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Articles 91 - 120 of 1904
Full-Text Articles in Life Sciences
Analysis Of Differential Gene Expression In Androgen-Independent Clones Derived From The Mycap Pca Cell Line, Jessie L. Tignor, Melanie Sinanian, Richard Inho Joh, David Gewirtz, Jason Reed
Analysis Of Differential Gene Expression In Androgen-Independent Clones Derived From The Mycap Pca Cell Line, Jessie L. Tignor, Melanie Sinanian, Richard Inho Joh, David Gewirtz, Jason Reed
UROP Posters
Androgen deprivation therapy (ADT) is a primary treatment strategy for prostate cancer (PCa), yet many tumors eventually develop androgen independence, leading to treatment resistance. To investigate the molecular changes underlying this transition, we analyzed differential gene expression in four androgen-independent (AI) clones derived from the Myc-CaP prostate cancer cell line using RNA sequencing. Gene expression profiles were compared to the parental Myc-CaP line, and differentially expressed genes (DEGs) were identified using DESeq2 and edgeR. The AI clones exhibited significant downregulation of senescence-associated genes, including Ezh2 and lamin B1, suggesting a loss of senescence-related chromatin repression. Additionally, upregulation of Wnt pathway …
Acer Rubrum: Descending Towards Forest Dominance, Elyssa L. Pearson, Christopher M. Gough
Acer Rubrum: Descending Towards Forest Dominance, Elyssa L. Pearson, Christopher M. Gough
UROP Posters
Acer rubrum, more commonly known as the red maple, is a hardwood, late successional species of tree commonly planted for its deciduous nature and vibrant coloring of its leaves in the beginning of autumn (Abrams, 1998). The species is very tolerant of varying light and soil moisture levels and often dominates sub and mid-canopy levels of hardwood forests (Missouri Botanical Gardens). It was hypothesized that as the I moved from an upland location to a lowland location near a wetland that the A. rubrum trees would be more productive and have a greater above ground biomass. This was not …
Using Fungal Dna Barcoding To Identify Fungal Species In A James River Park System Soil Microbiome, Erwin Murray, D Jennings
Using Fungal Dna Barcoding To Identify Fungal Species In A James River Park System Soil Microbiome, Erwin Murray, D Jennings
UROP Posters
Fungi in the soil have the ability to form mutualistic relationships with plant roots and improve the way they resist a variety of plant diseases and abiotic stressors, influencing the survivability of the plants. The James River Park System (JRPS) is home to a variety of ecosystems that support diverse plant and fungal populations, including native plants and invasive plants. Therefore, it is important to identify what is present in the soil microbiome. The purpose of this project is to isolate fungal sequences from soil samples collected in the JRPS to identify what fungal species are present in the JRPS …
Accurate Body Weight Class Prediction From Mirna And Gene Expression In Blood And Saliva Samples, Kimberly Lettner
Accurate Body Weight Class Prediction From Mirna And Gene Expression In Blood And Saliva Samples, Kimberly Lettner
Master of Science in Forensic Science Directed Research Projects
miRNA interference on protein abundance related to glucose uptake and lipid production has been evaluated in biomedical research and linked to metabolic disorders like severe obesity. The direct regulation of protein abundance caused by miRNAs on a person’s metabolism can lead to an increased weight and overall size. Body size, measured by BMI, provides additional physical descriptions that can be combined with hair color, eye color, age, and skin pigment to aid investigations of unidentified remains or unknown suspects not found in a database. The purpose of this project was to evaluate the miRNA expression of target biomarkers in dried …
Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher
Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher
Master of Science in Forensic Science Directed Research Projects
Xylazine is a nonopioid veterinary sedative and an α2 adrenergic receptor agonist. It emerged in the opioid epidemic as an adulterant of illicit fentanyl. As xylazine becomes more involved in fatal overdoses, it is relevant to elucidate its biodistribution post-exposure due to its exacerbation of adverse events, namely respiratory depression, as xylazine’s contributions to existing adverse effects of synthetic opioids is understudied. A bioanalytical method to quantify xylazine and select metabolites in tissue using LC-QToF was validated and applied to a preclinical mouse model in order to characterize xylazine’s biodistribution in whole blood and six tissues at a dose known …
Time Scale Separation In Life-Long Ovarian Follicles Population Dynamics Model, Romain Yvinec, Frédérique Clément, Guillaume Ballif
Time Scale Separation In Life-Long Ovarian Follicles Population Dynamics Model, Romain Yvinec, Frédérique Clément, Guillaume Ballif
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Mathematical Modeling Study On Hdv Rna, Alt, And Hbsag Dynamics Reveals Dual Mechanisms Of Peginterferon-Lambda., Adquate Mhlanga, Ohad Etzion, Harel Dahari
A Mathematical Modeling Study On Hdv Rna, Alt, And Hbsag Dynamics Reveals Dual Mechanisms Of Peginterferon-Lambda., Adquate Mhlanga, Ohad Etzion, Harel Dahari
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Of Intracellular Compartmentalized Gpcr Signaling, Léo Darrigade
Modeling Of Intracellular Compartmentalized Gpcr Signaling, Léo Darrigade
Biology and Medicine Through Mathematics Conference
No abstract provided.
Multi-Type Branching Processes In Time-Varying Environments, Arash Jamshidpey
Multi-Type Branching Processes In Time-Varying Environments, Arash Jamshidpey
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Model Of Oocyte Population Dynamics For Fish Oogenesis, Louis Fostier, Frédérique Clément, Romain Yvinec, Violette Thermes
A Model Of Oocyte Population Dynamics For Fish Oogenesis, Louis Fostier, Frédérique Clément, Romain Yvinec, Violette Thermes
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Histological Data-Driven Analysis Of The Hypoxic Microenvironment Of Preclinical Murine Bladder Tumors, Awino Maureiq E. Ojwang'
A Histological Data-Driven Analysis Of The Hypoxic Microenvironment Of Preclinical Murine Bladder Tumors, Awino Maureiq E. Ojwang'
Biology and Medicine Through Mathematics Conference
No abstract provided.
Time-Dependent Antibody Kinetics For Infected And Vaccinated Individuals Via Graph-Theoretic Modeling, Rayanne Luke, Prajakta P. Bedekar, Anthony Kearsley
Time-Dependent Antibody Kinetics For Infected And Vaccinated Individuals Via Graph-Theoretic Modeling, Rayanne Luke, Prajakta P. Bedekar, Anthony Kearsley
Biology and Medicine Through Mathematics Conference
No abstract provided.
Astrocyte Spatial Distribution Affects Growth Dynamics Of Breast Cancer Brain Metastases: An Agent-Based Modeling Study, Rupleen Kaur
Astrocyte Spatial Distribution Affects Growth Dynamics Of Breast Cancer Brain Metastases: An Agent-Based Modeling Study, Rupleen Kaur
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling And Control Of Drug Resistance In Cancer Dynamics, James Greene
Modeling And Control Of Drug Resistance In Cancer Dynamics, James Greene
Biology and Medicine Through Mathematics Conference
No abstract provided.
Reaction-Diffusions System Simulated On Irregular Shapes And Surfaces Model Petal Spot Patterns In Monkeyflower Hybrids, Emily Simmons, Arielle M. Cooley, Joshua R. Puzey, Gregory D. Conradi Smith
Reaction-Diffusions System Simulated On Irregular Shapes And Surfaces Model Petal Spot Patterns In Monkeyflower Hybrids, Emily Simmons, Arielle M. Cooley, Joshua R. Puzey, Gregory D. Conradi Smith
Biology and Medicine Through Mathematics Conference
No abstract provided.
On The Effect Of Liquid Crystal Orientation In The Lipid Layer On Tear Film Thinning And Breakup, Mary Taranchuk
On The Effect Of Liquid Crystal Orientation In The Lipid Layer On Tear Film Thinning And Breakup, Mary Taranchuk
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Model Of Shell Structure And Pattern In Mollusks, Rahnuma Islam, Bard Ermentrout, Sabrina Streipert
A Model Of Shell Structure And Pattern In Mollusks, Rahnuma Islam, Bard Ermentrout, Sabrina Streipert
Biology and Medicine Through Mathematics Conference
No abstract provided.
Exploring The Evolution Of Altruistic Punishment Using A Pde Model For Multilevel Selection, Daniel Cooney
Exploring The Evolution Of Altruistic Punishment Using A Pde Model For Multilevel Selection, Daniel Cooney
Biology and Medicine Through Mathematics Conference
No abstract provided.
Using Splines To Investigate The Effects Of Temperature On The Within-Mosquito Malaria Parasite Forms, Alexander J. Diefes, Miranda I. Teboh-Ewungkem
Using Splines To Investigate The Effects Of Temperature On The Within-Mosquito Malaria Parasite Forms, Alexander J. Diefes, Miranda I. Teboh-Ewungkem
Biology and Medicine Through Mathematics Conference
No abstract provided.
Identifiability Analysis And Model Reduction For Soft Tissue Models, Mansoor A. Haider
Identifiability Analysis And Model Reduction For Soft Tissue Models, Mansoor A. Haider
Biology and Medicine Through Mathematics Conference
No abstract provided.
Tracking Food Quality In Algae-Daphnia Ecosystems Through Stage Structured Models And Colimitation, Tomas Ascoli
Tracking Food Quality In Algae-Daphnia Ecosystems Through Stage Structured Models And Colimitation, Tomas Ascoli
Biology and Medicine Through Mathematics Conference
No abstract provided.
Identifiability For Pde Models Of Fluorescence Microscopy Experiments, Veronica Ciocanel
Identifiability For Pde Models Of Fluorescence Microscopy Experiments, Veronica Ciocanel
Biology and Medicine Through Mathematics Conference
No abstract provided.
Analysis Of Poroelastic Systems Describing Biological Tissues, Ellie Gurvich
Analysis Of Poroelastic Systems Describing Biological Tissues, Ellie Gurvich
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Mechanisms Of Microtubule Dynamics And Polarity In Neurons, Anna Nelson, Veronica Ciocanel, Scott Mckinley, Hannah Scanlon
Modeling Mechanisms Of Microtubule Dynamics And Polarity In Neurons, Anna Nelson, Veronica Ciocanel, Scott Mckinley, Hannah Scanlon
Biology and Medicine Through Mathematics Conference
No abstract provided.
Multiscale Modeling Of Microtubule Polarity Mechanisms Following Neuronal Axotomy, Hannah Scanlon
Multiscale Modeling Of Microtubule Polarity Mechanisms Following Neuronal Axotomy, Hannah Scanlon
Biology and Medicine Through Mathematics Conference
No abstract provided.
Statistical Mobility Of Aggregated Microswimmers, Yonatan Ashenafi
Statistical Mobility Of Aggregated Microswimmers, Yonatan Ashenafi
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematical Modeling Suggests Pathways Of Systemic Dissemination Of Mycobacterium Tuberculosis In Mice, Vitaly V. Ganusov
Mathematical Modeling Suggests Pathways Of Systemic Dissemination Of Mycobacterium Tuberculosis In Mice, Vitaly V. Ganusov
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Human Temporal Eeg Responses To Vr Visual Stimuli, Richard R. Foster, Connor Delaney, Dean J. Krusienski, Cheng Ly
Modeling Human Temporal Eeg Responses To Vr Visual Stimuli, Richard R. Foster, Connor Delaney, Dean J. Krusienski, Cheng Ly
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Deeper Understanding Of Cell Movement: A Mathematical Perspective On Egg Chamber Architecture, Naghmeh Akhavan
A Deeper Understanding Of Cell Movement: A Mathematical Perspective On Egg Chamber Architecture, Naghmeh Akhavan
Biology and Medicine Through Mathematics Conference
No abstract provided.
The Neural Dynamics Of Autism Spectrum Disorder And Typically Developing Individuals: Insights From Eeg Modeling And Mathematical Analysis, Sungwoo Ahn, Evie A. Malaia, Leonid L. Rubchinsky
The Neural Dynamics Of Autism Spectrum Disorder And Typically Developing Individuals: Insights From Eeg Modeling And Mathematical Analysis, Sungwoo Ahn, Evie A. Malaia, Leonid L. Rubchinsky
Biology and Medicine Through Mathematics Conference
No abstract provided.