Computer Engineering Commons^™

Ai In Precision Medicine: Redefining Blindness Treatment Via Retinal Stem Cell Differentiation, Calissa Leong, Tiffany Nguyen

Interdisciplinary Design Senior Theses

Age Macular Degeneration (AMD) is currently the leading cause of blindness, driven by the degradation of Retinal Pigment Epithelial (RPE) cells. Stem-cell based therapies, particularly those involving induced pluripotent stem cells (iPSCs), typically consists of differentiating stem cells into RPE cells in vitro and transplanting them into the subretinal space. Our goal is to improve the accuracy of differentiation into RPE cells to better promote retinal regeneration. Traditional methods to alleviate symptoms of AMD is through therapeutic medications to slow disease progression, though stem cell therapy has emerged as a promising alternative. However, despite its potential, stem cell therapy presents …

Bio-Payload Senior Design Report, Connor Bishop, Oliver Goodall, Marcus Kirk, Gabby Robles, Anish Shanmuganathan

Interdisciplinary Design Senior Theses

This project focuses on the design and development of an autonomous experimental platform capable of conducting cellular biology experiments in a well plate within a CubeSat environment. The system integrates microfluidics, robotics, and onboard sensors to remotely initiate experiments, monitor them, and collect data without human intervention. The objective is to create a platform for automated biological experimentation in microgravity, while reducing reliance on ground-based control and increasing mission efficiency and reproducibility. The team used Saccharomyces cerevisiae to assess the biocompatibility of the well plate and monitor changes in cell culture, including optical density and cell viability.

Statistical Monitoring Of Hard Faults In Digital Systems, Dany Akshay Deep Isukapalli

Electrical Engineering Theses and Dissertations

Achieving a high test coverage is crucial for helping to ensure that integrated circuits are working correctly and are non-defective. Although scan-based structural tests are used throughout the industry, high-level functional tests may be needed to detect some defects— especially those that are environmentally sensitive. Unfortunately, the character of functional test makes it difficult to obtain high coverage, and it is even hard to estimate coverage because fault simulation times of large circuits are long. As a result, some method is required for predicting the ability of a functional test that has not been fault simulated to detect defects. In …

Autonomous Search And Rescue: Real-Time Drone And Robotic Dog Integration, Robert Alexander

Electrical Engineering and Computer Science (MS) Theses

Common robotic navigation techniques often utilize GPS to set up the robot’s reference frame, which is not possible in environments, such as indoor facilities, underground passages, and disaster zones, where GPS is not available. This research explores the integration of a Boston Dynamics Spot robot with a Tello drone to form a non-GPS-based autonomous navigation system. By leveraging coordinate transformation logic, this study enables real-time aerial reconnaissance and ground-based waypoint navigation without reliance on GPS. The methodology includes software development using the Spot SDK and Tello APIs, a virtual networked solution for integration, and an experimental setup to validate navigation …

Swvl: A Custom Ai-Powered Face Tracking Camera Gimbal, Alexander J. Anderson-Mcleod, Jakub Jerzmanowski, Michael Laitarovsky, Trevor Allison, Jagger Tanner

Senior Theses

In response to the growing demand for smarter, more responsive face tracking cameras in the post-pandemic world, our team designed SWVL, a custom AI-powered face tracking gimbal meant to address the limitations commonly encountered by the commercial models currently on the market. These commercially available gimbals come with several issues, such as frequently losing track of the person in the frame and requiring manual resets, which we sought to fix with our implementation. We designed a system with fully custom hardware and software including a 3D printed dual-axis camera gimbal driven by stepper motors, a control PCB based around an …

Development And Evaluation Of Machine Learning Models For Early Pediatric Sepsis Prediction, Ancita M. Andrade

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Sepsis is a leading cause of pediatric mortality, claiming more lives in the United States annually than all childhood cancers combined. Early identification in Emergency Departments (EDs) remains challenging, as the current Phoenix criteria establishes an updated international consensus definition for sepsis, however is not designed for use as a screening tool. This study aimed to develop predictive models identifying pediatric patients at risk of sepsis within 24 hours of admission. Multiple tree-based and deep learning models were trained utilizing clinical and laboratory data from the initial four hours of presentation. Both the LightGBM and LSTM architectures demonstrated superior performance, …

Wearable Sensor Data Analysis For Machine Learning-Based Detection Of Posture And Autonomic Responses, Chaitanya Vardhini Anumula

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This study investigates how Iyengar yoga postures influence autonomic nervous system (ANS) activity by analyzing multimodal physiological signals collected via wearable sensors. The physiological mechanisms underlying Iyengar yoga’s therapeutic effects remain under-explored at the granular, pose-level. Using data collected from 16 participants, this research evaluates whether machine learning models can distinguish between baseline, parasympathetic-dominant, and sympathetic-dominant states based on wrist-worn sensor data. The goals were to explore whether subtle postural variations elicit measurable autonomic responses and to identify which sensor features most effectively capture these changes. Participants performed a sequence of yoga poses while wearing synchronized sensors measuring electrodermal activity …

Impact Of Graph Structures For Rag Outcomes In Llms, Chris Davis Jaldi

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Explainability, interpretability and adaptability (EIA) remain three central motivations for next-generation Artificial Intelligence (AI), especially as Large Language Models (LLMs) continue to engage with ever-increasing knowledge bodies. As the landscape pushes toward controllable agentic Retrieval-Augmented Generation (RAG) systems where AI agents engage in iterative, guided reasoning, a critical question arises as to the extent to which the knowledge design itself shapes these models' reasoning behavior. This work conducts a systematic evaluation of how different conceptualizations and representation of the identical knowledge affect an LLM's path-based reasoning capabilities. Through the introduction of controlled variations along graph structural complexity, linguistic and semantic …

Re-Parameterizing Adversarial Reprogramming In Low-Dimensional Subspace For Efficient Software Vulnerability Detection, Hootan Alavizadeh

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Software vulnerabilities are a major cause of security breaches, making effective detection critical. Traditional learning-based methods require large datasets and significant computational resources, which are often impractical due to high annotation costs and data scarcity. To address this, we propose an innovative system, RearVul, which Re-parameterizes adversarial reprogramming in a low-dimensional subspace for software vulnerability detection. Unlike conventional approaches, RearVul repurposes a pre-trained classification model using adversarial reprogramming, enabling detection with minimal modifications. It learns a universal perturbation applied to program representations, preserving the original model’s feature extraction capabilities while adapting it to a new domain. Furthermore, we introduce a …

Subjective Readiness Forecasting Using Supervised Machine Learning And Wearable Device Data, Nathaniel Michael Weiland

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Recent advances in wearable technology allow continuous monitoring of physiological and behavioral data, opening new opportunities for real-time assessments of readiness and well-being. However, creating predictive models that generalize across diverse users remains challenging, especially in high-stakes settings like the military, where preventable injuries, illnesses, and stress-related performance declines are frequent. This research assesses the feasibility of using supervised machine learning models trained on wearable device data to predict subjective readiness indicators—recovery, stress, injury, and illness. Data from over 10,000 users in the OHWS (Optimizing the Human Weapons System) program combined daily check ins with physiological metrics from Garmin, Polar, …

Dataset Generation For Routing Policy Study In Ad Hoc Wireless Networks, Vishnu Vishnu Priya

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Ad Hoc wireless networks, with their decentralized architecture and dynamic topology, present challenges in reliable and energy-efficient routing. While machine learning (ML) and reinforcement learning (RL) offer promising solutions, progress is limited by the lack of realistic, high-fidelity datasets. This research introduces a simulation-based framework for generating four diverse datasets representing combinations of node mobility (mobile vs. static) and spatial distribution (random vs. clustered). Each dataset captures critical metrics such as Signal-to-Interference-plus-Noise Ratio (SINR), bottleneck rate, and power consumption across multi-hop paths. A lookahead-based greedy routing algorithm with scenario-aware power control is implemented to emulate practical behavior. Supervised ML models, …

Isometric Centroid Encoder (Ice) And Synthetic Data Generation Approaches For Biological Datasets, Prathyusha Kanakamalla

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This thesis addressed two main challenges in biological data analysis: structure-preserving dimensionality reduction and synthetic data generation for small sample datasets. I proposed the Isometric Centroid Encoder (ICE), a supervised dimensionality reduction method that preserves pairwise distances between class centroids during dimension reduction. Unlike existing methods like Centroid Encoder and Super Encoder, ICE explicitly maintains geometric relationships between biological classes, achieving nearly perfect structure preservation at C dimensions (where C equals the number of classes) with strong performance even in 2D and 3D spaces. Additionally, I compared three generative models (VAE, LSH-GAN, and scDiffusion) for synthetic data generation on small …

Leveraging Counterfactuals For Enhanced Natural Language Inference: A Multitask Knowledge Distillation Approach, Brian J. Davis

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Natural-language inference (NLI) asks whether a hypothesis is entailed by, contradicts, or is neutral with respect to a premise. Modern transformers reach high raw accuracy on benchmarks such as SNLI, MNLI, and ANLI, yet they often rely on brittle lexical shortcuts and provide little insight into their decision process. This thesis shows that counterfactual-augmented knowledge distillation can simultaneously boost robustness and supply faithful, token-level explanations—without scaling model size. Four T5-v1_1 students (60M, 220M, 770M, 3B parameters) are trained under four curricula: (1) standard fine-tuning, (2) fine-tuning with free-text rationales, (3) multi-task distillation with naive counterfactuals, and (4) multi-task distillation with …

Optimizing Cloud Computing Resources For Operational Cost And Application Performance Using Machine Learning, Isaac K. Matthew

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As AI-driven workloads accelerate the growth of cloud initiatives and spending, resource waste also increases due to persistent inefficiencies in cloud compute and infrastructure management. Overprovisioned resources and suboptimal configurations often lead to operational inefficiencies and unnecessary financial overhead. These challenges arise from the difficulty of anticipating resource demands in dynamic workloads and selecting suitable virtual machines to ensure optimal performance. Our research proposes a holistic, data-driven framework for managing cloud compute resources that reduces costs without compromising application performance. We integrate a predictive, model-driven, threshold-based autoscaling solution for cloud-native applications with an optimized instance right-sizing approach to select cost-effective …

Reducing Operator Training Time Through Virtual Reality: A Case Study On The Lpkf Protomat E44 Machine, Joshua C. Patel

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This thesis presents the development of an immersive virtual reality (VR) simulation that replicates the operation of the LPKF ProtoMat E44 PCB milling machine. Aimed at reducing operator training time and improving procedural understanding, the simulation offers an interactive and realistic environment where users can safely engage with machine workflows and start-up sequences. The emphasis is on accurate representation, usability, and maintaining immersion to support intuitive learning. Although formal evaluation is outside the scope of this work, the system is designed to serve as a foundation for cost-effective, scalable training in technical and manufacturing contexts, offering a modern alternative to …

Scalable Real-Time Stream Clustering For Unbounded Text Streams, Nathaniel C. Crossman

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Social media, AI systems, IoT sensors, and other platforms generate vast amounts of streaming data. Given this vast volume of information, techniques that can reduce and aggregate data into meaningful topics are essential. One such technique is the two-phase stream clustering approach. In the first, online micro-clustering phase, the system forms micro-clusters from the incoming data stream, incrementally merges new items into related existing micro-clusters, and prunes or fades micro-clusters as they become inactive, producing a constantly updating yet compact set of micro-clusters representing potential topics and subtopics of the stream. In the second, offline macro-clustering phase, these micro-clusters are …

Patient Subset Classification Using Encoded Embeddings And Knowledge Graph Retrieval-Augmented Generation, Benjamin A. Holmes

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The widespread adoption of electronic medical records has created a vast reservoir of clinical data that can be leveraged to better understand how interventions relate to patient outcomes. Much of this information, however, exists as unstructured free-text, posing significant challenges for traditional statistical and machine-learning methods. Solving these challenges would allow the extraction of specific patient subpopulations (clinically relevant cohorts of individuals who share overlapping symptoms, risk factors, or diagnostic criteria), which could be used in precision medicine. Despite this promise, extracting these subpopulations from unstructured medical notes is an ongoing challenge due to the variability of clinical language and …

Generative Adversarial Networks (Gans) For High-Dimensional Biological Data, Harigovind Harikumar

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This thesis investigates the application of Generative AI models, mainly Generative Adversarial Network (GAN) models to high dimensional and low sample size biological datasets like Motion Sickness, Breast Cancer, Crohn, and Melanoma. We utilized and compared three generative AI frameworks: Vanilla GAN, Wasserstein GAN (WGAN), Locality-Sensitive Hashing GAN (LSH-GAN) and Omics GAN. To address the challenges associated with high-dimensionality and low sample size, which was leading to very poor outputs of biological synthetic samples, we came up with an approach to stop the model when it reaches its saturation level. That is, we printed the loss plots to see where …

Pixmix Attack: Implementation And Evaluation Of A Novel Pixel Injection On Digital Video Port (Dvp) Interface In Embedded Camera Systems With Pcb Hardware Trojan, Sayed Md Tashfi Nowroz

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Image sensors are at the heart of machine vision systems in robotics, industrial automation, and surveillance systems which ideally operate with minimal human supervision and only occasional maintenance. The image sensors convert visible light into electrical signals which are locally decoded to image on the printed circuit board (PCB) by an ordinary embedded processor System on Chip (SoC). This thesis investigates a critical vulnerability in such systems, targeting the communication protocol at the signal level during runtime. Specifically, it focuses on a novel attack in the Digital Video Port (DVP) protocol, possible to exploit with PCB-based hardware Trojans, to craft …

A Secure Ml-Assisted Framework For Resilient And Efficient Prediction Of Physiotherapy Sequence In Bilateral Carpal Tunnel Syndrome, Pratik Pandurang Kharat

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Bilateral idiopathic carpal tunnel syndrome (CTS) is a neuromuscular disorder characterized by compression of the median nerve at both wrists, leading to symptoms such as pain, numbness, tingling, and muscle weakness. Unlike unilateral cases, bilateral idiopathic CTS presents distinct therapeutic challenges due to the simultaneous involvement of both hands and the lack of an identifiable underlying cause. This study explores the application of machine learning techniques to predict the optimal sequence of physiotherapeutic interventions Stretching followed by Myofascial Mobilization (S/M) or the reverse (M/S) in female patients with bilateral idiopathic CTS and right hand dominance. Data were drawn from a …

Learning Under Data Scarcity: Reasoning And Negative Distillation For Texts And Graphs, Calvin T. Greenewald

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Modern machine learning (ML) models rely on large amounts of high-quality labeled data to achieve optimal performance. However, in many real-world domains, such as cyber security, acquiring sufficient labeled data is often infeasible due to cost, privacy concerns, and the rapid evolution of underlying phenomena. This challenge underscores the importance of learning under data scarcity. This thesis addresses this challenge by proposing distinct, modality-specific techniques for text and graph domains, which allow models to generalize effectively with minimal data. For text classification task, we incorporate distilled rationales from large language models and adversarial perturbations into the input space to improve …

Activity Map Generation And Event-Based Sensor Processing With Spiking Autoencoders And Sparse Dictionary Learning, Jack Easton

Computer Science and Engineering Theses and Dissertations

This thesis explores the potential of Spiking Neural Networks (SNNs) in processing event sensor data and generating high-fidelity activity maps. Event sensors capture asynchronous binary events with high dynamic range, but traditional processing methods often fail to leverage their advantages fully. SNNs, with their asynchronous, event-driven nature, offer a promising alternative.

A Spiking Autoencoder (SAE) was employed in this thesis to handle the stochastic and sparse event data, integrating deep dictionary learning to enhance the feature space and improve activity map quality. The encoder, modeled after the VGG network, extracts features from event streams generated by speckle patterns, which are …

Understanding Patient Profiles In Sickle Cell Disease Using Unsupervised Machine Learning, Raj Kamal Somavarapu

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Sickle Cell Disease (SCD) is one of the most prevalent genetic blood disorders affecting millions of people worldwide. It is often accompanied by acute and/or chronic pain leading to increased healthcare costs and adverse outcomes. Effective management of SCD requires an understanding of the diverse physiological profiles. This study employs unsupervised machine learning, specifically K-means clustering to categorize the patients suffering with SCD into different clusters based on their vital signs. The main aim is to identify the groups that reflect similarities in physiological and pain profiles, allowing an in-depth analysis to reveal distinctive features distinguishing patient clusters. The project …

Enhancing Robustness Of Graph Neural Network Against Adversarial Attacks By Balancing Local And Global Perspectives, Bibek Raj Joshi

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Graph Neural Networks (GNNs) have increasingly gained popularity as tools for analyzing graph data in areas like biology, knowledge-graphs, social networks, biology, and recommendation systems. However, their vulnerability to adversarial attacks - small, targeted manipulations of graph structures or node features - raises serious concerns about their reliability in real-world applications. Existing defense strategies, such as adversarial training, edge filtering, low-rank approximations, and randomization-based methods, often suffer from high computational costs, scalability issues, or reduced clean-data performance. Unlike these methods, the proposed approach integrates multi-hop relationships, applies adaptive regularization, and maintains a balance between feature-based and structural embeddings, ensuring improved …

Meta-Learning-Based Model Stacking Framework For Hardware Trojan Detection In Fpga Systems, Mani Rupak Gurram

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In today's technological landscape, hardware devices are integral to critical applications such as industrial automation, autonomous vehicles, and medical equipment, relying on advanced platforms like FPGAs for core functionalities. However, the multi-stage manufacturing process, often distributed across various foundries, introduces substantial security risks, notably the potential for hardware Trojan insertion. These malicious modifications compromise the reliability and safety of hardware systems. This research addresses the detection of hardware Trojans through side-channel analysis, utilizing power and electromagnetic signal data, combined with meta-learning techniques, specifically model stacking. By employing diverse base models and a meta-model to consolidate predictions, this non-invasive approach effectively …

An Efficient And Trusted Deep Learning Framework For Real-Time Ppe Detection In Secure Iomt Environment, Anusha Verma

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Occupationally-acquired infections impact thousands of healthcare workers (HCWs) in the U.S., with many cases preventable through proper use of personal protective equipment (PPE). This study seeks to develop a robust system to enhance PPE compliance and reduce infection risks among HCWs. The objectives of this thesis are twofold: (1) to create a hybrid machine learning model that combines object detection and keypoint detection to ensure correct donning and doffing of PPE, and (2) to design a real-time feedback system using LED indicators and a display interface to offer actionable guidance to HCWs during PPE usage. The goal is to optimize …

An Enhanced Real-Time Object Detection Of Helmets And License Plates Using A Lightweight Yolov8 Deep Learning Model, Mounika Thatikonda

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Traffic surveillance and enforcement heavily depend on the real-time detection of helmets and license plates, particularly in high-density urban environments. This study presents a dynamic and optimized lightweight model, the proposed G-YOLOv8n, designed for resource constrained edge devices like the Raspberry Pi. By integrating the GhostNet module into the YOLOv8n architecture, this research achieves a nearly 50% reduction in model size and computational load, while maintaining comparable detection accuracy to the original YOLOv8n. These enhancements enable real-time processing capabilities crucial for traffic monitoring operations. The growing demand for real-time, low-power solutions in intelligent transportation systems necessitates lightweight, efficient detection models. …

Integrating Knowledge Graphs With Large Language Models For Natural Language Querying, Rakesh Kandula

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This research explores the integration of knowledge graphs with large language models that have already been trained on a vast pool of unstructured text data. Large language models trained on this type of data have a tendency to hallucinate and produce factually inaccurate results. This behavior is primarily due to the data being trained is unstructured and huge text corpus, and large language model uses predictive text analysis methods to obtain a response. These issues can be addressed by applying Retrieval Augmented Generation and Fine-tuning to large language models, employing an underlying domainspecific knowledge graph. Integrating knowledge graph and large …

Prediction Interpretations Of Ensemble Models In Chronic Kidney Disease Using Explainable Ai, K M Tawsik Jawad

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Chronic Kidney Disease (CKD) poses significant health and financial threat to millions of patients all around the world. The irreversible nature of this disease not just leads to comorbid diseases like Diabetes Mellitus, Hypertension, Anemia, Bone Disease, Neurological Implants etc. It can permanently damage the kidney by progressing to Acute Kidney Injury (AKI) or End Stage Renal Diseases (ESRD). The risk factors of CKD become more dangerous as patients suffering from it have little to no idea about the presence of CKD in their body until it takes the shape of AKI or ESRD. There are severe economic burdens for …

An Ml-Assisted Golden-Free Hardware Trojan Localization And Detection Approach For Trusted Microelectronics, Ashutosh Ghimire

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Hardware Trojans are malicious circuits, hidden in integrated circuits (ICs) which pose a significant threat to security. Detection of hardware Trojans is important to build trust, verify, and make the semiconductor ICs process secure. The existing hardware Trojan detection methods are generally destructive, require intricate comparisons, or require a long time for reverse engineering. In the initial phase of this study, the substitution of supervised hardware Trojan detection methods in ASICs chips is explored with unsupervised approaches, thereby eliminating the dependence on golden references. The Trojan detection uses a ring oscillator (RO) based on NAND as the power monitor. Frequency …