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Full-Text Articles in Biomedical
Model-Based Approach For Diffuse Glioma Classification, Grading, And Patient Survival Prediction, Zeina A. Shboul
Model-Based Approach For Diffuse Glioma Classification, Grading, And Patient Survival Prediction, Zeina A. Shboul
Electrical & Computer Engineering Theses & Dissertations
The work in this dissertation proposes model-based approaches for molecular mutations classification of gliomas, grading based on radiomics features and genomics, and prediction of diffuse gliomas clinical outcome in overall patient survival. Diffuse gliomas are types of Central Nervous System (CNS) brain tumors that account for 25.5% of primary brain and CNS tumors and originate from the supportive glial cells. In the 2016 World Health Organization’s (WHO) criteria for CNS brain tumor, a major reclassification of the diffuse gliomas is presented based on gliomas molecular mutations and the growth behavior. Currently, the status of molecular mutations is determined by obtaining …
3d Bioprinting Systems For The Study Of Mammary Development And Tumorigenesis, John Reid
3d Bioprinting Systems For The Study Of Mammary Development And Tumorigenesis, John Reid
Electrical & Computer Engineering Theses & Dissertations
Understanding the microenvironmental factors that control cell function, differentiation, and stem cell renewal represent the forefront of developmental and cancer biology. To accurately recreate and model these dynamic interactions in vitro requires both precision-controlled deposition of multiple cell types and well-defined three-dimensional (3D) extracellular matrix (ECM). To achieve this goal, we hypothesized that accessible bioprinting technology would eliminate the experimental inconsistency and random cell-organoid formation associated with manual cell-matrix embedding techniques commonly used for 3D, in vitro cell cultures. The first objective of this study was to adapt a commercially-available, 3D printer into a 3D bioprinter. Goal-based computer simulations were …
Microbubble Generation By Piezoelectric Transducers For Biomedical Studies, Mohammed Alkhazal
Microbubble Generation By Piezoelectric Transducers For Biomedical Studies, Mohammed Alkhazal
Electrical & Computer Engineering Theses & Dissertations
Bubbles induced by blast waves or shocks are speculated as the major cause of damage in biological cells in mild traumatic brain injuries (TBI). Microbubble collapse was found to induce noticeable cell detachment from the cell substrate, changes in focal adhesion, and biomechanics. To better understand the bubble mechanism, a system needs to be constructed which allows clear differentiation on the impact of bubbles from that of shocks. Such a generator needs to be low profile in order to place under a microscope. A piezoelectric transducer system was designed to meet the need. The system uses either a flat or …
Deformable Contour Models For Digitizing A Printed Brainstem Atlas, Nirmal J. Patel
Deformable Contour Models For Digitizing A Printed Brainstem Atlas, Nirmal J. Patel
Electrical & Computer Engineering Theses & Dissertations
The brainstem is a part of the brain that is connected to the cerebrum and the spinal cord. Ten out of twelve pairs of cranial nerves emerge from the brainstem. The cranial nerves transmit information between the brain and various parts of the body. Due to its anatomical and physiological relevance, a descriptive digital brainstem is important for neurosurgery planning and simulation. For both of these neurosurgical applications, the complexity of the brainstem requires a digital atlas approach to segmentation that maps intensities to tissues rather than less descriptive voxel or surface-based approaches. However, a descriptive brainstem atlas with adequate …