Life Sciences Commons^™

Carrying The Weight Of Pregnancy Anxiety, Danielle Yates

Family Perspectives

No abstract provided.

Fostering Healthy Sexuality In The Emerging Generation: Reminders For Latter-Day Saints, Melina Myers

Family Perspectives

No abstract provided.

Family Meals: Expectation Vs. Reality, Lindsey Hair

Family Perspectives

No abstract provided.

How Parent-Child Attachment May Influence Relational Self-Efficacy In Adults, Rachel Abraham

Family Perspectives

No abstract provided.

Dollars And Daddy Issues: The Effect Of Parental Gambling On Children’S Attachment Style And Relational Outcomes, Mackenzie Pistritto

Family Perspectives

No abstract provided.

Viewing Adhd’S Impact On Children’S Social Development Through The Lens Of Peer Rejection, Bethany Sycamore

Family Perspectives

No abstract provided.

Equipping Future Physicians With Artificial Intelligence Competencies Through Student Associations, Spencer Hopson, Carson Mildon, Kyle Hassard, Paul Urie, Dennis Della Corte

Faculty Publications

Advances in artificial intelligence (AI) in the medical sector necessitate the development of AI literacy among future physicians. This article explores the pioneering efforts of the AI in Medicine Association (AIM) at Brigham Young University, which offers a framework for undergraduate pre-medical students to gain hands-on experience, receive principled education, explore ethical considerations, and learn appraisal of AI models. By supplementing formal, university-organized pre-medical education with a student-led, faculty-supported introduction to AI through an extracurricular academic association, AIM alleviates apprehensions regarding AI in medicine early and empowers students preparing for medical school to navigate the evolving landscape of AI in …

Diversification And Evolution Of Hawaiian Megalagrion Damselflies (Pinapinao, Odonata: Coenagrionidae), Robert K. Hadfield

Theses and Dissertations

The Megalagrion damselflies of HawaiÊ»i present a valuable study system for understanding the impacts of geology on evolutionary processes. Despite their significance, our understanding of the temporal, geographic, and phylogenetic origins of these damselflies remains incomplete. Prior phylogenetic studies have proposed adaptive ecological and morphological progressions, but evaluating these hypotheses relies on a sound understanding of phylogenetic relationships within the genus. Previous phylogenetic analyses have produced conflicting topologies. To resolve these uncertainties, we performed phylogenetic analyses including divergence time estimation with 90 nuclear loci (>50 kbp) and 2 mitochondrial loci (>1000 bp), sampling representatives from each genus within …

A Comprehensive Review And Meta-Analysis Of Breast Cancer Gene Expression Data: Understanding The Molecular Complexity Of A Silent Epidemic, Ifeanyichukwu O. Nwosu

Theses and Dissertations

Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death; it accounts for 23% of total cases and 14% of deaths, with over 2 million new cases diagnosed and 600,000 deaths in 2020. This is a huge public health burden. Traditionally, clinical subtypes of breast cancer are defined based on a patient's immunohistochemistry profile. These profiles are determined by the combined expression status of three receptors: estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. It has also been observed that women of African descent, more commonly present with ER, PR and …

Optimal Limb Regeneration Strategies In Hemigrapsus Sanguineus, Laura S. Fletcher

Theses and Dissertations

Diet quality and energy allocation influence an individual’s life-history traits by determining how much energy is available for processes such as growth and reproduction. One common method of assessing diet quality involves measuring gut length or size, which is typically inversely related to diet quality. However, this often requires animal sacrifice and time- consuming dissections. Similarly, many traditional bioenergetics models fail to capture the context-dependence of energy allocation, as these models rely on fixed energy allocation rules. One such rule is the κ-rule of dynamic energy budget theory, which assumes a fixed proportion (κ) of assimilated energy is always allocated …

Microbial Hydrolysis Process To Improve Anaerobic Digestion For Biofuel Generation, Caleb Michael Jensen

Theses and Dissertations

Human development results in billions of tons of waste per year, which contributes to major issues such as pollution, climate change, and habitat destruction. In this study, we explored the impact of bacterial inoculation on volatile fatty acid (VFA) production, volatile solids (VS), and gas output in anaerobic digesters under different substrate treatments. Our results reveal that bacterial inoculation significantly boosts VFA levels, especially acetic acid, with both Caldicellulosiruptor bescii and mixed Caldicellulosiruptor, cultures showing notable differences compared to controls, especially in untreated manure and WAS treatments. Acetic acid and VS/TS increased in untreated WAS when inoculated with C. bescii …

Exploring The Mechanism Of Increased Survival In Rb1-Mutant Glioblastoma Multiforme, Lucia Wesemann

Undergraduate Honors Theses

Glioblastoma Multiforme (GBM) is an incredibly invasive and particularly lethal central nervous system cancer. Recent work has shown that GBM patients with mutated RB1 have greater overall survival. A proposed mechanism for the improved prognosis of this molecular subgroup is mainly supported by previous research that is not specific to GBM. I utilize the Clinical Proteomic Tumor Analysis Consortium (CPTAC) dataset to interrogate this mechanism using GBM-specific data. The mechanism is largely not supported by the CPTAC GBM dataset, and the trend of significantly improved overall survival in RB1-mutant GBM patients is not validated here. This study highlights the …

The Effects Of Combining Β-Lactam Antibiotics And Mefloquine In Multi-Drug Resistant Pseudomonas Aeruginosa, Kayla C. Maas

Theses and Dissertations

Pseudomonas aeruginosa, a notorious opportunistic pathogen, is a leading cause of hospital-acquired infections. The newest generation of β-lactam antibiotics, the carbapenems, are often used to treat multi-drug resistant (MDR) P. aeruginosa infections. Treatment of P. aeruginosa has become increasingly difficult due to its remarkable ability to resist antibiotics through various intrinsic and acquired mechanisms. Physicians rely on a limited group of antibiotics to treat these infections, but many P. aeruginosa isolates are evolving to become resistant to all available antibiotics, including carbapenems. The multifaceted mechanisms underlying P. aeruginosa antibiotic resistance include β -lactamases, efflux pumps, altered membrane porins, and antibiotic …

Quantifying The Influence Of Air Resistance And Drafting On The Metabolic, Kinematic And Kinetic Demands Of Running, Jared Robert Deandreis Steele

Theses and Dissertations

Purpose: This study aimed to quantify the effects of air resistance on metabolic, kinetic, and kinematic parameters during treadmill running and to investigate how drafting influences these parameters. Methods: Thirty-three well-trained distance runners participated in biomechanical assessments, and seventeen of these also participated in metabolic assessments. The protocol involved running at 80-85% of critical speed on a force-instrumented treadmill facing a wind tunnel. Five wind conditions were tested: no fan (NF), headwind (HW), headwind with drafting (HWD), no wind (NW), and no wind with drafting (NWD). Ground reaction forces (GRF) and kinematic data were collected and analyzed using linear mixed-effects …

Laying Framework For A Novel In Vitro Eukaryotic System To Measure Rate Of Transcription Elongation, John Lucas Ramirez

Theses and Dissertations

Within each cell, genetic material is stored in the form of DNA. This DNA is compacted around proteins to form higher order structures called chromatin. The basic unit of chromatin is a histone protein octamer bound with DNA called a nucleosome. A nucleosome consists of eight core proteins, four pairs of histone proteins H2A, H2B, H3, and H4, wrapped by DNA. The DNA wraps around the histone protein roughly 1.7 times, helping facilitate the compaction of DNA within the nucleus of the cell. The location of nucleosomes makes genetic material that encodes various elements, such as promoters or enhancers, accessible …

Connecting Hiv-1 Viral Protein R Polymorphisms To Changes In Inflammatory Signals And Efficacy Testing Of Essential Oils As Disinfectants Against Sars-Cov-2, J. Brandon Lopez

Theses and Dissertations

Human Immunodeficiency Virus (HIV-1) is the causative agent for acquired immunodeficiency syndrome (AIDS). Different strains of HIV-1 have been linked to a long term non-progressor (LTNP) or rapid progressor (RP) form of disease depending on rate of AIDS progression. Viral protein R (Vpr) is a viral protein that has been linked to varying rates of AIDS progression depending on the sequence. In this work, the effects of two polymorphisms, a LTNP and a RP, on different cells are studied. The LTNP virus was linked to lower release of pro-inflammatory cytokines, such as TNF and IL-6, and an increase in apoptotic …

Impacts Of Managed Honeybee Apiaries On Native Bee Populations, Trapping Efficiencies Of Bee Sampling Methods, And Drone Based Floral Cover Analysis In High Elevation Tall Forb Communities In Central Utah, Nicholas Val Anderson

Theses and Dissertations

This dissertation investigates the impact of honeybee introductions on native bee populations, evaluates the efficiency of traditional bee sampling and monitoring methods, and explores the use of drone technology for assessing floral resources on federal lands in the United States. Federal lands, managed for multiple uses, present a valuable opportunity for the summer pasturing of honeybees. These lands produce vast floral resources and are largely free from pesticides and other pollutants that could weaken honeybee populations. The potential use of this resource is significant given the economic and agricultural concerns presented by declining pollinator trends and Colony Collapse Disorder (CCD). …

Functional & Evolutionary Analysis Of Tbx2a And Tbx2b In Zebrafish Heart Development, Maliha Tasnim

Theses and Dissertations

Congenital Heart Disease (CHD) is the most common birth defect, affecting approximately 1% of live births. This dissertation explores the genetic mechanisms underlying CHD, focusing on the T-box transcription factors Tbx2a and Tbx2b in zebrafish. Utilizing advanced bioinformatics techniques, we reconstructed the ancestral sequences of these genes to understand their evolutionary trajectory and functional divergence. Our analysis highlights the evolutionary conservation of the DNA-binding domain in tbx2a and tbx2b, suggesting its crucial role in maintaining correct gene expression patterns during development. We observed unique and shared amino acid substitutions in these proteins, indicating potential adaptive changes and conserved functions. Comparative …

Takiri Ake Nga Haeata: Lighting A Path To Increased Indigenous Leadership In Aotearoa, Kaylee Ihimaera

Theses and Dissertations

This thesis addresses the underrepresentation of indigenous Māori people in leadership positions and pursues the need to develop a Māori leadership framework aimed at empowering the next generation of indigenous people. Several frameworks have attempted to exhibit Māori leadership dynamics, each offering unique insights into the cultural and relational aspects of Māori leadership. However, existing frameworks often exhibit limitations in fully encapsulating the breadth of Māori leadership values and practices, necessitating the development of a comprehensive Māori leadership model independent of Western frameworks. Through an extensive review of existing literature and engaging with Māori experts, I synthesized key insights to …

The Role Of Nr4a Transcription Factors In The Body And Their Effects In The Pancreatic Beta Cell, Jacob A. Herring

Theses and Dissertations

A central aspect of type 1 and type 2 diabetes is decreased functional β-cell mass which leads to systemic glucose dysregulation. Functional β-cell mass takes into account β-cell insulin secretion, β-cell proliferation, and β-cell survival. Several treatments are currently used to help maintain glucose levels in individuals with diabetes. However, cures for these diseases are not available due to inability to expand functional β-cell mass. Transcription factors control expression of target genes critical for various functions, and transcription factors that control β-cell function, proliferation and survival play a significant role in β-cell development and function. A more thorough examination of …

Evaluating The Effects Of Cheatgrass On Western Burrowing Owls, Kaylee R. Draughon

Theses and Dissertations

There has been a global decline of specialist species observed in recent decades due to the impacts of climate change, invasive species, and habitat loss. Habitat loss and degradation may lead to a mismatch between habitat attractiveness and actual quality, otherwise known as an ecological trap. Ecological traps occur when an organism is constrained by its evolutionary past to select for cues that no longer accurately predict habitat quality. Specialist species are more susceptible to ecological traps due to greater reliance on and fidelity to historic sites and resources. The burrowing owl (Athene cunicularia), a specialist bird species adapted to …

Comparative Genomics Of Anax (Odonata: Aeshnidae), Ying Fei Lin

Theses and Dissertations

Insect migration is an important phenomenon characterized by the long-distance travel of various species in search of resources, safety, breeding, and/or suitable climates. However, relatively little is known about insect migration patterns and the genetic factors associated with them. Three closely related species of dragonflies (Odonata: Aeshnidae), Anax junius, A. strenuus, and A. walsinghami, form a clade of migratory and non-migratory species and present a natural laboratory to study the evolution of genes that may be related to muscle developments and insect migration. In this study, we sequence the whole genomes of these three Anax species to present a resource …

Chromosome-Scale Assemblies And A Pangenome Reveal Ltr Repeat Dynamics As A Major Driver Of Genome Evolution In Chenopodium, Kate E. Jaggi

Theses and Dissertations

The genus Chenopodium, which comprises around 150 species globally, is characterized by its wide geographic distribution and ecological adaptability, particularly in temperate regions. Some species, such as Chenopodium quinoa and Chenopodium pallidicaule, have served as domesticated staple crops in the Andean region of South America for centuries, valued for their robust nutritional profile and adaptability to adverse environmental conditions. In contrast, wild Chenopodium species exhibit broad geographic distributions and diverse niche adaptations, functioning as reservoirs for beneficial traits, including disease resistance and climate hardiness, essential for enhancing domesticated crops through introgression and breeding efforts. However, taxonomic classification within the genus …

Medial Temporal Lobe Surface Features And Cognition In Aging Amyloid-Positive Individuals, Jacob Johnston

Undergraduate Honors Theses

Memory consolidation and metabolism are known to differ between amyloid-beta plaque positive (A+) and negative (A-) amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's disease (AD) dementia participants despite similar medial temporal lobe (MTL) volume between groups. Using high-dimensional surface analysis (shape characterization), this study identified structural differences in the medial temporal lobe between A+ aMCI, A+ AD dementia, and amyloid-negative (A-) healthy control groups (CON), specifically in the CA1 and subiculum regions of the hippocampus and entorhinal cortex. Additionally, regional brain surface-based features were correlated with procedural and episodic memory measures, finding positive associations between CA1 integrity and episodic memory …

Using Rna Sequencing Methodologies To Uncover Common Pathways In Neural Tube Defects: A Comparative Study Of Three Oxidative Neurotoxicants, Aubrey Coleen Johansen

Theses and Dissertations

Neural tube defects (NTDs) are the second most common type of congenital birth defect that affect infants worldwide. There are several proposed mechanisms for NTDs, but no definitive mechanism has yet been described. One possible mechanism is oxidative disruption of normal developmental signaling. The purpose of this study is to culture whole mouse embryos with three common developmental toxicants, mono-2-ethylhexyl phthalate (MEHP, a plastic pollutant), Fumonisin B1 (FB1, a corn mold), and valproic acid (VPA, an anticonvulsant drug), all of which are known to cause NTDs, and compare their shifts in redox potential and changes to important signaling pathways through …

Church2024_Development Of A Rhizobium Seed Coating...Data, Bridget M. Church, Brad Geary, Curtis L. Drake, Joel Griffitts, Kate Ruebelmann, Shannon V. Nelson, Matthew D. Madsen

ScholarsArchive Data

This file contains the data description for the “Church2024_Development of a Rhizobium Seed Coating…” Supplementary File.

The excel file contains six worksheets: 1) Exceed Study Data, 2) Exceed Study Tiss TotN%, 3) Inoc Study data, 4) Inoc Study Tiss TotN%, 5) Seed Coat study data, Seed Coat study Tiss TotN%.

Maturation Of An Off-Channel Habitat Concept To Conserve Native Fishes In The Lower Colorado River, Paul C. Marsh, Thomas E. Dowling, Thomas F. Turner, Megan J. Osborne, Brian R. Kesner

Monographs of the Western North American Naturalist

Two endemic, “large river” fishes of the Colorado River basin of western North America, bonytail Gila elegans and razorback sucker Xyrauchen texanus, are among several critically endangered species in the system. Wild populations of bonytail are gone, and there are no self-sustaining populations of razorback sucker anywhere; reproduction occurs but recruitment does not. Both species have been under intensive management in the Lower Colorado River since the 1980s. Today, with the single exception of Lake Mead, remaining populations are composed entirely of repatriated individuals that depend on stocking for their continued existence. In 2003, a conceptual off-channel habitat (OCH) …

Just “Getting By” – Understanding Resource Deficits And Barriers To Medical Interpretation From The Perspectives Of Spanish-Speaking Patients And Emergency Department Nurses, Magdalena Scribner Briggs

Undergraduate Honors Theses

Introduction: Professional medical interpretation has been found to improve communication quality and health outcomes for patients with LEP. There are over 16 million LEP Spanish-speakers in the United States, yet the literature indicates that professional interpretation is lacking and underutilized in many clinical settings. Study Aims: Based on gaps in the literature pertaining to the perspectives of nurses and the cultural factors that influence patient experience, this study aims to qualitatively analyze the matter from the perspectives of both nurses and Spanish-speaking patients. The purpose of this study is to identify barriers to the utilization of professional interpreters, especially by …

Physical Activity, Cardiorespiratory Fitness And All-Cause Mortality, Jorin Dane Larsen

Theses and Dissertations

Introduction Both elevated levels of physical activity (PA) and high cardiorespiratory fitness (CRF) are associated with a decreased risk of all-cause mortality. The degree to which an individual's PA level and CRF status interact to influence mortality is not currently fully understood. This study investigated whether PA and CRF were independently related to all-cause mortality, and to what degree PA was associated with improved mortality risk in individuals with low CRF. Methods This is a prospective cohort study using health assessments on individuals gathered between 1975 and 2002. Health assessment data were matched with the National Death Registry to assess …

Conservation And Management Of Greater Sage-Grouse In Strawberry Valley: Quantifying Influences On A Traditional Capture Method And Long-Term Trends In Clutch Size, Janae Radke

Theses and Dissertations

The greater sage-grouse (Centrocercus urophasianus) is a species of conservation concern that has undergone serious declines in the last century. The Strawberry Valley sage grouse population in Utah underwent such a decline from an estimated 3,500 sage grouse in the 1930s to 150 sage grouse in the early 2000s. This decline initiated a long-term conservation and monitoring project in Strawberry Valley with the goal of preserving the sage grouse population. As part of this ongoing conservation project, we investigated factors that impact the success of capturing sage grouse using the night-lighting method (Chapter 1). We found that capture success is …