Life Sciences Commons^™

Evaluación De Impacto Ambiental En El Proyecto Red De Huertas Urbanas En Localidad Rafael Uribe Uribe De Bogotá D.C, Andrés Felipe Pinto Arias, René Alejandro Aguilar Díaz

Ingeniería Ambiental y Sanitaria

La siguiente investigación tiene por objeto realizar la evaluación de impacto ambiental EIA de la RED huertas agroecológicas de la localidad de Rafael Uribe Uribe de Bogotá D.C, para esto se inició un marco teórico de las huertas urbanas y agroecológicas en diferentes países de América latina , su incidencia y el debate teórico entre el modelo actual de desarrollo agrícola desarrollado por la revolución verde y el de la propuesta del modelo de desarrollo alternativo agroecológico, en donde se definió que sus principales debates se centran en los impactos negativos que genera por medio de la agricultura industrial e …

Tibial Strains And Tray-Bone Micromotions After Total Knee Arthroplasty: Computational Studies Evaluating The Tibial Fixation, Huizhou Yang

Electronic Theses and Dissertations

Cemented and cementless fixation in total knee arthroplasty (TKA) have been successfully used for decades. As the number of younger and more active patients treated with TKA continues to increase, long-term implant survivorship is of increasing importance. One of the most common complications and hence the reason for revision is mechanical loosening (23.1% of all revised TKA). The loosening mechanisms have been proposed for different fixation types. For cemented fixation, bone remodeling after surgery is regulated by the changes in strain energy density (SED). The recruitment of osteoclasts and osteoblasts is controlled by SED-related signals. Insufficient stimuli can promote bone …

Impact Of Hemodynamic Vortex Spatial And Temporal Characteristics On Analysis Of Intracranial Aneurysms, Kevin W. Sunderland

Dissertations, Master's Theses and Master's Reports

Subarachnoid hemorrhage is a potentially devastating pathological condition in which bleeding occurs into the space surrounding the brain. One of the prominent sources of subarachnoid hemorrhage are intracranial aneurysms (IA): degenerative, irregular expansions of area(s) of the cerebral vasculature. In the event of IA rupture, the resultant subarachnoid hemorrhage ends in patient mortality occurring in ~50% of cases, with survivors enduring significant neurological damage with physical or cognitive impairment. The seriousness of IA rupture drives a degree of clinical interest in understanding these conditions that promote both the development and possible rupture of the vascular malformations. Current metrics for the …

Stobe Photography Mapping Of Cell Membrane Potential With Nanosecond Resolution, Allen S. Kiester, Bennett L. Ibey, Zachary N. Coker, Andrei G. Pakhomov, Joel N. Bixler

Bioelectrics Publications

The ability to directly observe membrane potential charging dynamics across a full microscopic field of view is vital for understanding interactions between a biological system and a given electrical stimulus. Accurate empirical knowledge of cell membrane electrodynamics will enable validation of fundamental hypotheses posited by the single shell model, which includes the degree of voltage change across a membrane and cellular sensitivity to external electric field non-uniformity and directionality. To this end, we have developed a high-speed strobe microscopy system with a time resolution of ~ 6 ns that allows us to acquire time-sequential data for temporally repeatable events (non-injurious …

Analysis Of Modern Barn Design, Gunther Soehnlen

Williams Honors College, Honors Research Projects

The agriculture industry is always changing. Barn structures are one of the most important aspects of the agriculture industry. As the agriculture industry changes, so does the design and construction of barns. There are many types of barns, but over the last 300 years four of the most prevalent types have been the Bank Barn, Open Span Truss Barn, Hoop Barn, and Transverse Frame Barn. The Bank Barn and Transverse Frame Barn have been popularly built for over 200 years. The Hoop Barn and the Open Span Truss Barn have been recently introduced to the industry, becoming popular within the …

An Enumeration Of Nested Networks, Nathan Cornelius

Williams Honors College, Honors Research Projects

Nested networks have several applications in phylogenetics and electrical circuit theory. In many cases, there may exist more than one distinct network which correctly models a given data set. This proposes a combinatorial problem to determine all possible network solutions. In this paper, we partially solve this problem by developing exponential generating functions which enumerate all 1-nested and 2-nested unicyclic networks. We also describe our procedure to directly count all 1-nested and 2-nested networks and provide all 1-nested networks with 7, 8, and 9 terminal nodes.

Comparison Of Static And Active Downforce On Corn At The Kansas River Valley Experiment Field In 2020, E. A. Adee

Kansas Agricultural Experiment Station Research Reports

Uniformity of plant spacing and emergence have been shown to be significant contributing factors to increasing corn yields. Improved seed meters that offer very precise seed drop have been available on planters for a number of years. However, uniformity in plant emergence continues to be a challenge, especially with reduction of tillage and in fields with variable soils. Correct, consistent depth is critical for uniform corn emergence. By keeping the gauge wheels on the ground, consistent depth is achieved. An active downforce system, such as Precision Planting’s DeltaForce, applies hydraulic downforce or lift to the row unit. With a Precision …

Laboratory Calibration Of The Spectrum Field Scout Tdr 300, W. Dyer, D. Bremer, P. Rossini, M. Stone, A. Patrignani

Kansas Agricultural Experiment Station Research Reports

Soil moisture sensors (SMSs) are a useful tool that aid in data-driven water management decisions. However, default factory calibrations can be inaccurate and soil-specific calibrations are often required to obtain higher accuracy in the determination of soil water storage and plant available water. In this study, we conducted a lab calibration for the Field Scout TDR 300, which is a popular SMS used in the turfgrass industry. Five soils of different soil textural classes were packed in containers with known soil moisture for the laboratory calibration. The logarithmic model best fit the data for the course- and fine-textured soils, with …

Plasma-Treated Solutions (Pts) In Cancer Therapy, Hiromasa Tanaka, Sander Bekeschus, Dayun Yan, Masaru Hori, Michael Keidar, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Cold physical plasma is a partially ionized gas generating various reactive oxygen and nitrogen species (ROS/RNS) simultaneously. ROS/RNS have therapeutic effects when applied to cells and tissues either directly from the plasma or via exposure to solutions that have been treated beforehand using plasma processes. This review addresses the challenges and opportunities of plasma-treated solutions (PTSs) for cancer treatment. These PTSs include plasma-treated cell culture media in experimental research as well as clinically approved solutions such as saline and Ringer’s lactate, which, in principle, already qualify for testing in therapeutic settings. Several types of cancers were found to succumb to …

Computational Analysis And Prediction Of Intrinsic Disorder And Intrinsic Disorder Functions In Proteins, Akila I. Katuwawala

Theses and Dissertations

COMPUTATIONAL ANALYSIS AND PREDICTION OF INTRINSIC DISORDER AND INTRINSIC DISORDER FUNCTIONS IN PROTEINS

By Akila Imesha Katuwawala

A dissertation submitted in partial fulfillment of the requirements for the degree of Engineering, Doctor of Philosophy with a concentration in Computer Science at Virginia Commonwealth University.

Virginia Commonwealth University, 2021

Director: Lukasz Kurgan, Professor, Department of Computer Science

Proteins, as a fundamental class of biomolecules, have been studied from various perspectives over the past two centuries. The traditional notion is that proteins require fixed and stable three-dimensional structures to carry out biological functions. However, there is mounting evidence regarding a “special” class …

Nature-Inspired Material Strategies Towards Functional Devices, Sayantan Pradhan

Theses and Dissertations

Naturally sourced, renewable biomaterials possess outstanding advantages for a multitude of biomedical applications owing to their biodegradability, biocompatibility, and excellent mechanical properties. Of interest in this dissertation are silk (protein) and chitin (polysaccharide) biopolymers for the fabrication of functional biodevices. One of the major challenges restricting these materials beyond their traditional usage as passive substrate materials is the ability to combine them with high-resolution fabrication techniques. Initial research work is directed towards the fabrication of micropatterned, flexible 2D substrates of silk fibroin and chitin using bench-top photolithographic techniques. Research is focused on imparting electrochemical properties to silk proteins using conducting …

Evaluating Neuromuscular Function Of The Biceps Brachii After Spinal Cord Injury: Assessment Of Voluntary Activation And Motor Evoked Potential Input-Output Curves Using Transcranial Magnetic Stimulation, Thibault Roumengous

Theses and Dissertations

Activation of upper limb muscles is important for independent living after cervical spinal cord injury (SCI) that results in tetraplegia. An emerging, non-invasive approach to address post-SCI muscle weakness is modulation of the nervous system. A long-term goal is to develop neuromodulation techniques to reinnervate (i.e. resupply nerve to) muscle fiber and thereby increase muscle function in individuals with tetraplegia. Towards this goal, developing monitoring techniques to quantify neuromuscular function is needed to better direct neurorehabilitation. Assessment of voluntary activation (VA) is a promising approach because the location of the stimulus can be applied cortically using transcranial magnetic stimulation (TMS) …

Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence

Theses and Dissertations

Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …

Covid-19 And Biocybersecurity's Increasing Role On Defending Forward, Xavier Palmer, Lucas N. Potter, Saltuk Karahan

Electrical & Computer Engineering Faculty Publications

The evolving nature of warfare has been changing with cybersecurity and the use of advanced biotechnology in each aspect of the society is expanding and overlapping with the cyberworld. This intersection, which has been described as “biocybersecurity” (BCS), can become a major front of the 21st-century conflicts. There are three lines of BCS which make it a critical component of overall cybersecurity: (1) cyber operations within the area of BCS have life threatening consequences to a greater extent than other cyber operations, (2) the breach in health-related personal data is a significant tool for fatal attacks, and (3) health-related misinformation …

The Resistive Barrier Discharge: A Brief Review Of The Device And Its Biomedical Applications, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

This paper reviews the principles behind the design and operation of the resistive barrier discharge, a low temperature plasma source that operates at atmospheric pressure. One of the advantages of this plasma source is that it can be operated using either DC or AC high voltages. Plasma generated by the resistive barrier discharge has been used to efficiently inactivate pathogenic microorganisms and to destroy cancer cells. These biomedical applications of low temperature plasma are of great interest because in recent times bacteria developed increased resistance to antibiotics and because present cancer therapies often are accompanied by serious side effects. Low …

Joint Modeling Of Rnaseq And Radiomics Data For Glioma Molecular Characterization And Prediction, Zeina A. Shboul, Norou Diawara, Arastoo Vossough, James Y. Chen, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

RNA sequencing (RNAseq) is a recent technology that profiles gene expression by measuring the relative frequency of the RNAseq reads. RNAseq read counts data is increasingly used in oncologic care and while radiology features (radiomics) have also been gaining utility in radiology practice such as disease diagnosis, monitoring, and treatment planning. However, contemporary literature lacks appropriate RNA-radiomics (henceforth, radiogenomics) joint modeling where RNAseq distribution is adaptive and also preserves the nature of RNAseq read counts data for glioma grading and prediction. The Negative Binomial (NB) distribution may be useful to model RNAseq read counts data that addresses potential shortcomings. …

Bibliometric Review On Image Based Plant Phenotyping, Shrikrishna Ulhas Kolhar, Jayant Jagtap

Library Philosophy and Practice (e-journal)

Plant phenotyping is a quantitative description of structural, physiological and temporal traits of plants resulting from interaction of plant genotypes with the environment. A rapid development is in progress in the field of image-based plant phenotyping. Plant phenotyping has wide range of applications in plant breeding research, plant growth prediction, biotic and abiotic stress analysis, crop management and early disease detection. The main motive is to provide detailed bibliometric review in order to know the available literature and current research trends in the area of plant phenotyping using plant images. The bibliometric analysis is primarily based on Scopus, web of …

Investigating The Antitumor Effects Of A Dsrna-Nanoparticle Complex In An In Vitro Ovarian Cancer Model, Aaron Lewis

Theses and Dissertations (Comprehensive)

An estimated 1 in 70 women will be diagnosed with ovarian cancer in their lifetime. Despite advanced detection and treatment methods, it remains a silent killer with an expected survival rate of 50%. A developing method in cancer treatment is the use of compounds that stimulate the immune system to aid in the body's fight against the disease. This project focused on the use of the potent immune stimulant double-stranded RNA (dsRNA), commercially available as polyinosinic:polycytidylic acid, poly(I:C), to induce cytotoxicity in two ovarian cancer cell lines; SKOV-3 and OVCAR-3. Some challenges exist with the delivery of dsRNA due to …

Optimisation Of Grass Measurement Technologies Through Field Experimentation And Numerical Simulation Methods, Darren Joseph Murphy

Theses

Maximising pasture utilisation through optimal grassland management is vital in terms of ensuring the economic sustainability and mitigating the environmental impact of both Irish and global pasture-based livestock production. Frequent and accurate measurement of grass quantity and quality is one of the main methods of maximising grass production and utilisation on pasture-based farms. The most prominent grass measurement tool used on Irish pasture is the rising plate meter (RPM), however, there are a range of issues with this method including operator bias, precision and difficulties in accounting for spatial variation. Currently, there is no definitive protocol for grass measurement which …