Life Sciences Commons^™

Biofilm Characterization And The Potential Role Of Edna In Horizontal Gene Transfer In Hospital And Meat Isolates Of Staphylococcus Aureus And Their Biofilms, Ashley Lynne Ball

Theses and Dissertations

Staphylococcus aureus is a pathogen responsible for a wide variety of life-threatening diseases such as bacteremia, endocarditis, and pneumoniae. S. aureus has been a major concern in recent years due to the rampant spread of antibiotic resistance. The ability of S. aureus to form biofilms aids in the spread of antibiotic resistance as biofilms are a known hotspot for horizontal gene transfer. Biofilms also protect cells from host immune responses and antibiotics, making these infections very difficult to treat. The matrix of S. aureus biofilms can be made of polysaccharides, protein, and DNA. In these studies, we sought to elucidate …

The Role Of Chitinase A In Mastitis-Associated Escherichia Coli Pathogenesis, Weston D. Hutchison

Theses and Dissertations

Bovine mastitis is a common disease among dairy cattle characterized by the inflammation of the udders and loss of milk production. Mastitis-associated Escherichia coli (MAEC) are frequent causes of the disease, but the features that distinguish them from other E. coli strains remain enigmatic. MAEC infections can range from sub-clinical to severe, acute cases that can be fatal. Historically, the severity of mastitis has been attributed to host factors but more recently, a few bacterial genes have been shown to contribute to virulence in mastitis infections. In a large-scale genomic analysis of >100 MAEC isolates the gene for Chitinase A …

Does Predation Environment Affect Repeated Responses To Predation Cuesâ In The Fishâ Brachyrhaphis Rhabdophora?, Madeleine S. Nate

Theses and Dissertations

Individual organisms face trade-offs when dealing with predation—more time spent avoiding predators often results in less time allocated to energy acquisition and reproductive-related activities. Individuals that optimize this trade-off and respond appropriately to current risk levels in their environment should be at an advantage. What is less clear is whether this tradeoff changes when individuals are repeatedly exposed to a predation threat. There may be advantages to responding consistently to every signal of threat, but it might also be advantageous to modulate individual behavior. Moreover, it is unclear how evolutionary history of a population might affect such individual responses. Our …

Quantifying Shape Variation In An Antisymmetrical Trait In Xenophallus Umbratilis, Mary-Elise Johnson Nielsen

Theses and Dissertations

Antisymmetry is a striking, yet puzzling form of biological asymmetry. The livebearing fish Xenophallus umbratilis exhibits antisymmetry in the male intromittent organ and provides a system that is well-suited for studying the nature of variation in antisymmetrical traits. Using geometric morphometrics, I test the hypothesis that because the gonopodium is critical to fitness there will not be significant differences in gonopodium shape between the two gonopodial morphs in this species. My results are consistent with this prediction, though I found that gonopodium shape did differ with gonopodium size.

Novel Patterns For Nucleosome Positioning: From In Vitro To In Vivo, David Andrew Bates

Theses and Dissertations

The fundamental unit of chromatin is the nucleosome, which consists of a core of eight proteins wrapped by DNA. This core is composed of four pairs of histone proteins: H2A, H2B, H3, and H4. The DNA wraps around the protein core ~1.7 times, facilitating compaction of DNA length in the cell. Further, the location of nucleosomes makes genomic elements encoded in the DNA, such as promoters or enhancers, accessible or inaccessible to RNA polymerase and transcription factors. Thus, where nucleosomes are located (or positioned), can play a major role in transcription or other cellular processes. Additionally, histone proteins are frequently …

Effects Of Microbial Transglutaminase On Gluten-Free Sourdough Bread Structure And Loaf Characteristics, Anna J. Redd

Theses and Dissertations

In an effort to mimic the continuous protein matrix found in gluten-containing breads, the effects of the enzyme microbial transglutaminase were tested in gluten-free (GF) sourdough breads containing five different GF flours: chickpea, brown rice, white rice, oat, and quinoa. The utilization of transglutaminase in GF sourdough bread applications was shown to improve some of the final bread characteristics of GF breads. White and brown rice GF sourdough loaves at 24 hours showed a 28% and 13% decrease in crumb firmness with the addition of 2 U/g dough, respectively. Quinoa-GF sourdough breads at 24 hours showed a 6% increase in …

Deep-Brain Shape Features Differentially Relate To Social Outcomes In Pediatric Traumatic Brain Injury, Braydon Lee

Undergraduate Honors Theses

Pediatric traumatic brain injury (TBI) is a global issue with major health consequences. The integrity of brain structures and their social functional correlates are at risk in children with TBI. In this study, magnetic resonance images of the thalamus, caudate, putamen, and globus pallidus were examined in a pediatric TBI group from the Social Outcomes of Brain Injury in Kids (SOBIK). Shape deformations of these structures were compared to an orthopedically injured (OI) control. Additionally, the correlation between shape deformation and theory of mind (ToM) measures were mapped and compared. This study found inward deformations in the ventral thalamic nuclei …

Motivation Toward Sport, Physical Activity And Exercise Between College Students In Hungary And The United States During Covid-19, Whitney Gene Davies

Theses and Dissertations

During the COVID-19 pandemic many researchers noted changes in exercise, physical activity, and sports behaviors. The current study attempts to identify aspects of motivation for physical activity, exercise, and sport for students in two countries, the USA and Hungary. The current study used the Sports Motivation Scale II to measure students’ motivation based on the Self-Determination Theory. Results indicated that students in the USA were more motivated for exercise, physical activity, and sport during the COVID-19 pandemic than were their Hungarian counterparts. Students in the United States scored higher (MUS = 17.88) in overall motivation than their Hungarian counterparts (MHungary …

An Examination Of The Associations Between Relationship Education, Trust, Communication, Relationship Satisfaction, And Sexual Satisfaction, Samantha Baker

Undergraduate Honors Theses

Relationship education courses are commonly used by couples seeking to increase their relationship and sexual satisfaction. In this study, I examined the mediating roles of trust and communication between marriage education classes and relationship and sexual satisfaction. This study used data from the Couple Relationships and Transition Experiences (CREATE) study, a longitudinal, nationally representative survey of newlywed couples. While the present study did not find a significant relationship between marriage preparation and relationship and sexual satisfaction, it does not rule out the possibility of a relationship existing due to some limitations of the present study. This study did find significant …

The Use Of Inertial Measurement Unit For The Characterization Of Multiple Functional Movement Patterns In Individuals With Chronic Ankle Instability, Seunguk Han

Theses and Dissertations

Patients with a history of lateral ankle sprain (LAS) may experience different levels of mechanical and/or sensorimotor deficits following their injuries. Although various factors, such as structural damage, sensorimotor adaptation, perceived instability, swelling and/or pain, can develop and perpetuate the condition of chronic ankle instability (CAI), most previous CAI research on biomechanics has considered all patients with CAI as a homogeneous group. Recent research has clustered patients with CAI into six distinct movement patterns during a maximal jump-landing/cutting task. This approach could motivate clinicians to develop appropriate rehabilitation programs for each patient with CAI depending on their movement patterns. However, …

Are Changes In Muscle Blood Flow Associated With The Age-Related Decrease In Critical Power?, Abigail Dorff

Theses and Dissertations

Aging results in lower exercise tolerance, manifested as decreased Critical Power (PCRIT). Aging is also associated with reduced physical activity, decreased muscle mass, and altered muscle blood flow, all of which may contribute to the age-related decrease in PCRIT. Purpose: The purpose of this study was to determine if the age-related decrease in PCRIT occurs independently of changes in physical activity and muscle mass and if it is related to impaired muscle blood flow. Methods: 10 Old (63.1 ± 2.5 years, 5 female and 5 male) and 10 Young (24.4 ± 4.0 years, 5 female and 5 male) physically active …

Sitting Time And Insulin Resistance In 6,931 United States Adults: The Role Of Abdominal Adiposity, Kayla Marie Parker

Theses and Dissertations

This cross-sectional investigation of 6,931 U.S. adults examined the relationship between sitting time and insulin resistance. A primary objective was to evaluate how this relationship was mediated by the following variables: age, sex, race, year of assessment, cigarette smoking, physical activity, body mass index (BMI), and waist circumference. Self-reported sitting time, measured in minutes per day, was the exposure variable. Insulin resistance, indexed by the homeostatic model assessment of insulin resistance (HOMA-IR), was the outcome variable. Data were used from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Results showed a strong, positive association between sitting time and insulin …

The Development Of A Genomic Toolbox For Studying The Evolutionary Genetics Of Reptilian Lungs Using The Chicken Model, Logan Thomas Edvalson

Theses and Dissertations

There is a vast diversity in tetrapod lung branching morphology. Phylogenetically, much of the pulmonary diversity among vertebrates appears to arise from the way epithelial tubes branch or form saccular (cyst) structures. Fgf10 activity has been shown to play a critical role in regulating branch versus cyst morphology. We hypothesize that the species-specific differences in lung morphology may be primarily due to species-specific differences in Fgf10 expression. To test this hypothesis, we have performed bioinformatic analyses on the Fgf10 locus and have identified a conserved 11 kb noncoding region that potentially contains the Fgf10 lung enhancer. We are taking a …

Why You Should Have Story Time With Your Child Today, Lindsay Medaris

Family Perspectives

No abstract provided.

Barrier Or Benefit? Media Use During Infant Feedings, Shannon Haddock

Family Perspectives

No abstract provided.

How To Make Fomo Work For You, Lauren Hansen

Family Perspectives

No abstract provided.

Family Outcomes And Resilience In Adult Children Of Late-Life Divorce, Kaitlyn Larsen Dyshkant

Family Perspectives

No abstract provided.

Caring For Your Marriage When Your Child Has Disabilities, Meghan Cawley

Family Perspectives

No abstract provided.

Devices: Tools Or Vices?, Rebekah Case

Family Perspectives

No abstract provided.

Loving Your Partner Enough To Give Them Space, Dallie Johnson

Family Perspectives

No abstract provided.

Breaking The Cycle Of Mutual Hostility, Daniel Frost

Family Perspectives

No abstract provided.

Mindfulness In University Students: A Tool For Managing Stress, Lyndsey Kunzler

Family Perspectives

Mindfulness can be a meaningful practice across different stages of life: it can help improve well-being for young children (Becker & Whitaker, 2018; Esmaeilian et al., 2018; Li et al., 2019), adolescents (Leavitt et al., 2020; Oppo et al., 2019), and adults (Berk et al., 2018; Pierson et al., 2019). Mindfulness is the act of clearing the mind, being present, and paying attention with the intent to improve well-being (Greeson et al., 2014). Mindfulness began as a common Buddhist practice, but in the 1970s Jon Kabat-Zinn created mindfulness-based stress reduction (MBSR) in an attempt to aid mental health issues (Greeson …

Effects Of Parents’ Avoidant And Anxious Attachment On Children, Nicole Busacker

Family Perspectives

Avoidant and anxious attachment styles are both negative ways of dealing with the need for connection or bonding. One reason these attachment styles develop is in “the absence of a secure bond with an available and responsive ‘other,’ rigid, repetitive internal and interpersonal coping patterns or attachment strategies develop” (Brubacher, 2017, p. 52–53). These coping patterns are made manifest in either avoidant or anxious attachment behaviors and are mainly expressed in relation to spouses and children.

Stemficohort1preinterviewdata, Rebecca L. Sansom, Bryn Stclair, Jamie Jensen, Richard West

ScholarsArchive Data

The science, technology, engineering, and mathematics faculty institute (STEMFI) is a National Science Foundation funded project designed to provide support, measurement, and training to BYU faculty developing their own student-centered curriculum.

This PDF file contains pre-institute participation interview data from the first cohort of faculty involved in the STEM faculty institute (2018).

Analysis Of The Cytopathogenic Effect Of Different Hiv-1 Vpr Isoforms On Primary Human Cd4+ T Cells And A Model Cell Line, Jonatan Josue Fierro Nieves

Theses and Dissertations

Human Immunodeficiency Virus (HIV) is the causal agent of acquired immunodeficiency syndrome (AIDS), a disease characterized by the depletion of CD4+ T cells which impairs immune response. Analysis of HIV-1 infected patients has identified two distinctive phenotypes that differ in length of time towards the development of AIDS, Rapid Progressor (RP) and Long-Term Non-Progressor (LTNP) patients. The cause of the differences between these two groups is a process that is still under investigation. Hints about a possible cause have been attributed to the discovery of mutations in the viral protein R (Vpr) that have been associated with these phenotypes: mutations …

From The Headlines: A Textual Analysis Of Social Polarization And Discord In Times Of Pandemic Across A Century In The United States, Alexa Demarco

Undergraduate Honors Theses

Within the past century, three major pandemics have affected the United States – the Spanish Flu, AIDS, and COVID-19. Each of these pandemics has tested the capabilities of the public health sector and the social resilience of the population. Scientists have studied the viruses and implemented public health measures to limit viral transmission, but the social responses to these preventative measures proved to be difficult to predict and control. The dissonance and polarization between the public health initiatives and the response of the general public in the most recent pandemic was apparent. Was this a pattern in other pandemics? Was …

An Exploration Of Factors That Impact Uptake Of Human Papillomavirus Vaccines, David Samuel Redd

Theses and Dissertations

Introduction The discovery and continued development of vaccines is arguably one of the most important innovations in human history. Vaccination greatly reduces the worldwide incidence and transmission of diseases, preventing permanent injury and premature death. Mass vaccination campaigns have led to the eradication or partial eradication of severe infectious such as smallpox and polio, have reduced childhood mortality, and has led to an overall increase in average health in the human population globally. Despite the documented benefits of vaccination, vaccine hesitancy is increasing, and the uptake of some vaccines is low. Vaccines have been so successful at preventing disease that …

Big Data Meta-Analyses Of Transcriptional Responses Of Human Samples To Orthohantavirus Infection And Shotgun Metagenomics From Crohn's Disease Patients., John L. Krapohl

Theses and Dissertations

Hantavirus is a dangerous zoonotic viral pathogen that is found across Asia, Europe, and the Americas. This virus causes a range of symptoms from flu-like malaise to heart failure and death. It is normally transmitted to humans via the aerosolized feces or urine of infected rodents. Currently, there are no known treatments for the disease, and it continues to threaten human health in endemic areas. In order to identify possible future therapeutic targets, we ran a meta-analysis of existing transcriptomic data collected from infected human tissue. Several genes and cellular pathways were identified, in addition to several potential therapeutics that …

Regulation Of T Cell Activation By The Cd5 Co-Receptor And Altered Peptides, Characterization Of Thymidine Kinase-Specific Antibodies, And Integrating Genomics Education In Society, Kiara Vaden Whitley

Theses and Dissertations

Helper T cells (Th) are a vital component of the immune system responsible for directing other immune cells to eliminate pathogens and cancer. Specifically, Th cells facilitate B cell and cytotoxic T cell (Tc) activation and recruitment and enhance their function against cancer and infectious diseases. Th cells are a valuable resource for improving Tc responses in cancer treatment and have become a focus of immunotherapeutic research. While it is increasingly clear that helper T cells serve an important role, the details about which entities produce an effective Th cell response remain unclear. CD5 is a T cell co-receptor that …

Effects Of Localized Irrigation And Fertilizer On Woody Plant Establishment In Degraded Semi-Arid Environments, Holley M. Lund

Theses and Dissertations

Semi-arid native plant communities worldwide are often disturbed either intentionally or incidentally by human activity. In order to restore ecological function after human activities cease, native plant communities need to be restored. Woody plants are important to ecological function for many reasons including reducing erosion and providing food and shelter for wildlife. Unfortunately, woody plant establishment in these areas has proven to be challenging. Direct seeding efforts can be hindered by poor germination and low seedling emergence. To overcome this, seedling transplants are often used in harsh sites. However, transplanted woody seedlings often experience high mortality during the first year, …