Nanoscience and Nanotechnology Commons^™

Yap Mechanotransduction Under Cyclic Mechanical Stretch Loading For Mesenchymal Stem Cell Osteogenesis Is Regulated By Rock, Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

While yes-associated protein (YAP) is now recognized as a potent mechanosensitive transcriptional regulator to affect cell growth and differentiation including the osteogenic transcription of mesenchymal stem cells (MSCs), most studies have reported the YAP mechanosensing of static mechanophysical cues such as substrate stiffness. We tested MSC response to dynamic loading, i.e., cyclic mechanical stretching, and assessed YAP mechanosensing and resultant MSC osteogenesis. We showed that cyclic stretching at 10% strain and 1 Hz frequency triggered YAP nuclear import in MSCs. YAP phosphorylation at S127 and S397, which is required for YAP cytoplasmic retention, was suppressed by cyclic stretch. We also …

Long-Term Simulation Of Stem Cell Mechanobiology, Manoochehr Rabiei

Mechanical and Aerospace Engineering Dissertations - Archive

An accurate representation of cellular mechanobiology necessitates the inclusion of subcellular elements characterized by minute masses and dimensions. These minute objects yield multiscale dynamic models with disproportionate terms, which require inordinate amounts of computational time to simulate. The computational requirements limit the time span of the simulation to time histories shorter than one second, even when employing supercomputers. This work presents a high-speed approach to simulating the mechanobiology of stem cells. The proposed approach separates the computational time from the size, and distribution, of masses of the subcellular elements, enabling the simulation of weeks-long cellular processes within hours on a …

Study Of Nanoparticle Dispersed Phase Change Materials And The Impact Of Temperature Gradient On The Potential For Particle Migration, Udit Sharma

Dissertations, Master's Theses and Master's Reports

Supercooling in phase change materials (PCMs) and the associated challenges in enhancing thermal conductivity through nanoparticle dispersion prompted this investigation. Existing literature exhibits inconsistencies in thermal conductivity improvements, suggesting a potential correlation with nanoparticle migration induced by thermophoresis. To address this, a novel temperature-dependent scaling parameter, \(\xi\), was introduced to predict particle migration propensity. A strong association was observed between higher \(\xi\) values and diminished thermal conductivity enhancements, indicating a significant influence of nanoparticle movement on heat transfer.

To further elucidate this relationship, a Nanoparticle Interaction Parameter \(N_\text{{pl}}\) was developed, incorporating critical fluid properties and interfacial effects. The derived critical …

Exploring Regular And Turbulent Flow States In Active Nematic Channel Flow Via Exact Coherent Structures And Their Invariant Manifolds, Caleb G. Wagner, Rumayel H. Pallock, Jae Sung Park, Michael M. Norton, Piyush Grover

Department of Mechanical and Materials Engineering: Faculty Publications

This work is a unified study of stable and unstable steady states of 2D active nematic channel flow using the framework of Exact Coherent Structures (ECSs). ECSs are stationary, periodic, quasiperiodic, or traveling wave solutions of the governing equations that, together with their invariant manifolds, organize the dynamics of nonlinear continuum systems. We extend our earlier work on ECSs in the preturbulent regime by performing a comprehensive study of stable and unstable ECSs for a wide range of activity values spanning the preturbulent and turbulent regimes. In the weakly turbulent regime, we compute more than 200 unstable ECSs that coexist …

What Does It Mean To Be “Prepared For Work”? Perceptions Of New Engineers, Jessica R. Deters, Marie C. Paretti, Logan A. Perry, Robin Ott

Department of Mechanical and Materials Engineering: Faculty Publications

Background: Engineering education seeks to prepare students for engineering practice, but the concept of preparedness is often ill-defined. Moreover, findings from studies of different populations or in different contexts vary regarding how well new graduates are prepared. These variations, coupled with the lack of clarity, suggest the need to better understand what it means to be prepared for engineering work.

Purpose: This study contributes to research on workplace preparation by exploring how new graduates describe being prepared for engineering work.

Method: Applying secondary analysis to data from the multi-institution Capstone To Work (C2W) project, we used thematic …

Impact Of Silicon Ion Irradiation On Aluminum Nitride-Transduced Microelectromechanical Resonators, David D. Lynes, Joshua Young, Eric Lang, Hengky Chandrahalim

Faculty Publications

Microelectromechanical systems (MEMS) resonators use is widespread, from electronic filters and oscillators to physical sensors such as accelerometers and gyroscopes. These devices' ubiquity, small size, and low power consumption make them ideal for use in systems such as CubeSats, micro aerial vehicles, autonomous underwater vehicles, and micro-robots operating in radiation environments. Radiation's interaction with materials manifests as atomic displacement and ionization, resulting in mechanical and electronic property changes, photocurrents, and charge buildup. This study examines silicon (Si) ion irradiation's interaction with piezoelectrically transduced MEMS resonators. Furthermore, the effect of adding a dielectric silicon oxide (SiO₂) thin film is …

A Review On The Coalescence Of Confined Drops With A Focus On Scaling Laws For The Growth Of The Liquid Bridge, Sangjin Ryu, Haipeng Zhang, Udochukwu John Anuta

Department of Mechanical and Materials Engineering: Faculty Publications

The surface–tension-driven coalescence of drops has been extensively studied because of the omnipresence of the phenomenon and its significance in various natural and engineering systems. When two drops come into contact, a liquid bridge is formed between them and then grows in its lateral dimensions. As a result, the two drops merge to become a bigger drop. The growth dynamics of the bridge are governed by a balance between the driving force and the viscous and inertial resistances of involved liquids, and it is usually represented by power–law scaling relations on the temporal evolution of the bridge dimension. Such scaling …

Revealing Interface-Assisted Plastic Anisotropy Via In Situ Transmission Electron Microscopy Tension Of Lamellar Tial, Zhixiang Qi, Qi Zhu, Jian Wang, Yuede Cao, Fengrui Chen, Jiangwei Wang, Yang Chen, Gong Zheng, Guang Chen

Department of Mechanical and Materials Engineering: Faculty Publications

Assembling functional units into specific orientation organizations based on functional unit and organization (FUO) paradigm can maximize utilizing mechanical property anisotropy of lamellar-structured materials. However, the origin of their anisotropic deformation behaviors has not been clearly understood. Taking the fully lamellar γ-TiAl/ α₂-Ti₃Al dual-phase single crystal as an example, we decouple the interface functional units governed anisotropic plastic deformation through in situ transmission electron microscopy tensile testing and multiscale microstructural characterizations. The orientation organization-dependent slip continuity across the γ/α₂ interface and interface strength play a determinant role in plastic anisotropy beyond intrinsic dislocation activities within …

Top-Down Nanomanufacturing Of Anisotropic Two-Dimensional Metals, Md Rubayat-E Tanjil

USF Tampa Graduate Theses and Dissertations

Two-dimensional (2D) materials have introduced a transformative era in materials science with extensive research being performed to gain a fundamental understanding of their diverse properties and applications. Amongst the broader 2D material family, 2D metals or 2D metallic nanosheets (2DMNSs) typically denotes the nanometer-scale thin elemental metals, compound, or alloys, which shows superlative chemical and physical properties compared to bulk counterparts due to the reduced dimensionality. 2D materials’ widespread direct physical or chemical isolation techniques have been facilitated due to their intrinsic van der Waals layered morphology, whereas 3D close-packed bulk metals with isotropic bonding hinder their facile isolation in …

Steerable Acoustically Powered Starfish-Inspired Microrobot, Cornel Dillinger, Justin Knipper, Nitesh Nama, Daniel Ahmed

Department of Mechanical and Materials Engineering: Faculty Publications

Soft polymeric microrobots that can be loaded with nanocargoes and driven via external field stimuli can provide innovative solutions in various fields, including precise microscale assembly, targeted therapeutics, microsurgery, and the capture and degradation of unwanted wastewater fragments. However, in aquatic environments, it remains challenging to operate with microrobotic devices due to the predominant viscous resistances and the robots’ limited actuation and sensing capabilities attributed to their miniaturization. The miniature size prevents the incorporation of onboard batteries that can provide sufficient power for propulsion and navigation, necessitating a wireless power supply. Current research examines untethered microrobot manipulation using external magnetic, …

Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label-Free Delivery, Justin R. Brooks, Tyler C. Heiman, Sawyer R. Lorenzen, Ikhlaas Mungloo, Siamak Mirfendereski, Jae Sung Park, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Porous substrate electroporation (PSEP) is a promising new method for delivering molecules such as proteins and nucleic acids into cells for biomedical research. Although many applications have been demonstrated, fundamentals of the PSEP delivery process are not yet well understood, partly because most PSEP studies rely solely on fluorescent imaging for evaluating delivery and quantifying successful outcomes. Although effective, only utilizing imaging alone limits our understanding of the intermediate processes leading to intracellular delivery. Since PSEP is an electrical process, electrical impedance measurements are a natural addition to fluorescent imaging for PSEP characterization. In this study, we developed an integrated …

Increased Ductility Of Ti-6al-4v By Interlayer Milling During Directed Energy Deposition, Rakeshkumar Karunakaran, Luz D. Sotelo, Hitarth Maharaja, Calsey Nez, Monsuru Ramoni, Scott Halliday, Sushil Mishra, Joseph A. Turner, Michael P. Sealy

Department of Mechanical and Materials Engineering: Faculty Publications

Additive manufacturing (AM) often results in high strength but poor ductility in titanium alloys. Hybrid AM is a solution capable of improving both ductility and strength. In this study, hybrid AM of Ti-6Al-4V was achieved by coupling directed energy deposition with interlayer machining. The microstructure, residual stress, and microhardness were examined to explain how interlayer machining caused a 63% improvement in ductility while retaining an equivalent strength to as-printed samples. Interlayer machining introduced recurrent interruptions in printing that allowed for slow cooling-induced coarsening of acicular α laths at the machined interfaces. The coarse α laths on the selectively machined layers …

Acoustophoresis Around An Elastic Scatterer In A Standing Wave Field, Khemraj Gautam Kshetri, Nitesh Nama

Department of Mechanical and Materials Engineering: Faculty Publications

Acoustofluidic systems often employ prefabricated acoustic scatterers that perturb the imposed acoustic field to realize the acoustophoresis of immersed microparticles. We present a numerical study to investigate the timeaveraged streaming and radiation force fields around a scatterer. Based on the streaming and radiation force field, we obtain the trajectories of the immersed microparticles with varying sizes and identify a critical transition size at which the motion of immersed microparticles in the vicinity of a prefabricated scatterer shifts from being streaming dominated to radiation dominated. We consider a range of acoustic frequencies to reveal that the critical transition size decreases with …

Stomatal Opening Efficiency Is Controlled By Cell Wall Organization In Arabidopsis Thaliana, Sedighe Keynia, Leila Jaafar, You Zhou, Charles T. Anderson, Joseph A. Turner

Department of Mechanical and Materials Engineering: Faculty Publications

Stomatal function in plants is regulated by the nanoscale architecture of the cell wall and turgor pressure, which together control stomatal pore size to facilitate gas exchange and photosynthesis. The mechanical properties of the cell wall and cell geometry are critical determinants of stomatal dynamics. However, the specific biomechanical functions of wall constituents, for example, cellulose and pectins, and their impact on the work required to open or close the stomatal pore are unclear. Here, we use nanoindentation in normal and lateral directions, computational modeling, and microscopic imaging of cells from the model plant Arabidopsis thaliana to investigate the precise …

A Review Of Nano And Microscale Heat Transfer: An Experimental And Molecular Dynamics Perspective, Samyabrata Chatterjee, Paras, Han Hu, Monojit Chakraborty

Mechanical Engineering Faculty Publications and Presentations

Significant progress in the development of micro and nanoscale devices has been observed for the past three decades. The thermal transportation in these small-length scales varies significantly, and it is difficult to explain the underlying physics using the pre-existing theoretical formulations. When the bulk dimension of a system is comparable to or smaller than the mean free path (MFP) of the thermal carriers, classical theories, such as Fourier’s Law of heat conduction, are unable to accurately explain the system energy dynamics. The phenomena of energy transit and conversion at the micro to nanoscale is an interesting topic of research due …

Influence Of Swirl And Turbulence In The Particle Removal Using Fog In A Pipe Flow, Nisarg T. Patel

All Theses

Fog-and-tube scrubbers are employed to remove harmful ultrafine aerosols, such as Diesel particulate matter (DPM), from an airflow. The underlying principle of this removal process involves enlarging the aerosol particles by coagulating them with fog drops, which are subsequently eliminated through inertial impaction onto the tube wall. Previous research conducted by Tabor et al. (2021) demonstrated an increase in scavenging of ultrafine DPM particles, ranging from 11.5 nm to 154 nm, by as large as 45% over the no fog case. This finding is crucial in addressing the challenges associated with conventional filtration methods for capturing ultrafine particles.

The present …

Two-Dimensional Nanomaterials And Nanocomposites For Sensing, Separation, And Energy Applications, Md Ashiqur Rahman

Theses and Dissertations

Two-dimension (2D) nanomaterials have gained popularity for the last few decades due to their excellent mechanical, electrical and thermal properties. These unique properties of 2D nanomaterials can be exploited in various applications specially in sensor, energy, and separation devices. In this study, the sensing and energy generation performance of PVDF/PAni fiber mat systems made by the forcespinning method with and without graphene coating. The graphene-coated nanocomposites show an average output voltage of 75 mV (peak-to-peak) which is 300% higher compared to bare fiber mats and an output current of 24 mA (peak-to-peak) by gentle finger pressing. Moreover, the graphene-coated PVDF/PAni …

Chemical And Physical Interaction Mechanisms And Multifunctional Properties Of Plant Based Graphene In Carbon Fiber Epoxy Composites, Daniel W. Mulqueen

Mechanical & Aerospace Engineering Theses & Dissertations

Graphene has generated substantial interest as a filler due to its exceptional strength, flexibility, and conductivity but faces obstacles in supply and implementation. A renewable, plant-based graphene nanoparticle (pGNP) presents a more accessible and sustainable filler with the same properties as mineral graphenes. In this study, the mechanisms of graphene reinforcement in carbon fiber reinforced plastic (CFRP) were examined, along with the resulting improvements to mechanical strength, resistance to crack propagation, electrical and thermal conductivity at elevated temperatures. pGNP, produced from renewable biomass, was shown to have a graphitic structure with flakes 3-10 layers thick and a median lateral size …

Twin-Solute, Twin-Dislocation And Twin-Twin Interactions In Magnesium, Materials Yue, Jian Wang, Jian-Feng Nie

Department of Mechanical and Materials Engineering: Faculty Publications

Magnesium alloys have received considerable research interest due to their lightweight, high specific strength and excellent castability. However, their plastic deformation is more complicated compared to cubic materials, primarily because their low-symmetry hexagonal closepacked (hcp) crystal structure. Deformation twinning is a crucial plastic deformation mechanism in magnesium, and twins can affect the evolution of microstructure by interacting with other lattice defects, thereby affecting the mechanical properties. This paper provides a review of the interactions between deformation twins and lattice defects, such as solute atoms, dislocations and twins, in magnesium and its alloys. This review starts with interactions between twin boundaries …

Atomistic Simulations Of Twin Facets Associated With Three-Dimensional { []011 } Twins In Magnesium, Qiyu Zeng, Mingyu Gong, Houyu Ma, Yao Shen, Jian-Feng Nie, Jian Wang, Yue Liu

Department of Mechanical and Materials Engineering: Faculty Publications

Twinning is a deformation mechanism that creates three-dimensional (3D) twin domains through the migration of twin facets. This occurs via the nucleation and glide of twinning disconnections (TDs), which can pile up to create twin facets. A comprehensive under- standing of twin facets associated with 3D twins, including their atomic structures and energies, is crucial for understanding deformation twinning. In this study, we propose a molecular statics/dynamics (MS/MD) approach to determine characteristic twin facets enclosing 3D non-equilibrium/equilibrium { [] 011 } twin domains, which has been much less studied than the counterpart { [] 012 } twin domains. The stability …

The Essential Work Of Fracture In Peridynamics, Christer Stenström, Kjell Eriksson, Florin Bobaru, Stefan Golling, Pär Jonsén

Department of Mechanical and Materials Engineering: Faculty Publications

In this work, the essential work of fracture (EWF) method is introduced for a peridynamic (PD) material model to characterize fracture toughness of ductile materials. First, an analytical derivation for the path-independence of the PD J -integral is provided. Thereafter, the classical J -integral and PD J-integral are computed on a number of analytical crack problems, for subsequent investigation on how it performs under large scale yielding of thin sheets. To represent a highly nonlinear elastic behavior, a new adaptive bond stiffness calibration and a modified bonddamage model with gradual softening are proposed. The model is employed for two …

Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors For Tendon Tissue Engineering, Chiara Rinoldi, Ewa KijeńSka-GawrońSka, Marcin Heljak, Jakub Jaroszewicz, Artur KamińSki, Ali Khademhosseini, Ali Tamayol, Wojciech Swieszkowski

Department of Mechanical and Materials Engineering: Faculty Publications

In recent years, fiber-based systems have been explored in the frame of tissue engineering due to their robustness in recapitulating the architecture and mechanical properties of native tissues. Such scaffolds offer anisotropic architecture capable of reproducing the native collagen fibers’ orientation and distribution. Moreover, fibrous constructs might provide a biomimetic environment for cell encapsulation and proliferation as well as influence their orientation and distribution. In this work, we combine two fiber fabrication techniques, such as electrospinning and wet-spinning, in order to obtain novel cell-laden 3D fibrous layered scaffolds which can simultaneously provide: (i) mechanical support; (ii) suitable microenvironment for 3D …

Nitric Oxide: Physiological Functions, Delivery, And Biomedical Applications, Syed Muntazir Andrabi, Navatha Shree Sharma, Anik Karan, S. M. Shatil Shahriar, Brent Cordon, Bing Ma, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth). Due to its gaseous form, NO has a short half-life, and its physiology role is concentration dependent, often restricting its function to a target site. Providing NO from an external source is beneficial in promoting cellular functions and treatment of different pathological conditions. Hence, the multifaceted role of NO in physiology and pathology has garnered massive interest in developing strategies to deliver exogenous NO for the treatment of various regenerative and biomedical …

Design And Development Of Ultrabroadband, High-Gain, And High-Isolation Thz Mimo Antenna With A Complementary Split-Ring Resonator Metamaterial, Ammar Armghan, Khaled Aliqab, Meshari Alsharari, Osamah Alsalman, Juveriya Parmar, Shobhit K. Patel

Department of Mechanical and Materials Engineering: Faculty Publications

The need for high-speed communication has created a way to design THz antennas that operate at high frequencies, speeds, and data rates. In this manuscript, a THz MIMO antenna is designed using a metamaterial. The two-port antenna design proposed uses a complementary splitring resonator patch. The design results are also compared with a simple patch antenna to show the improvement. The design shows a better isolation of 50 dB. A broadband width of 8.3 THz is achieved using this complementary split-ring resonator design. The percentage bandwidth is 90%, showing an ultrabroadband response. The highest gain of 10.34 dB is achieved …

Restoration Of Normal Blood Flow In Atherosclerotic Arteries Promotes Plaque Stabilization, Morgan A. Schake, Ian Mccue, Evan T. Curtis, Thomas J. Ripperda Jr., Samuel Harvey, Bryan T. Hackfort, Anna Fitzwater, Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Blood flow is a key regulator of atherosclerosis. Disturbed blood flow promotes atherosclerotic plaque development, whereas normal blood flow protects against plaque development. We hypothesized that normal blood flow is also therapeutic, if it were able to be restored within atherosclerotic arteries. Apolipoprotein E-deficient (ApoE^-/-) mice were initially instrumented with a blood flow-modifying cuff to induce plaque development and then five weeks later the cuffwas removed to allowrestoration of normal blood flow. Plaques in decuffed mice exhibited compositional changes that indicated increased stability compared to plaques in mice with the cuff maintained. The therapeutic benefit of decuffingwas comparable …

Exploring The Intersection Of Biology And Design For Product Innovations, Ajay P. Malshe, Salil Bapat, Kamlakar Rajurkar, Ang Ang, Jean-Marc Linares

Department of Mechanical and Materials Engineering: Faculty Publications

Design, development, productization, and applications of advanced product concepts are pressing for higher multifunctionality, resilience, and maximization of available resources equitably to meet the growing and continuing demands of global customers. These demands have further accelerated during the recent COVID- 19 pandemic and are continuing to be a challenge. Engineering designs are one of the most effective ways to endow products with functions, resilience, and sustainability. Biology, through millions of years of evolution, has met these acute requirements under severe resource and environmental constraints. As the manufacturing of products is reaching the fundamental limits of raw materials, labor, and resource …

Self-Assembly Of Exfoliated Graphene Flakes As Anticorrosive Coatings For Additive Manufactured Steels, Kaleb Hood, Wen Qian, Yi Xia, Savannah Krupa, Annie Dao, Sarah Ahmed, Samuel Olson, Nam Nguyen, Joseph A. Turner, Jun Jiao

Department of Mechanical and Materials Engineering: Faculty Publications

This study demonstrates the feasibility of using liquid exfoliation of expandable graphite into multilayer exfoliated graphene flakes (EGFs) to form a self-assembled thin film on an air–water interface. The film can coat the surface of additive manufactured (AM) steel substrates to enhance surface properties, specifically AM 316 stainless-steel (AM316), AM 8620 steel (AM8620), and samples of the same alloys made by conventional manufacturing (CM) processes. Liquid exfoliation offers a high yield route for an EGF coating that can cover up to 95% of the sample surface with a single application. The thin, flexible EGFs can coat a rough AM metal …

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …

Editorial: Disease Biomarker Analysis Based On Optical Biosensing, Tianshu Chen, Fanben Meng, Binwu Ying, Xiaoli Zhu

Department of Mechanical and Materials Engineering: Faculty Publications

Disease biomarker analysis has become a crucial tool for diagnosing and evaluating disease prognosis, especially with the increasing understanding of diseases at the molecular level. Abnormalities in various biomarkers can indicate diseased states, and can be used to rapidly and specifically detect and quantify diseases using optical biosensing techniques (Gao et al., 2023). Optical biosensing techniques have several advantages over traditional methods including higher sensitivity, specificity, and faster analysis times (Plikusiene and Ramanaviciene, 2023). It also allows for non-invasive sample collection. With advancements in optical biosensing technology, many medical conditions including cancers, infectious diseases, and autoimmune disorders can be accurately …

Considering The Influence Of Coronary Motion On Artery‑Specific Biomechanics Using Fluid–Structure Interaction Simulation, Nicholas A. T. Fogell, Miten Patel, Pan Yang, Roosje M. Ruis, David B. Garcia, Jarka Naser, Fotios Savvopoulos, Clint Davies Taylor, Anouk L. Post, Ryan M. Pedrigi, Ranil De Silva, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

The endothelium in the coronary arteries is subject to wall shear stress and vessel wall strain, which influences the biology of the arterial wall. This study presents vessel-specific fluid–structure interaction (FSI) models of three coronary arteries, using directly measured experimental geometries and boundary conditions. FSI models are used to provide a more physiologically complete representation of vessel biomechanics, and have been extended to include coronary bending to investigate its effect on shear and strain. FSI both without- and with-bending resulted in significant changes in all computed shear stress metrics compared to CFD (p = 0.0001). Inclusion of bending within …