Biomedical Commons^™

Brain Science = Biology + Engineering, Jennifer Welborn, Guangyu Xu, Morton Sternheim, Chris Emery

Science and Engineering Saturday Seminars

This interdisciplinary (physical and life sciences) seminar exposes participants to cutting edge research at UMASS, Amherst, on cell imaging using a chip which gathers a variety of data on the activities of single cells. Part of the seminar will be a presentation of current research in this area, followed by hands-on activities and a visit to the lab where this research is conducted. Application of this new technology to brain research will be discussed as well as the NGSS standards alignment and classroom applications at various levels and disciplines.

Activity Intent Recognition Of The Torso Based On Surface Electromyography And Inertial Measurement Units, Zhe Zhang

Masters Theses 1911 - February 2014

This thesis presents an activity mode intent recognition approach for safe, robust and reliable control of powered backbone exoskeleton. The thesis presents the background and a concept for a powered backbone exoskeleton that would work in parallel with a user. The necessary prerequisites for the thesis are presented, including the collection and processing of surface electromyography signals and inertial sensor data to recognize the user’s activity. The development of activity mode intent recognizer was described based on decision tree classification in order to leverage its computational efficiency. The intent recognizer is a high-level supervisory controller that belongs to a three-level …

Rbc Lifespan Uncertainty: Models And Anemia Management Robustness, Rui Dai

Masters Theses 1911 - February 2014

This thesis discusses the modeling of uncertainty of red blood cell (RBC) lifespan distribution in patients suffering from Chronic Kidney Disease(CKD) patients, whose anemia is managed through periodic dosing of erythropoietin (EPO).

In healthy individuals, RBCs containing hemoglobin (Hgb) are produced in the bone marrow. When oxygen carried by hemoglobin is transported to human tissues throughout the body, the kidneys sense reduced level of Hgb and secretes EPO that simulates proliferation of red cell precursors and eventually producing red blood cells. However, in CKD patients, their kidneys fail to secrete enough EPO, so that too few of RBCs are produced …

The Measurement Of Internal Temperature Anomalies In The Body Using Microwave Radiometry And Anatomical Information: Inference Methods And Error Models, Tamara V. Sobers

Masters Theses 1911 - February 2014

The ability to observe temperature variations inside the human body may help in detecting the presence of medical anomalies. Abnormal changes in physiological parameters (such as metabolic and blood perfusion rates) cause localized tissue temperature change. If the anatomical information of an observed tissue region is known, then a nominal temperature profile can be created using the nominal physiological parameters. Temperature-varying radiation emitted from the human body can be captured using microwave radiometry and compared to the expected radiation from nominal temperature profiles to detect anomalies. Microwave radiometry is a passive system with the ability to capture radiation from tissue …

Terahertz Imaging For Cancer Detection, Benjamin A. St. Peter

Masters Theses 1911 - February 2014

This project evaluates the ability of terahertz (THz) radiation to differentiate cancerous from non-cancerous human breast lumpectomy and mastectomy tissue. This is done by aiming a narrow-band THz beam at medical samples and measuring reflected power. THz images of specimens from Breast Conservation Surgery (BCS) were created using a gas laser source and mechanical scanning. The design and characterization of this system is discussed in detail. The images were correlated with optical histological micrographs of the same specimens and discrimination values of more than 70% were found for five of the six samples using Receiver Operating Characteristic (ROC) analysis.