Life Sciences Commons^™

The Photochemical Evolution Of Polycyclic Aromatic Hydrocarbons And Nontronite Clay On Early Earth And Mars, Nina Kopacz, Maria Angela Corazzi, Giovanni Poggiali, Ayla Von Essen, Vincent Kofman, Teresa Fornaro, Hugo Van Ingen, Eloi Camprubi, Helen E. King, John Brucato, Inge Loes Ten Kate

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The photochemical evolution of polycyclic aromatic hydrocarbons (PAHs), an abundant form of meteoritic organic carbon, is of great interest to early Earth and Mars origin-of-life studies and current organic molecule detection efforts on Mars. Fe-rich clay environments were abundant on early Earth and Mars, and may have played a role in prebiotic chemistry, catalyzing the breakdown of PAHs and freeing up carbon for subsequent chemical complexification. Current Mars is abundant in clay-rich environments, which are most promising for harboring organic molecules and have comprised the main studied features by the Curiosity rover in search of them. In this work …

Co-Alteration Network Architecture Of Major Depressive Disorder: A Multi-Modal Neuroimaging Assessment Of Large-Scale Disease Effects, Jodie P. Gray, Jordi Manuello, Aaron F. Alexander-Bloch, Cassandra Leonardo, Crystal Franklin, Sueng Choi, Franco Cauda, Tommaso Costa, John Blangero, David C. Glahn, Peter T. Fox

School of Medicine Publications

Major depressive disorder (MDD) exhibits diverse symptomology and neuroimaging studies report widespread disruption of key brain areas. Numerous theories underpinning the network degeneration hypothesis (NDH) posit that neuropsychiatric diseases selectively target brain areas via meaningful network mechanisms rather than as indistinct disease effects. The present study tests the hypothesis that MDD is a network-based disorder, both structurally and functionally. Coordinate-based meta-analysis and Activation Likelihood Estimation (CBMA-ALE) were used to assess the convergence of findings from 92 previously published studies in depression. An extension of CBMA-ALE was then used to generate a node-and-edge network model representing the co-alteration of brain areas …

Air Pollution In South Texas: A Short Communication Of Health Risks And Implications, Sai Deepak Pinakana, Esmeralda Mendez, Ismaila Ibrahim, Md. Salahuddin Majumder, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Air pollution is a major public health concern. The region of South Texas in the United States has experienced high levels of air pollution in recent years due to an increase in population, cross-border trade between the U.S.A. and Mexico, and high vehicular activity. This review assesses the relationships between human health and air pollution in South Texas. A thorough scientific search was performed using PubMed, Science Direct, and ProQuest, with most of the literature focusing on the source apportionment of particulate matter that is 2.5 microns or less in width (PM2.5), Carbon Dioxide (CO2), carbon monoxide (CO), Black Carbon …

Morphological Characterization Of Intraspecific Variation For Trichome Traits In Tomato (Solanum Lycopersicum), Satinderpal Kaur, Neetu Khanal, Robert K. Dearth, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Trichomes, the hairlike protuberances in plants, have been well known to act as the first line of defense against herbivores, and abiotic stresses, along with other structural defenses such as spines, thorns, and waxes. We previously reported the tremendous variation in trichome traits among different wild and cultivated Solanum species and demonstrated that trichomes types and density are traditionally miscalculated and often misnamed. However, intraspecific variation in trichome traits is poorly understood, although this has implications for stress tolerance and resistance breeding programs in economically important crop species and can also mediate ecological interactions at multiple trophic levels in their …

Assessment Of Air Pollution Levels During Sugarcane Stubble Burning Event In La Feria, South Texas, Usa, Sai Deepak Pinakana, Edward Robles, Esmeralda Mendez, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agricultural stubble burning is the third largest source of air pollution after vehicular and industrial emissions. Fine particulate matter (PM2.5), volatile organic compounds (VOCs), carbon monoxide (CO), nitrogen dioxide (NO2), and black carbon (BC) are some of the pollutants emitted during such burning events. The Lower Rio Grande Valley (RGV) region of South Texas is a major hub of agricultural activity, and sugarcane farming is one of them. Unfortunately, this activity results in episodic events of high air pollution in this low-resourced, Hispanic/Latino majority region of the U.S.–Mexico border. This study presents results from a sugarcane site in La Feria, …

Health And Safety Effects Of Airborne Soil Dust In The Americas And Beyond, Daniel Q. Tong, Thomas E. Gill, William A. Sprigg, Robert Scott Van Pelt, Alexander Baklanov, Bridget Marie Barker, Jesse E. Bell, Juan Castillo, Santiago Gassó, Cassandra Gaston, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Risks associated with dust hazards are often underappreciated, a gap between the knowledge pool and public awareness that can be costly for impacted communities. This study reviews the emission sources and chemical, physical, and biological characteristics of airborne soil particles (dust) and their effects on human and environmental health and safety in the Pan-American region. American dust originates from both local sources (western United States, northern Mexico, Peru, Bolivia, Chile, and Argentina) and long-range transport from Africa and Asia. Dust properties, as well as the trends and interactions with criteria air pollutants, are summarized. Human exposure to dust is associated …

Isomerization Of Galactose To Tagatose: Recent Advances In Non-Enzymatic Isomerization, Jikai Zhao, Zhuo Wang, Qing Jin, Danyi Feng, Juhee Lee

School of Earth, Environmental, & Marine Sciences Faculty Publications

The valorization of galactose derived from acid whey to low-calorie tagatose has gained increasing attention. Enzymatic isomerization is of great interest but faces several challenges, such as poor thermal stability of enzymes and a long processing time. In this work, non-enzymatic (supercritical fluids, triethylamine, arginine, boronate affinity, hydrotalcite, Sn-β zeolite, and calcium hydroxide) pathways for galactose to tagatose isomerization were critically discussed. Unfortunately, most of these chemicals showed poor tagatose yields (70%). The latter is able to form a tagatose–calcium hydroxide–water complex, which stimulates the equilibrium toward tagatose and prevents sugar degradation. Nevertheless, the excessive use of calcium hydroxide may …

Predicting The Impact Of Climate Change On The Distribution Of Rhipicephalus Sanguineus In The Americas, Marcos Sánchez Pérez, Teresa Patricia Feria-Arroyo, Crystian Sadiel Venegas Barrera, Carolina Sosa-Gutiérrez, Javier Torres, Katherine A. Brown, Guadalupe Gordillo Pérez

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Climate change may influence the incidence of infectious diseases including those transmitted by ticks. Rhipicephalus sanguineus complex has a worldwide distribution and transmits Rickettsial infections that could cause high mortality rates if untreated. We assessed the potential effects of climate change on the distribution of R. sanguineus in the Americas in 2050 and 2070 using the general circulation model CanESM5 and two shared socioeconomic pathways (SSPs), SSP2-4.5 (moderate emissions) and SSP2-8.5 (high emissions). A total of 355 occurrence points of R. sanguineus and eight uncorrelated bioclimatic variables were entered into a maximum entropy algorithm (MaxEnt) to produce 50 replicates per …

The Strength Of Migratory Connectivity In Painted Buntings Is Spatial Scale Dependent And Shaped By Molting Behavior, Andrew J. Sharp, Andrea Contina, Viviana Ruiz-Gutiérrez,, T. Scott Sillett, Eli S. Bridge, Elizabeth M. Besozzi, John A. Muller, Jeffrey Kelly, Aaron M. Given, Clark S. Rushing

School of Integrative Biological & Chemical Sciences Faculty Publications

As migratory species move through the stages of their annual cycle, individuals often display variation in the degree to which they remain in proximity to one another, a phenomenon called migratory connectivity. We show scale dependence in the strength of migratory connectivity in Painted Buntings (Passerina ciris), a North American passerine with disjunct eastern and interior breeding populations. Based on light-level geolocator data from 112 individuals at 11 breeding sites, migratory connectivity between breeding and wintering grounds was strong at the range-wide scale, with interior and eastern Painted Buntings remaining separated throughout the annual cycle. Conversely, migratory connectivity …

Are Avocados Toast? A Framework To Analyze Decision-Making For Emerging Epidemics, Applied To Laurel Wilt, Berea A. Etherton, Robin A. Choudhury, R. I. Alcalá-Briseño, Y. Xing, A. I. Plex Sulá, D. Carrillo, J. Wasielewski, L. L. Stelinski, K. A. Grogan, F. Ballen

School of Earth, Environmental, & Marine Sciences Faculty Publications

CONTEXT

When emerging pathogens threaten global food security, collective actionfor disease management is key for protecting food systems. We evaluate how the informal exchange of information about epidemic and economic outcomes can influence the management decisions of individuals and the resulting epidemics, in the context of the avocado laurel wilt epidemic in south Florida.

OBJECTIVES

In scenario analyses, we addressed how socioeconomic networks, laurel wilt epidemic networks, policy incentive structures, and social behaviors combine to influence (a) information exchange across this region, (b) growers' decisions about disease management, and (c) epidemic spread and yield loss. We identified the scenarios …

Hemodynamics And Arterial Stiffness In Response To Oral Glucose Loading In Individuals With Type Ii Diabetes And Controlled Hypertension, Yu Lun Tai, Smaran Marupudi, Gabriel A. Figueroa, Ryan D. Russell

Health & Human Performance Faculty Publications

Introduction: Type 2 diabetes (T2D), the fastest growing pandemic, is typically accompanied by vascular complications. A central hallmark of both T2D and vascular disease is insulin resistance which causes impaired glucose transport and vasoconstriction concomitantly. Those with cardiometabolic disease display greater variation in central hemodynamics and arterial elasticity, both potent predictors of cardiovascular morbidity and mortality, which may be exacerbated by concomitant hyperglycemia and hyperinsulinemia during glucose testing. Thus, elucidating central and arterial responses to glucose testing in those with T2D may identify acute vascular pathophysiologies triggered by oral glucose loading.

Aim: This study compared hemodynamics and arterial stiffness to …

Increased Floodplain Inundation In The Amazon Since 1980, Ayan Fleischmann, Fabrice Papa, Stephen K. Hamilton, Alice Fassoni-Andrade, Sly Wongchuig, Jhan Carlo Espinoza, Rodrigo Paiva, John Melack, Etienne Fluet-Chouinard, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Extensive floodplains throughout the Amazon basin support important ecosystem services and influence global water and carbon cycles. A recent change in the hydroclimatic regime of the region, with increased rainfall in the northern portions of the basin, has produced record-breaking high water levels on the Amazon River mainstem. Yet, the implications for the magnitude and duration of floodplain inundation across the basin remain unknown. Here we leverage state-of-the-art hydrological models, supported by in situ and remote sensing observations, to show that the maximum annual inundation extent along the central Amazon increased by 26% since 1980. We further reveal increased flood …

On The Architecture Of Collaboration In Inter-Organizational Natural Resource Management Networks, Gordon M. Hickey, Evelyn Roozee, Remko Voogd, Jasper R. De Vries, Antonia Sohns, Dongkyu Kim, Owen Temby

School of Earth, Environmental, & Marine Sciences Faculty Publications

This paper reviews the architecture of collaboration that exists within inter-organizational natural resource management (NRM) networks. It presents an integrative conceptual framework designed to help operationalize the multi-level interactions that occur between different dimensions of trust, risk perception, and control as key concepts in inter-organizational collaboration. The objective is to identify and justify a series of propositions considered suitable for assessing inter-organizational NRM network collaboration through empirical work. Such an integrative conceptualization goes beyond the existing trust scholarship related to collaborative NRM, and, we argue, offers a useful starting point for further exploring some of the ‘inner’ social dynamics affecting …

Greenbug Feeding-Induced Resistance To Sugarcane Aphids In Sorghum, Heena Puri, Edith Ikuze, Jessica Ayala, Isabella Rodriguez, Rupesh R. Kariyat, Joe Louis, Sajjan Grover

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Plants are attacked by multiple insect pest species and insect herbivory can alter plant defense mechanisms. The plant defense responses to a specific herbivore may also contribute to the herbivore growth/survival on plants. Feeding by one insect species can modulate the plant defenses, which can either facilitate or hamper the colonization of subsequent incoming insects. However, little is known about the effect of sequential herbivory on sorghum plants. In this study, we demonstrate that a specialist aphid, sugarcane aphid (SCA; Melanaphis sacchari) grows faster on sorghum than a generalist aphid species, greenbug (GB; Schizaphis graminum). We also determined …

Metal Contents In House Geckos (Squamata: Gekkonidae) From Industrial And Urban Areas Of Southern Tamaulipas, Mexico And Western Andalucía, Spain, May Reflect Airborne Metal Pollution, Luisiana Morales-Zamudio, Alejandro Fierro-Cabo, Md. Saydur Rahman, Miguel Antonio Dominguez-Crespo

School of Earth, Environmental, & Marine Sciences Faculty Publications

House geckos share living quarters with humans in the tropical and subtropical regions inhabited by these reptiles. Gecko behavior, biological traits, continuous exposure to suspended particulate matter 0 µm in diameter (PM10) and dust, as well as status as exotic species, motivated the choice of these species to examine environmental exposure to ambient air pollutants, in particular metals, and subsequent accumulation in these organisms. One part of the study was conducted in Tamaulipas (Mexico) where Hemydactylus frenatus is abundant in urban and industrial environments, the other part was conducted in Andalucia (Spain) where Tarentola mauritanica is found in similar environments. …

Impacts Of Tectonic Subsidence On Basin Depth And Delta Lobe Building, Tian Y. Dong, Jeffrey A. Nittrouer, Brandee Carlson, Brandon Mcelroy, Elena Il’Icheva, Maksim Pavlov, Hongbo Ma

School of Earth, Environmental, & Marine Sciences Faculty Publications

Channel avulsions on river deltas are the primary means to distribute sediment and build land at the coastline. Many studies have detailed how avulsions generate delta lobes, whereby multiple lobes amalgamate to form a fan-shaped deposit. These studies often assume steady subsidence and uniform basin depth. In nature, however, lobe building is disrupted by variable subsidence, and progradation of lobes into basins with variable depth: conditions that are prevalent for tectonically active areas. Herein, we explore sediment dispersal and deposition patterns across scales using measurements of delta and basin morphology compiled from field surveys and remote sensing, collected over 150 …

Winter Connectivity And Leapfrog Migration In A Migratory Passerine, Rafael Rueda‐Hernández, Christen M. Bossu, Thomas B. Smith, Andrea Contina, Ricardo Canales Del Castillo, Kristen Ruegg, Blanca E. Hernández-Baños

School of Integrative Biological & Chemical Sciences Faculty Publications

Technological advances in migratory tracking tools have revealed a remarkable diversity in migratory patterns. One such pattern is leapfrog migration, where individuals that breed further north migrate to locations further south. Here, we analyzed migration patterns in the Painted Bunting (Passerina ciris) using a genetic‐based approach. We started by mapping patterns of genetic variation across geographic space (called a genoscape) using 386 individuals from 25 populations across the breeding range. We then genotyped an additional 230 samples from 31 migration stopover locations and 178 samples from 16 wintering locations to map patterns of migratory connectivity. Our analyses of …

Effective Farm Management Promotes Native Amf And Benefit Organic Farming Systems, Pushpa Soti, Rupesh R. Kariyat, Alexis Racelis

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Highlights

• Agricultural practices have significant influence on the AMF community dynamics.

• Soil nutrients regulate AMF spore abundance and diversity.

• Using grass cover crops can promote native AMF in farms.

Abstract

Using soil inoculants containing naturally occurring beneficial microorganisms has become a popular practice in sustainable agriculture. However, an understanding of the environmental variables that affect plant-microbe interactions and the benefit of using commercial inoculum is relatively sparse. To address this, we examined the efficiency of three different methods to inoculate AMF (Arbuscular Mycorrhizal Fungi) in organic vegetable farms in south Texas: cover cropping, application of farm-produced (indigenous) AMF inoculum, …

Evidence Of An Established Population Of Cherax Quadricarinatus (Von Martens, 1868) In South Texas, Usa, Adam Sanjar, Drew R. Davis, Richard J. Kline

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Cherax quadricarinatus (von Martens, 1868) is a large parastacid crayfish (Decapoda: Parastacidae) native to Australia and Papua New Guinea. Due to various factors, C. quadricarinatus is an emerging invasive species in an increasing number of regions across the world. Deleterious ecological effects of C. quadricarinatus introduction have been documented in many of these regions, and its spread has been monitored and restricted where possible. Previously, only a small, isolated population of C. quadricarinatus in southern California had been reported within the continental United States. Here, we report the collection of three adult C. quadricarinatus from Brownsville, Cameron County, Texas, the …

The Known And Unknowns Of Aphid Biotypes, And Their Role In Mediating Host Plant Defenses, Neetu Khanal, Christopher Vitek, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Insect species are subjected to disparate selection pressure due to various biotic and abiotic stresses. Management practices including the heavy use of chemical insecticides and introduction of insect-resistant plant cultivars have been found to accelerate these processes. Clearly, natural selection coupled with human intervention have led to insect adaptations that alter phenotypes and genetic structure over time, producing distinct individuals with specialized traits, within the populations, commonly defined as biotypes. Biotypes are commonly found to have better fitness in the new environment and, in the case of aphids, the most commonly studied system for biotypes, have the ability to successfully …

Diel Activity Patterns Of Vector Mosquito Species In The Urban Environment: Implications For Vector Control Strategies, André Barretto B. Wilke, Adequate Mhlanga, Allisandra G. Kummer, Chalmers Vasquez, Maday Moreno, William D. Petrie, Art Rodriguez, Christopher Vitek, Gabriel L. Hamer, John-Paul Mutebi, Marco Ajelli

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Mathematical models have been widely used to study the population dynamics of mosquitoes as well as to test and validate the effectiveness of arbovirus outbreak responses and mosquito control strategies. The objective of this study is to assess the diel activity of mosquitoes in Miami-Dade, Florida, and Brownsville, Texas, the most affected areas during the Zika outbreak in 2016–2017, and to evaluate the effectiveness of simulated adulticide treatments on local mosquito populations. To assess variations in the diel activity patterns, mosquitoes were collected hourly for 96 hours once a month from May through November 2019 in Miami-Dade County, Florida, and …

Revisiting Plant Defense-Fitness Trade-Off Hypotheses Using Solanum As A Model Genus, Sakshi Watts, Satinderpal Kaur, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Plants possess physical and chemical defenses which have been found to deter herbivores that feed and oviposit on them. Despite having wide variety of defenses which can be constitutive or induced, plants are attacked and damaged by insects associated with different mouthparts and feeding habits. Since these defenses are costly, trade-offs for growth and defense traits play an important role in warding off the herbivores, with consequences for plant and herbivore growth, development and fitness. Solanum is a diverse and rich genus comprising of over 1,500 species with economic and ecological importance. Although a large number of studies on Solanum …

Genetic And Ecological Drivers Of Molt In A Migratory Bird, Andrea Contina, Christen M. Bossu, Daniel Allen, Michael B. Wunder, Kristen Ruegg

School of Integrative Biological & Chemical Sciences Faculty Publications

The ability of animals to sync the timing and location of molting (the replacement of hair, skin, exoskeletons or feathers) with peaks in resource availability has important implications for their ecology and evolution. In migratory birds, the timing and location of pre-migratory feather molting, a period when feathers are shed and replaced with newer, more aerodynamic feathers, can vary within and between species. While hypotheses to explain the evolution of intraspecific variation in the timing and location of molt have been proposed, little is known about the genetic basis of this trait or the specific environmental drivers that may result …

Inter-Seasonal Comparison Of Acoustic Propagation In A Thalassia Testudinum Seagrass Meadow In A Shallow Sub-Tropical Lagoon, Kevin M. Lee, Megan S. Ballard, Andrew R. Mcneese, Preston S. Wilson, Gabriel R. Venegas, Mathew C. Zeh, Abdullah Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acoustic propagation measurements were collected in a seagrass meadow in a shallow lagoon for periods of over 65 h in winter and 93 h in summer. A bottom-deployed sound source transmitted chirps (0.1–100 kHz) every 10 min that were received on a four-receiver horizontal hydrophone array. Oceanographic probes measured various environmental parameters. Daytime broadband acoustic attenuation was 2.4 dB greater in summer than winter, and the median received acoustic energy levels were 8.4 dB lower in summer compared to winter. These differences were attributed in part to seasonal changes in photosynthesis bubble production and above-ground seagrass biomass.

Inter-Seasonal Comparison Of Acoustic Propagation In A Thalassia Testudinum Seagrass Meadow In A Shallow Sub-Tropical Lagoon, Kevin M. Lee, Megan S. Ballard, Andrew R. Mcneese, Preston S. Wilson, Gabriel R. Venegas, Mathew C. Zeh, Abdullah Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acoustic propagation measurements were collected in a seagrass meadow in a shallow lagoon for periods of over 65 h in winter and 93 h in summer. A bottom-deployed sound source transmitted chirps (0.1–100 kHz) every 10 min that were received on a four-receiver horizontal hydrophone array. Oceanographic probes measured various environmental parameters. Daytime broadband acoustic attenuation was 2.4 dB greater in summer than winter, and the median received acoustic energy levels were 8.4 dB lower in summer compared to winter. These differences were attributed in part to seasonal changes in photosynthesis bubble production and above-ground seagrass biomass.

Balancing Renewable Energy And River Resources By Moving From Individual Assessments Of Hydropower Projects To Energy System Planning, Jeffrey J. Opperman, Juan Pablo Carvallo, Rafael Kelman, Rafael J. P. Schmitt, Rafael M. Almeida, Emily Chapin, Alexander Flecker, Marc Goichot, Guenther Guenther Grill, Julien J. Harou

School of Earth, Environmental, & Marine Sciences Faculty Publications

As governments and non-state actors strive to minimize global warming, a primary strategy is the decarbonization of power systems which will require a massive increase in renewable electricity generation. Leading energy agencies forecast a doubling of global hydropower capacity as part of that necessary expansion of renewables. While hydropower provides generally low-carbon generation and can integrate variable renewables, such as wind and solar, into electrical grids, hydropower dams are one of the primary reasons that only one-third of the world’s major rivers remain free-flowing. This loss of free-flowing rivers has contributed to dramatic declines of migratory fish and sediment delivery …

Nilgai, Boselaphus Tragocamelus And White-Tailed Deer, Odocoileus Virginianus Use Of Water Troughs With And Without Remotely Operated Field Sprayers For Potential Treatment Of Cattle Fever Ticks, John A. Goolsby, Mauricio Cruz, Reyes Garcia Iii, Lauren P. Maestas, Teresa Patricia Feria-Arroyo

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Nilgai antelope, Boselaphus tragocamelus and white-tailed deer (WTD), Odocoileus virginianus are hosts of cattle fever ticks, Rhipicephalus (=Boophilus) microplus, in the Lower Rio Grande Valley of South Texas. Daily use of water troughs and ponds were observed to determine if these locations could be used for field treatment methods for cattle fever ticks using remotely operated field sprayers. Game cameras (n=16) were deployed between June 2020 and September 2022 at two private ranches in Cameron County, TX. Both nilgai and WTD visited water troughs equipped with motion detecting sprayers in similar numbers to ponds, but numbers of animal visits were …

Are Epicuticular Waxes A Surface Defense Comparable To Trichomes? A Test Using Two Solanum Species And A Specialist Herbivore., Sakshi Watts, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Although plants possess a suite of structural defenses, most studies have focused on trichomes. Trichomes can have both pre- and post-ingestive effects and have been consistently found to reduce herbivory. Along with trichomes, a few studies have focused on epicuticular waxes as an important defense; however, manipulated comparisons examining herbivore growth and development is limited. In this study, using two Solanum species (Solanum glaucescens and Solanum macrocarpon) that vary in both defenses, we tested the hypothesis that variation in defenses will affect herbivore feeding, primarily by restricting feeding commencement. We used electron microscopy together with a series of plant- and …

The Foxo1 Inhibitor As1842856 Triggers Apoptosis In Glioblastoma Multiforme And Basal-Like Breast Cancer Cells, David Flores, Alma Lopez, Shreya Udawant, Bonnie Gunn, Megan Keniry

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Basal-like breast cancer (BBC) and glioblastoma multiforme (GBM) are poor-prognosis cancers that lack effective targeted therapies and harbor embryonic stem gene expression signatures. Recently, our group and others found that forkhead box transcription factor FOXO1 promotes stem gene expression in BBC and GBM cell lines. Given the critical role of cancer stem cells in promoting cancer progression, we examined the impact of FOXO1 inhibition with AS1842856 (a cell-permeable small molecule that directly binds to unphosphorylated FOXO1 protein to block transcriptional regulation) on BBC and GBM cell viability. We treated a set of BBC and GBM cancer cell lines with increasing …

The Justice Challenge: Honors Endeavors Innovative Pedagogies Through The Grand Challenge Scholars Program, Jonathan Kotinek, Rebecca C. Bott-Knutson, Leigh E. Fine, Joy L. Hart, William Ziegler, Paul Knox, Timothy Nichols, Susan Sumner, Heidi Appel, Mark C. Andersen

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Honors practitioners from fourteen colleges and programs across the country at land-grant, public, and minority-serving institutions partner with agricultural experts to secure a United States Department of Agriculture (USDA) Higher Education Challenge grant focused on the themes of food justice, climate justice, and sustainable agriculture. Authors describe the program’s origin, objectives, and curricular outgrowths, highlighting its efficacy for empowering students in areas of systems thinking, career readiness, leadership in the service of addressing social needs, and learning through civic engagement.