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Developing A Drug Delivery System For Treatment Of Vocal Fold Scarring, Aaron Michael Kosinski
Developing A Drug Delivery System For Treatment Of Vocal Fold Scarring, Aaron Michael Kosinski
Open Access Dissertations
Vocal fold scarring is an affliction that results in the formation of a disorganized and stiff extracellular matrix (ECM) with abnormal ECM component densities & structures including a significant increase in collagen deposition. It is caused by improper healing post injury and results in profound changes in the biomechanical properties of the vocal folds impairing their ability to generate a normal mucosal wave during phonation.
Finding an effective treatment for vocal fold scarring has been elusive. Currently, treatments seek temporary solutions that correct glottal incompetence and reduce stiffness caused by the scar through the augmentation of the vocal folds using …