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Rbc Lifespan Uncertainty: Models And Anemia Management Robustness, Rui Dai
Rbc Lifespan Uncertainty: Models And Anemia Management Robustness, Rui Dai
Masters Theses 1911 - February 2014
This thesis discusses the modeling of uncertainty of red blood cell (RBC) lifespan distribution in patients suffering from Chronic Kidney Disease(CKD) patients, whose anemia is managed through periodic dosing of erythropoietin (EPO).
In healthy individuals, RBCs containing hemoglobin (Hgb) are produced in the bone marrow. When oxygen carried by hemoglobin is transported to human tissues throughout the body, the kidneys sense reduced level of Hgb and secretes EPO that simulates proliferation of red cell precursors and eventually producing red blood cells. However, in CKD patients, their kidneys fail to secrete enough EPO, so that too few of RBCs are produced …