Life Sciences Commons^™

Can We Measure Distress In Animals?, David Fraser

Ethology Collection

When scientists try to identify and mitigate distress in animals, an obvious first question is: can we actually measure distress? Today, after three decades of scientific research on animal welfare it must seem obvious that this is possible, but let me offer a more guarded response.

Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan

Experimentation Collection

While most people recognize that biomedical scientists are searching for knowledge that will improve the health of humans and animals, the image of someone deliberately causing harm to an animal in order to produce data that may lead to some future benefit has always prompted an uncomfortable reaction outside the laboratory. However, proponents of animal research have usually justified the practice by reference to greater benefits (new knowledge and medical treatments) over lesser costs (in animal suffering and death). Given that one of the costs of animal research is the suffering experienced by the animals, the goal of eliminating distress …

Recognition Of Distress In Animals – A Philosophical Prolegomenon, Bernard E. Rollin

Sentience Collection

For those who continue to doubt the studiability of distress or suffering or misery in all of its forms in animals, consider the following thought experiment: If the government were to come up with a billion dollars in research funding for animal distress, would that money go a-begging? We can study these states just as we studied pain—excellent work on boredom by Franciose Wemelsfelder in a volume on laboratory animal welfare I co-edited made the methodology for such study quite explicit. (Wemelsfelder, 1990) And when the ideological scales fall from our eyes, we realize that the work of scientists like …

Distress Or Suffering: What Should Be Measured To Determine Animal Well-Being?, Ian J. H. Duncan

Sentience Collection

It is generally accepted that all the vertebrates and some of the invertebrates (those with large neural ganglia such as the cephalopods) are capable of subjective experiences. Amongst those experiences are the subjective, affective states, sometimes called 'feelings' or 'emotions'. The strong negative feelings are often lumped together as 'suffering' and the positive feelings as 'pleasure'. I have argued for many years that animal welfare/well-being is completely dependent on what the animal feels (Duncan, 1993, 1996, 2002). An animal's well-being is decreased by experiencing suffering and increased by experiencing pleasure. It's as simple as that.

Concepts Of Distress, Suffering And Their Operational Interpretation, Marian Stamp Dawkins

Ethology Collection

The major concern of this paper is with the operational interpretation of animal distress and suffering – that is, with the issue of how we can measure the extent of an animal’s distress in practice. I shall probably make myself very unpopular by expressing the view right from the outset that I think it is neither possible nor desirable to try to discover universal ‘indicators’ of distress that will apply to all animals in all situations.

International Regulatory Definitions Of Animal Distress In Animal Research And Animal Production – An Overview., Jon Richmond

Laws and Legislation Collection

Various systems already exist to judge animal welfare - of which distress can be one component - in the laboratory setting (see Hendriksen and Morton 1998). Many rely on nonspecific measures; that is they may be manifestations of a number of states, not all of them necessarily indicative of poor welfare. Certainly, there is already good provision for methods to recognise some of the commoner manifestations of distress, arguably they are sufficiently meaningful to categorise various distress states, though to my mind they are for the present still not suited for use as means of strictly quantifying the negative impact/suffering …

Measurement And Mitigation Of Laboratory Animal Distress Sources Of Distress In The Animal Laboratory, Larry Carbone

Laboratory Experiments Collection

Pain and distress differ, but overlap. For the purposes of this discussion, we will consider pain to involve nociceptive input of stimuli that are potentially tissue damaging, and that further include an unpleasant emotional component (Merskey and Bogduk 1994). Pain need not necessarily induce distress, as when an animal or human willingly undergoes some painful situation in order to achieve a desired reward. In that case, while the pain may be unpleasant, it is not so severe as to be intolerable. Likewise, there are many potential causes of distress that do not involve physical pain.

The Role Of Clinical Veterinary Medicine In The Assessment And Treatment Of Laboratory Animal Distress, V. Hampshire

Veterinary Science and Medicine Collection

It is doubtful that the scientific community will ever arrive at a consensus definition for distress as it may be attempted for the purposes of improving animal welfare in and across the myriad of research, testing and teaching facilities in the United States and throughout the minuet of protocols that exist for animals. The stakeholders in this attempt can however address most causes of physiologic distress by instituting time-honored veterinary and agrarian approaches to animal surveillance. In this manner, the majority of individuals who participate in responsible and humane animal care might be assuaged in that a condition of maximum …

Distress In Animals: Its Recognition And A Hypothesis For Its Assessment, David B. Morton

Sentience Collection

This essay deals with the recognition of non-painful emotional experiences in animals, how they relate to animal wellbeing and animal welfare, and how they can be assessed, monitored and mitigated. While it is written often from a mammalian perspective, the general principles will apply to all animals that are sentient.

Resolving Animal Distress And Pain: Principles And Examples Of Good Practice In Various Fields Of Research, Alicia Karas, Matthew C. Leach, Karl A. Andrutis, Kathleen Conlee, John P. Gluck, Andrew N. Rowan, Martin L. Stephens

Laboratory Experiments Collection

Pain and distress are central topics in legislation, regulations, and standards regarding the use of animals in research. However, in practice, pain has received greatly increased attention in recent years, while attention to distress has lagged far behind, especially for distress that is not induced by pain. A contributing factor is that there is less information readily available on distress, including practical information on its recognition, assessment and alleviation.

This chapter attempts to help fill that void by reversing the usual pattern and giving greater attention to distress than to pain. In addition, we also bypass the pain versus distress …

What Is New On The Animal Protection Radar?, John Hadidian

Animal Welfare Collection

American attitudes toward wildlife have often been cast as falling within an urban/rural dichotomy that separates protectionist from utilitarian value orientations. Long held as a major challenge to wildlife managers the urban/rural dichotomy may be yielding to change as new attitude and value orientations arise from direct conflicts people have with wild animals as well as from a generational disenfranchisement of young people who lack direct experience with the outdoors. Both may loom as larger challenges for the future and shift the focus of once opposing interests more toward efforts to establish cooperation. Currently, much of the disagreement over wildlife …

The “Babe” Vegetarians: Bioethics, Animal Minds And Moral Methodology, Nathan Nobis

Attitudes Towards Animals Collection

Here I discuss the role the film “Babe” has played in helping people address these challenges and make this moral progress. It is thought that a significant number of young people (mostly girls, now young women) became vegetarians due to their seeing “Babe.” These people are often called “Babe Vegetarians,” influence by what has been called “The Babe Effect.” Many of their stories are found on the internet.

Understanding Norms Without A Theory Of Mind, Kristin Andrews

Sentience Collection

I argue that having a theory of mind requires having at least implicit knowledge of the norms of the community, and that an implicit understanding of the normative is what drives the development of a theory of mind. This conclusion is defended by two arguments. First I argue that a theory of mind likely did not develop in order to predict behavior, because before individuals can use propositional attitudes to predict behavior, they have to be able to use them in explanations of behavior. Rather, I suggest that the need to explain behavior in terms of reasons is the primary …

Welfare Assessment: Correlations And Integration Between A Qualitative Behavioural Assessment And A Clinical/Health Protocol Applied In Veal Calves Farms, Marta Brscic, Françoise Wemelsfelder, Elena Tessitore, Flaviana Gottardo, Giulio Cozzi, Cornelis G. Van Reenen

Agribusiness Collection

This study is aimed at finding correlations and possible integration among Qualitative Behavioural assessment (QBA) and a specific protocol of clinical/health evaluation. Both welfare assessment methods were based on direct animal observation and were applied in 24 Italian veal calves farms at 3 weeks (wks) of rearing. Principal component analysis (PCA) summarized 20 QBA descriptors on two main components (PC1 and PC2) with eigenvalues above 4 and explaining 29.6 and 20.3% of the variation respectively. PCA on residuals obtained after correcting for housing condition yielded highly similar results, indicating that the rearing environment of the calves was not an important …

Resources, Not Kinship, Determine Social Patterning In The Territorial Gunnison’S Prairie Dog (Cynomys Gunnisoni), J. L. Verdolin, C. N. Slobodchikoff

Sentience Collection

In this study, we describe patterns of relatedness in Gunnison’s prairie dog (Cynomys gunnisoni) social groups. Kin selection is often cited as a mechanism for the evolution and maintenance of social groups, and Gunnison’s prairie dog females are occasionally described as being strongly philopatric. Overall, randomization tests revealed that females within territorial groups were not more closely related to each other than expected at random. A similar pattern was found among males and between males and females, indicating that there was no sex-biased dispersal occurring in these populations. Ecological variables measured in this study, such as food abundance and food …

Personal Reflections On Russell And Burch, Frame, And The Hsus, Martin Stephens

Animal Welfare Collection

The coincidence of anniversaries associated with the publication of William Russell and Rex Burch’s The Principles of Humane Experimental Technique, the founding of the Fund for the Replacement of Animals in Medical Experiments (FRAME), and the establishment of the collaboration between FRAME and the University of Nottingham, provides an opportunity to reflect on Russell and Burch’s legacy and how it was carried forward by FRAME. The Principles, published in 1959, was the pioneering work in what later became the alternatives or Three Rs field of replacement, reduction, and refinement of animal use. Such was the book’s initial and undeserved obscurity, …

Constructive And Deconstructive Tool Modification By Chimpanzees (Pan Troglodytes), Amanda E. Bania, Stephany Harris, Hannah R. Kinsley, Sarah T. Boysen

Sentience Collection

Nine chimpanzees (Pan troglodytes) were tested for their ability to assemble or disassemble the appropriate tool to obtain a food reward from two different apparatus. In its deconstructed form, the tool functioned as a probe for one apparatus. In its constructed form, the tool functioned as a hook, appropriate for a second apparatus. Each subject completed four test trials with each apparatus type. Tool types were randomized and counter-balanced between the two forms. Results demonstrated that adult and juvenile chimpanzees (N = 7) were successful with both tool types, while two infant chimpanzees performed near chance. Off-line video analyses revealed …

Landscape Heterogeneity And Marine Subsidy Generate Extensive Intrapopulation Niche Diversity In A Large Terrestrial Vertebrate, Chris T. Darimont, Paul C. Paquet, Thomas E. Reimchen

Population Distribution and Habitat Collection

1 Inquiries into niche variation within populations typically focus on proximate ecological causes such as competition. Here we examine how landscape heterogeneity and allochthonous (marine) subsidy might ultimately generate intrapopulation niche diversity.

2 Using stable isotope analysis, we detected extensive terrestrial–marine isotopic niche variation among subpopulations, social groups, and individual grey wolves (Canis lupus) that occupy a spatially heterogeneous landscape in coastal British Columbia comprising a mainland area and adjacent archipelago.

3 The inner island subpopulation exhibited the widest isotopic niche in the population, consuming extensive terrestrial and marine resources. Mainland and outer island subpopulations occupied comparatively narrow …

Animal Welfare: Review Of The Scientific Concept And Definition, Corrado Carenzi, Marina Verga

Assessment of Animal Welfare Collection

The aim of this paper is to present a review of the current scientific viewpoints about the concept and definition of animal welfare. The need of interaction among different disciplines is stressed, as well as the need to scientifically assess welfare, using validated indicators. The role of applied ethology in animal welfare science is stressed.

The paper provides a brief overview of the historical steps in the development of the concept and presents scientific viewpoints, briefly explaining their theoretical foundation.

The possibility of defining welfare on a scientific basis is explained, identifying the main problems according to the scientific, cultural …

Effect Of Restricted Access Time To Pasture On Dairy Cow Milk Production, Grazing Behavior, And Dry Matter Intake, E. Kennedy, M. Mcevoy, J. P. Murphy, M. O'Donovan

Housing and Confinement of Farm Animals Collection

The objective of this experiment was to investigate the effect of restricting pasture access time on milk production and composition, body weight and body condition score change, dry matter intake, and grazing behavior of autumn calving dairy cows in midlactation. Fifty-two (19 primiparous and 33 multiparous) Holstein-Friesian dairy cows (mean calving date, August 17 ± 91.2 d) were randomly assigned to a 4-treatment (n = 13) randomized block design grazing study. The 4 grazing treatments were: (i) full-time access to pasture (22H; control), (ii) 9-h access to pasture (9H), (iii) two 4.5-h periods of access to pasture after both milkings …

Reviewing Existing Knowledge Prior To Conducting Animal Studies, Andrew Knight

Experimentation Collection

Highly polarised viewpoints about animal experimentation have often prevented agreement. However, important common ground between advocates and opponents was demonstrated within a discussion forum hosted at www.research-methodology.org.uk in July–August 2008, by the independent charity, SABRE Research UK. Agreement existed that many animal studies have methodological flaws — such as inappropriate sample sizes, lack of randomised treatments, and unblinded outcome assessments — that may introduce bias and limit statistical validity. There was also agreement that systematic reviews of the human utility of animal models yield the highest quality of evidence, as their reliance on methodical and impartial methods to select significant …

Developmental Toxicity Testing: Protecting Future Generations?, Jarrod Bailey

Experimentation Collection

A recent editorial is discussed, which implied that animal-based developmental and reproductive toxicology tests will continue to be crucial, that the thalidomide disaster could have been prevented by more animal testing, and that tests on juvenile animals would help to protect children (as developing adults) from the adverse effects of pharmaceuticals. It is argued that animal tests in these scientific areas do not provide reliable data that are predictive for human responses and, even if they did, the tests are too expensive and time-consuming for application to the very large number of substances that need to be tested. It is …

Faecal-Centric Approaches To Wildlife Ecology And Conservation; Methods, Data And Ethics, C. T. Darimont, T. E. Reimchen, H. M. Bryan, P. C. Paquet

Ethics and Conservation Biology Collection

Abundant and commonly encountered in the field, wildlife faeces have long attracted scientists. Recent advances in molecular techniques, however, especially when coupled with creative study designs, can now yield a great variety of high quality data. Herein, we review the opportunities and challenges of faecal-centric approaches to address ecological and conservation questions using wolves of coastal British Columbia, Canada, as a case system. We begin by discussing methodological considerations, which should have broad applicability to any wildlife study system. We then summarize the extensive and unique variety of data that has emerged from our ‘facts from faeces’ approach with wolves, …

It's In Your Nature: A Pluralistic Folk Psychology, Kristin Andrews

Sentience Collection

I suggest a pluralistic account of folk psychology according to which not all predictions or explanations rely on the attribution of mental states, and not all intentional actions are explained by mental states. This view of folk psychology is supported by research in developmental and social psychology. It is well known that people use personality traits to predict behavior. I argue that trait attribution is not shorthand for mental state attributions, since traits are not identical to beliefs or desires, and an understanding of belief or desire is not necessary for using trait attributions. In addition, we sometimes predict and …

Behavioural Analysis Of A Nociceptive Event In Fish: Comparisons Between Three Species Demonstrate Specific Responses, Siobhan C. Reilly, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon

Sentience Collection

Nociception is the sensory mechanism by which potentially harmful stimuli are detected in animals and humans. The behavioural responses to noxious stimulation have been studied in two fish species thus far. However, since species-specific differences are seen in mammals, more species need to be examined to determine whether nociceptive responses are generic in fish. The present study investigated the behavioural and respiratory response to an acute noxious or potentially painful stimulus in common carp (Cyprinus carpio), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss). Behavioural parameters such as frequency of swimming, use of cover and any anomalous behaviour were measured …

On Measuring Progress In Animal Welfare, James A. Serpell

Assessment of Animal Welfare Collection

Improvements in the welfare of animals arise from two primary sources: Changes in public attitudes and beliefs regarding what constitutes acceptable treatment of animals, and mandatory changes in behavior toward animals imposed by governments and regulatory authorities. During the last 30-40 years, public and political support for improvements in animal welfare has increased dramatically in many countries. Funding from both governmental and non-governmental sources continues to grow, and the relatively new field of animal welfare science has emerged and expanded to support and inform these efforts. Many experts in the field recognize, however, that there is still a distinct gap …

When To Be A Dear Enemy: Flexible Acoustic Relationships Of Neighbouring Skylarks, Alauda Arvensis, Elodie Briefer, Fanny Rybak, Thierry Aubin

Ethology Collection

Numerous territorial species are less aggressive towards neighbours than strangers. This tolerance towards neighbouring conspecifics, termed the ‘dear enemy’ effect, seems to be a flexible feature of the relationship between neighbours, and has been shown to disappear in some species after experimental or natural modifications of the context. However, the maintenance over time of this singular relationship has been poorly studied. In this study, we followed the change of dear enemy relationships during the breeding season in a territorial songbird with a complex song, the skylark. We examined in the field the response of territory owners to playbacks of neighbour …

Visual Attention And Its Relation To Knowledge States In Chimpanzees, Pan Troglodytes, Megan J. Bulloch, Sarah T. Boysen, Ellen E. Furlong

Sentience Collection

Primates rely on visual attention to gather knowledge about their environment. The ability to recognize such knowledge-acquisition activity in another may demonstrate one aspect of Theory of Mind. Using a series of experiments in which chimpanzees were presented with a choice between an experimenter whose visual attention was available and another whose vision was occluded, we asked whether chimpanzees understood the relationship between visual attention and knowledge states. The animals showed sophisticated understanding of attention from the first presentation of each task. Under more complex experimental conditions, the subjects had more difficulty with species-typical processing of attentional cues and those …

An Assessment Of The Role Of Chimpanzees In Aids Vaccine Research, Jarrod Bailey

Laboratory Experiments Collection

Prior to Simian Immunodeficiency Virus (SIV)-infected macaques becoming the ‘model of choice’ in the 1990s, chimpanzees were widely used in AIDS vaccine research and testing. Faced with the continued failure to develop an effective human vaccine, some scientists are calling for a return to their widespread use. To assess the past and potential future contribution of chimpanzees to AIDS vaccine development, databases and published literature were systematically searched to compare the results of AIDS vaccine trials in chimpanzees with those of human clinical trials, and to determine whether the chimpanzee trials were predictive of the human response. Protective and/or therapeutic …

Spawning Salmon Disrupt Trophic Coupling Between Wolves And Ungulate Prey In Coastal British Columbia, Chris T. Darimont, Paul C. Paquet, Thomas E. Reimchen

Nonindigenous Pests and Biological Invasions Collection

Background: As a cross-boundary resource subsidy, spawning salmon can strongly affect consumer and ecosystem ecology. Here we examine whether this marine resource can influence a terrestrial wolf-deer (Canis lupus-Odocoileus hemionus) predator-prey system in coastal British Columbia, Canada. Data on resource availability and resource use among eight wolf groups for three seasons over four years allow us to evaluate competing hypotheses that describe salmon as either an alternate resource, consumed in areas where deer are scarce, or as a targeted resource, consumed as a positive function of its availability. Faecal (n = 2203 wolf scats) and isotopic analyses (n = 60 …