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Full-Text Articles in Electronic Devices and Semiconductor Manufacturing
Development Of A Low Cost Biosensing Platform For Highly Sensitive And Specific On-Site Detection Of Pathogens And Infections, Cheng Cheng
Doctoral Dissertations
A highly sensitive, specific, real time, and field-deployable surveillance tool is critical to the control of pathogens and infections, as well as ecological impact of chemicals exposure. This work investigates the development of a low cost biosensing platform that can be used for viral disease diagnosis and chemical detection. The sensing mechanism is known as AC electrokinetics (ACEK) capacitive sensing. By applying an inhomogeneous AC electric field on sensor electrodes, positive dielectrophoresis is induced to accelerate the travel of analytes. The same applied AC signal also directly measures the capture of target by the probe on sensor surface. The realized …
Alternating Current Electrokinetics Based Capacitive Affinity Biosensor: A Point-Of-Care Diagnostic Platform, Haochen Cui
Alternating Current Electrokinetics Based Capacitive Affinity Biosensor: A Point-Of-Care Diagnostic Platform, Haochen Cui
Doctoral Dissertations
Capacitive bioaffinity detection using microelectrodes is considered as a promising label-free method for point-of-care diagnosis, though with challenges in sensitivity, specificity and the time “from sample to result.” This work presents an alternating current (AC)-electrokinetic based capacitive affinity sensing method that is capable of realizing rapid in-situ detection of specific biomolecular interactions such as probe-analyte binding. The capacitive biosensor presented here employs elevated AC potentials at a fixed frequency for impedimetric interrogation of the microelectrodes. Such an AC signal is capable of inducing dielectrophoresis (DEP) and AC electrothermal (ACET) effects, so as to realize in-situ enrichment of macro and even …