Operations Research, Systems Engineering and Industrial Engineering Commons^™

Purification Of A Recombinant Heavy Chain Fragment C Vaccine Candidate Against Botulinum Serotype C Neurotoxin [Rbontc(HC)] Expressed In Pichia Pastoris, Michael P. Dux, Jicai Huang, Rick Barent, Mehmet Inan, S. Todd Swanson, Jayanta Sinha, John T. Ross, Leonard A. Smith, Theresa J. Smith, Ian Henderson, Michael M. Meagher

United States Army: Publications

A purification process for the manufacture of a recombinant C-terminus heavy chain fragment from botulinum neurotoxin serotype C [rBoNTC(H_c)], a potential vaccine candidate, has been defined and successfully scaled-up. The rBoNTC(H_c) was produced intracellularly in Pichia pastoris X-33 using a three step fermentation process, i.e., glycerol batch phase, a glycerol fed-batch phase to achieve high cell densities, followed by a methanol induction phase. The rBoNTC(H_c) was captured from the soluble protein fraction of cell lysate using hydrophobic charge induction chromatography (HCIC; MEP HyperCel™), and then further purified using a CM 650M ion exchange chromatography …

The Role Of Conflict Management On Virtual Team Performance And Satisfaction, Pilar Pazos, Anil Ustun, Rolando Delaguila

Engineering Management & Systems Engineering Faculty Publications

The role that input factors from project planning processes play on conflict emergence and conflict resolution in virtual teams is not well understood. Of particular interest for this paper is the role that factors during planning stages play in preventing interpersonal conflict, supporting conflict resolution and ultimately enhancing team outcomes in virtual team settings. This study examines the relationships among commitment to team goals, conflict management and team outcomes in virtual teams. First we provide an in depth review of relevant empirical findings. Next, we describe a study examining the relationships between three sets of variables: 1) goal commitment, 2) …

Process Modeling System For Press Cure, Closed-Cavity Tooled Thick Composites, Arven H. Saunders

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Thick structural composite parts often use press curing with closed-cavity tooling for achieving dimensional tolerances. A commonly encountered defect for these parts is fiber waviness, whick limits its structural strength. The yield for such parts often suffers due to trial and error methods used to develop successful cure processes. In addition, yield for these parts suffers due to material variation. The objectives of this research were to: develop and validate a simplified yet practical cure process model for press cured thick composite parts, utilize the model in order to seek time-efficient optimized cure processes, investigate the effects of material variation …

Improving Throughput And Predictability Of High-Volume Business Processes Through Embedded Modeling, Joseph S. Dekeyrel

Electronic Theses and Dissertations

Being faster is good. Being predictable is better. A faithful model of a system, loaded to reflect the system's current state, can then be used to look into the future and predict performance. Building faithful models of processes with high degrees of uncertainty can be very challenging, especially where this uncertainty exists in terms of processing times, queuing behavior and re-work rates. Within the context of an electronic, multi-tiered workflow management system (WFMS) the author builds such a model to endogenously quote due dates. A WFMS that manages business objects can be recast as a flexible flow shop in which …

Models For Evaluation Of Supply Chain Risk With Application To Healthcare Management, Ford Guangfu Zeng

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Over the past two decades, supply chain management has come to be a key component of organization competitiveness and effectiveness. In the same period, most organizations have put a great deal of effort into improving their own and their supplier's supply chain performance. To a large extent, much of this effort has been aimed at improving the efficiency of supply chain operations. However, organizations have ignored or played down the risks from supply chain disruptions when developing supply strategies, which focus on cost reduction. It is proposed, therefore, that one such standard measure should measure the risk involved with organizations …

Mathematical Optimization Techniques For Managing Selective Catalytic Reduction For Coal-Fired Power Plants, Passakorn Phananiramai

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Coal is one of the most important energy sources in the U.S. However, it is also one of the biggest air polluters where the major emissions generated from coal combustion are oxides of nitrogen (NOx). NOx leads to ozone formation and make people more susceptible to respiratory illness. The US Environmental Protection Agency (EPA) has steadily tightened the regulation for NOx emissions that can be discharged into the atmosphere. Many techniques and technologies can all assist with NOx removal. However, to meet upcoming EPA mandates, more aggressive technique such as Selective Catalytic Reduction (SCR) is highly recommended. SCR is an …

Design Of The Layout Of A Manufacturing Facility With A Closed Loop Conveyor With Shortcuts Using Queueing Theory And Genetic Algorithms, Vernet Michael Lasrado

Electronic Theses and Dissertations

With the ongoing technology battles and price wars in today's competitive economy, every company is looking for an advantage over its peers. A particular choice of facility layout can have a significant impact on the ability of a company to maintain lower operational expenses under uncertain economic conditions. It is known that systems with less congestion have lower operational costs. Traditionally, manufacturing facility layout problem methods aim at minimizing the total distance traveled, the material handling cost, or the time in the system (based on distance traveled at a specific speed). The proposed methodology solves the looped layout design problem …

A Model To Integrate Sustainability Into The User-Centered Design Process, Adrienne Shevonne Brown

Electronic Theses and Dissertations

With concerns for the environment becoming more prevalent in business and the government, it is increasingly important to re-evaluate and update processes to include sustainability considerations early in the design process. In response to this charge, this research effort was designed to integrate sustainability factors into the usercentered design process. The results of this research highlight the benefits of sustainability requirement planning, as well as those derived from integrating sustainability into the current user-centered design model

A Framework For Quantifying Sustainability Of Lean Implementation In Healthcare Organizations, Haitham Ahmed Bahaitham

Electronic Theses and Dissertations

Due to the remarkable positive effect of lean adoption in various firms in the manufacturing sector, it has been adopted by several organizations within the healthcare industry. Although the rate of adopting lean by hospitals in the developed countries is slower than it should be, it proved to be effective in helping healthcare organizations maintain or even improve their quality of care while containing their related costs. However, such adoption did not take place until the beginning of the new millennium. And with such adoption, it has been accompanied with major challenges related to proper lean implementation, sustainability of achieved …

Dynamic Routing On Stochastic Time-Dependent Networks Using Real-Time Information, Ali R. Guner

Wayne State University Dissertations

In just-in-time (JIT) manufacturing environments, on-time delivery is one of the key performance measures for dispatching and routing of freight vehicles. Both the travel time delay and its variability impact the efficiency of JIT logistics operations, that are becoming more and more common in many industries, and in particular, the automotive industry. In this dissertation, we first propose a framework for dynamic routing of a single vehicle on a stochastic time dependent transportation network using real-time information from Intelligent Transportation Systems (ITS). Then, we consider milk-run deliveries with several pickup and delivery destinations subject to time windows under same network …

Modeling And Surveillance Of Pandemic Influenza Outbreaks, Diana Prieto

USF Tampa Graduate Theses and Dissertations

Pandemic outbreaks are unpredictable as to their virus strain, transmissibility, and impact on our quality of life. Hence, the decision support models for mitigation of pandemic outbreaks must be user-friendly and operational, and also incorporate valid estimates of disease transmissibility and severity. This dissertation research is aimed at 1) reviewing the existing pandemic simulation models to identify their implementation gaps with regard to usability and operability, and suggesting research remedies, 2) increasing operability of simulation models by calibrating them via an epidemiological model that estimates infection probabilities using viral shedding profiles of concurrent pandemic and seasonal influenza, and 3) developing …

Cap-And-Trade Modeling And Analysis For Electric Power Generation Systems, Patricio Rocha

USF Tampa Graduate Theses and Dissertations

Cap-and-trade is the most discussed CO₂ emissions control scheme in the U.S. It is a market-based mechanism that has been used previously to successfully reduce the levels of SO₂ and NO_x emitted by power generators. Since electricity generators are responsible for about 40% of the CO₂ emissions in the U.S., the implementation of CO₂ cap-and-trade will have a significant impact on electric power generation systems. In particular, cap-and-trade will influence the investment decisions made by power generators. These decisions in turn, will affect electricity prices and demand. If the allowances (or emission permits) created by …

Mixed Integer Programming Models For Selecting Ground-Level Ozone Control Strategies, Wei-Che Hsu

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Under the Clean Air Act (CAA) in 1990, the U.S Environmental Protection Agency (EPA) was required to set National Ambient Air Quality Standards (NAAQS) for six common air pollutants that are considered harmful to public health and the environment. Ground–level ozone was one of the six criteria pollutants monitored by the EPA and considered the most widespread health threat. Two precursors of ground level ozone are nitrogen oxides (NO_x) and volatile organic compounds (VOC) and the common sources of these two precursors include on–road vehicles, non–road engines, area sources, point sources, and biogenic and miscellaneous sources. An area …

Acuta Enews January 2011 Vol. 40, No. 1

ACUTA Newsletters

In this issue.....

Board approves slate of nominees

From ACUTA headquaters: rebalancing IT for the future.......... Jeri A. Semer, CAE, Executive Dir.

Nominate now for ACUTA Ruth A. Michalecki Leadership Award

Tech Talk: doing more with less, but in a good way........ Kevin Tanzillo, Dux PR

Washington Update Newsletter

Video Surveillance Technology........ Ron Walczak, RCDD, Walczak Techology Consultants

Forensic Tools: keeping up with the bad guys.......... Gary Audin, Delphi, Inc.

Board Report.............. George Denbow, Univ. of Texas, Austin

Thanks to Event Sponsors for 2010

ACUTA 2011 Event Calender

Info links......... Randy Hayes, Univ. of Northern Iowa

Welcome New Members

Check …

Decision Aid Models For Resource Sharing Strategies During Global Influenza Pandemics, Alfredo Santana Reynoso

USF Tampa Graduate Theses and Dissertations

Pandemic influenza outbreaks have historically entailed significant societal and economic disruptions. Today, our quality of life is threatened by our inadequate preparedness for the imminent pandemic. The key challenges we are facing stem from a significant uncertainty in virus epidemiology, limited response resources, inadequate international collaboration, and the lack of appropriate science-based decision support tools. The existing literature falls short of comprehensive models for global pandemic spread and mitigation which incorporate the heterogeneity of the world regions and realistic travel networks. In addition, there exist virtually no studies which quantify the impact of resource sharing strategies among multiple countries. This …

Multivariate Adaptive Regression Spline Based Framework For Statistically Parsimonious Adaptive Dynamic Programming, Subrat Sahu

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Central to Dynamic Programming (DP) is the `cost-to-go' or `future value' function, which is obtained via actually solving the Bellman's equation and central to Approximate Dynamic Programming (ADP) is the use of an approximation of the future value function. The exact DP algorithm seeks to compute and store a table consisting of one cost-to-go value for each point in the state space and its usefulness is limited by the curse of dimensionality, which renders the methodology computationally intractable in the face of real life problems with high dimensional state space and in the face of continuous state variables. ADP methodology …

Life Cycle Inventory Of Hdpe Bottle-Based Liquid Milk Packaging Systems, Jay Singh, Aric Krasowski, S. Paul Singh

Industrial Technology and Packaging

This study aims at providing a relatively straightforward methodology to serve as a decision-making tool when more than one packaging solution could be available to a user. It involves a life cycle inventory (LCI) analysis and comparison of three currently available 3.79 l (1 gallon) packaging systems for liquid milk. Two of the primary container types studied use reusable plastic crates (RPCs) for stacking and shipping,
while the third type is a heavier duty container that does not require secondary shipping containers. The three primary containers studied are identified as original, cube and stackable throughout this paper. The study shows …

A Multiple Performance Analysis Of Market-Capacity Integration Policies, Ahmed M. Deif, Hoda A. Elmaraghy

Industrial Technology and Packaging

A model that uses simulation augmented with Design of Experiments (DOE) is presented to analyse the performance of a Make-to-Order (MTO) reconfigurable manufacturing system with scalable capacity. Unlike the classical capacity scaling policies, the proposed hybrid capacity scaling policy is determined using multiple performance measures that reflect cost, internal stability and responsiveness. The impact of both tactical capacity and marketing policies and their interaction on the overall performance was analysed using DOE techniques and real case data. In addition to the different insights about the trade-offs involved in capacity planning decisions, the presented results challenged the conventional capacity planning wisdoms …

Toward A Technology Management Core: Defining What The Technology Manager Needs To Know, Mark Doggett, Pam Mcgee, Sophia Scott

SEAS Faculty Publications

With the increasing demands on organizations to do “more with less,” and produce acceptable market results, productivity and performance standards continually raise the expectations on competitive success. To meet these expectations, organizations should create learning opportunities that combine the application of technical management skills along with the softer skills involved in people management. Technical managers with little training or past experience with nontechnical skills often perform poorly in technical management positions (Kroecker, 2007). Because this generation lives in a highly technical environment, managers need to be proficient in dealing with knowledge workers and systems; therefore, there is a growing emphasis …

Critical Success Factors In The Re-Engineering Of 21st Century Supply Chains, Edward Sweeney

Practitioner Journals

No abstract provided.

An Integrated Decision Support Framework For Remanufacturing In The Automotive Industry, Akhilesh Kumar

Wayne State University Dissertations

In today's global economy, firms are seeking any and every opportunity to differentiate from competitors by reducing supply chain costs and adding value to end customers. One increasingly popular option, under growing consumer awareness and increasing legislation, is to reintegrate returned products into the supply chain to achieve economic benefits as well as improve sustainability. An important class of such "reverse" goods flows has to do with remanufacturing (reman), which refers to activities that restore returned products ("cores") or their major modules to operational condition for using in place of new product or distributing through other channels (e.g., spare parts). …

Ambient- And High-Temperature Mechanical Properties Of Isochronally Aged Al–0.06sc, Al–0.06zr And Al–0.06sc–0.06zr (At.%) Alloys, Keith E. Knipling, David N. Seidman, David C. Dunand

United States Navy: Publications

Ambient- and high-temperature precipitation strengthening are investigated in Al–0.06Sc, Al–0.06Zr and Al–0.06Sc–0.06Zr (at.%) alloys. Following solidification, Sc is concentrated at the dendrite peripheries while Zr is segregated at the dendrite cores. During isochronal aging, precipitation of Al3Sc (L1₂) commences between 250 and 300 °C for Al–0.06Sc, and reaches a 429 MPa peak microhardness at 325 °C. For Al–0.06Zr, precipitation of Al3Zr (L1₂) first occurs between 400 and 425 °C and reaches a 295 MPa peak microhardness at 475 °C. A pronounced synergistic effect is observed when both Sc and Zr are present. Above 325 °C, Zr …

A Phase Field Model Of Deformation Twinning: Nonlinear Theory And Numerical Simulations, J. D. Clayton, J. Knap

United States Army: Publications

A continuum phase field theory and corresponding numerical solution methods are developed to describe deformation twinning in crystalline solids. An order parameter is associated with the magnitude of twinning shear, i.e., the lattice transformation associated with twinning. The general theory addresses the following physics: large deformations, nonlinear anisotropic elastic behavior, and anisotropic phase boundary energy. The theory is applied towards prediction of equilibrium phenomena in the athermal and non-dissipative limit, whereby equilibrium configurations of an externally stressed crystal are obtained via incremental minimization of a free energy functional. Outcomes of such calculations are elastic fields (e.g., displacement, strain, stress, and …

Investigations Of Transcript Expression In Fathead Minnow (Pimephales Promelas) Brain Tissue Reveal Toxicological Impacts Of Rdx Exposure, Kurt A. Gust, Mitchell S. Wilbanks, Xin Guan, Mehdi Pirooznia, Tanwir Habib, Leslie Yoo, Henri Wintz, Chris D. Vulpe, Edward J. Perkins

United States Army: Publications

Production, usage and disposal of the munitions constituent (MC) cyclotrimethylenetrinitramine (RDX) has led to environmental releases on  military facilities. The chemical attributes of RDX are conducive for leaching to surface water which may put aquatic organisms at risk of exposure. Because RDX has been observed to cause aberrant neuromuscular effects across a wide range of animal phyla, we assessed the effects of RDX on central nervous system (CNS) functions in the representative aquatic ecotoxicological model species, fathead minnow (Pimephales promelas). We developed a fathead minnow brain-tissue cDNA library enriched for transcripts differentially expressed in response to RDX and …

Fatigue-Induced Grain Coarsening In Nanocrystalline Platinum Films, Roi A. Meirom, Daan Hein Alsem, Amber L. Romasco, Trevor Clark, Ronald G. Polcawich, Jeffrey S. Pulskamp, Madan Dubey, Robert O. Ritchie, Christopher L. Muhlstein

United States Army: Publications

Mechanisms to explain the unique mechanical behavior of nanograined metals focus primarily on grain and grain boundary mobility. In most nanograined metal materials systems (both pure and alloyed) it has not been possible to decouple these time- and cycle-dependent contributions. In contrast, the 460 nm thick, (1 1 1) textured, nanograined platinum thin films evaluated in this work have robust grain morphologies that allow us to uniquely identify the fatigue damage accumulation processes. Unlike other reports of face-centered cubic metal behavior, the platinum films exhibited a particularly limited range of fatigue crack growth (<3 MPa √m) with extremely large (~10.5) power law exponents typically associated with fatigue of structural ceramics and ordered intermetallics. Transmission electron microscopy and fatigue crack growth data suggest that the crack growth mechanism appears to be intrinsic in origin and dislocation mediated.

Thermoreversible And Remendable Glass–Polymer Interface For Fiber-Reinforced Composites, Amy M. Peterson, Robert E. Jensen, Giuseppe R. Palmese

United States Army: Publications

Adhesion of the reinforcement to the polymer matrix is essential for load transfer from the polymer matrix to the reinforcement material in fiber-reinforced composites. The reversible Diels–Alder reaction between a furan-functionalized epoxy-amine thermosetting matrix with a maleimide-functionalized glass fiber was used to impart remendability at the polymer–glass interface for potential application in glass fiber-reinforced composites. At room temperature the Diels–Alder adduct is formed spontaneously and above 90 °C the adduct breaks apart to reform the original furan and maleimide moieties. Healing of the interface was investigated with single fiber microdroplet pull-out testing. Following complete failure of this interface, significant healing …

Micro-Cracks Informed Damage Models For Brittle Solids, Xiaodan Ren, Jiun-Shyan Chen, Jie Li, T. R. Slawson, M. J. Roth

United States Army: Publications

A class of micro-cracks informed damage models for describing the softening behavior of brittle solids is proposed, in which damage evolution is treated as a consequence of micro-crack propagation. The homogenized stress–strain relation in the cracked microscopic cell defines the degradation tensor, which can be obtained by the equivalence between the averaged strain energy of the microscopic cell and the strain energy density of the homogenized material. This energy equivalence relationship serves as an energy bridging vehicle between the damaged continuum and the cracked microstructure. Several damage evolution equations are obtained by this energy bridging method. The size effect of …

Antimicrobial Decapeptide Ksl-W Attenuates Candida Albicans Virulence By Modulating Its Effects On Toll-Like Receptor, Human Β-Defensin, And Cytokine Expression By Engineered Human Oral Mucosa, A. Semlali, K. P. Leung, S. Curt, M. Rouabhia

United States Army: Publications

We investigated the toxicity of synthetic antimicrobial decapeptide KSL-W on normal human gingival epithelial cell cultures, its effect on Candida albicans adhesion and growth, and the activation of epithelial cell innate immunity. Our results indicate that KSL-W had no toxic effect on cell adhesion or growth, suggesting its safe use with human cells. Pre-treating C. albicans with KSL-W attenuated the yeast’s virulence as demonstrated by its reduced adhesion and growth on engineered human oral mucosa epithelium and the subsequent decreased expression of some innate defense molecules by targeted epithelial cells. Indeed, the expression of Toll-like receptors and human β-defensins was …

Protective Efficacy Of Catalytic Bioscavenger, Paraoxonase 1 Against Sarin And Soman Exposure In Guinea Pigs, Manojkumar Valiyaveettil, Yonas Alamneh, Peter Rezk, Lionel Biggemann, Michael W. Perkins, Alfred M. Sciuto, Bhupendra P. Doctor, Madhusoodana P. Nambiar

United States Army: Publications

Human paraoxonase 1 (PON1) has been portrayed as a catalytic bioscavenger which can hydrolyze large amounts of chemical warfare nerve agents (CWNAs) and organophosphate (OP) pesticides compared to the stoichiometric bioscavengers such as butyrylcholinesterase. We evaluated the protective efficacy of purified human and rabbit serum PON1 against nerve agents sarin and soman in guinea pigs. Catalytically active PON1 purified from human and rabbit serum was intravenously injected to guinea pigs, which were 30 min later exposed to 1.2 × LCt₅₀ sarin or soman using a microinstillation inhalation exposure technology. Pre-treatment with 5 units of purified human and rabbit serum …

Improving Service Through Just-In-Time Concept In A Dynamic Operational Environment, Kar Way Tan, Hoong Chuin Lau, Na Fu

Research Collection School Of Computing and Information Systems

This paper is concerned with the problem of Just-In-Time (JIT) job scheduling in a dynamic environment under uncertainty to attain timely service. We provide an approach, based on robust scheduling concepts, to analytically evaluate the expected cost of earliness and tardiness for each job and also the project. In addition, we search for a schedule execution policy with the minimum robust cost such that for a given risk level (epsilon), the actual realized schedule has (1 - epsilon) probability of completing with less than or equal to this robust cost. Our method is quite generic, and can be applied to …