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Articles 1321 - 1350 of 1744

Full-Text Articles in Life Sciences

Factors Contributing To Interannual Variability In The Abundance Of Bay Anchovy (Anchoa Mitchilli) Larvae, Steven B. Vega Jr. Jan 2015

Factors Contributing To Interannual Variability In The Abundance Of Bay Anchovy (Anchoa Mitchilli) Larvae, Steven B. Vega Jr.

Theses and Dissertations

Coastal ecosystems have been subject to increasing stressors over recent decades due to coastal development, human population growth, and climate change. Improving scientific understanding of the environmental factors which influence the productivity of fish populations in coastal ecosystems is vital to their prudent management, especially as the potential influence of anthropogenic climate change grows. Estuaries serve as critical habitats for many fishes of primary ecological, economic, and recreational importance. One such fish, the planktivorous Bay Anchovy (Anchoa mitchilli), is abundant along the Atlantic and Gulf coasts of the US and is a key prey resource for many estuarine and coastal …

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The Effect Of 3d Collagen Scaffolds On Regulating Cellular Responses, Chad Simmons Jan 2015

The Effect Of 3d Collagen Scaffolds On Regulating Cellular Responses, Chad Simmons

Theses and Dissertations

Epithelial cells, as well as other differentiated cell types, remodel surrounding collagen in vitro, to self organize into 3D structures. When placed on-top or inside of a collagen hydrogel, cells organize into a toroid or spheroid form. It is not clearly understood how these cell types modulate surrounding collagen to form 3D shapes. The goal of this project was to determine if cell type, collagen type, or cell placement are factors that can alter how cells reorganize and remodel collagen hydrogels. We hypothesize that the positioning, cell type and the type of collagen they are in contact with affect the …

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Tipping The Balance Of Double-Strand Break Repair In Cells Modeling Hutchinson-Gilford Progeria Syndrome, Andrew Robert Patrick Jan 2015

Tipping The Balance Of Double-Strand Break Repair In Cells Modeling Hutchinson-Gilford Progeria Syndrome, Andrew Robert Patrick

Theses and Dissertations

Hutchinson-Gilford Progeria Syndrome is disease of highly accelerated aging. In addition to appearing physically old mere months after birth, patients suffer from maladies typical of the elderly, including heart attack and stroke, two factors which contribute to an average life expectancy of 14 years. The source of progeria has been identified as progerin, a defective variant of nuclear lamina protein lamin A. Progerin has also been found natively in healthy cells (concentration increasing with age), and is known to adversely affect nuclear morphology and chromosomal integrity. This thesis sought to investigate the effect of progerin upon which pathways were favored …

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Cardiorespiratory Fitness, Body Fatness Effect On Submaximal Systolic Blood Pressure And Cardiovascular Prognosis Among Young Adults, Vivek Kumar Prasad Jan 2015

Cardiorespiratory Fitness, Body Fatness Effect On Submaximal Systolic Blood Pressure And Cardiovascular Prognosis Among Young Adults, Vivek Kumar Prasad

Theses and Dissertations

Cardiovascular (CV) diseases (CVDs) are known to be the leading cause of death globally, as CVDs account for the highest rate of mortality compared to any other causes. The mortality from CVDs, is projected to increase to nearly 23.3 million by 2030. Mortality number due to CVD in the United States is 600,000 per year, thus representing nearly 1 in every 4 deaths. Exercise blood pressure (BP) is an important marker of CV events that are associated with incident CV morbidity and mortality among individuals with or without any CVD at present. Elevated exercise BP among individuals with normal resting …

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Characterization Of The Sufc Atpase During Fe-S Cluster Assembly By The Suf Pathway In Escherichia Coli, Khaleh Mykel Thomas Jan 2015

Characterization Of The Sufc Atpase During Fe-S Cluster Assembly By The Suf Pathway In Escherichia Coli, Khaleh Mykel Thomas

Theses and Dissertations

The gram-negative bacterium E. coli encodes the Suf pathway to assemble iron-sulfur (Fe-S) clusters under iron starvation and oxidative stress conditions. The ATPase activity of SufC is critical for in vivo Fe-S cluster assembly by the Suf pathway. SufC shares homology with the nucleotide binding domain (NBD) of ATP-binding cassette (ABC) transporters and belongs to the AAA+ (ATPases Associated with diverse cellular Activities) ATPase superfamily, a family of proteins that utilizes energy from ATP hydrolysis to perform a variety of cellular functions. SufC forms a stable SufBC2D complex with partner proteins SufB and SufD. The SufBC2D complex serves as a …

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Evaluating Muscle Fiber Architecture, Morgan Ashley Flahive Jan 2015

Evaluating Muscle Fiber Architecture, Morgan Ashley Flahive

Theses and Dissertations

Mastication is the first step in the preparation of food for digestion. The masticatory anatomy of several families of Carnivorans (i.e., Family Canidae, Family Mustelidae, Family Hyaenidae, and Family Ursidae of the order Carnivora) will be compared in this study. The goal is to better understand masticatory adaptations through an examination of bite force and muscle fiber architecture in the various groups of carnivores, and to provide a proper protocol in acid dissection of fiber architecture.

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Changing Cigarette Consumption Patterns And Their Relationship To Tobacco Control Policies In A Population Of Low-Intensity Smokers, Santosha Kamala Swayampakala Jan 2015

Changing Cigarette Consumption Patterns And Their Relationship To Tobacco Control Policies In A Population Of Low-Intensity Smokers, Santosha Kamala Swayampakala

Theses and Dissertations

Tobacco use is the single most preventable cause of premature death and disability in the world. Every year six million people will die from tobacco-related diseases. To curb the growing tobacco epidemic, World Health Organization (WHO) adopted its first-ever global public health treaty, Framework Convention on Tobacco Control (FCTC) that obligates ratifying countries to implement a range of tobacco control policies. Most of the evidence for the effectiveness of the WHO’s FCTC recommended tobacco control policies comes from high-income countries (HICs). This evidence suggests that as smoking prevalence declines in response to tobacco control policies and programs, the proportion of …

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Extensive Genome Rearrangements Of Caulobacter K31 And Genomic Diversity Of Type B3 Bacteriophages Of Caulobacter Crescentus, Kurt Taylor Ash Jan 2015

Extensive Genome Rearrangements Of Caulobacter K31 And Genomic Diversity Of Type B3 Bacteriophages Of Caulobacter Crescentus, Kurt Taylor Ash

Theses and Dissertations

The genus Caulobacter is found in a variety of habitats and is known for its ability to thrive in low-nutrient conditions. K31 is a novel Caulobacter isolate that has the ability to tolerate copper and chlorophenols, and can grow at 48°C with a doubling time of 40 h. K31 contains a 5.5 Mb chromosome that codes for more than 5500 proteins and two large plasmids (234 and 178 kb) that code for 438 additional proteins. A comparison of the K31 genome and the Caulobacter crescentus NA1000 genome, the representative strain and most well studied isolate of the Caulobacter genus, revealed …

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Adiponectin And Selenium Rich Diet Can Act As A Complimentary Medicine In The Treatment Of Intestinal And Chronic Inflammation Induced Colon Cancer, Arpit Saxena Jan 2015

Adiponectin And Selenium Rich Diet Can Act As A Complimentary Medicine In The Treatment Of Intestinal And Chronic Inflammation Induced Colon Cancer, Arpit Saxena

Theses and Dissertations

Colon cancer is the second largest cause of cancer death in United States. Chronic inflammation and obesity predispose patients to colon cancer. Adipose tissue is a source of bioactive substances called adipokines. Adiponectin (APN), an adipokine has anti-inflammatory property and found at lower levels in obese patients. Selenium (Se), a trace mineral and a dietary supplement, is inversely associated with cancer risk and possess anti-inflammatory and anti-carcinogenic properties. The overall purpose of this dissertation is to determine if chronic inflammation leading to colon and intestinal cancer are regulated by APN or Se rich diet or both. The working hypothesis is …

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Novel Drug 2-Benzoyl-3-Phenyl 6,7-Dichloroquinoxaline 1,4-Dioxide Induces Colon Cancer Cell Apoptosis Through Hif-1Α Pathway, Alexander-Jacques Theodore Sougiannis Jan 2015

Novel Drug 2-Benzoyl-3-Phenyl 6,7-Dichloroquinoxaline 1,4-Dioxide Induces Colon Cancer Cell Apoptosis Through Hif-1Α Pathway, Alexander-Jacques Theodore Sougiannis

Theses and Dissertations

Recent developments in the field of cancer genomics have shown transcription factor HIF-1α as a major player in the survival and proliferation of colorectal tumors. Hypoxia targeted drug engineering has led to significant advancements in cancer treatments as a method of directly utilizing the hypoxic regions against the tumor. Novel drug DCQ (2-benzoyl-3-phenyl 6,7-dichloroquinoxaline 1,4-dioxide) has shown promising anti-tumor results in-vitro and in-vivo. The purpose of this study was to utilize a tumor xenograft and genetic mouse model of colorectal cancer to investigate the safety, clinical effectiveness, and mechanism of action of DCQ. Methods: 10 week old Balb/c mice were …

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Species Responses To Climate Change And Environmental Heterogeneity: A Multi-Focal Approach, Megan Riley Jan 2015

Species Responses To Climate Change And Environmental Heterogeneity: A Multi-Focal Approach, Megan Riley

Theses and Dissertations

Changes in global climate trends have the potential to influence diverse ecosystems at multiple levels of organization, from the species to the community. Changes in other environmental variables, such as those resulting from pollution and habitat modification, also have the potential to impact species fitness and alter species interactions. This dissertation employs a multi-focal approach to investigate species responses to two main topics: climate change and environmental heterogeneity. To investigate the first topic, this work focuses on the climate change-induced range expansion of the mangrove tree crab Aratus pisonii into novel salt marsh habitats. It investigates latitudinal patterns of life …

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The Recovery Of Gut Barrier Function With Selenium Rich Diet In Acute Dss-Induced Colitis, Sarah Depaepe Jan 2015

The Recovery Of Gut Barrier Function With Selenium Rich Diet In Acute Dss-Induced Colitis, Sarah Depaepe

Theses and Dissertations

Background: Acute Dextran Sodium Sulfate (DSS)-induced colitis is an inflammatory ailment limited to the colon. It works to destroy the morphology and gut barrier goblet and epithelial cells that aid in providing homeostasis. Selenium (Se) is an essential micronutrient that has anti-inflammatory and antioxidant properties and is known to play a role in reducing inflammation in areas elsewhere in the body. The current study is focused on how Se alters gut barrier permeability and functionality related to the recovery of tight junction regulation and mucin secretion. Methods: C57BL/6 mice were randomly placed into control (normal water) and 2% DSS water …

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Fate And Behavior Of Silver Nanoparticles To The Estuarine Organisms, Prorocentrum Minimum And Crassostrea Virginica, Shelby Victoria Butz Jan 2015

Fate And Behavior Of Silver Nanoparticles To The Estuarine Organisms, Prorocentrum Minimum And Crassostrea Virginica, Shelby Victoria Butz

Theses and Dissertations

Nanoparticles are known to be entering the environment and are shown to have adverse effects on aquatic organisms (Fabrega et.al. 2011, Lapresta-Fernandez et.al. 2012, Matranga and Corsi 2012, Moore 2006). The purpose of this study was to quantify the uptake of AgNPs by two estuarine organisms and determine the associated toxic effects of accumulation. There are multiple procedures for nanoparticle (NP) synthesis that involve various core and surface materials, which result in various characteristics such as size, shape, and surface coating. In this study silver nanoparticles (AgNPs) were synthesized by a chemical reduction of silver salts and characterized in stock …

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Factors Influencing Level Of Implementation Of Physical Activity Interventions In Youth-Serving Organizations, Yuen Yan Lau Jan 2015

Factors Influencing Level Of Implementation Of Physical Activity Interventions In Youth-Serving Organizations, Yuen Yan Lau

Theses and Dissertations

In the past decade, numerous interventions have been developed and tested to increase physical activity in children and adolescents. Among these interventions, those that reported higher levels of program implementation appear to have better program outcomes. However, relatively little is known about the specific factors that contributed to successful implementation in youth physical activity interventions. The overall purpose of this dissertation was to identify a set of core factors that are most important in explaining implementation of physical activity interventions in youth-serving settings. Three studies, an expert panel study and two prospective observational studies, were conducted to address the purpose …

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Correlations Between White Matter Integrity, Structural Connectivity, And Upper And Lower Extremity Motor Function In Individuals With Chronic Stroke, Denise M. Peters Jan 2015

Correlations Between White Matter Integrity, Structural Connectivity, And Upper And Lower Extremity Motor Function In Individuals With Chronic Stroke, Denise M. Peters

Theses and Dissertations

Great variability is seen in the clinical manifestation of and recovery from stroke. Structural abnormalities often extend beyond the infarction site, indirectly affecting nonlesioned areas which can further contribute to motor deficits. Advances in neuroimaging have enabled the examination of white matter integrity and anatomical connectivity within the brain. Evidence is limited, however, regarding the relationship between the structural integrity and connectivity of primary and secondary motor tracts/brain regions and chronic upper and (especially) lower extremity motor impairments post-stroke. Therefore, the current study examined the relationship between upper/lower extremity motor impairments and structural integrity (Aim 1) and connectivity (Aim 2) …

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Tp53 And Hras Influence On Hpv16 E7 Expression In Hpv16-Transformed Human Keratinocytes, Nella Christie Delva Jan 2015

Tp53 And Hras Influence On Hpv16 E7 Expression In Hpv16-Transformed Human Keratinocytes, Nella Christie Delva

Theses and Dissertations

Head and Neck Squamous Carcinoma (HNSCC) is one of the most common cancers worldwide. HNSCC affects regions of the upper aerodigestive tract such as the lip, tongue, nasopharynx, oropharynx, larynx, and hypopharynx. About 25% of all HNSCC cases and up to 65% of Oropharyngeal Carcinoma (OPC) cases are positive for HPV DNA. African American patients, especially males, present primarily with HPV-negative HNSCC. HNSCC’s that are HPV-positive tend to be HPV-active at initial presentation: these cancers contain HPV DNA and express HPV RNA. However, recurring HPV-positive cancers of the head and neck are more often inactive: these tumors contain HPV DNA, …

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The Evolutionary Biology Of Vision In Daphnia, Christopher S. Brandon Jan 2015

The Evolutionary Biology Of Vision In Daphnia, Christopher S. Brandon

Theses and Dissertations

Eyes have attracted the attention of evolutionary biologist since the field’s infancy. In On the Origin of Species, in fact, Darwin famously remarked on the proposition that natural selection could engineer the eye, saying “[it is] absurd in the highest possible degree.” Though, he goes on to explain, beautifully and simply, how his theory of evolution by natural selection could produce such an organ. Indeed, eyes are remarkable examples of complex information acquisition systems that have evolved from simple beginnings. Eyes allow animals to extract environmental information from light, which informs physiological and behavioral responses to resources, predation, and mates. …

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Exploring Birthparent’S Experiences Of Creating An Adoption Plan For Their Children With Special Needs, Sanjukta Tawde Jan 2015

Exploring Birthparent’S Experiences Of Creating An Adoption Plan For Their Children With Special Needs, Sanjukta Tawde

Theses and Dissertations

Very little information is available regarding the experience and needs of families who create an adoption plan for their child with disability. The purpose of this study was to learn more about the experiences of birthparents who created an adoption plan after the diagnosis of Down syndrome so as to understand their needs during the process. Birthparents were invited to participate in the study through National Down Syndrome Adoption Network (NDSAN) by membership emails. Information about the study was made available on the organization’s website and social media pages. Potential participants also learned about the study from one of the …

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Potential Range Expansion Of The Invasive Lionfish In The Western Atlantic Ocean, Brian Grieve Jan 2015

Potential Range Expansion Of The Invasive Lionfish In The Western Atlantic Ocean, Brian Grieve

Theses and Dissertations

Lionfish (Pterois volitans) are an invasive, predatory fish native to the reefs of the Indo-Pacific. In the mid-1980s, lionfish were introduced off the coast of Miami, FL and have since transformed many of the reef ecosystems throughout the Western Atlantic Ocean. Although lionfish are found year-round as far north as Cape Hatteras, NC, they are confined to the warm Gulf Stream during winter months. Seasonal inshore expansion is possible in the summer, and further poleward expansion is limited by cold bottom-water temperatures in winter. Here, I use an ensemble of 17 different climate models to project lionfish habitat by the …

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Patterns Of Selection Amongst Dengue Virus Serotypes And Efficacy Of Computational Epitope Prediction Applications, April Christina Hall South Jan 2015

Patterns Of Selection Amongst Dengue Virus Serotypes And Efficacy Of Computational Epitope Prediction Applications, April Christina Hall South

Theses and Dissertations

Dengue virus (DENV) is a mosquito-borne virus of global concern that leads to infections with symptoms ranging from high fevers and headaches to death. Current estimates place almost half the world’s population living in areas that are at-risk for infection by dengue and that area continues to expand over time. There are four distinct serotypes of dengue (DENV1, DENV2, DENV3, and DENV4). Disease severity from dengue infection is significantly worse if there is a secondary infection by a heterotypic serotype. The problems of increased severity with secondary infection as well as host immune response evasion by the virus itself have …

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Patient And Provider Perceptions Of Weight Gain, Physical Activity, And Nutrition In Pregnancy, Kara M. Whitaker Jan 2015

Patient And Provider Perceptions Of Weight Gain, Physical Activity, And Nutrition In Pregnancy, Kara M. Whitaker

Theses and Dissertations

Background: The high percentage of women who enter pregnancy overweight or obese and gain excessive weight during pregnancy is a growing public health problem. Health care providers are recommended to counsel women on weight gain, physical activity (PA), and nutrition during pregnancy. However, little is known about patient or provider perceptions of these topics. Purpose: Guided by the Theory of Planned Behavior (TPB), this study examined women’s and health care providers’ perceptions of weight gain, PA, and nutrition in pregnancy. This study also examined the role of the health care provider in optimizing pregnancy weight gain. Methods: Pregnant women between …

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Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy, Kristen Publicover Miller Jan 2015

Bacterial Communication And Its Role As A Target For Nanoparticle-Based Antimicrobial Therapy, Kristen Publicover Miller

Theses and Dissertations

The goal of this dissertation is to establish the environmental and public health importance of alternative forms of antimicrobial therapy, specifically those that utilize nanotechnology to combat quorum sensing-controlled bacterial infections. Quorum sensing (i.e. chemical communication) is an inherent characteristic that is essential to bacterial pathogenesis and biofilm formation (where most infections occur). A thorough review of the literature has been conducted to establish an understanding of the state of nanotechnology research as it relates to combatting bacterial infections. This synthesis, provided in Chapter 1, demonstrates how the chemical and structural designs of nanoparticles can be manipulated to specifically target …

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Healthy Eating And Physical Activity Environmental And Policy Assessment – Measurement Issues And Implications, Rahma Jamea Yousef Ajja Jan 2015

Healthy Eating And Physical Activity Environmental And Policy Assessment – Measurement Issues And Implications, Rahma Jamea Yousef Ajja

Theses and Dissertations

Current research has suggested that supportive healthy eating and physical activity (HEPA) policy and practice environments play a significant role in shaping the physical activity levels and eating habits of youth. Subsequently, a wide array of audit tools assessing policy and practice environment characteristics across settings that care for youth were developed. However, the extent that available audit tools accurately reflect the policy environment characteristics of the settings that care for the youth population remains unknown. Therefore, this dissertation encompasses four studies. The purpose of the first study was to examine the measurement properties of audit tools currently in use …

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High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant, Tara Diane Raftery Jan 2015

High-Content Screening In Zebrafish Embryos Identifies Abamectin As A Potent Neurotoxicant, Tara Diane Raftery

Theses and Dissertations

During development, the nervous system is a sensitive target for chemical exposure in both humans and animal models, and early life-stage exposures can lead to long-term effects on motor activity, sensory function, and cognition. Currently, there are minimal to no developmental neurotoxicity (DNT) data available for thousands of chemicals used in commerce, and it is impractical to screen these chemicals in rodent models using the existing DNT test guideline, as this test is costly, time- and animalintensive, and low-throughput. Therefore, there is a recognized need to use alternative non-mammalian models to support screening and prioritization of chemicals for DNT testing, …

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Examining The Sensitivity Of Surface Chlorophyll To Upwelling Events Of Variable Frequency In The California Current System, John Thomas Bartlett Jan 2015

Examining The Sensitivity Of Surface Chlorophyll To Upwelling Events Of Variable Frequency In The California Current System, John Thomas Bartlett

Theses and Dissertations

Eastern Boundary Upwelling Systems (EBUS) spatially encompass approximately 1% of the ocean surface area, but are responsible for nearly 20% of global fisheries production. This significant biological production is primarily attributed to the nutrient-rich waters brought to the euphotic zone through a physical process called upwelling. In an attempt to understand the various physical and biological processes occurring on a wide range of temporal and spatial scales, the California Current System (CCS), one of the major EBUS, has been subject to a multitude of scientific studies over the past several decades. Recent modeling enhancements have enabled researchers to investigate mesoscale …

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Climatic Controls On Organic Matter Decomposition In Boreal Peatlands, Michael J. Philben Dec 2014

Climatic Controls On Organic Matter Decomposition In Boreal Peatlands, Michael J. Philben

Theses and Dissertations

Boreal peatlands currently contain 550 Pg C and are located at high latitudes where mean annual temperatures are expected to increase by as much as 7°C by the end of the century. There is growing concern that warming will stimulate decomposition, transforming peatlands from a sink to a source of atmospheric carbon dioxide and accelerating climate change. A primary goal of this dissertation was to evaluate the effect of climate change on organic matter decomposition in peatlands. This was achieved by developing and employing biochemical tracers to indicate the extent of peat decomposition across a range of naturally occurring climatic …

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Marine Population Connectivity: Range Boundaries And Climate Change, Rhiannon Leigh Rognstad Dec 2014

Marine Population Connectivity: Range Boundaries And Climate Change, Rhiannon Leigh Rognstad

Theses and Dissertations

Population connectivity, particularly in open systems, is an important metric for understanding population-level processes on both ecological and evolutionary timescales. In coastal marine systems, adults are typically sedentary and dispersal occurs primarily during a larval stage when individuals are transported in ocean currents. Because coastal marine populations exist as networks of interconnected subpopulations, variation in the magnitude and extent of population connectivity can have profound effects on population dynamics and species distribution limits. Connectivity is a complex process, affected by a multitude of factors, including adult inputs and physical dispersal, which operate at multiple scales and may interact. This dissertation …

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Global Climate Change And The Southern Ocean: How Antarctic Fishes Physiologically Respond To A Changing Environment From The Cellular To The Organismal Level, Laura A. Enzor Dec 2014

Global Climate Change And The Southern Ocean: How Antarctic Fishes Physiologically Respond To A Changing Environment From The Cellular To The Organismal Level, Laura A. Enzor

Theses and Dissertations

Studies have projected that future changes in sea surface temperature and pCO2 levels will impact higher latitudes to a greater extent than in temperate regions. For notothenioid fishes of the Southern Ocean, evolution in extremely stable, cold waters has resulted in several adaptations which have left these fishes poorly prepared for global climate change. I have analyzed the metabolic and cellular response of Trematomus bernacchii, Pagothenia borchgrevinki and Trematomus newnesi to a long-term, multi-stressor scenario relevant to the predicted changes in the Southern Ocean. By combining whole animal respirometry with cellular level analysis of energy allocation, osmoregulatory mechanisms and cellular …

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The Roles Of Gsk-3ss And Apc In Cytoplasmic Dynein Regulation, Feng Gao Dec 2014

The Roles Of Gsk-3ss And Apc In Cytoplasmic Dynein Regulation, Feng Gao

Theses and Dissertations

Dynein is a microtubule minus-end directed molecular motor, participating in a broad range of cellular functions, such as organelle transport, cell migration and mitosis. Dynein dysfunction is linked to many diseases including ALS, schizophrenia, Alzheimer’s disease, Parkinson’s disease and cancer. The mechanism of dynein regulation is largely unknown. We have provided evidence that glycogen synthase kinase 3β (GSK-3β) directly regulates dynein in both neurons and non-neuronal cells. GSK-3β interacts with and phosphorylates dynein in vitro. Dynein phosphorylation by GSK-3β reduces its interaction with Ndel1, a regulator contributing to dynein force generation. Dynein motility is stimulated both by pharmacological GSK-3β inhibitors …

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Methods For Identifying Regions Of Brain Activation Using Fmri Meta-Data, Meredith A. Ray Dec 2014

Methods For Identifying Regions Of Brain Activation Using Fmri Meta-Data, Meredith A. Ray

Theses and Dissertations

Functional neuroimaging is a relatively young discipline within the neurosciences that has led to significant advances in our understanding of the human brain and progress in neuroscientific research related to public health. Accurately identifying activated regions in the brain showing a strong association with an outcome of interest is crucial in terms of disease prediction and prevention. Functional magnetic resonance imaging (fMRI) is the most widely used method for this type of study as it has the ability to measure and identify the location of changes in tissue perfusion, blood oxygenation, and blood volume. In practice, the three-dimensional brain locations …

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