Operations Research, Systems Engineering and Industrial Engineering Commons^™

Achieving Ultrafine Grains In Mg Az31b-O Alloy By Cryogenic Friction Stir Processing And Machining, Anwaruddin Mohammed

Theses and Dissertations--Manufacturing Systems Engineering

This thesis presents results from the application of cryogenic cooling on multiple-pass friction stir processing and the subsequent orthogonal machining on friction stir processed and as-received Mg AZ31B-O disks, and shows their combined effects on microstructure and microhardness values. A simple friction stir tool, a specially designed fixture and liquid nitrogen are used to perform multiple-pass friction stir processing experiments on Mg AZ31B-O alloy. The friction stir processed and as-received sheets are then made into disks for the orthogonal machining experiments. This study analyzes the microhardness, microstructure changes by cryogenic friction stir processing and the effect of machining conditions such …

Eating Rate During A Fixed-Portion Meal Does Not Affect Postprandial Appetite And Gut Peptides Or Energy Intake During A Subsequent Meal, J. Phillip Karl, Andrew J. Young, Scott J. Montain

United States Army: Publications

Eating rate has recently been shown to influence energy intake and appetite during an ad libitummeal, and alter postprandial secretion of glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) following a fixed-portionmeal. Whether these effects influence satiety, as measured by energy intake at the subsequent meal, is unclear. We manipulated eating rate during a fixed-portion meal in order to examine how eating behavior and associated periprandial and postprandial responses of putative endocrine mediators of appetite would affect energy intake at the following meal in fifteen non-obese (BMI ≥ 25 kg/m²) and ten obese (BMI ≥ 30 kg/m²) healthy adult men and …

Effects Of Gage Length, Loading Rates, And Damage On The Strength Of Ppta Fibers, Jaeyoung Lim, James Q. Zheng, Karl Masters, Weinong W. Chen

United States Army: Publications

Axial tension and transverse compression experiments on single fibers were performed to investigate the mechanical behavior of three high-performance fibers (Kevlar ®, Kevlar ® 129, and Twaron ®) with diameters in the order of 9-12 μm. The single fibers were manufactured from 1998 through 2008. A miniaturized tensile Kolsky bar was used to determine the tensile response of PPTA single fibers at a high strain rate. Gage length and strain rate were found to have minimum effects on the tensile strength of PPTA single fibers. Manufacturing time over a decade was found to have negligible effects on the tensile strength …

Recombinant Paraoxonase 1 Protects Against Sarin And Soman Toxicity Following Microinstillation Inhalation Exposure In Guinea Pigs, Manojkumar Valiyaveettil, Yonas Alamneh, Peter Rezk, Michael W. Perkins, Alfred M. Sciuto, Bhupendra P. Doctor, Madhusoodana P. Nambiar

United States Army: Publications

To explore the efficacy of paraoxonase 1 (PON1) as a catalytic bioscavenger, we evaluated human recombinant PON1 (rePON1) expressed in Trichoplusia ni larvae against sarin and soman toxicity using microinstillation inhalation exposure in guinea pigs. Animals were pretreated intravenously with catalytically active rePON1, followed by exposure to 1.2 X LCt₅₀ sarin or soman. Administration of 5 units of rePON1 showed mild increase in the blood activity of the enzyme after 30 min, but protected the animals with a significant increase in survival rate along with minimal signs of nerve agent toxicity. Recombinant PON1 pretreated animals exposed to sarin or …

The Utility Of Shewanella Japonica For Microbial Fuel Cells, Justin C. Biffinger, Lisa A. Fitzgerald, Ricky Ray, Brenda J. Little, Stephen E. Lizewski, Emily R. Petersen, Bradley R. Ringeisen, Wesley C. Sanders, Paul E. Sheehan, Jeremy J. Pietron, Jeffrey W. Baldwin, Lloyd J. Nadeau, Glenn R. Johnson, Meghann Ribbens, Steven E. Finkel, Kenneth H. Nealson

United States Navy: Publications

Shewanella-containing microbial fuel cells (MFCs) typically use the fresh water wild-type strain Shewanella oneidensis MR-1 due to its metabolic diversity and facultative oxidant tolerance. However, S. oneidensis MR-1 is not capable of metabolizing polysaccharides for extracellular electron transfer. The applicability of Shewanella japonica (an agar-lytic Shewanella strain) for power applications was analyzed using a diverse array of carbon sources for current generation from MFCs, cellular physiological responses at an electrode surface, biofilm formation, and the presence of soluble extracellular mediators for electron transfer to carbon electrodes. Critically, air-exposed S. japonica utilizes biosynthesized extracellular mediators for electron transfer to carbon …

Investigation Of Electrical Transport In Hydrogenated Multiwalled Carbon Nanotubes, Adam L. Friedman, Hyunkyung Chun, Don Heiman, Yung Joon Jung, Latika Menon

United States Navy: Publications

Highly disordered multiwalled carbon nanotubes of large outer diameter (~60 nm) fabricated by means of chemical vapor deposition process inside porous alumina templates exhibit ferromagnetism when annealed in a H₂/Ar atmosphere. In the presence of an applied magnetic field, there is a transition from positive to negative magnetoresistance. The transition may be explained in terms of the Bright model for ordered and disordered carbon structures. Additionally, temperature dependent electrical transport experiments exhibit a zero-bias anomaly at low temperature.

Derivation Radical Subspace Arrangements, Will Taves, Max Wakefield

United States Navy: Publications

In this note we study modules of derivations on collections of linear subspaces in a finite dimensional vector space. The central aim is to generalize the notion of freeness from hyperplane arrangements to subspace arrangements. We call this generalization ‘derivation radical’. We classify all coordinate subspace arrangements that are derivation radical and show that certain subspace arrangements of the Braid arrangement are derivation radical. We conclude by proving that under an algebraic condition the subspace arrangement consisting of all codimension c intersections, where c is fixed, of a free hyperplane arrangement are derivation radical.

Bedside Method To Estimate Actual Body Weight In The Emergency Department, Robert G. Buckley, Christine R. Stehman, Frank L. Dos Santos, Robert H. Riggenburgh, Aaron Swenson, Nathan Mjos, Matt Brewer, Sheila Mulligan

United States Navy: Publications

Background:

Actual body weight (ABW) is important for accurate drug dosing in emergency settings. Oftentimes, patients are unable to stand to be weighed accurately or clearly state their most recent weight.

Objective:

Develop a bedside method to estimate ABW using simple anthropometric measurements.

Methods:

Prospective, blinded, cross-sectional convenience sampling of adult Emergency Department (ED) patients. A multiple linear regression equation from Derivation Phase (n = 208: 121 males, 87 females) found abdominal and thigh circumferences (AC and TC) had the best fit and an inter-rater correlation of 0.99 and 0.96, respectively: Male ABW (kg) = -47.8 + 0.78 * (AC) …

Relationship Of Surface Changes To Metal Leaching From Tungsten Composite Shot Exposed To Three Different Soil Types, Deborah Felt, Steven Larson, Chris Griggs, Catherine Nestler, Michelle Wynter

United States Army: Publications

Physical changes that occur on the surface of fired shots due to firing and impact with soil may increase the dissolution of muniton metals. Increased metal dissolution could potentially increase metal transport and leaching, affecting metal concentrations in surface and groundwater. This research describes the relationship between the surface changes on fired tungsten–nickel–iron (94% W:2% Ni:4% Fe) composite shots and metals leaching from those shots. Tungsten composite shot was fired into, and aged in, three soil types (Silty Sand, Sandy Clay, and Silt) in mesoscale rainfall lysimeters to simulate live-fire conditions and subsequent interactions between the metals of the composite …

Safety And Protective Efficacy Of Ina-Inactivated Venezuelan Equine Encephalitis Virus: Implication In Vaccine Development, Anuj Sharma, Paridhi Gupta, Pamela J. Glass, Michael D. Parker, Radha K. Maheshwari

United States Army: Publications

We have previously shown that a hydrophobic alkylating compound, 1,5-iodonaphthyl-azide (INA) can efficiently inactivate the virulent strain of Venezuelan equine encephalitis virus (VEEV), V3000 in vitro. In this study, we have evaluated the safety of INA-inactivated V3000 and V3526 and the protective efficacy of INA-inactivated V3000. INA-inactivated V3000 and V3526 did not cause disease in suckling mice. RNA isolated from the INA-inactivated V3000 and V3526 was also not infectious. Immunization of adult mice with INA-inactivated V3000 induced an anti-VEEV antibody response and protected mice from virulent VEEV challenge. The protective efficacy of INA-inactivated V3000 increased with the use of adjuvants. …

Dislocation–Twin Interactions In Nanocrystalline Fcc Metals, Y. T. Zhu, X. L. Wu, X. Z. Liao, J. Narayan, L. J. Keckés, S. N. Mathaudhu

United States Army: Publications

Dislocation interaction with and accumulation at twin boundaries have been reported to significantly improve the strength and ductility of nanostructured face-centered cubic (fcc) metals and alloys. Here we systematically describe plausible dislocation interactions at twin boundaries. Depending on the characteristics of the dislocations and the driving stress, possible dislocation reactions at twin boundaries include cross-slip into the twinning plane to cause twin growth or de-twinning, formation of a sessile stair-rod dislocation at the twin boundary, and transmission across the twin boundary. The energy barriers for these dislocation reactions are described and compared.

The Impact Of 3pl’S Green Initiatives On The Purchasing Of Transport And Logistics Services: An Exploratory Study, Pietro Evangelista, Maria Huge-Brodin, Karin Isaksson, Edward Sweeney

Conference papers

There is a lack of research investigating the interaction and reciprocal influences between the buyer perspective and the supplier of transport and logistics services. Studies on the buyer perspective analyse the selection criteria to buy 3PL services, while research focused on green 3PL services examine initiatives undertaken by these companies to provide more environmentally sustainable services. The objective of this paper is to fill this void through an explorative case study analysis on the environmental attitude of 3PL companies in order to derive relevant implications for buyer’s behaviour. The results provide useful guidelines to buyers for understanding awareness, initiatives as …

An Alternative Approach To Integrating Plasticity Relations, Richard Becker

United States Army: Publications

A new plasticity integration algorithm is proposed based upon observations from the closed form integration of a generalized quadratic yield function over a single time step. The key to the approach is specification of the normal to the plastic flow potential as a function of the current state and strain increment. This uniquely defines the direction of the stress tensor for a convex, non-faceted flow potential. The stress magnitude and plastic strain increment are computed to satisfy the yield function. A non-quadratic, isotropic, associative flow model is coded to demonstrate accuracy and time step convergence following a step change in …

Nanoindentation Characterization Of Deformation And Failure Of Aluminum Oxynitride, J. J. Guo, K. Wang, T. Fujita, J. W. Mccauley, J. P. Singh, M. W. Chen

United States Army: Publications

A systematic study of the mechanical deformation and failure of transparent ceramic aluminum oxynitride (AlON) has been conducted using a depth-sensitive nanoindentation technique combined with transmission electron microscopy (TEM) and Raman spectroscopy. Although discrete displacement bursts appear in the load–depth profiles at high applied forces, a detectable high-pressure phase transition has not been found by means of micro-Raman spectroscopy and TEM. Instead, a high density of dissociated (1 1 0) dislocations can be observed underneath the nanoindenters, suggesting that extensive plastic deformation takes place in the brittle ceramic at high contact pressures. Moreover, nanoindentation-induced micro-cracks oriented along well-defined crystallographic planes …

Development Of A Cognitive Work Analysis Framework Tutorial Using Systems Modeling Language, Wilfred Henry Wells

Electronic Theses and Dissertations

At the present time, most systems engineers do not have access to cognitive work analysis information or training in terms they can understand. This may lead to a disregard of the cognitive aspect of system design. The impact of this issue is system requirements that do not account for the cognitive strengths and limitations of users. Systems engineers cannot design effective decision support systems without defining cognitive work requirements. In order to improve system requirements, integration of cognitive work requirements into the systems engineering process has to be improved. One option to address this gap is the development of a …

Introduction: Advances In E-Business Engineering, Ling Li

Information Technology & Decision Sciences Faculty Publications

(First paragraph) E-business is more than just e-commerce. It is one of the most challenging areas for industry and research communities. E-business has evolved from business-to-business, business-to-customer, customer-to-business, customer-to-customer, and business-to-government systems to the integrated and collaborative business services among various information systems and e-marketplaces. In this evolving process, integrated e-business systems and their related supporting platforms have to be rapidly designed and developed in order to meet different requirements. A variety of e-business engineering paradigms and technologies have been developed to tackle these challenges. There are many research issues needed to be addressed. These issues include heterogeneous services integration, …

Protective Immunity To Pre-Erythrocytic Stage Malaria, Robert J. Schwenk, Thomas L. Richie

United States Army: Publications

The development of a vaccine against malaria is a major research priority given the burden of disease, death and economic loss inflicted upon the tropical world by this parasite. Despite decades of effort, however, a vaccine remains elusive. The best candidate is a subunit vaccine termed RTS,S but this provides only partial protection against clinical disease. This review examines what is known about protective immunity against pre-erythrocytic stage malaria by considering the humoral and T cell-mediated immune responses that are induced by attenuated sporozoites and by the RTS,S vaccine. On the basis of these observations a set of research priorities …

A New Explanation Of The Extinction Paradox, Matthew J. Berg, C. M. Sorensen, A. Chakrabarti

United States Army: Publications

This work presents a new explanation for the extinction paradox and shows that the canonical explanations are incorrect. This paradox refers to the large size limit of a particle’s extinction cross section. It is called a paradox because the geometrical optics approximation, which should be valid in this limit, predicts a cross section that is half of the true value. The new explanation is achieved by formulating the scattered wave in terms of an integral over the particle’s surface where the seemingly unrelated Ewald–Oseen theorem appears in the formulation. By expressing the cross section in terms of this surface integral, …

Clostridium Difficile Infections In Patients With Severe Burns, Scott J. Crabtree, Janelle L. Robertson, Kevin K. Chung, Evan M. Renz, Steven E. Wolf, Duane R. Hospenthal, Clinton K. Murray

United States Army: Publications

With improved survival in burn patients, Clostridium difficile infection (CDI) remains a significant potential complication. The incidence of, risk factors for, and outcomes of CDI in severely burned patients are poorly studied and remain unclear. This study involves retrospective case control and cohort studies using electronic medical records from February 1, 2002 to January 31, 2009 at the US Department of Defense’s only burn unit. Demographic, risk factor, and outcome data were collected for all C. difficile toxin positive patients in the burn, medical, and surgical intensive care units and the hospital’s step down unit along with an additional analysis …

Determination Of Threshold Adverse Effect Doses Of Percutaneous Vx Exposure In African Green Monkeys, Raymond F. Genovese, Bernard J. Benton, John L. Oubre, Christopher E. Byers, E. Michael Jakubowski, Robert J. Mioduszewski, Timothy J. Settle, Thomas J. Steinbach

United States Army: Publications

Percutaneous exposure to the chemical warfare nerve agent VX was evaluated in African green monkeys (n = 9). Doses of VX (7.5–100 μg/kg) were applied to the skin for 60 min and residual agent was quantified (before decontamination) to estimate the absorbed dose. Monkeys were evaluated for the presence or absence of clinical signs of toxicity and blood was sampled periodically (30 min–12 weeks) following exposure to measure the degree of circulating acetylcholinesterase (AChE) inhibition. Monkeys were also evaluated for behavioral changes fromVXexposure using a serial probe recognition (SPR) task. The lowest observable adverse effect level (LOAEL) for the production …

Mechanical Response Of Pig Skin Under Dynamic Tensile Loading, Jaeyoung Lim, Jihye Hong, Weinong W. Chen, Tusit Weerasooriya

United States Army: Publications

Uniaxial tensile experiments were performed on pig skin to investigate the tensile stressestrain response at both quasi-static and dynamic rates of deformation. A Kolsky tension bar, also called a split Hopkinson tension bar (SHTB), was modified to conduct the dynamic experiments. Semiconductor strain gages were used to measure the low levels of the transmitted signal from pig skin. A pulse shaper technique was used for generating a suitable incident pulse to ensure stress equilibrium and approximate constant strain rate in the specimen of a thin skin sheet wrapped around the ends of the bars for minimizing radial inertia. In order …

Detection Of Six Serotypes Of Botulinum Neurotoxin Using Fluorogenic Reporters, Daniel R. Ruge, F. Mark Dunning, Timothy M. Piazza, Brian E. Molles, Michael Adler, Füsûn N. Zeytin, Ward C. Tucker

United States Army: Publications

Methods that do not require animal sacrifice to detect botulinum neurotoxins (BoNTs) are critical for BoNT antagonist discovery and the advancement of quantitative assays for biodefense and pharmaceutical applications. Here we describe the development and optimization of fluorogenic reporters that detect the proteolytic activity of BoNT/A, B, D, E, F, and G serotypes in real time with femtomolar to picomolar sensitivity. Notably, the reporters can detect femtomolar concentrations of BoNT/A in 4 h and BoNT/E in 20 h, sensitivity that equals that of animal-based methods. The reporters can be used to determine the specific activity of BoNT preparations with intra- …

Prophylaxis With Human Serum Butyrylcholinesterase Protects Guinea Pigs Exposed To Multiple Lethal Doses Of Soman Or Vx, Ashima Saxena, Wei Sun, James M. Fedorko, Irwin Koplovitz, Bhupendra P. Doctor

United States Army: Publications

Human serum butyrylcholinesterase (Hu BChE) is currently under advanced development as a bioscavenger for the prophylaxis of organophosphorus (OP) nerve agent toxicity in humans. It is estimated that a dose of 200 mg will be required to protect a human against 2 × LD₅₀ of soman. To provide data for initiating an investigational new drug application for the use of this enzyme as a bioscavenger in humans, we purified enzyme from Cohn fraction IV-4 paste and initiated safety and efficacy evaluations in mice, guinea pigs, and non-human primates. In mice, we demonstrated that a single dose of enzyme that …

Microstructure And Mechanical Properties At Different Length Scales And Strain Rates Of Nanocrystalline Tantalum Produced By High-Pressure Torsion, Q. Wei, Z. L. Pan, X. L. Wu, B. E. Schuster, L. J. Kecdkes, R. Z. Valiev

United States Army: Publications

Fully dense, nanocrystalline tantalum (average grain size as small as ~40 nm) has been processed for the first time by high-pressure torsion. High-resolution transmission electron microscopy reveals non-equilibrium grain boundaries and grains decorated with high-density dislocations. Microhardness measurements and instrumented nanoindentation experiments indicate that the mechanical property is quite uniform except for the central area of the disks. Nanoindentation experiments at different strain rates suggest that the strain rate sensitivity of nanocrystalline tantalum is increased compared to the coarse- and ultrafine-grained counterparts and is accompanied by an activation energy of the order of a few ~b3 (b is the magnitude …

Self Learning Strategies For Experimental Design And Response Surface Optimization, Adel Alaeddini

Wayne State University Dissertations

Most preset RSM designs offer ease of implementation and good performance over a wide range of process and design optimization applications. These designs often lack the ability to adapt the design based on the characteristics of application and experimental space so as to reduce the number of experiments necessary. Hence, they are not cost effective for applications where the cost of experimentation is high or when the experimentation resources are limited. In this dissertation, we present a number of self-learning strategies for optimization of different types of response surfaces for industrial experiments with noise, high experimentation cost, and requiring high …

Novel Models And Algorithms For Systems Reliability Modeling And Optimization, Dingzhou Cao

Wayne State University Dissertations

Recent growth in the scale and complexity of products and technologies in the defense and other industries is challenging product development, realization, and sustainment costs. Uncontrolled costs and routine budget overruns are causing all parties involved to seek lean product development processes and treatment of reliability, availability, and maintainability of the system as a true "design parameter". To this effect, accurate estimation and management of the system reliability of a design during the "earliest stages" of new product development is not only critical for managing product development and manufacturing costs but also to control life cycle costs (LCC). In this …

Hazard Rate Models For Early Warranty Issue Detection Using Upstream Supply Chain Information, Chongwen Zhou

Wayne State University Dissertations

This research presents a statistical methodology to construct an early automotive warranty issue detection model based on upstream supply chain information. This is contrary to extant methods that are mostly reactive and only rely on data available from the OEMs (original equipment manufacturers). For any upstream supply chain information with direct history from warranty claims, the research proposes hazard rate models to link upstream supply chain information as explanatory covariates for early detection of warranty issues. For any upstream supply chain information without direct warranty claims history, we introduce Bayesian hazard rate models to account for uncertainties of the explanatory …

Model Development Of A Virtual Learning Environment To Enhance Lean Education, Akalpit Gadre, Elizabeth Cudney, Steven Corns

Engineering Management and Systems Engineering Faculty Research & Creative Works

Modern day industry is becoming leaner by the day. This demands engineers with an in-depth understanding of lean philosophies. Current methods for teaching lean include hands-on projects and simulation. However, simulation games available in the market lack simplicity, ability to store the results, and modeling power. the goal of this research is to develop a virtual simulation platform which would enable students to perform various experiments by applying lean concepts. the design addresses these deficiencies through the use of VE-Suite, a virtual engineering software. the design includes user-friendly dialogue boxes, graphical models of machines, performance display gauges, and an editable …

Digital Holographic Imaging Of Aerosol Particles In Flight, Matthew J. Berg, Gorden Videen

United States Army: Publications

This work describes the design and application of an apparatus to image aerosol
particles using digital holography in a flow-through, contact-free manner. Particles in an aerosol stream are illuminated by a triggered, pulsed laser and the pattern produced by the interference of this light with that scattered by the particles is recorded by a digital camera. The recorded pattern constitutes a digital hologram from which an image of the particles is computationally reconstructed using a fast Fourier transform. This imaging is validated using a cluster of ragweed pollen particles. Examples involving mineral-dust aerosols demonstrate the technique’s in situ imaging capability …

Application Of Hyperspectral Vegetation Indices To Detect Variations In High Leaf Area Index Temperate Shrub Thicket Canopies, Steven T. Brantley, Julie C. Zinnert, Donald R. Young

United States Army: Publications

Accurate measurement of leaf area index (LAI), an important characteristic of plant canopies directly linked to primary production, is essential for monitoring changes in ecosystem C stocks and other ecosystem level fluxes. Direct measurement of LAI is labor intensive, impractical at large scales and does not capture seasonal or annual variations in canopy biomass. The need to monitor canopy related fluxes across landscapes makes remote sensing an attractive technique for estimating LAI. Many vegetation indices, such as Normalized Difference Vegetation Index (NDVI), tend to saturate at LAI levels >4 although tropical and temperate forested ecosystems often exceed that threshold. Using …