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Full-Text Articles in Life Sciences
Long-Term Characterization Of The Chronic Dopamine Microelectrode And Effect Of Electrical Conditioning, Eric P. Marr
Long-Term Characterization Of The Chronic Dopamine Microelectrode And Effect Of Electrical Conditioning, Eric P. Marr
EWU Masters Thesis Collection
"Background: Dopamine (DA) is a neurotransmitter involved in movement, reward learning and addiction. Fast-scan cyclic voltammetry (FSCV) has long been an indispensable tool for monitoring real-time DA signaling. Development of polyimide fused silica-encased FSCV microelectrodes have made the technique more suitable for chronic DA monitoring (months) in vivo. Methods: In this study, electrically stimulated DA signals were evoked weekly in an effort to characterize the recovery time and stability of DA signals recorded long-term with silica-encased chronic DA microelectrodes. Additionally, electrical conditioning (etching), previously shown to improve microelectrode sensitivity in vitro, was performed to investigate the long-term impact on DA …
Thymoquinone Decreases Oxidative Dna Damage (8-Ohdg) In Dmba Treated Female Sprague Dawley Rats, Abrar A. Sindi
Thymoquinone Decreases Oxidative Dna Damage (8-Ohdg) In Dmba Treated Female Sprague Dawley Rats, Abrar A. Sindi
EWU Masters Thesis Collection
"Tamoxifen (TAM) is used widely for treatment and prevention of breast cancer. However, TAM has been reported to have a negative effect on glutathione (GSH) levels and 8-hydroxydeoxyguanosine (8-OHdG). Thymoquinone (TQ), the main active ingredient of Nigella sativa, or Black seeds, is used in the Middle East for treatment of several diseases, especially cancer. The aim of my research was to investigate the role of thymoquinone in improving 8-OHdG and GSH compared with tamoxifen in female Sprague Dawley rats treated with 7,12 dimethylbenz (a)anthracene (DMBA, a drug that induces mammary cancer). 8-OHdG is the most commonly assayed fingerprint of free …
Efficacy Of Tamoxifen And Thymoquinone On Tumor Development, Lipid Peroxidation, And Total Antioxidant Capacity In Dmba Induced Mammary Carcinoma In Female Sprague-Dawley Rats, Nadiah S. Alotaibi
Efficacy Of Tamoxifen And Thymoquinone On Tumor Development, Lipid Peroxidation, And Total Antioxidant Capacity In Dmba Induced Mammary Carcinoma In Female Sprague-Dawley Rats, Nadiah S. Alotaibi
EWU Masters Thesis Collection
"Tamoxifen (TAM) is a drug used for treatment and prevention of breast cancer. However, TAM has been reported to induce liver tumors in several animal models due to overproduction of free radicals and lipid peroxidation. Thymoquinone (TQ), from Nigella sativa seeds, is a Middle East natural medicine and it has been used to treat a number of diseases, including cancer. The aim of my study was to investigate the effect of TQ and TAM on tumor development, lipid peroxidation level, and total antioxidant capacity in DMBA treated female Sprague-Dawley rats. Five groups of 10 rats (control, DMBA, TAM, TQ, and …