Life Sciences Commons^™

Processes Driving The Networked Economy, Amit P. Sheth, Will Van Der Aalst, I. Budak Arpinar

Kno.e.sis Publications

The authors propose that an organic workflow-process technology will power the evolution of information system architectures. The authors outline three likely stages of architectural evolution in the context of a networked economy and discuss critical gaps in the current technology with respect to their envisioned future.

Logical Information Modeling Of Web-Accessible Heterogeneous Digital Assets, Kshitij Shah, Amit P. Sheth

Kno.e.sis Publications

This paper introduces the MREF framework for representing and correlating information at a higher semantic level than is possible with Web-based information systems today. The role that metadata plays in this framework is described, together with a metadata based infrastructure to support our media independent information correlation paradigm. To keep it consistent with evolving standards, broader acceptance and ease of implementation, MREF abstraction is structured on top of RDF and XML. Its central role in the context of the InfoQuilt system, for exploiting heterogeneous digital media using a federated and scalable architecture, is briefly described.

Zebra Image Access System, Srilekha Mudumbai, Kshitij Shah, Amit P. Sheth, Krishnan Parasuraman, Clemens Bertram

Kno.e.sis Publications

The ZEBRA system, which is part of the VisualHarness platform for managing heterogeneous data, supports three types of access to distributed image repositories: keyword based, attribute based, and image content based. A user can assign different weights (relative importance) to each of the three types, and within the last type of access, to each of the image properties. The image based access component (IBAC) supports access based on computable image properties such as those based on spatial domain, frequency domain or statistical and structural analysis. However, it uses a novel black box approach of utilizing a Visual Information Retrieval (VIR) …

Strictly Level-Decreasing Logic Programs, Pascal Hitzler, Anthony K. Seda

Computer Science and Engineering Faculty Publications

We study strictly level-decreasing logic programs (sld-programs) as defined earlier by the present authors. It will be seen that sld-programs, unlike most other classes of logic programs, have both a highly intuitive declarative semantics, given as a unique supported model, and are computationally adequate in the sense that every partial recursive function can be represented by some sld-program P. Allowing for a safe use of cuts, an interpreter based on SLDNF-resolution, as implemented for example in standard Prolog systems, is shown to be sound and complete with respect to this class of programs. Furthermore, we study connections between topological …

Interestingness Of Discovered Association Rules In Terms Of Neighborhood-Based Unexpectedness, Guozhu Dong, Jinyan Li

Kno.e.sis Publications

One of the central problems in knowledge discovery is the development of good measures of interestingness of discovered patterns. With such measures, a user needs to manually examine only the more interesting rules, instead of each of a large number of mined rules. Previous proposals of such measures include rule templates, minimal rule cover, actionability, and unexpectedness in the statistical sense or against user beliefs.

In this paper we will introduce neighborhood-based interestingness by considering unexpectedness in terms of neighborhood-based parameters. We first present some novel notions of distance between rules and of neighborhood of rules. The neighborhood-based interestingness of …

Web Browser As Medical Educator/Researcher Using Html & Javascript, Craig W. Johnson, George Oser, Allan J. Abedor

Faculty, Staff and Student Publications

No abstract provided.

Phosphorylation Of Elongation Factor 1 And Ribosomal Protein S6 By Multipotential S6 Kinase And Insulin Stimulation Of Translational Elongation, Y W Chang, J A Traugh

Faculty, Staff and Student Publications

Stimulation of protein synthesis in response to insulin is concomitant with increased phosphorylation of initiation factors 4B and 4G and ribosomal protein S6 (Morley, S. J., and Traugh, J. A. (1993) Biochimie 75, 985-989) and is due at least in part to multipotential S6 kinase. When elongation factor 1 (EF-1) from rabbit reticulocytes was examined as substrate for multipotential S6 kinase, up to 1 mol/mol of phosphate was incorporated into the alpha, beta, and delta subunits. Phosphorylation of EF-1 resulted in a 2-2. 6-fold stimulation of EF-1 activity, as measured by poly(U)-directed polyphenylalanine synthesis. The rate of elongation was also …

From Contemporary Workflow Process Automation To Adaptive And Dynamic Work Activity Coordination And Collaboration, Amit P. Sheth

Kno.e.sis Publications

The article outlines a research agenda for researchers in the area of workflow. We believe that today's workflow systems should evolve to what is termed as work coordination and collaboration systems (WCCSs). A WCCS will: (a) adapt to various changes in the organization (including its interactions with external organizations) and the organizational processes by being able to change the process definitions as well as change the processes and component activities while they are being enacted or executed; and (b) support a unified framework for managing coordination, collaboration, and information based decision making activities that naturally occur as part of organizational …

A Vhdl-93 Hardware Description Browser, Laura C. Debrock, Krishnaprasad Thirunarayan

Kno.e.sis Publications

This paper describes the design and implementation of the VHDL-93 Hardware Description Browser, which is a tool for the intelligent retrieval of information from VHDL designs. The Browser consists of two UNIX processes: a TCL/TK Graphical User Interface and a Prolog search engine. The GUI elicits queries from the user and submits them to the Prolog search engine via a two-way communication pipe. The search engine satisfies queries by traversing a forest of parse trees corresponding to the associated VHDL designs. The results are then sent to the GUI for posting.

Two public-domain tools were used to implement the Browser: …

The Carnot Heterogeneous Database Project: Implemented Applications, Munindar Singh, Phil Cannata, Michael N. Huhns, Nigel Jacobs, Tomasz Ksiezyk, Kayliang Ong, Amit P. Sheth, Christine Tomlinson, Darrell Woelk

Kno.e.sis Publications

The Carnot project was an ambitious research project in heterogeneous databases. It integrated a variety of techniques to address a wide range of problems in achieving interoperation in heterogeneous environments. Here we describe some of the major implemented applications of this project. These applications concern(a) accessing a legacy scientific database, (b) automating a workflow involving legacy systems, (c) cleaning data, and (d) retrieving semantically appropriate information from structured databases in response to text queries. These applications support scientific decision support, business process management, data integrity enhancement, and analytical decision support, respectively. They demonstrate Carnot‘s capabilities for (a) heterogeneous query processing, …

Characterizing A Portable Subset Of Behavioral Vhdl-93, Krishnaprasad Thirunarayan, Robert Ewing

Kno.e.sis Publications

Goossens defined a structural operational semantics for a subset of VHDL-87 and proved that the parallelism present in VHDL is benign. We extend this work to include VHDL-93 features such as shared variables and postponed processes that change the underlying semantic model. In the presence of shared variables, nondeterministic execution of VHDL-93 processes destroys the unique meaning property. We identify and characterize a class of portable VHDL-93 descriptions for which unique meaning property can be salvaged. Our specification can serve as a correctness criteria for a VHDL-93 simulator.

Some Relationships Between Foies And Sigma 1 1 Arity Hierarchies, Guozhu Dong, Limsoon Wong

Kno.e.sis Publications

No abstract provided.

Structural Issues In Active Rule Systems, James Bailey, Guozhu Dong, Kotagiri Ramamohanarao

Kno.e.sis Publications

Active database systems enhance the functionality of traditional databases through the use of active rules or ‘triggers’. There is little consensus, though, on what components should be included in a rule system. In this paper, the expressive power of some simple active database rule systems is examined and the effect of choosing different features studied. Four important parameters of variation are presented, namely the rule language, the external query language, the meta rule language and the pending rule structure. We show that each of these is highly influential in determining the expressiveness of the rule system as a whole, and …

An Error Handling Framework For The Orbwork Workflow Enactment Service Of Meteor, Davasish Worah, Amit P. Sheth, Krzysztof J. Kochut, John A. Miller

Kno.e.sis Publications

Workflow Management Systems (WFMSs) can be used to re-engineer, streamline, automate, and track organizational processes involving humans and automated information systems. However, the state-of-the-art in workflow technology suffers from a number of limitations that prevent it from being widely used in large-scale mission critical applications. Error handling is one such issue. What makes the task of error handling challenging is the need to deal with errors that appear in various components of a complex distributed application execution environment, including various WFMS components, workflow application tasks of different types, and the heterogeneous computing infrastructure.

In this paper, we discuss a top-down …

Algorithms For Adapting Materialised Views In Data Warehouses, Mukesh Mohania, Guozhu Dong

Kno.e.sis Publications

In this paper we consider the problem of materialised view adaptation in data warehouses. Materialised views are important in data warehousing where they are used to speed up query processing on large amounts of data. User requirements change over time, which may change the definitions of views dynamically. For such situations, the question arises whether the materialised views should be recomputed from scratch for every change in the definition or they should be obtained by adapting old materialised views. Changes to a view definition may be expensive, if the view is recomputed from scratch. Therefore, it is worthwhile to examine …

On The Portability Of Behavioral Vhdl-93, Krishnaprasad Thirunarayan, Robert Ewing

Kno.e.sis Publications

Goossens defined a structural operational semantics for a subset of VHDL-87 and proved that the parallelism present in VHDL is benign. We extend this work to include shared variables in VHDL-93 that changes the underlying semantic model. In the presence of shared variables, non-deterministic execution of VHDL-93 processes destroys the unique meaning property. We identify and characterize a class of portable VHDL-93 descriptions for which unique meaning property can be salvaged.

Managing Multiple Information Sources Through Ontologies: Relationship Between Vocabulary Heterogeneity And Loss Of Information, Eduardo Mena, Vipul Kashyap, Arantza Illarramendi, Amit P. Sheth

Kno.e.sis Publications

The ability to deal with a huge number of independent and heterogeneous repositories is the most critical problem in Global Information Systems. One approach to enable efficient query processing is by utilizing semantic descriptions (organized as ontologies) of such repositories whenever available.

In this context semantic relationships among ontologies can be used Query Processors. Three kind of relationships are considered: synonyms and hypernyms. Using synonyms the semantic of the query is preserved; however, when synonyms are not available and hypernyms or hyponyms are used there exists some loss of information that must be measured.

1: "To Know Ourselves", The U.S. Department Of Energy, The Human Genome Project

Genomics: Past & Future

AT THE END OF THE ROAD in Little Cottonwood Canyon, near Salt Lake City, Alta is a place of near-mythic renown among skiers. In time it may well assume similar status among molecular geneticists. In December 1984, a conference there, co-sponsored by the U.S. Department of Energy, pondered a single question: Does modern DNA research offer a way of detecting tiny genetic mutations—and, in particular, of observing any increase in the mutation rate among the survivors of the Hiroshima and Nagasaki bombings and their descendants? In short the answer was, Not yet. But in an atmosphere of rare intellectual fertility, …

Observer: An Approach For Query Processing In Global Information Systems Based On Interoperation Across Pre-Existing Ontologies, Eduardo Mena, Vipul Kashyap, Amit P. Sheth, Arantza Illarramendi

Kno.e.sis Publications

The huge number of autonomous and heterogeneous data repositories accessible on the “global information infrastructure” makes it impossible for users to be aware of the locations structure/organization, query languages and semantics of the data in various repositories. There is a critical need to complement current browsing, navigational and information retrieval techniques with a strategy that focuses on information content and semantics. In any strategy that focuses on information content, the most critical problem is that of different vocabularies used to describe similar information across domains. We discuss a scalable approach for vocabulary sharing. The objects in the repositories are represented …

Ultrasound Three- Dimensional Velocity Measurements By Feature Tracking, Gregory R. Bashford, Olaf T. Von Ramm

Biomedical Imaging and Biosignal Analysis Laboratory

This article describes a new angle-independent method suitable for three-dimensional (3-D) blood flow velocity measurement that tracks features of the ultrasonic speckle produced by a pulse echo system. In this method, a feature is identified and followed over time to detect motion. Other blood flow velocity measurement methods typically estimate velocity using one- (1-D) or two-dimensional (2-D) spatial and time information. Speckle decorrelation due to motion in the elevation dimension may hinder this estimate of the true 3-D blood flow velocity vector. Feature tracking is a 3-D method with the ability to measure the true blood velocity vector rather than …

Proof Strategies For Hardware Verification, Robert Eastham, Krishnaprasad Thirunarayan

Kno.e.sis Publications

Ascertaining correctness of digital hardware designs through simulation does not scale-up for large designs because of the sheer combinatorics of the problem. Formal verification of hardware designs holds promise because its computational complexity is of the order of number of different types of components (and not number of components in the design). This approach requires the specification of the behavior and the design in a formal language, and reason with them using a theorem prover. In this paper we attempt to develop a methodology for writing and using these specifications for some important classes of hardware circuits. We examine digital …

Chaos And Detection, Andrew M. Fraser

Complex Systems Faculty Publications and Presentations

I report on numerical experiments in which a detector reliably found chaotic signals at signal to noise ratios as low as -15 dB. The detector was based on a variant of the hidden Markov models used in speech research. The task was particularly difficult because the Fourier power spectrum of the noise was constructed to match the spectrum of the signal. I review likelihood ratio detectors, limitations on the performance of linear models implied by the broad Fourier power spectra of chaotic signals, and the upper limit that the Kolmogorov-Sinai (KS) entropy of a chaotic system places on the expected …

Semantic And Schematic Similarities Between Database Objects: A Context-Based Approach, Vipul Kashyap, Amit P. Sheth

Kno.e.sis Publications

In a multidatabase system, schematic conflicts between two objects are usually of interest only when the objects have some semantic similarity. We use the concept of semantic proximity, which is essentially an abstraction/mapping between the domains of the two objects associated with the context of comparison. An explicit though partial context representation is proposed and the specificity relationship between contexts is defined. The contexts are organized as a meet semi-lattice and associated operations like the greatest lower bound are defined. The context of comparison and the type of abstractions used to relate the two objects form the basis of a …

Spieltheorie, Alexander Chocholaty, Pascal Hitzler

Computer Science and Engineering Faculty Publications

No abstract provided.

Simulation Modeling Within Workflow Technology, John A. Miller, Amit P. Sheth, Krzysztof J. Kochut, Xuzhong Wang, Arun Murugan

Kno.e.sis Publications

This paper presents an approach for integrating simulation modeling and analysis capabilities within the workflow management system (WFMS) being developed in the Large Scale Distributed Information Systems (LSDIS) Lab at the University of Georgia. Simulation modeling can be used for studying the efficiency of workflow designs as well as studying the general performance and reliability of WFMSs. We also discuss the importance of using sophisticated monitoring and animation capabilities, and the use of workflow management technology to advance simulation technology itself. Finally, we demonstrate a sample simulation where tasks and task managers are simulated.

On The Equivalence Of Upward And Downward Inheritance Reasoners, Krishnaprasad Thirunarayan

Kno.e.sis Publications

In this paper, we analyze systematically the downward (property flow) and the upward (individual flow) views of inheritance for different categories of inheritance networks. We observe that both these views assign the same meaning to tree-structured hierarchies, and explain the divergence in the interpretation of more general networks in terms of their expressive power. This simple analysis sheds light on the inherent nature of nonmonotonic inheritance and can form the basis for the design of efficient algorithms for certain classes of queries. In addition, we describe the notion of preferential inheritance to specify additional conflict resolution information that can be …

Power Systems Marginal Cost Curve And Its Applications, Shaojun Wang, S. M. Shahidehpour, Nian-De Xiang

Kno.e.sis Publications

This paper presents a forward recursive procedure to calculate the expected system marginal cost curve (EMC). The EMC formulation allows for multi-state and multi-block dispatch of generating units and is used to determine the optimal energy of pumped-storage units. A new approach is developed to compute the first and second derivatives of the expected generation energy of a thermal unit with respect to the capacity of all thermal units in the system. The salient feature of the proposed approach is that it applies to hydro-thermal systems with multiple limited-energy hydro units.

Predicting Conserved Water-Mediated Interactions In Protein Active Sites, Michael L. Raymer, Sridhar Venkataraman, William F. Punch, Erik D. Goodman, Brenda Kuhn

Kno.e.sis Publications

No abstract provided.

A Meta-Interpreter For Circuit-Extraction, Krishnaprasad Thirunarayan

Kno.e.sis Publications

The design of a VLSI circuit consists of a description of the circuit in terms of its components and subcomponents, at various levels of detail. To verify that the layout of a VLSI circuit conforms to its design, one needs to work backwards from the lowest-level description of the circuit and recognize the higher-level components it constitutes. This paper is concerned with the application of logic programming techniques in the formal verification of the structural correctness of the VLSI circuit layouts. In particular, we review Michael Dukes' Generalized Extraction System (1990) that compiles design descriptions into a set of extraction …

Nonrecursive Incremental Evaluation Of Datalog Queries, Guozhu Dong, Jianwen Su, Rodney Topor

Kno.e.sis Publications

We consider the problem of repeatedly evaluating the same (computationally expensive) query to a database that is being updated between successive query requests. In this situation, it should be possible to use the difference between successive database states and the answer to the query in one state to reduce the cost of evaluating the query in the next state. We use nonrecursive Datalog (which are unions of conjunctive queries) to compute the differences, and call this process “incremental query evaluation using conjunctive queries”. After formalizing the notion of incremental query evaluation using conjunctive queries, we give an algorithm that constructs, …