Computer-Aided Engineering and Design Commons^™

Computational Insights Into Nucleosome Dynamics In Epigenetics Using Molecular Dynamics Simulations, Rutika Patel

Dissertations, Theses, and Capstone Projects

Nucleosome core particles (NCP) are the building blocks that form a highly organized and compact chromatin structure. Nucleosomes package DNA in the nucleus of eukaryotic cells. The NCP consists of about 147 base pairs of DNA wrapped around the histone octamer, with 1.65 superhelical turns in a left-handed manner. The histone octamer is composed of two copies of H3, H4, H2A, and H2B. Together with histone H1 and linker DNA, they further assemble into a higher-order chromatin structure. The nucleosome complex is stabilized by electrostatic interactions between positively charged histone residues and the negatively charged DNA backbone. To effectively access …

Nasa Design And Analysis Of Pegda Hydrogels For Microgreen Cultivation In Space, Fabiha Samiha, Luis E. Luna, Kelly Wu, Gabriel Antigua, Artur Abramyan

Publications and Research

Through multiple experiments, Polyethylene Glycol Diacrylate (PEGDA), a biocompatible polymer, has shown potential as a soilless growing medium for microgreens like arugula. However, a challenge arises when the roots run out of space within the hydrogel capsule, pushing the plant out of position and preventing it from absorbing nutrients from the PEGDA.

This study aims to address this challenge by analyzing different 3D-printed mold designs for the creation of the hydrogel capsules. The most promising designs include coil and tree-branch models, which encourage roots to grow in a way that relieves pressure on the leaf side of the plant, helping …

Computational Fluid Dynamics Analysis Of A Turbine Blade, Luis Luna, Fabiha Samiha

Publications and Research

In Aerospace engineering, the use of computer-aided design (CAD) software, such as SolidWorks, is crucial when designing and validating high-performance parts. SolidWorks provides a valuable tool for simulating computational fluid dynamics (CFD), allowing engineers to analyze and visualize how parts behave under real-world aerodynamic conditions.

One such part is a turbine blade, an airfoil-shaped component inside a jet engine that compresses and redirects airflow to generate thrust. This study aims to perform aerodynamic testing of a single turbine blade design while evaluating SolidWorks' ability to simulate external flow conditions. By visualizing velocity profiles, pressure distribution, and vortex formation, the simulation …

Valve Train Design And Material Testing, Luis Luna

Publications and Research

In automotive engineering, CAD software like SolidWorks enables engineers to design and simulate mechanical components efficiently, reducing the need for extensive prototyping. This project examines the rocker arm's performance and durability within a valve train system. Components like pushrods, camshafts, and rocker arms control air intake and exhaust timing. Due to its high-impact motion and exposure to elevated temperatures, the rocker arm endures considerable wear. This study uses SolidWorks and Finite Element Analysis (FEA) to analyze the rocker arm's stress, deformation, and wear potential during camshaft movement. Material testing and motion analysis results provide insights into improving the durability of …

Code To Combustion: Cnc Rotor Replication Using Cam, Luis Luna

Publications and Research

In the current landscape, computer-aided design (CAD) and computer numerical control (CNC) technologies have greatly enhanced manufacturing processes, allowing rapid and high-precision production. This project will focus on recreating a Wankel engine rotor, using SolidWorks for design and Mastercam for Computer-Aided Manufacturing (CAM) simulations. The process begins with SolidWorks, which is used for a template of a high-precision rotor model. Mastercam is then utilized for the CAM programming, allowing for the creation of intricate tool paths and tool usage simulations. This approach is vital for complex objects like the Wankel engine rotor, which demands high precision. The primary objective of …

Exploring Methods For Recycling Filament Waste In 3d Printing, Max Rios Carballo

Publications and Research

The goal of the current study is to investigate cutting-edge techniques for recycling filament waste from 3D printing procedures. Appropriate waste management techniques are required to reduce this trash's harmful environmental consequences. The goal of the project is to look at new methods for recycling filament waste in order to minimize disposal and encourage reuse. To acquire data from pertinent papers and research, a thorough literature review methodology was used. The findings show that this issue may be resolved utilizing a variety of recycling techniques, including shredding, melting, and re-extrusion. The type of filament waste and the intended goal will …

Use Of Bioheat Modeling To Characterize And Optimize Implantable Medical Devices And Neuromodulation Technologies, Adantchede Louis Zannou

Dissertations and Theses

Medical device development includes prototyping, benchtop characterization, preclinical studies, and clinical trials. Understanding the limitations and potential adverse effects of medical devices prior to their administration in humans is a crucial first step. Optimizing medical devices is essential to employing technology and improving patients care. Computational modeling is widely adopted as a powerful tool to predict stimulation/recording parameter optimization, rapid electrode/device prototyping, investigating novel mechanism of action, and testing working principles of any medical devices. Many implantable neuromodulation technologies including Spinal Cord Stimulation (SCS), which provide substantial therapeutic benefit for patient population with lower back pain, produces heat via the …

Exploring Solidworks Simulation And Structural Analysis Tools To Predict Real-World Physical Behaviors, Itay Rubin

Publications and Research

Computer Aided Design (CAD) Software can optimize the product design process prior to manufacturing. This project examines engineering solutions using CAD software called SolidWorks. It simulates how the product will behave under a variety of engineering constraints. These simulations allow designers to optimize performance, cost, and speed efficiencies. The project uses simulations and finite element analysis to replicate real world behavior. It presents high-level capabilities in the design process, exposing new engineers to simulation tools that are available and relevant in mechanical engineering design. This project required independent research to obtain an advanced understanding of the software interface and capabilities.

Adhesively Bonded Multi-Material Single Lap Joints Under Static Tensile Loading, Yesim Kokner

Dissertations and Theses

Adhesive joints are widely used in a variety of industrial applications utilizing the improved mechanical properties they provide over traditional mechanical joining methods. [1] The lap joint is a usual test specimen with a view to assessing the strength and properties of joints.

This study deals with the stiffness, strength and fracture behavior of multi-material single-lap joints. It describes the mechanical behavior of a multi-material single lap joints subjected to static tensile loading in the longitudinal direction. First, steel-to-steel and aluminum-to-aluminum joints are tested to establish baseline data. Subsequently, multi-material joints consisting of aluminum-to-steel, aluminum-to-composite, and steel-to-composite joints were tested …

Workforce Development Strategies In Additive Manufacturing, Mel Cossette, Ismail Fidan, Gaffar Gailani, Angran Xiao

Publications and Research

Additive Manufacturing (AM), also known as 3D Printing (3DP), is one of the newest manufacturing technologies with growing utilization in our daily life. Parallel to this growth, new materials, machines, and specific processes are being developed to produce parts in better-finished quality, at lower cost, and with shorter production time. However, workforce education in this evolving field has not advanced at the same pace as the technology, lacking proven curriculums, high-quality/accredited degree programs, and specialized advanced degrees. In this paper, some best practices established by the authors are introduced. The list is far from exhaustive but is proven to be …

The Study Of 3d Micro-Fluid Printing In Aqueous Two-Phase System, Mian Huang

Dissertations and Theses

Aqueous two-phase system (ATPS) is a technology that allows phase separation in an aqueous environment. This technology can be used for the separation, extraction and purification of a variety of biomolecules and thus gained great attention in industry and academia. This thesis is a combination of ATPS, 3D printing, and microfluidics technologies and realizes the printing of biocompatible aqueous structures in another aqueous matrix. The objectives of this thesis include 1) customizing a regular thermal extrusion 3D printer for printing 3D aqueous structures, 2) printing 3D aqueous structure in an aqueous matrix, and 3) studying the stability of the printed …

Fly Ash Based Geopolymer For High Temperature And High Compressive Strength Applications In Aggressive Environment, Aaryan Manoj Nair, Akm S. Rahman

Publications and Research

Geopolymers are the results of geosynthetic reactions between aluminosilicates and strong bases. This results in chemical bonds between aluminum (Al), Silicon (Si)and oxygen (O) composing polymer rings in tetrahedral coordination. These bonds give them widespread useful applications such as high heat bearing ceramics, and base construction material whilst being far more environmentally conscious. The purpose of the experiment is to examine the effect of Silicon Carbide whisker and inorganic glass particles on thermal and mechanical properties of Geopolymers. This study will help understand the effect of various compositions and concentrations of SiO₂ in mechanical strength. In this experiment, the …

High Tech, High Risk: Tech Ethics Lessons For The Covid-19 Pandemic Response, Emanuel Moss, Jacob Metcalf

Publications and Research

The COVID-19 pandemic has, in a matter of a few short months, drastically reshaped society around the world. Because of the growing perception of machine learning as a technology capable of addressing large problems at scale, machine learning applications have been seen as desirable interventions in mitigating the risks of the pandemic disease. However, machine learning, like many tools of technocratic governance, is deeply implicated in the social production and distribution of risk and the role of machine learning in the production of risk must be considered as engineers and other technologists develop tools for the current crisis. This paper …

Static Analysis Of Circular Plates Under Mechanical Loads, Harpreet Lalia

Publications and Research

In this research statics analysis of circular plates is performed using SolidWorks.

Circular plates with different material properties, thickness to radius ratios, and boundary conditions under mechanical loads are modeled and analyzed in SolidWorks.

The results are obtained for deflections of circular plates under uniform and point loads.

A three-dimensional (3D) model of circular plates is first created in SolidWorks. Then the material properties, mechanical loads and boundary conditions are defined for the plate.

It is found deflection of plates is depended on magnitude of mechanical loads, geometrical parameters, boundary conditions and material properties. Responses of SolidWorks for deflections of …

Restore-L Satellite Servicing Internship Final Report, Giovanni Campos

Publications and Research

This paper reviews the Restore-L mission purpose and the necessary research and simulations to meet mission specification for the Propellant Transfer Subsystem (PTS). It is essential the PTS undergoes functionality testing, environmental testing, and calculations to understand the capabilities of the system. For the testing of components from PTS, a proper test setup is required. It is vital for test hardware, such as hoses and valves, to stay in place while the test is being performed. For the test hardware to operate correctly, positioning, orientation, and alignment are critical as well. In addition to the testing, calculations for pressure drop …

Coalescence-Induced Jumping Of Droplet: Inertia And Viscosity Effects, Samaneh Farokhirad, Jeffrey F. Morris, Taehun Lee

Publications and Research

The problem of coalescence-induced self-propelled jumping of droplet is studied using three-dimensional numerical simulation. The focus is on the effect of inertia and in particular the effect of air density on the behavior of the merged droplet during jumping. A lattice Boltzmann method is used for two identical, static micro-droplets coalescing on a homogeneous substrate with contact angle ranging from 0◦ to 180◦. The results reveal that the effect of air density is significant on detachment of the merged droplet from the substrate at the later stage of the jumping process; the larger the air density, the larger the jumping …

Morphology Of Brain Sulci Trabeculae And Its Effect On Brain During Impacts, Sharlin Anwar

Dissertations and Theses

Traumatic brain injury (TBI) is an intracranial injury caused by direct contact or non-contact head impacts to the brain. TBI is a major problem that accounts for high incidents of hospitalizations each year. Thus, it is important to understand and predict the occurrence of TBI in an impact. It has been shown that the subarachnoid space (SAS) trabeculae play an important role in damping the effect of an impact, thus reducing the injuries. However, the influence of sulci parameters and the sulci trabeculae in TBI due to impact is unexplored. Studies have shown that inclusion of sulci in brain models …