Life Sciences Commons^™

Age-Changes Of The Neuronal Component Of Meissner Corpuscles In The Mouse Digital Pad, Roger C. Mathewson

Loma Linda University Electronic Theses, Dissertations & Projects

Silver impregnated sections of mouse digital pads were studied using light microscopy to detect age-related changes of the neuronal component of Meissner corpuscles. Direct microscopic observation, photomicrographs and camera lucida tracing were utilized. From qualitative observation, the corpuscular neurites were found to undergo morphological age-related changes of diameter, tortuosity, varicosity, branching and terminal expansion size. Quantitative examination was made of the number of corpuscles, corpuscular neurites, branching neurites, cross-innervations, terminal neurite expansions, neurite intraepidermal continuations and terminal axonal processes. The number of corpuscles and neurite intraepidermal continuations decreased with age while having significant linear correlation; whereas, branching increased with age …

The Copper Status Of Vegetarian And Non-Vegetarian Men, Susan Bruce

Loma Linda University Electronic Theses, Dissertations & Projects

In this study, the copper status of 18 vegetarian and 17 non-vegetarian men were compared. Copper status was assessed by determining red blood cell superoxide dismutase (RBC-SOD) activity and plasma copper. Plasma copper levels were measured by atomic absorption spectroscopy. Plasma cholesterol, triacyclglycerols, HDL cholesterol, LDL cholesterol VLDL cholesterol were also determined. Twenty-four hour recalls and three-day food records were obtained to determine copper, zinc, energy, protein, fat, fiber, saturated fat, oleic acid, linoleic acid and cholesterol intake. Non-vegetarians had a significantly higher plasma cholesterol and LDL cholesterol than vegetarians. They also had a significantly higher cholesterol, saturated fat, percent …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Current Management Of Pregnancy In The Diabetic: A Team Approach, Seth G. Kivnick, J. David Fachnie, Chang Y. Lee

Henry Ford Hospital Medical Journal

We reviewed details of 89 pregnancies in diabetic women who were delivered from 1980 through 1982. Data are presented on the obstetrical outcome and the level of diabetic control in patients with White classifications of B through R. Although the mean blood glucose levels of all groups failed to meet the criteria for ideal metabolic control (fasting less than 105 mg/dl, postprandial less than 120 mg/dl), the perinatal mortality rate of 4% compared favorably with reports from other centers. Fifty-six percent of our patients were delivered at 37 weeks gestation or later. The primary Caesarean section rate was 37%, and …

Drug-Induced Glomerulopathy: A Selective Review, Francis Dumler

Henry Ford Hospital Medical Journal

Tbe pathogenesis of drug-induced glomerular disease is becoming better understood because of recent advances in the study of glomerular physiology and metabolism. Various classes of drugs may produce nephrotoxicity. This review is limited to types of drugs whose use may result in glomerular functional and metabolic abnormalities leading to proteinuria and/or renal insufficiency. Drugs which cause tubular necrosis are excluded. Nonsteroidal anti-inflammatory agents are examples of drugs that induce glomerular proteinuria and minimal change nephropathy. Gold, penicillamine, and captopril produce drug-induced glomerular proteinuria in association with membranous nephropathy. Finally, semustine and mitomycin are examples of drugs that induce glomerular sclerosis …

Santa Clara Magazine, Volume 25 Number 8, Spring 1983, Santa Clara University

Santa Clara Magazine

2 - FIRST FRIEND by Robert Meyers. Nevada Senator Paul Laxalt talks about his special relationship with the President of the United States.

6 - A CONVERSATION WITH BROTHER ROGER by Patrick Samway, S.J. An interview with the founder of a remarkable ecumenical community that has become a source of inspiration for Christians everywhere.

11 - JESUIT CHAPLAINS IN WORLD WAR II by Donald F. Crosby, S.J. Chronicling the involvement of 273 Sons of Loyola who marched off as chaplains in World War II.

15 - PSYCHOLOGY AT THE STOCK EXCHANGE by Jerry Kroth. Can psychology provide us with an …

The Correlation Between Expressive Language Delay In Children And Their Motor Abilities, Gail G. Cunningham

Dissertations and Theses

The purpose of the present study was to determine the correlation between expressive language delay in children and their gross and fine motor skills. Twenty children five years through six years, eleven months with a diagnosed expressive language delay, were selected to participate in the study. Each was screened on the basis of normal hearing, receptive vocabulary skills, motor functioning, and an expressive language delay of one year or more. After screening procedures, each child was administered the Preschool Language Scale-PLS (Zimmerman, et al., 1969) and the short form of the Bruininks-Oseretsky Test of Motor Proficiency-BOMP (Bruininks, 1978). …

Longitudinal Pantothenic Acid Status Of Pregnant And Lactating Women, Won Oack Song

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Pantothenic acid nutritional status was evaluated in a cohort of twenty-nine Caucasian pregnant women, aged 20-35, during their third trimester of pregnancy, at two-weeks postpartum and at three months postpartum. Seventeen non-pregnant, non-lactating women who had similar demographic backgrounds as the pregnant women were selected as a control group and followed the same experimental schedule as the pregnant women. A fasting blood sample, two days 24-h urine specimens and diet record were obtained for each of two days from each subject at each period.

The mean dietary pantothenic acid intakes of the women during pregnancy (5.30±1.74 mg/day) and during lactation …

Human Performance Lab, Vol. 3, No. 1, St. Cloud State University

Human Performance Lab Newsletter

Contents of this issue include:

• Minnesota Life Expectancy Beats the Nation
• Lowering the Slope of the Hill
• Where There's Smoke, There's a Rat! By Art Buchwald
• Rise and Shine by Bev Oehrlein, Graduate Assistant

Evidence For Hydrated Spermidine-Calf Thymus Dna Toruses Organized By Circumferential Dna Wrapping, Kenneth A. Marx, George C. Ruben

Dartmouth Scholarship

In spermidine-condensed calf thymus DNA preparations, torus–shaped condensates were shown by transmission electron microscopy to exist under the hydrated conditions of the freeze fracture experiment. Using extremely low Pt metal deposition levels (9 A Pt/C) high–contrast replicas of the spermidine–DNA toruses were obtained that showed circumferential wrapping of single DNA double helix–size surface fibres. Stereoscopic analysis of high magnification stereomicrographs established some details of the three-dimensional organization of two DNA double helix sections winding circumferentially on the inner surface of one such torus. These measurements demonstrate the usefulness of stereoscopic analysis of these high macromolecular organization magnification. Measurements on a …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Regional Acceleratory Phenomenon: A Review, Harold M. Frost

Henry Ford Hospital Medical Journal

The regional acceleratory phenomenon (RAP) is a complex reaction of mammalian tissues to diverse noxious stimuli. The phenomenon occurs regionally in the anatomical sense, involves both soft and hard tissues, and is characterized by an acceleration and domination of most ongoing normal vital tissue processes. It may represent an "SOS" mechanism which evolved to potentiate tissue healing and local tissue defensive reactions. When a RAP is obtunded, retarded healing and lowered resistance to infection and mechanical abuse may ensue. When ignored in experimental design, the phenomenon can seriously perturb studies of metabolic bone disease and of the effects of mechanical, …

Endoscopic Sclerotherapy In The Treatment Of Recurrent Bleeding From Esophageal Varices, Martin C. Zonca, Dominic K. H. Wong, Surinder K. Batra, Bernard M. Schuman

Henry Ford Hospital Medical Journal

Endoscopic sclerotherapy as a method to treat bleeding esophageal varices was first performed by Crafoord and Erenckner in 1939 but was not widely accepted. Surgical therapy, using the portocaval shunt, became the preferred method of preventing hemorrhage from bleeding varices. Over the years, enthusiasm for the surgical approach has waned because the mortality rate with certain patients is prohibitively high. Conversely, interest in endoscopic sclerotherapy is growing as a result of several favorable reports. We present our initial experience with this procedure in the management of patients with bleeding esophageal varices.

Management Of Colonic Trauma: Six-Year Experience At Henry Ford Hospital, Farouck N. Obeid, Victor Sorensen, Gilford Vincent, Deepak Vij, H. Mathilda Horst, D. Paul Horan

Henry Ford Hospital Medical Journal

Surgical management of 114 patients with colonic injuries related to trauma who were treated over a six-year period is reviewed. Eighty-three (73%) injuries were secondary to gunshot wounds. Twenty-six patients (24%) had isolated colonic injuries. The majority of patients (60%)) were treated with colostomies: exteriorization of the injury, repair with proximal colostomy, or resection with colostomy and mucous fistula. Exteriorization of repaired colon, primary repair, and resection with primary anastomosis were performed in 40% of the patients. Six patients (5.3%) in our series died, and 24% had complications directly related to the colon injury. Based on this study, no standard …

The Other Breast: Indications For Biopsy And/Or Mastectomy, Charles S. Rogers

Henry Ford Hospital Medical Journal

A search for malignant and premalignant lesions in 162 contralateral biopsy and/or mastectomy specimens yielded 45 (27.8%,) malignancies and 54 (33%) premalignant lesions (atypical epithelial hyperplasia, Wellings grades III and IV). In those with no palpable or mammographic suspicion of malignancy, the cancer incidence was 73.8%. Eight malignancies occurred one month to three years after antecedent biopsies which revealed premalignant lesions. No cancer has been detected after biopsies which revealed hyperplasia of grade II or less. Cancer size at time of discovery varied significantly with the method of detection: average 2.7 cm by palpation; 1.6 cm by mammography; 0.5 cm …

Current Concepts In Otitis Media, Michael M. Paparella

Henry Ford Hospital Medical Journal

Otitis media continues to be a common and disabling problem which has become, in recent years, a fertile area for research. Based on studies in animals and humans, otitis media is classified into four groups: acute purulent otitis media (POM), serous otitis media (SOM), and mucoid or secretory otitis media (MOM). Together, these are referred to as otitis media with effusion (OME). The types can overlap and evolve into another type to become chronic otitis media and mastoiditis, characterized by the presence of granulation tissue or cholesteatoma. The biochemistry, microbiology, and pathology as well as clinical features of the disease …

Clinical Note: Excision Of A Large Ovarian Leiomyoma In A Centenarian, James A. Sapala, M. Andrew Sapala

Henry Ford Hospital Medical Journal

Leiomyoma of the ovary is a rare neoplasm; only 28 cases in the literature are known to us. In 1979, we encountered a tumor of this type and are reporting it here because of its great size and its occurrence in a 103-year-old woman. The patient has been well for two years since the tumor was removed.

How Useful Is Peritoneal Lavage Amylase?, Eugene Meyer, James C. Gruenberg

Henry Ford Hospital Medical Journal

Prospectively for 23 months, 289 patients with penetrating and 317 patients with blunt trauma to the lower chest and/or abdomen had amylase determinations in the peritoneal lavage as part of their initial evaluation. In nine (1.5%) of the 606 patients, the amylase in the lavage was higher than normal serum values and, when elevated, it identified intra-abdominal injury. Intra-abdominal injuries usually involved a hollow viscus injury—either isolated or combined with solid organ injuries—rather than pancreatic injury. Although elevation of the lavage amylase was a reliable indication of intra-abdominal injury in this series, we feel that routine use of this test …

The Role Of Splenectomy In Endocarditis, Donald J. Magilligan Jr., Edward L. Quinn

Henry Ford Hospital Medical Journal

Five patients with endocarditis, persistent sepsis, and positive liver-spleen scans underwent splenectomy. Three had splenectomy performed concomitantly with cardiac valve replacement, one after valve replacement and one as an isolated procedure. Four of five spleens contained abscesses, and bacterial cultures of two were positive. Histologic study of one spleen revealed splenitis. All patients improved after splenectomy, and all are well two to twenty months postoperatively. An aggressive approach to splenic abscess in endocarditis may lead to reduced mortality from bacterial endocarditis and infected prosthetic valves.

Therapeutic Hemapheresis, Sheikh M. Saeed, B. K. S. Raman

Henry Ford Hospital Medical Journal

No abstract provided.

Conformational Analysis Of Nonsteroidal Estrogen Analogs, Robert N. Spady

Loma Linda University Electronic Theses, Dissertations & Projects

In target tissue, estrogens initiate a series of events, ending in protein synthesis, by binding to a cytoplasmic receptor. Once the estrogen binds, the receptor complex is activated--a process including dimerization of the estrogen complex with another subunit. In order to study the possible receptor-ligand interactions, conformational analysis was performed on several nonsteroidal estrogen analogs, using the CAMSEQ8 molecular mechanics program.

The probability that a molecule will exist in a given conformational energy well depends both on the energy and the shape of the well. A method has been previously worked out to calculate probabilities using both of these variables, …

The Acquired Double Pylorus, Klaus Anselm, Arthur H. Halprin

Henry Ford Hospital Medical Journal

Four patients with the double pylorus are reported. In view of an earlier history of peptic ulcer disease, the double pylorus is considered to have been acquired in all four. The literature involving 54 reported cases is reviewed, and the natural history of the double pylorus is discussed.

The Role Of Major Hepatic Resections For Liver Metastases From Colorectal Cancer, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

Of the more than 120,000 new patients with colorectal cancer in 1982, at least 20% will develop liver metastases either at initial presentation or after treatment of the primary lesion. The median survival in such patients has been variously estimated at between five and nine months, and in spite of treatment by chemotherapeutic agents, only rarely do such patients survive five years. By contrast, patients who survive the longest after treatment of liver metastases from colorectal cancer have had major hepatic resections alone or combined with chemotherapy as part of their management. The present report describes five patients who were …

Editorials

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Life History Of The Lahontan Cutthroat Trout, Salmo Clarki Henshawi, In Pyramid Lake, Nevada, William F. Sigler, William T. Helm, Paul A. Kucera, Steven Vigg, Gar W. Workman

Great Basin Naturalist

The Pyramid Lake Lahontan cutthroat trout (Salmo clarki henshawi) population was sampled on a monthly basis from November 1975 through December 1977. A subsample of 676 trout, stratified by fish size and lake habitat, provided biological data. The entire population is presently derived from hatchery production, stocked at lengths of approximately 75 to 300 mm. Peak annulus formation occurs in March and April, followed by the period of maximum growth. Scale patterns illustrate a variable growing season. Maximum growth in length is in the first three years of life; after that males begin to grow faster than females. …

Foliar Diseases Of Wheat, A. G. P. Brown

Experimental Summaries - Plant Research

Leaf disease in the wheatbelt. Wheat leaf diseases were common north of Perth. They were severe in the Moora district and catastrophic in the northern wheatbelt. Yellow spot (Pyrenophora tritici-repentis) and glume blotch (Septoria nodorum) were the major pathogens in most areas with yellow spot exceeding glume blotch in area of leaf affected for the first time since surveys began in 1971. In the south dry conditions prevailed and diseases were hard to find. Figure 1 gives the distribution in the various zones for 1983 excluding the Esperance district which was not surveyed. Stress damage induced mostly by water stress …

Barley Foliage Diseases, T N. Khan, K. Brain, M Judges

Experimental Summaries - Plant Research

General comments and highlights

Scald: Effect of time of application - 83BA10, 83MT9.

Scald: Effect of rate of fungicide – 83BA11.

Scald: Comparing fungicides – 83BA42.

Scald: Effect of seeding rate – 83BA12, 83MT10.

Scald: Response to fungicide in farmer's field – 83AL18, 83AL81, 83AL82.

Scald: Variation in pathogenicity – 83AB11, 83BA13, 83MT11, 83WH7.

Scald: Cultivar x fungicide in farmer's field – 83LG63.

Net Blotch: Potential yield losses – 83A15, 83BA15, 83WH6.

Net Blotch: Screening new fungicides – 83BA43.

Spot-type net blotch: Potential yield losses – 83C5.

Spot-type net blotch: Sources of resistance - Chapman Research Station, Nabawa.

Powdery mildew …

Lupin Diseases, P Mcr Wood

Experimental Summaries - Plant Research

Fungicide treatment of lupin seed - 83GE45, 83GE46, 83GE47. Fungicide treatment of lupin seed in polyculture - 83NO48, 83BU21. Levels of Pleiochaeta in different organic fractions - 83AL51 (2 sites). Phomopsis levels on post-harvest samples - 83AL51.

Thoughtful Use Of Animals, Hyram Kitchen

Experimentation Collection

As part of a symposium held in Cincinnati entitled, "Ethical Issues Related to the Use of Research Animals," I was asked by the program director to consider whether further legislation regarding the use of animals might be necessary to ensure more thoughtful use of animals at universities. The following is my response.