–Activity Relationship Modeling Of S-Triazines And 2-Arylpyrimidines As Selective Pde4b Inhibitors, Anand Gaurav, Gabriel Akyirem Akowuah, Choo Shiuan Por

The Thai Journal of Pharmaceutical Sciences

A QSAR analysis was conducted on a series of 2-arylpyrimidine and s-triazine derivatives as selective PDE4B inhibitors. Primary objective of the study is to develop predictive QSAR models for s-triazines and 2-arylpyrimidines as selective PDE4B and to id.


Ethical Cases On Pharmacy Profession Practice In Thailand During A.D. 1995 To 2015, Wanna Sriviriyanupap, Usawadee Sutapuk Jan 2018

Ethical Cases On Pharmacy Profession Practice In Thailand During A.D. 1995 To 2015, Wanna Sriviriyanupap, Usawadee Sutapuk

The Thai Journal of Pharmaceutical Sciences

Background: Code of ethics for the pharmacy profession was established to enforce all pharmacists to abide by a rule for a good pharmacy professional practice. Objective: to study the ethical problems, related to the pharmacy profession practice, and to .


Population Pharmacokinetics Analysis Of Vancomycin In Critically Ill Patients, Wanchai Treyaprasert Jan 2018

Population Pharmacokinetics Analysis Of Vancomycin In Critically Ill Patients, Wanchai Treyaprasert

The Thai Journal of Pharmaceutical Sciences

Objectives: The aim of this study was to determine population pharmacokinetic parameters of vancomycin in adult critically ill patients and to investigate the covariates affecting population pharmacokinetic parameters. Methods: Plasma concentration data..


Effect Of Temperature And Time On Free Amino Acid Profile In Thai Chicken Bone Soup Stock Preparation, Nattida Chotechuang, Matichon Lokkhumlue, Pawinee Deetae Jan 2018

Effect Of Temperature And Time On Free Amino Acid Profile In Thai Chicken Bone Soup Stock Preparation, Nattida Chotechuang, Matichon Lokkhumlue, Pawinee Deetae

The Thai Journal of Pharmaceutical Sciences

Soup stock is the basic material for cooking various types of food, including Thai food. General practice to prepare Thai soup stock is to gentle boil chicken bone soup stock between 85-95°C for 1-3 hours to get good quality soup stock. Free amino aci..


Apigenin And Baicalin, Each Alone Or In Low Dose Combination, Attenuated Chloroquine Induced Male Infertility In Adult Rats, Amira Akilah, Mohamed Balaha, Mohamed-Nabeih Abd-El Rahman, Sabiha Hedya Jan 2018

Apigenin And Baicalin, Each Alone Or In Low Dose Combination, Attenuated Chloroquine Induced Male Infertility In Adult Rats, Amira Akilah, Mohamed Balaha, Mohamed-Nabeih Abd-El Rahman, Sabiha Hedya

The Thai Journal of Pharmaceutical Sciences

Male infertility is a worldwide health problem, which accounts for about 50% of all cases of infertility and considered as the commonest single defined cause of infertility. Recently, apigenin and baicalin exhibited a powerful antioxidant and antiapoptot.


The Protective Effect Of Lycopene-Rich Products On Skin Photodamage: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Witoo Dilokthornsakul, Teerapon Dhippayom, Piyameth Dilokthornsakul Jan 2018

The Protective Effect Of Lycopene-Rich Products On Skin Photodamage: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Witoo Dilokthornsakul, Teerapon Dhippayom, Piyameth Dilokthornsakul

The Thai Journal of Pharmaceutical Sciences

Background: Ultraviolet (UV) radiation has known as a major cause of photodamage, photoaging and skin cancer as it involves in reactive oxygen species generation. Several natural antioxidants including lycopene has been suggested for photoprotection. How.


Suitability Of Alternative Atp Potency Assay For Lot Release Of Tokyo Bcg- 172-1 Vaccines In Thailand, Supaporn Phumiamorn Jan 2018

Suitability Of Alternative Atp Potency Assay For Lot Release Of Tokyo Bcg- 172-1 Vaccines In Thailand, Supaporn Phumiamorn

The Thai Journal of Pharmaceutical Sciences

The potency assay of the BCG vaccine is routinely performed by a conventional viable count on a solid medium. This assay method is not only time-consuming, but can give variable results because of the tendency to clump of mycobacterium. The intracellular.


A Simple High-Performance Liquid Chromatographic Method For Quantitative Analysis Of Brazilin In Caesalpinia Sappan L. Extracts, Sakan Warinhomhaun, Boonchoo Sritularak, Dusadee Charnvanich Jan 2018

A Simple High-Performance Liquid Chromatographic Method For Quantitative Analysis Of Brazilin In Caesalpinia Sappan L. Extracts, Sakan Warinhomhaun, Boonchoo Sritularak, Dusadee Charnvanich

The Thai Journal of Pharmaceutical Sciences

The specific aim of the study was to develop and validate a simple reversed-phase high-performance liquid chromatographic (HPLC) method for assay of brazilin in Caesalpinia sappan L. (sappanwood) extracts. Validation of the HPLC method was conducted unde.


Access To Medicines For Breast, Colorectal, And Lung Cancer In Thailand, Pornsroung Saerekul, Tharin Limsakun, Puree Anantachoti, Rungpetch Sakulbumrungsil Jan 2018

Access To Medicines For Breast, Colorectal, And Lung Cancer In Thailand, Pornsroung Saerekul, Tharin Limsakun, Puree Anantachoti, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

Cancer drugs have become prohibitive, and consequently their accessibility has increasingly been of great concern in many countries. Particularly, the information about cancer drug access in Thailand has been sporadic. Therefore, the goal of the study wa.


Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats, Amalia Anita Hawas, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Sadli Syarifuddin, Rahmi Ayu Wijayaningsih, Ngatidjan Jan 2018

Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats, Amalia Anita Hawas, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Sadli Syarifuddin, Rahmi Ayu Wijayaningsih, Ngatidjan

The Thai Journal of Pharmaceutical Sciences

Objectives: To explore the effect of C. asiatica extract on intima-media thickness, eNOS expression, and macrophage M1/M2 ratio in diabetic rats aorta. Materials and Methods: Wistar rats consisted of normal group and diabetic group which divided into neg.


Effect Of Ipomoea Hederacea Jacq. Methanolic Extract On Blood Pressure And Relaxation Of Rat Thoracic Aorta: Evidence Indicated The Release Of No And H2s, Chaweewan Jansakul Jan 2018

Effect Of Ipomoea Hederacea Jacq. Methanolic Extract On Blood Pressure And Relaxation Of Rat Thoracic Aorta: Evidence Indicated The Release Of No And H2s, Chaweewan Jansakul

The Thai Journal of Pharmaceutical Sciences

Seeds of Ipomoeahederacea Jacq. (IH) are used in traditional medicine to manage ailments pertaining to the vasculature, circulatory system and related disorders. However no study exists to validate their usage for said ailments. The present study was con.


Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong Jan 2018

Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong

The Thai Journal of Pharmaceutical Sciences

Fluocinolone acetonide (FA) buccal solution was prepared for treatment of oral lichen planus using cosolvents and surfactant to enhance FA solubility. Based on solubility power (s), cosolvents enhanced FA solubility in the order; polyethylene glycol 400 .


Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane Jan 2018

Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane

The Thai Journal of Pharmaceutical Sciences

Objective: The aim of the present study was to evaluate the phytochemicals and antioxidant activity of leaf and fruit of wild Bottle gourd. Methods: Successive extraction of dried material was done by soxhlet apparatus and phytochemicals such as total p..


Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung Jan 2018

Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung

The Thai Journal of Pharmaceutical Sciences

Introduction: The history of Dendropanax morbifera LEV., which is indigenous plant in Korea, is quit old and simultaneously, known for locals as remedy of various diseases such as migraine and inflammation. The aim of this study is evaluating the antioxi.


Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara Jan 2018

Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara

The Thai Journal of Pharmaceutical Sciences

The diabetic animal model is very useful for developing functional foods and medicinal drugs. Spontaneously Diabetic Torii (SDT) rat, a non-obese type 2 diabetic model, is one of the hopeful models to play an important role for research and development o.