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Adaptive Interventions Treatment Modelling And Regimen Optimization Using Sequential Multiple Assignment Randomized Trials (Smart) And Q-Learning, Abiral Baniya

Electronic Theses and Dissertations

Nowadays, pharmacological practices are focused on a single best treatment to treat a disease which sounds impractical as the same treatment may not work the same way for every patient. Thus, there is a need of shift towards more patient-centric rather than disease-centric approach, in which personal characteristics of a patient or biomarkers are used to determine the tailored optimal treatment. The “one size fits all” concept is contradicted by research area of personalized medicine. The Sequential Multiple Assignment Randomized Trial (SMART) is a multi-stage trials to inform the development of dynamic treatment regimens (DTR’s). In SMART, a subject is …