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Articles 1861 - 1890 of 2229
Full-Text Articles in Life Sciences
Phylogeography And Genetic Ancestry Of Tigers (Panthera Tigris), Shu-Jin Luo, Jae-Heup Kim, Warren E. Johnson, Joelle Van Der Walt, Janice S. Martenson, Naoya Yuhki, Dale Miquelle, Olga Uphyrkina, John M. Goodrich, Howard Quigley, R. Tilson, Gerald Brady, Paolo Martelli, Vellayan Subramaniam, Charles Mcdougal, Sun Hean, Shi-Qiang Huang, Wenshi Pan, Ullas K. Karanth, Melvin Sunquist, James L. D. Smith, Stephen J. O'Brien
Phylogeography And Genetic Ancestry Of Tigers (Panthera Tigris), Shu-Jin Luo, Jae-Heup Kim, Warren E. Johnson, Joelle Van Der Walt, Janice S. Martenson, Naoya Yuhki, Dale Miquelle, Olga Uphyrkina, John M. Goodrich, Howard Quigley, R. Tilson, Gerald Brady, Paolo Martelli, Vellayan Subramaniam, Charles Mcdougal, Sun Hean, Shi-Qiang Huang, Wenshi Pan, Ullas K. Karanth, Melvin Sunquist, James L. D. Smith, Stephen J. O'Brien
Biology Faculty Articles
Eight traditional subspecies of tiger (Panthera tigris), of which three recently became extinct, are commonly recognized on the basis of geographic isolation and morphological characteristics. To investigate the species' evolutionary history and to establish objective methods for subspecies recognition, voucher specimens of blood, skin, hair, and/or skin biopsies from 134 tigers with verified geographic origins or heritage across the whole distribution range were examined for three molecular markers: (1) 4.0 kb of mitochondrial DNA (mtDNA) sequence; (2) allele variation in the nuclear major histocompatibility complex class II DRB gene; and (3) composite nuclear microsatellite genotypes based on 30 loci. Relatively …
Fall 2004, Nsu Oceanographic Center
Evidence Of Shark Predation And Scavenging On Fishes Equipped With Pop-Up Satellite Archival Tags, David W. Kerstetter, J. Polovina, John E. Graves
Evidence Of Shark Predation And Scavenging On Fishes Equipped With Pop-Up Satellite Archival Tags, David W. Kerstetter, J. Polovina, John E. Graves
Marine & Environmental Sciences Faculty Articles
No abstract provided.
Apobec3g Genetic Variants And Their Influence On The Progression To Aids, Ping An, Gabriela Bleiber, Priya Duggal, George Nelson, Margaret May, Bastien Mangeat, Irene Alobwede, Didier Trono, David Vlahov, Sharyne Donfield, James J. Goedert, John Phair, Susan Buchbinder, Stephen J. O'Brien, Amalio Telenti, Cheryl Winkler
Apobec3g Genetic Variants And Their Influence On The Progression To Aids, Ping An, Gabriela Bleiber, Priya Duggal, George Nelson, Margaret May, Bastien Mangeat, Irene Alobwede, Didier Trono, David Vlahov, Sharyne Donfield, James J. Goedert, John Phair, Susan Buchbinder, Stephen J. O'Brien, Amalio Telenti, Cheryl Winkler
Biology Faculty Articles
The cytosine deaminase APOBEC3G, in the absence of the human immunodeficiency virus type 1 (HIV-1) accessory gene HIV-1 viral infectivity factor (vif), inhibits viral replication by introducing G→A hypermutation in the newly synthesized HIV-1 DNA negative strand. We tested the hypothesis that genetic variants of APOBEC3G may modify HIV-1 transmission and disease progression. Single nucleotide polymorphisms were identified in the promoter region (three), introns (two), and exons (two). Genotypes were determined for 3,073 study participants enrolled in six HIV-AIDS prospective cohorts. One codon-changing variant, H186R in exon 4, was polymorphic in African Americans (AA) (f < 37%) and rare in European Americans (f < 3%) or Europeans (f …
Southeast Florida Coral Reef Evaluation And Monitoring Project 2003 Year 1 Final Report, Jennifer Wheaton, Carl Beaver, Walter Jaap, Michael Callahan, Selena Kupfner, Shannon Wade, Jim Kidney, Stopher Slade, Erin Mcdevitt, Eric Ault, Fred Voss, David S. Gilliam, B. D. Ettinger, Daniel P. Fahy, Elizabeth Glynn Fahy, Shaun M. Gill, Jamie A. Monty, Lauren F. Shuman, Brian K. Walker, Richard E. Dodge, Tim Mcintosh, Steven Blair, Kenneth Banks, Louis E. Fisher, David Stout, Joe Ligas, Janet Phipps
Southeast Florida Coral Reef Evaluation And Monitoring Project 2003 Year 1 Final Report, Jennifer Wheaton, Carl Beaver, Walter Jaap, Michael Callahan, Selena Kupfner, Shannon Wade, Jim Kidney, Stopher Slade, Erin Mcdevitt, Eric Ault, Fred Voss, David S. Gilliam, B. D. Ettinger, Daniel P. Fahy, Elizabeth Glynn Fahy, Shaun M. Gill, Jamie A. Monty, Lauren F. Shuman, Brian K. Walker, Richard E. Dodge, Tim Mcintosh, Steven Blair, Kenneth Banks, Louis E. Fisher, David Stout, Joe Ligas, Janet Phipps
Marine & Environmental Sciences Faculty Reports
No abstract provided.
Spring 2004, Nsu Oceanographic Center
Patterns Of Feline Immunodeficiency Virus Multiple Infection And Genome Divergence In A Free-Ranging Population Of African Lions, Jennifer L. Troyer, Jill Pecon-Slattery, Melody E. Roelke, Lori Black, Craig Packer, Stephen J. O'Brien
Patterns Of Feline Immunodeficiency Virus Multiple Infection And Genome Divergence In A Free-Ranging Population Of African Lions, Jennifer L. Troyer, Jill Pecon-Slattery, Melody E. Roelke, Lori Black, Craig Packer, Stephen J. O'Brien
Biology Faculty Articles
Feline immunodeficiency virus (FIV) is a lentivirus that causes AIDS-like immunodeficiency disease in domestic cats. Free-ranging lions, Panthera leo, carry a chronic species-specific strain of FIV, FIV-Ple, which so far has not been convincingly connected with immune pathology or mortality. FIV-Ple, harboring the three distinct strains A, B, and C defined by pol gene sequence divergences, is endemic in the large outbred population of lions in the Serengeti ecosystem in Tanzania. Here we describe the pattern of variation in the three FIV genes gag, pol-RT, and pol-RNase among lions within 13 prides to assess the occurrence of FIV infection and …
Genomically Intact Endogenous Feline Leukemia Viruses Of Recent Origin, Alfred L. Roca, Jill Pecon-Slattery, Stephen J. O'Brien
Genomically Intact Endogenous Feline Leukemia Viruses Of Recent Origin, Alfred L. Roca, Jill Pecon-Slattery, Stephen J. O'Brien
Biology Faculty Articles
We isolated and sequenced two complete endogenous feline leukemia viruses (enFeLVs), designated enFeLV-AGTT and enFeLV-GGAG. In enFeLV-AGTT, the open reading frames are reminiscent of a functioning FeLV genome, and the 5′ and 3′ long terminal repeat sequences are identical. Neither endogenous provirus is genetically fixed in cats but polymorphic, with 8.9 and 15.2% prevalence for enFeLV-AGTT and enFeLV-GGAG, respectively, among a survey of domestic cats. Neither provirus was found in the genomes of related species of the Felis genus, previously shown to harbor enFeLVs. The absence of mutational divergence, polymorphic incidence in cats, and absence in related species suggest that …
Cultivation Of Wrack Collected Seagrasses, Irene Arpayoglou
Cultivation Of Wrack Collected Seagrasses, Irene Arpayoglou
HCNSO Student Theses and Dissertations
No abstract provided.
Seroprevalence Of Bartonella Infection In American Free-Ranging And Captive Pumas (Felis Concolor) And Bobcats (Lynx Rufus), Bruno B. Chomel, Yoko Kikuchi, Janice S. Martenson, Melodie E. Roelke-Parker, Chao Chin Chang, Rickie W. Kasten, Janet E. Foley, John Laudre, Kerry Murphy, Pamela K. Swift, Vicki L. Kramer, Stephen J. O'Brien
Seroprevalence Of Bartonella Infection In American Free-Ranging And Captive Pumas (Felis Concolor) And Bobcats (Lynx Rufus), Bruno B. Chomel, Yoko Kikuchi, Janice S. Martenson, Melodie E. Roelke-Parker, Chao Chin Chang, Rickie W. Kasten, Janet E. Foley, John Laudre, Kerry Murphy, Pamela K. Swift, Vicki L. Kramer, Stephen J. O'Brien
Biology Faculty Articles
Bartonella henselae is the main agent of cat scratch disease in humans and domestic cats are the main reservoir of this bacterium. We conducted a serosurvey to investigate the role of American wild felids as a potential reservoir of Bartonella species. A total of 479 samples (439 serum samples and 40 Nobuto strips) collected between 1984 and 1999 from pumas (Felis concolor) and 91 samples (58 serum samples and 33 Nobuto strips) collected from bobcats (Lynx rufus) in North America, Central America and South America were screened for B. henselae antibodies. The overall prevalence of B. henselae antibodies was respectively …
New Species Of Eustomias (Teleostei: Stomiidae) From The Western North Atlantic, With A Review Of The Subgenus Neostomias, Tracey Sutton, Karsten E. Hartel
New Species Of Eustomias (Teleostei: Stomiidae) From The Western North Atlantic, With A Review Of The Subgenus Neostomias, Tracey Sutton, Karsten E. Hartel
Marine & Environmental Sciences Faculty Articles
A new species of the deep-sea dragonfish genus Eustomias is described from 14 specimens from the western North Atlantic. This species belongs to the subgenus Neostomias, which is defined principally by the presence of a single pectoral ray, plus one small rudimentary ray. It is unique among members of the subgenus in having a combination of characters that includes a short mental barbel, multiple proximal bulbs on the barbel main stem, and a unique terminal bulb morphology. Analysis of similar species warrants resurrection of Eustomias monodactylus, previously placed in synonymy with Eustomias filifer. A revised key to …
Trophic Ecology Of The Deep-Sea Fish Malacosteus Niger (Pisces: Stomiidae): An Enigmatic Feeding Ecology To Facilitate A Unique Visual System?, Tracey Sutton
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
The ‘dragonfishes’ and their relatives (family Stomiidae) are among the top predators of the mesopelagic zone of the open ocean. Based on feeding morphology (e.g., large gape, long fangs, and no gill-rakers or ethmoid membrane), the meso/bathypelagic fish Malacosteus niger would also be expected to be a large-item predator, as are the other members of its family. However, analysis of specimens from different ocean basins revealed that the most common prey items are calanoid copepods, despite an apparent inability to handle such small prey. Malacosteus niger is considered advanced within the Stomiidae, so this feeding mode represents a secondary reversion …
Predicting Biodiversity Patterns In Deep Water Coral Ecosystems: Lessons From Phylogenetic Studies Of Shallow Water Coral Reef Crustacea, James Darwin Thomas
Predicting Biodiversity Patterns In Deep Water Coral Ecosystems: Lessons From Phylogenetic Studies Of Shallow Water Coral Reef Crustacea, James Darwin Thomas
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
Comprehensive studies of coral reef biodiversity suggest that diversity patterns may be more congruent with geotectonic events than with the reigning paradigms of dispersal, center of origin, and vicariance. Geotectonic processes slowly accumulate taxa in areas exemplified by the presence of composite or lineage-based evolutionary diversity. This process-pattern model can suggest additional areas where similar patterns are likely to occur. Information on types and levels of diversity should be a primary concern in emerging conservation efforts for deepwater coral ecosystems. Current marine conservation efforts in shallow reef systems rely primarily on identifying “hotspots” that reflect measures of species richness and …
Interactions Between Zooplankton And Karenia Brevis In The Gulf Of Mexico., Kristen M. Lester, Gabriel A. Vargo, John J. Walsh, Cynthia A. Heil, Mary B. Neely, Danylle N. Spence, Susan Murasko, Tracey Sutton, Scott E. Burghart, Andrew Remsen, T. L. Hopkins, Richard N. Bohrer
Interactions Between Zooplankton And Karenia Brevis In The Gulf Of Mexico., Kristen M. Lester, Gabriel A. Vargo, John J. Walsh, Cynthia A. Heil, Mary B. Neely, Danylle N. Spence, Susan Murasko, Tracey Sutton, Scott E. Burghart, Andrew Remsen, T. L. Hopkins, Richard N. Bohrer
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
Blooms of the toxic dinoflagellate K. brevis are common in the Gulf of Mexico, yet no in situ studies of the interactions between zooplankton and K. brevis in the Gulf of Mexico have been conducted. Zooplankton numerical abundance, biomass and taxonomic composition of nonbloom and K. brevis bloom stations within the ECOHAB study area were compared. At nonbloom stations, the most important determinant species were Parvolcalanus crassirostris, Oithona colcarva and Paracalanus quasimodo at the 5-m isobath and P. quasimodo, O. colcarva and Oikopleura dioka at the 25-m isobath. There was considerable overlap between the 5 and 25-m isobaths, with …
D1s80 Single-Locus Discrimination Among African Populations, Rene J. Herrera, Leslie R. Adrien, Luis M. Ruiz, Nahir Y. Sanabria, George Duncan
D1s80 Single-Locus Discrimination Among African Populations, Rene J. Herrera, Leslie R. Adrien, Luis M. Ruiz, Nahir Y. Sanabria, George Duncan
Biology Faculty Articles
The highly polymorphic D1S80 locus has no known genetic function. However, this variable number of tandem repeats (VNTR) locus has been highly valuable in forensic identification. In this study we report the allele and genotype frequencies of five African populations (Benin, Cameroon, Egypt, Kenya, and Rwanda), which can be used as databases to help characterize populations and identify individuals. The allele frequencies were used to infer genetic associations through phylogenetic, principal component, and G test statistical analyses. Compliance with Hardy-Weinberg equilibrium expectations was determined as were FST estimates, theta p values, and power of discrimination assessment for each population. …
Development Of Gis Maps For Southeast Florida Coral Reefs, Bernhard Riegl, Brian K. Walker, Ryan P. Moyer, Luz Hernandez-Cruz, Greg Foster, Christy Foster
Development Of Gis Maps For Southeast Florida Coral Reefs, Bernhard Riegl, Brian K. Walker, Ryan P. Moyer, Luz Hernandez-Cruz, Greg Foster, Christy Foster
Marine & Environmental Sciences Faculty Reports
The present report outlines the results of an integrated mapping project undertaken to provide a habitat map of the shallow Broward County seafloor between the 0m and 35m contour. The study area stretched from Golden Beach in northern Dade County to just north of the Palm Beach County line. To produce this map and assure its compatibility with other, in particular NOAA, mapping products, a series of data were integrated. Data types included Laser Airborne Depth Sounder (LADS) bathymetry, multi- and single-beam bathymetry, acoustic seafloor discrimination, ecological assessments, and groundtruthing. The method used for acoustic seafloor discrimination was based on …
Biozonation On Deep-Water Carbonate Mounds And Associated Hardgrounds Along The Western Margin Of Little Bahama Bank, With Notes On The Caicos Platform Island Slope, Charles G. Messing
Biozonation On Deep-Water Carbonate Mounds And Associated Hardgrounds Along The Western Margin Of Little Bahama Bank, With Notes On The Caicos Platform Island Slope, Charles G. Messing
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
Carbonate mounds found in a broad band from about 325 to 700 m along the western margin of Little Bahama Bank exhibit consistent faunal zonations characterized by assemblages of attached, suspension-feeding macroinvertebrates dominated by sponges, octocorals, crinoids and stylasterid and scleractinian corals. Biozonation on hard substrates appears chiefly dependent on depth (and associated parameters, e.g., temperature) and current flow. Mounds in 325-435 m with up to 30 m vertical relief reveal dense assemblages on gentler up current slopes and flanks, and an almost complete lack of macrofauna on steep downcurrent slopes. Macrofauna include stalked crinoids on upcurrent slopes and crest, …
Spatial And Temporal Recruitment Patterns Of Juvenile Grunts (Haemulon Spp.) In South Florida, L. K. B. Jordan, David S. Gilliam, Robin L. Sherman, Paul T. Arena, Fleur M. Harttung, Robert M. Baron, Richard E. Spieler
Spatial And Temporal Recruitment Patterns Of Juvenile Grunts (Haemulon Spp.) In South Florida, L. K. B. Jordan, David S. Gilliam, Robin L. Sherman, Paul T. Arena, Fleur M. Harttung, Robert M. Baron, Richard E. Spieler
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
Grunts (Haemulidae) are important fisheries species and represent a major component of reef fish communities in the Greater Caribbean region. To date, little is known about their recruitment pattems. Data from more than 2,000 visual fish counts from multiple natural and artificial reef studies in Broward County, Florida, over a seven-year period, were examined to identify both spatial and temporal trends in recruitment of juvenile (i.e., < 5cm TL) grunts of the genus Haemulon. In general, data from these studies indicate that juvenile Haemulon spp. recruitment increases in the spring and peaks in the early summer months (i.e., June and July). Data from natural reef surveys revealed a predominantly nearshore preference for recruitment in water depths less than 8 m. However, on artificial reefs, recruitment commoniy occurred at 20 m depths. The biotic and abiotic factors determining the settlement of grunts are not clear and will be examined in future studies.
Presence Of Juvenile Blackfin Snapper, Lutjanus Buccanella, And Snowy Grouper, Epinephelus Niveatus, On Shallow-Water Artificial Reefs, Paul T. Arena, Patrick Quinn, Lance K. B. Jordan, Robin L. Sherman, Fleur M. Harttung, Richard E. Spieler
Presence Of Juvenile Blackfin Snapper, Lutjanus Buccanella, And Snowy Grouper, Epinephelus Niveatus, On Shallow-Water Artificial Reefs, Paul T. Arena, Patrick Quinn, Lance K. B. Jordan, Robin L. Sherman, Fleur M. Harttung, Richard E. Spieler
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
The inshore environment of Broward County, Florida consists of three reef tracts, each separated by sand substrate, running parallel to the coastline in sequentially deeper water. A wide variety of artificial reef designs have been deployed in Broward County, many lying in sand flats between the reeftracts. From 1995 through 2002, over 1,100 visual fish censuses (predominantly point-counts) were completed on the three natural reeftracts in water depths from 3 m to 30 m and over 1,100 censuses were done on artificial reefs at depths of 7 m to 23 m. Curiously, the juvenile stages of two deeper-water species of …
Habitat Preferences And Diving Behavior Of White Marlin (Tetrapturus Albidus) Released From The Recreational Rod-And-Reel And Commercial Pelagic Longline Fisheries In The Western North Atlantic Ocean: Implications For Habitat-Based Stock Assessment Models, Andrij Horodysky, David W. Kerstetter, John E. Graves
Habitat Preferences And Diving Behavior Of White Marlin (Tetrapturus Albidus) Released From The Recreational Rod-And-Reel And Commercial Pelagic Longline Fisheries In The Western North Atlantic Ocean: Implications For Habitat-Based Stock Assessment Models, Andrij Horodysky, David W. Kerstetter, John E. Graves
Marine & Environmental Sciences Faculty Reports
To improve billfish assessments, researchers have applied habitat-based models that incorporate behavioral and oceanographic parameters to standardize historical catch-per-uniteffort time -series data, accounting for significant gear changes over time. However, there has been little behavioral data from Atlantic billfishes to support these models. We provide information on habitat preferences of white marlin released from recreational and commercial fisheries in the western North Atlantic. White marlin were tagged with pop-up satellite archival tags (PSATs) from recreational rod and reel (n=22) and commercial pelagic longline (n=2) fisheries between May-November 2002. Our data indicate that each surviving white marlin spent the majority of …
Sea Turtle Conservation Program, Broward County, Fl 2004 Report, Curtis M. Burney, Stefanie Ouellette
Sea Turtle Conservation Program, Broward County, Fl 2004 Report, Curtis M. Burney, Stefanie Ouellette
Marine & Environmental Sciences Faculty Reports
No abstract provided.
Microfauna As Tracers Of Sediment Transport: Ft. Pierce Dredge Spoils Sediment Study, Patricia Blackwelder, Carlos Alvares Zarikian, Terry Hood, Charles M. Featherstone, John Proni, Jules Craynock
Microfauna As Tracers Of Sediment Transport: Ft. Pierce Dredge Spoils Sediment Study, Patricia Blackwelder, Carlos Alvares Zarikian, Terry Hood, Charles M. Featherstone, John Proni, Jules Craynock
Marine & Environmental Sciences Faculty Reports
No abstract provided.
Ncri Work And Projects: Abstracts Of Oral Presentations And Scientific Poster Presentations, National Coral Reef Institute (Ncri)
Ncri Work And Projects: Abstracts Of Oral Presentations And Scientific Poster Presentations, National Coral Reef Institute (Ncri)
Marine & Environmental Sciences Faculty Reports
No abstract provided.
Diel Activity Patterns, Space Utilization, Seasonal Distribution And Population Structure Of The Yellow Stingray, Urobatis Jamaicensis (Cuvier, 1817) In South Florida With Comments On Reproduction., Daniel P. Fahy
HCNSO Student Theses and Dissertations
The yellow stingray, Urobatis jamaicensis is the most common elasmobranch in the coastal waters of Southeast Florida. Despite their common occurrence the ecology of yellow stingrays remains poorly understood. In particular, yellow stingray daily movements, space utilization, seasonal distribution and population structure have not been described. This study was conducted to address the lack of knowledge of these fundamental life history parameters and to provide further information on the ecology of U. jamaicensis in coastal waters of Broward County, Florida.
The activity patterns and space utilization of U. jamaicensis were assessed by manual tracking with ultrasonic telemetry. Telemetry tracking of …
Winter 2004, Nsu Oceanographic Center
Summer 2004, Nova Southeastern University
Case 3270: Isometrinae Clark, 1917 (Ecinodermata, Crinoidea): Proposed Emendation Of Spelling To Isometrainae To Remove Homonymy With Isometrinae Kraepelin, 1891 (Arachnida, Scorpiones), Victor Fet, Charles G. Messing
Case 3270: Isometrinae Clark, 1917 (Ecinodermata, Crinoidea): Proposed Emendation Of Spelling To Isometrainae To Remove Homonymy With Isometrinae Kraepelin, 1891 (Arachnida, Scorpiones), Victor Fet, Charles G. Messing
Marine & Environmental Sciences Faculty Articles
The purpose of this application, under Articles 55 and 29 of the Code, is to remove the homonymy between the crinoid subfamily name ISOMETRINAE Clark, 1917 (type genus Isometra Clark, 1908; family ANTEDONIDAE) and the scorpion subfamily name ISOMETRINAE Kraepelin, 1891 (type genus Isometrus Ehrenberg in Hemprich & Ehrenberg, 1828; family BUTHIDAE). It is proposed that the entire generic name of Isometra should be adopted as the stem, so that the correct spelling of the crinoid subfamily will become ISOMETRAINAE Clark, 1917.
Reviewed Work(S): Electronic Tagging And Tracking In Marine Fisheries., David W. Kerstetter
Reviewed Work(S): Electronic Tagging And Tracking In Marine Fisheries., David W. Kerstetter
Marine & Environmental Sciences Faculty Articles
No abstract provided.
Age, Growth And The Annual Cycles Of Lipogenesis And Reproduction Of Acanthurus Bahianus In Southeastern Florida, Stacy M. Wolfe
Age, Growth And The Annual Cycles Of Lipogenesis And Reproduction Of Acanthurus Bahianus In Southeastern Florida, Stacy M. Wolfe
HCNSO Student Theses and Dissertations
The ocean surgeon, Acanthurus bahianus, is a coral reef fish inhabiting the tropical and subtropical waters of the western Atlantic, including southeastern Florida. This study was a 23-month analysis of the reproductive cycle correlated with the annual build up and depletion of fat reserves in the fish. In addition, an age and growth analysis of this species was conducted. A total of 507 fish were analyzed for length, weight, gonad weight and fat body weight. 478 were aged by microscopic examination of the transverse section of the sagittae otolith. The von Bertalannfy growth equation was used to determine length at …
Comprehensive Analysis Of Class I And Class Ii Hla Antigens And Chronic Hepatitis B Virus Infection, Chloe L. Thio, David L. Thomas, Peter Karacki, Xiaojiang Gao, Darlene Marti, Richard A. Kaslow, James J. Goedert, Margaret Hilgartner, Steffanie A. Strathdee, Priya Duggal, Stephen J. O'Brien, Jacquie Astemborski, Mary Carrington
Comprehensive Analysis Of Class I And Class Ii Hla Antigens And Chronic Hepatitis B Virus Infection, Chloe L. Thio, David L. Thomas, Peter Karacki, Xiaojiang Gao, Darlene Marti, Richard A. Kaslow, James J. Goedert, Margaret Hilgartner, Steffanie A. Strathdee, Priya Duggal, Stephen J. O'Brien, Jacquie Astemborski, Mary Carrington
Biology Faculty Articles
Following an acute hepatitis B virus (HBV) infection, clearance or persistence is determined in part by the vigor and breadth of the host immune response. Since the human leukocyte antigen system (HLA) is an integral component of the immune response, we hypothesized that the highly polymorphic HLA genes are key determinants of viral clearance. HLA class I and II genes were molecularly typed in 194 Caucasian individuals with viral persistence and 342 matched controls who had cleared the virus. A single class I allele, A*0301 (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.30 to 0.72; P = 0.0005) was …