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Articles 61 - 90 of 164
Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering
Tomato Bushy Stunt Virus (Tbsv), A Versatile Platform For Polyvalent Display Of Antigenic Epitopes And Vaccine Design, Shantanu Kumar, Wendy Ochoa, Pratik Singh, Catherine Hsu, Anette Schneemann, Marianne Manchester, Mark Olson, Vijay Reddy
Tomato Bushy Stunt Virus (Tbsv), A Versatile Platform For Polyvalent Display Of Antigenic Epitopes And Vaccine Design, Shantanu Kumar, Wendy Ochoa, Pratik Singh, Catherine Hsu, Anette Schneemann, Marianne Manchester, Mark Olson, Vijay Reddy
United States Army: Publications
Viruses-like particles (VLPs) are frequently being used as platforms for polyvalent display of foreign epitopes of interest on their capsid surface to improve their presentation enhancing the antigenicity and host immune response. In the present study, we used the VLPs of Tomato bushy stunt virus (TBSV), an icosahedral plant virus, as a platform to display 180 copies of 16 amino acid epitopes of ricin toxin fused to the C-terminal end of a modified TBSV capsid protein (NΔ52). Expression of the chimeric recombinant protein in insect cells resulted in spontaneous assembly of VLPs displaying the ricin epitope. Cryo-electron microscopy and image …
Simulated Rainfall-Driven Dissolution Of Tnt, Tritonal, Comp B And Octol Particles, Susan Taylor, James H. Lever, Jennifer Fadden, Nancy Perron, Bonnie Packer
Simulated Rainfall-Driven Dissolution Of Tnt, Tritonal, Comp B And Octol Particles, Susan Taylor, James H. Lever, Jennifer Fadden, Nancy Perron, Bonnie Packer
United States Army: Publications
Live-fire military training can deposit millimeter-sized particles of high explosives (HE) on surface soils when rounds do not explode as intended. Rainfall-driven dissolution of the particles then begins a process whereby aqueous HE solutions can enter the soil and groundwater as contaminants. We dripped water onto individual particles of TNT, Tritonal, Comp B and Octol to simulate how surface-deposited HE particles might dissolve under the action of rainfall and to use the data to verify a model that predicts HE dissolution as a function of particle size, particle composition and rainfall rate. Particle masses ranged from 1.1 to 17 mg …
Complementary And Alternative Medicine For The Allergist-Immunologist: Where Do I Start?, Renata J. M. Engler, Catherine M. With, Philip J. Gregory, Jeff M. Jellin
Complementary And Alternative Medicine For The Allergist-Immunologist: Where Do I Start?, Renata J. M. Engler, Catherine M. With, Philip J. Gregory, Jeff M. Jellin
United States Army: Publications
Complementary and alternative medicine (CAM) therapies present a growing information management challenge for physicians because nearly 40% of their patients may be using and another 50% may be considering use of CAM as part of their health care regimen. The National Health Statistics Reports for 2007 described the most commonly used nonvitamin, nonmineral therapy as natural products (eg, herbals at 17.7%). More than5% of children under the age of 18 years used CAM for allergic conditions including asthma. The amount and quality of information available and concerns about liability risk represent a challenge for most physicians. This review focuses on …
First Results From Radar Profiles Collected Along The Us-Itase Traverse From Taylor Dome To South Pole (2006–2008), Brian C. Welch, Robert W. Jacobel, Steven A. Arcone
First Results From Radar Profiles Collected Along The Us-Itase Traverse From Taylor Dome To South Pole (2006–2008), Brian C. Welch, Robert W. Jacobel, Steven A. Arcone
United States Army: Publications
The 2006/07 and 2007/08 US-ITASE traverses from Taylor Dome to South Pole in East Antarctica provided opportunities to survey the subglacial and englacial environments using 3MHz and 200MHz radar. We present first results of these new ground-based radar data. A prominent basal deformation layer indicates different ice-flow regimes for the northern and southern halves of the Byrd Glacier drainage. Buried dune stratigraphy that appears to be related to the megadunes towards the west occurs at depths of up to 1500 m. At least two new water-filled subglacial lakes were discovered, while two recently drained lakes identified from repeat ICESat surface …
Photophysical Properties Of C60 Colloids Suspended In Water With Triton X-100 Surfactant: Excited-State Properties With Femtosecond Resolution, Andrew F. Clements, Joy E. Haley, Augustine M. Urbas, Alan Kost, R. David Rauh, Jane F. Bertone, Fei Wang, Brian M. Wiers, De Gao, Todd S. Stefanik, Andrew G. Mott, David M. Mackie
Photophysical Properties Of C60 Colloids Suspended In Water With Triton X-100 Surfactant: Excited-State Properties With Femtosecond Resolution, Andrew F. Clements, Joy E. Haley, Augustine M. Urbas, Alan Kost, R. David Rauh, Jane F. Bertone, Fei Wang, Brian M. Wiers, De Gao, Todd S. Stefanik, Andrew G. Mott, David M. Mackie
United States Army: Publications
We examine the photophysics of a colloidal suspension of C60 particles in a micellar solution of Triton X-100 and water, prepared via a new synthesis which allows high-concentration suspensions. The particle sizes are characterized by transmission electron microscopy and dynamic light scattering and found to be somewhat polydisperse in the range of 10-100 nm. The suspension is characterized optically by UV-vis spectroscopy, femtosecond transient absorption spectroscopy, laser flash photolysis, and z-scan. The ground-state absorbance spectrum shows a broad absorbance feature centered near 450 nm which is indicative of colloidal C60. The transient absorption dynamics, presented for the …
Retrieval Of Subpixel Snow Covered Area, Grain Size, And Albedo From Modis, Thomas H. Painter, Karl Rittger, Ceretha Mckenzie, Peter Slaughter, Robert E. Davis, Jeff Dozier
Retrieval Of Subpixel Snow Covered Area, Grain Size, And Albedo From Modis, Thomas H. Painter, Karl Rittger, Ceretha Mckenzie, Peter Slaughter, Robert E. Davis, Jeff Dozier
United States Army: Publications
We describe and validate a model that retrieves fractional snow-covered area and the grain size and albedo of that snow from surface reflectance data (product MOD09GA) acquired by NASA's Moderate Resolution Imaging Spectroradiometer (MODIS). The model analyzes the MODIS visible, near infrared, and shortwave infrared bands with multiple endmember spectral mixtures from a library of snow, vegetation, rock, and soil. We derive snow spectral endmembers of varying grain size from a radiative transfer model specific to a scene's illumination geometry; spectra for vegetation, rock, and soil were collected in the field and laboratory. We validate the model with fractional snow …
Pseudomonas Aeruginosa Infection Of The Auricular Cartilage Caused By “High Ear Piercing”: A Case Report And Review Of The Literature, Henry H. Rowshan, Karen Keith, Dale Baur, Peter Skidmore
Pseudomonas Aeruginosa Infection Of The Auricular Cartilage Caused By “High Ear Piercing”: A Case Report And Review Of The Literature, Henry H. Rowshan, Karen Keith, Dale Baur, Peter Skidmore
United States Army: Publications
Piercing of various parts of the body has gained tremendous popularity among adolescent and adult populations in recent years. There are no exact statistical reports on the number of body piercings being performed in the United States. One study among 481 college students in New York revealed that 42% of men and 60% of women had body piercing. In the past, the majority of complications of ear piercing were associated with the lobule. Torn ear lobes, localized infection, hypertrophic scars, allergic contact dermatitis, and keloid formations were among the most common, with no significant morbidity. However, “high ear piercing,” defined …
Influence Of Snow And Ice Crystal Formation And Accumulation On Mercury Deposition To The Arctic, Thomas A. Douglas, Matthew Sturm, William R. Simpson, Joel D. Blum, Laura Alvarez-Aviles, Gerald J. Keeler, Donald K. Perovich, Abir Biswas, Kelsey Johnson
Influence Of Snow And Ice Crystal Formation And Accumulation On Mercury Deposition To The Arctic, Thomas A. Douglas, Matthew Sturm, William R. Simpson, Joel D. Blum, Laura Alvarez-Aviles, Gerald J. Keeler, Donald K. Perovich, Abir Biswas, Kelsey Johnson
United States Army: Publications
Mercury is deposited to the Polar Regions during springtime atmospheric mercury depletion events (AMDEs) but the relationship between snow and ice crystal formation and mercury deposition is not well understood. The objective of this investigation was to determine if mercury concentrations were related to the type and formation of snow and ice crystals. On the basis of almost three hundred analyses of samples collected in the Alaskan Arctic, we suggest that kinetic crystals growing from the vapor phase, including surface hoar, frost flowers, and diamond dust, yield mercury concentrations that are typically 2-10 times higher than that reported for snow …
The Phylogeny Of The Four Pan-American Mtdna Haplogroups: Implications For Evolutionary And Disease Studies, Alessandro Achilli, Ugo A. Perego, Claudio M. Bravi, Michael D. Coble, Qing-Peng Kong, Scott R. Woodward, Antonio Salas, Antonio Torroni, Hans-Jürgen Bandelt
The Phylogeny Of The Four Pan-American Mtdna Haplogroups: Implications For Evolutionary And Disease Studies, Alessandro Achilli, Ugo A. Perego, Claudio M. Bravi, Michael D. Coble, Qing-Peng Kong, Scott R. Woodward, Antonio Salas, Antonio Torroni, Hans-Jürgen Bandelt
United States Army: Publications
Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub-haplogroups but suggest that the ancestral Beringian …
Effective Elution Of Rdx And Tnt From Particles Of Comp B In Surface Soil, John S. Furey, Herbert L. Fredrickson, Margaret J. Richmond, Michael Michel
Effective Elution Of Rdx And Tnt From Particles Of Comp B In Surface Soil, John S. Furey, Herbert L. Fredrickson, Margaret J. Richmond, Michael Michel
United States Army: Publications
During live fire training exercises, large amounts of explosives are consumed. Low order detonations of high explosive payloads result in the patchy dispersal of particles of high explosive formulations over large areas of firing range soils. Dissolution of explosives from explosive formulation particles into soil pore water is a controlling factor for transport, fate, and effects of explosive compounds. We developed an empirical method to evaluate soils based on functionally defined effective dissolution rates. An automated Accelerated Solvent Extractor was used to determine the effective elution rates under controlled conditions of RDX and TNT from soil columns containing particles of …
Detection Of The Superoxide Radical Anion Using Various Alkanethiol Monolayers And Immobilized Cytochrome C, Xiaojun J. Chen, Alan C. West, Donald M. Cropek, Scott Banta
Detection Of The Superoxide Radical Anion Using Various Alkanethiol Monolayers And Immobilized Cytochrome C, Xiaojun J. Chen, Alan C. West, Donald M. Cropek, Scott Banta
United States Army: Publications
The superoxide radical anion (SO) is a critical biomarker for monitoring cellular stress responses. Electrochemical SO biosensors are frequently constructed through the covalent immobilization of cytochrome c (Cyt c) onto self-assembled monolayers (SAMs); however, a detailed comparison of these systems as well as configuration influence on SO detection is needed to enable robust applications. Two reaction pathways, oxidation of SO by the SAM-modified gold electrode or electron transfer through a protein and monolayer relay, may be involved during the electrochemical detection of SO with Cyt c, depending on the SAM that is used. Although electrodes with SAMs alone can exhibit …
Phase 2a Trial Of 0, 1, And 3 Month And 0, 7, And 28 Day Immunization Schedules Of Malaria Vaccine Rts,S/As02 In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Kent E. Kester, James F. Cummings, Christian F. Ockenhouse, Robin Nielsen, B. Ted Hall, Daniel M. Gordon, Robert J. Schwenk, Urszula Krzych, Carolyn A. Holland, Gregory Richmond, Megan G. Dowler, Jackie Williams, Robert A. Wirtz, Nadia Tornieporth, Laurence Vigneron, Martine Delchambre, Marie-Ange Demoitie, W. Ripley Ballou, Joe Cohen, D. Gray Heppner Jr.
Phase 2a Trial Of 0, 1, And 3 Month And 0, 7, And 28 Day Immunization Schedules Of Malaria Vaccine Rts,S/As02 In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Kent E. Kester, James F. Cummings, Christian F. Ockenhouse, Robin Nielsen, B. Ted Hall, Daniel M. Gordon, Robert J. Schwenk, Urszula Krzych, Carolyn A. Holland, Gregory Richmond, Megan G. Dowler, Jackie Williams, Robert A. Wirtz, Nadia Tornieporth, Laurence Vigneron, Martine Delchambre, Marie-Ange Demoitie, W. Ripley Ballou, Joe Cohen, D. Gray Heppner Jr.
United States Army: Publications
Background: Immunization with RTS,S/AS02 consistently protects some vaccinees against malaria infection in experimental challenges and in field trials. A brief immunization schedule against falciparum malaria would be compatible with the Expanded Programme on Immunization, or in combination with other prevention measures, interrupt epidemic malaria or protect individuals upon sudden travel to an endemic area.
Methods: We conducted an open label, Phase 2a trial of two different full dose schedules of RTS,S/AS02 in 40 healthy malaria-naıve adults. Cohort 1 (n = 20) was immunized on a 0, 1, and 3 month schedule and Cohort 2 (n = 20) on a 0, …
Vietnam: Historians At War, Mark Moyar
Vietnam: Historians At War, Mark Moyar
United States Army: Publications
By the early 1990s, when I began studying the Vietnam War, the American public had largely lost interest in the history of that conflict. The Civil War and World War II were the wars that historians were advised to cover if they wanted to reach the public. Among government officials, military officers, and political scientists, Vietnam was considered irrelevant, because the United States would never get caught in protracted counterinsurgency warfare again. Iraq changed all that. Ever since the outbreak of insurgency in the former empire of Saddam Hussein, people of all persuasions have been mining the history of Vietnam …
Influenza Immunization And Subsequent Diagnoses Of Group A Streptococcus-Illnesses Among U.S. Army Trainees, 2002–2006, Seung-Eun Lee, Angelia Eick, Michael S. Bloom, John F. Brundage
Influenza Immunization And Subsequent Diagnoses Of Group A Streptococcus-Illnesses Among U.S. Army Trainees, 2002–2006, Seung-Eun Lee, Angelia Eick, Michael S. Bloom, John F. Brundage
United States Army: Publications
To assess the association between influenza immunization and subsequent diagnosis of group A streptococcus (GAS)-illness in Army recruits during influenza seasons 2002–2006. A case–control study was employed with cases as trainees with outpatient GAS diagnosis (ICD-9-CM codes: 034.0, 035, 038.0, 041.01, 320.2, 390–392, 482.31) during the influenza season, and controls as trainees with no outpatient GAS diagnosis during the influenza season. Primary exposure was influenza immunization during 1st September to 30th April of each season. Estimated protective effects of influenza immunization against GAS-illness ranged from 50% to 77%. A strong protective effect was suggested for Army trainee influenza immunization on …
Utility Of Lipid Biomarkers In Support Of Bioremediation Efforts At Army Sites, D. Ringelberg, M. Richmond, K. Foley, C. Reynolds
Utility Of Lipid Biomarkers In Support Of Bioremediation Efforts At Army Sites, D. Ringelberg, M. Richmond, K. Foley, C. Reynolds
United States Army: Publications
Lipid biomarker analysis has proven valuable in testing the hypothesis that attributes of the extant microbiota can directly reflect the occurrence of contaminant biodegradation. Two past research efforts have demonstrated this utility and are described here.
A 4.5 m vertical core was obtained from a diesel fuel oil contamination plume. Core material was assayed for total petroleum hydrocarbons (TPH) and bacterial membrane phospholipids (PLFA) via a single solvent extraction. Microbial viable biomass and the relative abundance of Gram-negative bacterial PLFA biomarkers were found to be significantly correlated with TPH concentration. The core TPH profile also revealed two distinct areas where …
"Making It Fresh - Your Choice For Performance", The Army's Hospital Foodservice Program, S. Spielmann, M. Worley, R. Harris
"Making It Fresh - Your Choice For Performance", The Army's Hospital Foodservice Program, S. Spielmann, M. Worley, R. Harris
United States Army: Publications
To describe the Army’s new foodservice design and concept, “Making it Fresh—Your Choice for Performance” and its application for customer and patient feeding in a fixed medical treatment facility.
Moderate Zinc Restriction Affects Intestinal Health And Immune Function In Lipopolysaccharide-Challenged Mice, Daniel G. Peterson, Angus G. Scrimgeour, James P. Mcclung, Elizabeth A. Koutsos
Moderate Zinc Restriction Affects Intestinal Health And Immune Function In Lipopolysaccharide-Challenged Mice, Daniel G. Peterson, Angus G. Scrimgeour, James P. Mcclung, Elizabeth A. Koutsos
United States Army: Publications
Zinc (Zn) is an essential nutrient that affects immune function, especially within the digestive system, although the underlying mechanisms are not well understood. This study examined the effects of short-term moderate Zn restriction on intestinal health and immune function in lipopolysaccharide (LPS)-challenged mice through plasma cytokine profiling and histological evaluation of intestinal tissue sections. Adult male mice were fed with a Zn-adequate (40 ppm) or a Zn-marginal (4 ppm) diet for 4 weeks, and then a bacterial challenge was simulated by intraperitoneal injection of LPS (10 μg/g body weight [BW]) or saline (control). BW was recorded weekly, and feed intake …
Historical Perspective And Contribution Of Us Researchers Into The Field Of Self-Propagating High-Temperature Synthesis (Shs)/Combustion Synthesis (Cs): Personal Reflections, J. W. Mccauley, J. A. Puszynski
Historical Perspective And Contribution Of Us Researchers Into The Field Of Self-Propagating High-Temperature Synthesis (Shs)/Combustion Synthesis (Cs): Personal Reflections, J. W. Mccauley, J. A. Puszynski
United States Army: Publications
In 1967, Merzhanov, Skhiro, and Borovinskaya published the first comprehensive paper describing self-sustaining character of reactions in a condensed phase, which could be utilized for synthesis of many ceramic and intermetallic materials [1]. In this paper, the authors demonstrated the principle of the so called “solid flame” using reactions between transition metals and boron, carbon or nitrogen. The world-wide combustion synthesis community considers this comprehensive paper and subsequent integrated experimental and theoretical research effort conducted in the former Soviet Union as the beginning of a new approach and method of synthesizing advanced high temperature materials. The main research was conducted …
Anaerobic Treatment Of Army Ammunition Production Wastewater Containing Perchlorate And Rdx, Emina Atikovic, Makram T. Suidan, Stephen W. Maloney
Anaerobic Treatment Of Army Ammunition Production Wastewater Containing Perchlorate And Rdx, Emina Atikovic, Makram T. Suidan, Stephen W. Maloney
United States Army: Publications
Perchlorate is an oxidizer that has been routinely used in solid rocket motors by the Department of Defense and National Aeronautics and Space Administration. Royal Demolition Explosive (RDX) is a major component of military high explosives and is used in a wide variety of munitions. Perchlorate bearing wastewater typically results from production of solid rocket motors, while RDX is transferred to Army industrial wastewaters during load, assemble and pack operations for new munitions, and hot water or steam washout for disposal and deactivation of old munitions (commonly referred to as demilitarization, or simply demil).
Biological degradation in Anaerobic Fluidized Bed …
The Army Dietetic Mentorship Program: Making The Most Out Of Mentoring, M.A. Worley, M.B. Salgueiro, D.R. Hernandez, C.J. Buck
The Army Dietetic Mentorship Program: Making The Most Out Of Mentoring, M.A. Worley, M.B. Salgueiro, D.R. Hernandez, C.J. Buck
United States Army: Publications
To describe the Army’s Dietetic Mentorship Program and its effect on personnel and professional development of recent internship graduates.
Remediation Of Rdx- And Hmx-Contaminated Groundwater Using Organic Mulch Permeable Reactive Barriers, Farrukh Ahmad, Stephen P. Schnitker, Charles J. Newell
Remediation Of Rdx- And Hmx-Contaminated Groundwater Using Organic Mulch Permeable Reactive Barriers, Farrukh Ahmad, Stephen P. Schnitker, Charles J. Newell
United States Army: Publications
Organic mulch is a complex organic material that is typically populated with its own consortium of microorganisms. The organisms in mulch breakdown complex organics to soluble carbon, which can then be used by these and other microorganisms as an electron donor for treating RDX and HMX via reductive pathways. A bench-scale treatability study with organic mulch was conducted for the treatment of RDX- and HMX-contaminated groundwater obtained from a plume at the Pueblo Chemical Depot (PCD) in Pueblo, Colorado. The site-specific cleanup criteria of 0.55 ppb RDX and 602 ppb HMX were used as the logical goals of the study. …
Weak Base Dispiro-1,2,4-Trioxolanes: Potent Antimalarial Ozonides, Yuanqing Tang, Yuxiang Dong, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C. K. Chiu, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Saroj Bajpai, Xiaofang Wang, Maniyan Padmanilayam, Jean M. Karle, Reto Brun, Jonathan L. Vennerstrom
Weak Base Dispiro-1,2,4-Trioxolanes: Potent Antimalarial Ozonides, Yuanqing Tang, Yuxiang Dong, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C. K. Chiu, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Saroj Bajpai, Xiaofang Wang, Maniyan Padmanilayam, Jean M. Karle, Reto Brun, Jonathan L. Vennerstrom
United States Army: Publications
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
Synthesis And Antimalarial Activity Of New Isotebuquine Analogues, Olga V. Miroshnikova, Thomas H. Hudson, Lucia Gerena, Dennis E. Kyle, Ai J. Lin
Synthesis And Antimalarial Activity Of New Isotebuquine Analogues, Olga V. Miroshnikova, Thomas H. Hudson, Lucia Gerena, Dennis E. Kyle, Ai J. Lin
United States Army: Publications
Amodiaquine (AQ) and tebuquine are 4-aminoquinoline antimalarials with Mannich base side chain and are highly effective against chloroquine (CQ)-resistant strains of Plasmodium falciparum. Clinical use of AQ has been severely restricted due to hepatoxicity and agranulocytosis side effects associated with its long term use. Lysosomal accumulation and bioactivation to generate reactive quinoneimine metabolite are implicated to be the cause of the observed AQ toxicities. To avoid the quinoneimine formation and thus the toxicity, a series of isotebuquine analogues and their Nω-oxides with hydroxy group meta to the amino rather than in para position of the aniline moiety …
Army Research Needs For Automated Neuropsychological Tests: Monitoring Soldier Health And Performance Status, Karl E. Friedl, Stephen J. Grate, Susan P. Proctor, James W. Ness, Brian J. Lukey, Robert L. Kane
Army Research Needs For Automated Neuropsychological Tests: Monitoring Soldier Health And Performance Status, Karl E. Friedl, Stephen J. Grate, Susan P. Proctor, James W. Ness, Brian J. Lukey, Robert L. Kane
United States Army: Publications
Information on the mental status of soldiers operating at the limits of human tolerance will be vital to their management in future deployments; it may also allow earlier intervention for conditions such as undiagnosed Gulf War illnesses and Parkinson’s Disease. The Army needs a parsimonious set of neuropsychological tests that reliably identify subtle changes for: (1) early detection of individual health and military performance impairments and (2) management of occupational and deployment health risks. Testing must characterize cognitive lapses in healthy individuals faced with relevant operational stressors (i.e., anxiety, information overload, thermal strain, hypoxia, fatigue, head impact, chemical or radiation …
Thermally Driven Assembly Of Nanoparticles In Polymer Matrices, Philip J. Costanzo, Frederick L. Beyer
Thermally Driven Assembly Of Nanoparticles In Polymer Matrices, Philip J. Costanzo, Frederick L. Beyer
United States Army: Publications
Thermally responsive bulk polymer films utilizing reversible Diels-Alder chemistry have been developed. Gold nanoparticles (AuNPs) were passivated with thiol-terminated poly(styrene)-b-poly(ethylene glycol) (PS-b-PEG) copolymer ligand, where the PS and PEG blocks are joined via a Diels-Alder (DA) linkage. The ligand-functionalized nanoparticles were dispersed within a microphase-separated PS-b-poly(methyl methacrylate) (PS-b-PMMA) block copolymer. Nanoparticle location was dictated by the compatibility of the external shell with the block copolymer matrix. As cast, the PEG shell compatibilized the nanoparticles with the PMMA domains. Subsequent thermal treatment caused the Diels-Alder linkages between the polymer blocks to dissociate, leaving the AuNPs functionalized by PS ligands. Immiscibility within …
Improved Formulation Of A Recombinant Ricin A-Chain Vaccine Iincreases Its Stability And Effective Antigenicity, John H. Carra, Robert W. Wannemacher, Ralph F. Tammariello, Changhong Y. Lindsey, Richard E. Dinterman, Rowena D. Schokman, Leonard A. Smith
Improved Formulation Of A Recombinant Ricin A-Chain Vaccine Iincreases Its Stability And Effective Antigenicity, John H. Carra, Robert W. Wannemacher, Ralph F. Tammariello, Changhong Y. Lindsey, Richard E. Dinterman, Rowena D. Schokman, Leonard A. Smith
United States Army: Publications
Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable, non-toxic and immunogenic recombinant ricin A-chain vaccine (RTA 1-33/44-198) has been developed by protein engineering. We identified optimal formulation conditions for this vaccine under which it remained stable and potent in storage for up to 18 months, and resisted multiple rounds of freeze–thawing without stabilizing co-solvents. Reformulation from phosphate buffer to succinate buffer increased adherence of the protein to aluminum hydroxide adjuvant from 15 to 91%, with a concomitant increase of nearly threefold in effective antigenicity in a mouse model. …
A Refined Pharmacophore Identifies Potent 4-Amino-7-Chloroquinoline-Based Inhibitors Of The Botulinum Neurotoxin Serotype A Metalloprotease, James C. Burnett, Dejan Opsenica, Kamaraj Sriraghavan, Rekha G. Panchal, Gordon Ruthel, Ann R. Hermone, Tam L. Nguyen, Tara A. Kenny, Douglas J. Lane, Connor F. Mcgrath, James J. Schmidt, Jonathan L. Vennerstrom, Rick Gussio, Bogdan A. Solaja, Sina Bavari
A Refined Pharmacophore Identifies Potent 4-Amino-7-Chloroquinoline-Based Inhibitors Of The Botulinum Neurotoxin Serotype A Metalloprotease, James C. Burnett, Dejan Opsenica, Kamaraj Sriraghavan, Rekha G. Panchal, Gordon Ruthel, Ann R. Hermone, Tam L. Nguyen, Tara A. Kenny, Douglas J. Lane, Connor F. Mcgrath, James J. Schmidt, Jonathan L. Vennerstrom, Rick Gussio, Bogdan A. Solaja, Sina Bavari
United States Army: Publications
We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including antimalarial drugs) contained a 4-amino-7-chloroquinoline (ACQ) substructure and a separate positive ionizable amine component. The same antimalarials have also been found to interfere with BoNT/A translocation into neurons, via pH elevation of the toxin-mediated endosome. Thus, this structural class of small molecules may serve as dual-function BoNT/A inhibitors. In this study, we used a refined pharmacophore for BoNT/A LC inhibition to identify four new, potent inhibitors of this structural class (IC50’s ranged from 3.2 to 17 …
Phase I Dose Escalation Safety And Immunogenicity Trial Of Plasmodium Falciparum Apical Membrane Protein (Ama-1) Fmp2.1, Adjuvanted With As02a, In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Mark E. Polhemus, Alan J. Magill, James F. Cummings, Kent E. Kester, Chris F. Ockenhouse, David E. Lanar, Sheetij Dutta, Arnoldo Barbosa, Lorraine Soisson, Carter L. Diggs, Sally A. Robinson, John D. Haynes, V. Ann Stewart, Lisa A. Ware, Clara Brando, Urszula Krzych, Robert A. Bowden, Joe D. Cohen, Marie-Claude Dubois, Opokua Ofori-Anyinam, Els De-Kock, W. Ripley Ballou, D. Gray Heppner Jr.
Phase I Dose Escalation Safety And Immunogenicity Trial Of Plasmodium Falciparum Apical Membrane Protein (Ama-1) Fmp2.1, Adjuvanted With As02a, In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Mark E. Polhemus, Alan J. Magill, James F. Cummings, Kent E. Kester, Chris F. Ockenhouse, David E. Lanar, Sheetij Dutta, Arnoldo Barbosa, Lorraine Soisson, Carter L. Diggs, Sally A. Robinson, John D. Haynes, V. Ann Stewart, Lisa A. Ware, Clara Brando, Urszula Krzych, Robert A. Bowden, Joe D. Cohen, Marie-Claude Dubois, Opokua Ofori-Anyinam, Els De-Kock, W. Ripley Ballou, D. Gray Heppner Jr.
United States Army: Publications
We report the first safety and immunogenicity trial of the Plasmodium falciparum vaccine candidate FMP2.1/AS02A, a recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. We conducted an open-label, staggered-start, dose-escalating Phase I trial in 23 malaria-naıve volunteers who received 8, 20 or 40 _g of FMP2.1 in a fixed volume of 0.5mL of AS02A on a 0, 1, and 2 month schedule. Nineteen of 23 volunteers received all three scheduled immunizations. The most frequent solicited local and systemic adverse events associated with immunization were injection site pain (68%) …
An In Vitro Comparative Study On The Reactivation Of Nerve Agent-Inhibited Guinea Pig And Human Acetylcholinesterases By Oximes, Chunyuan Luo, Min Tong, Nageswararao Chilukuri, Karen Brecht, Donald M. Maxwell, Ashima Saxena
An In Vitro Comparative Study On The Reactivation Of Nerve Agent-Inhibited Guinea Pig And Human Acetylcholinesterases By Oximes, Chunyuan Luo, Min Tong, Nageswararao Chilukuri, Karen Brecht, Donald M. Maxwell, Ashima Saxena
United States Army: Publications
The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning. Since the evaluation of nerve agent antidotes cannot be conducted in humans, results from animal experiments are extrapolated to humans. Guinea pig is one of the animal models that is frequently used for conducting nerve agent antidote evaluations. Several investigations have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited AChE. If the in Vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely …
A Dendroclimatic Record Of Paleoclimate Of The Last 10,000 Years, Glacier Bay National Park And Preserve: Progress Understanding Climate Change In Southeast Alaska, Daniel Lawson, Greg Wiles, David Finnegan
A Dendroclimatic Record Of Paleoclimate Of The Last 10,000 Years, Glacier Bay National Park And Preserve: Progress Understanding Climate Change In Southeast Alaska, Daniel Lawson, Greg Wiles, David Finnegan
United States Army: Publications
Our investigations in 2007 focused on continuing collection and analyses of tree rings from living trees and building a long ring-width series from interstadial wood. These interstadial forests were extensive and their preservation, although discontinuous and fragmented, is remarkable. In situ stumps, still rooted in growth position, and logs held within sediments remain from forests that existed at various times between glaciations over approximately the last 10,000 years.
We have analyzed previous and new collections of ring-width tree-ring series, including a multiple species collection from near Excursion Ridge in the southeast portion of the Park. These tree-ring series have a …