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The Effect Of Αct-1 Peptide On Bone Marrow Stromal Cells Following Injury, Adam Clay Vandergriff
The Effect Of Αct-1 Peptide On Bone Marrow Stromal Cells Following Injury, Adam Clay Vandergriff
Theses and Dissertations
Connexin43 (Cx43) is a component of gap junctions and is involved in intercel- lular signaling following injury to tissues. The carboxyl terminus of Cx43 binds to the PDZ2 domain of ZO-1 in order to form gap junction plaques and connect to the cytoskeleton. A biomimetic peptide known as αCT-1, replicating the last 9 amino acids found in the carboxyl terminus of CX43, has been shown to improve wound healing by preferentially binding to the PDZ2 domain of ZO-1. A possible mecha- nism for its action is through the Epithelial-Mesenchymal Transformation (EMT). Scratch assays were performed on rat bone marrow stromal …