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Full-Text Articles in Computer Engineering

Sensitive And Makeable Computational Materials For The Creation Of Smart Everyday Objects, Te-Yen Wu Mr May 2023

Sensitive And Makeable Computational Materials For The Creation Of Smart Everyday Objects, Te-Yen Wu Mr

Dartmouth College Ph.D Dissertations

The vision of computational materials is to create smart everyday objects using the materi- als that have sensing and computational capabilities embedded into them. However, today’s development of computational materials is limited because its interfaces (i.e. sensors) are unable to support wide ranges of human interactions , and withstand the fabrication meth- ods of everyday objects (e.g. cutting and assembling). These barriers hinder citizens from creating smart every day objects using computational materials on a large scale.

To overcome the barriers, this dissertation presents the approaches to develop compu- tational materials to be 1) sensitive to a wide variety of …


Unobtrusive Data Collection In Clinical Settings For Advanced Patient Monitoring And Machine Learning, Walker Arce May 2023

Unobtrusive Data Collection In Clinical Settings For Advanced Patient Monitoring And Machine Learning, Walker Arce

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

When applying machine learning to clinical practice, a major hurdle that will be encountered is the lack of available data. While the data collected in clinical therapies is suitable for the types of analysis that are needed to measure and track clinical outcomes, it may not be suitable for other types of analysis. For instance, video data may have poor alignment with behavioral data, making it impossible to extract the videos frames that directly correlate with the observed behavior. Alternatively, clinicians may be exploring new data modalities, such as physiological signal collection, to research methods of improving clinical outcomes that …


Anticancer Activities Of Tetra-, Penta-, And Hexacyclic Phenothiazines Modified With Quinoline Moiety., Małgorzata Jel, Beata Morak-Młodawska, Rafał Korlacki May 2023

Anticancer Activities Of Tetra-, Penta-, And Hexacyclic Phenothiazines Modified With Quinoline Moiety., Małgorzata Jel, Beata Morak-Młodawska, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

The quinoline molecule is a chemical motif showing a highly promising pharmacological potential. Its numerous derivatives introduced into medicine revolutionized in the treatment of many entities of disease. The presence of the quinoline system in the structure of phenothiazines made it possible to obtain new aza- and diazaphenothiazine derivatives that show promising anticancer potential. The aza-analogs of the phenothiazines are structurally modified phenothiazines by the substitution of one or both benzene rings in the phenothiazine ring system with various azine rings. This approach to the strategy of obtaining new substances with biological potential can be classified as molecular hybridization methods …


Enabling High Throughput And Reliable Low Latency Communication Over Vehicular Mobility In Next-Generation Cellular Networks, Snigdhaswin Kar May 2023

Enabling High Throughput And Reliable Low Latency Communication Over Vehicular Mobility In Next-Generation Cellular Networks, Snigdhaswin Kar

All Dissertations

The fifth-generation (5G) networks and beyond need paradigm shifts to realize the exponentially increasing demands of next-generation services for high throughputs, low latencies, and reliable communication under various mobility scenarios. However, these promising features have critical gaps that need to be filled before they can be fully implemented for mobile applications in complex environments like smart cities. Although the sub-6 GHz bands can provide reliable and larger coverage, they cannot provide high data rates with low latencies due to a scarcity of spectrum available in these bands. Millimeter wave (mmWave) communication is a key enabler for a significant increase in …


Uibee: An Improved Deep Instance Segmentation And Classification Of Ui Elements In Wireframes, Cahi̇t Berkay Kazangi̇rler, Caner Özcan, Buse Yaren Teki̇n May 2023

Uibee: An Improved Deep Instance Segmentation And Classification Of Ui Elements In Wireframes, Cahi̇t Berkay Kazangi̇rler, Caner Özcan, Buse Yaren Teki̇n

Turkish Journal of Electrical Engineering and Computer Sciences

User Interface (UI) is a basic concept in which individuals interact with any computer program or technological device to create a graphical design. In the initial stages of app development, UI prototype is a must. An automatic analysis system for the basic execution of UI designs will considerably speed up the development of designs according to old-fashioned methods. In this approach, it is aimed at saving cost and time by automating the process. For the aforesaid objective, we present a new approach rather than the traditional methods. For this reason, a high amount of elements in wireframes are detected and …


Efficient Modelling Of Random Access Memory Cell: An Approach Using Qca Nanocomputing, Ali Newaz Bahar, Angshuman Khan May 2023

Efficient Modelling Of Random Access Memory Cell: An Approach Using Qca Nanocomputing, Ali Newaz Bahar, Angshuman Khan

Turkish Journal of Electrical Engineering and Computer Sciences

Quantum-dot cellular automata (QCA) is innovative and potentially fruitful nanotechnology that provides a solution for transistor-based circuits with enhanced switching frequency, large-scale integration, and low power consumption. The random-access memory (RAM) cell is a fundamental component that is designed to operate quickly and effectively since memory is a core part of the semiconductor industry, thus the QCA family. The RAM cell design in this work is based on a multiplexer structure and is implemented without using coplanar crossovers of QCA technology. QCADesigner-2.0.3, a standard QCA layout design and verification tool, is used in the simulation and validation processes for the …


Task Offloading And Resource Allocation Based On Dl-Ga In Mobile Edge Computing, Hang Gu, Minjuan Zhang, Wenzao Li, Yuwen Pan May 2023

Task Offloading And Resource Allocation Based On Dl-Ga In Mobile Edge Computing, Hang Gu, Minjuan Zhang, Wenzao Li, Yuwen Pan

Turkish Journal of Electrical Engineering and Computer Sciences

With the rapid development of 5G and the Internet of Things (IoT), the traditional cloud computing architecture struggle to support the booming computation-intensive and latency-sensitive applications. Mobile edge computing (MEC) has emerged as a solution which enables abundant IoT tasks to be offloaded to edge services. However, task offloading and resource allocation remain challenges in MEC framework. In this paper, we add the total number of offloaded tasks to the optimization objective and apply algorithm called Deep Learning Trained by Genetic Algorithm (DL-GA) to maximize the value function, which is defined as a weighted sum of energy consumption, latency, and …


Modeling And Visualization Of Competing Escalation Dynamics: A Multilayer Multiagent Network Approach, Josh Allen May 2023

Modeling And Visualization Of Competing Escalation Dynamics: A Multilayer Multiagent Network Approach, Josh Allen

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

Recent advances in military technology, such as hypersonic missiles, which can travel at more than five times the speed of sound and descend quickly into the atmosphere, give world nuclear superpowers a new edge. These advances up the game for nuclear superpowers with an extremely rapid, intense burst of military striking capability to secure upfront gains before encountering potentially overwhelming military confrontation. However, this so-called fait accompli has not been systematically studied by the United States in the perspective of the escalation philosophies of nuclear power competitors, or the mathematical modeling and visualization of multi-modal escalation dynamics. This gap may …


Modeling, Simulation And Control Of Microrobots For The Microfactory., Zhong Yang May 2023

Modeling, Simulation And Control Of Microrobots For The Microfactory., Zhong Yang

Electronic Theses and Dissertations

Future assembly technologies will involve higher levels of automation in order to satisfy increased microscale or nanoscale precision requirements. Traditionally, assembly using a top-down robotic approach has been well-studied and applied to the microelectronics and MEMS industries, but less so in nanotechnology. With the boom of nanotechnology since the 1990s, newly designed products with new materials, coatings, and nanoparticles are gradually entering everyone’s lives, while the industry has grown into a billion-dollar volume worldwide. Traditionally, nanotechnology products are assembled using bottom-up methods, such as self-assembly, rather than top-down robotic assembly. This is due to considerations of volume handling of large …


Deep Reinforcement Learning And Game Theoretic Monte Carlo Decision Process For Safe And Efficient Lane Change Maneuver And Speed Management, Shahab Karimi May 2023

Deep Reinforcement Learning And Game Theoretic Monte Carlo Decision Process For Safe And Efficient Lane Change Maneuver And Speed Management, Shahab Karimi

All Dissertations

Predicting the states of the surrounding traffic is one of the major problems in automated driving. Maneuvers such as lane change, merge, and exit management could pose challenges in the absence of intervehicular communication and can benefit from driver behavior prediction. Predicting the motion of surrounding vehicles and trajectory planning need to be computationally efficient for real-time implementation. This dissertation presents a decision process model for real-time automated lane change and speed management in highway and urban traffic. In lane change and merge maneuvers, it is important to know how neighboring vehicles will act in the imminent future. Human driver …


Enhanced Mobile Networking Using Multi-Connectivity And Packet Duplication In Next-Generation Cellular Networks, Prabodh Mishra May 2023

Enhanced Mobile Networking Using Multi-Connectivity And Packet Duplication In Next-Generation Cellular Networks, Prabodh Mishra

All Dissertations

Modern cellular communication systems need to handle an enormous number of users and large amounts of data, including both users as well as system-oriented data. 5G is the fifth-generation mobile network and a new global wireless standard that follows 4G/LTE networks. The uptake of 5G is expected to be faster than any previous cellular generation, with high expectations of its future impact on the global economy. The next-generation 5G networks are designed to be flexible enough to adapt to modern use cases and be highly modular such that operators would have the flexibility to provide selective features based on user …


Analysis And Implementation Of A New High-Buck Dc-Dc Converter With Interleaved Output Inductors And Soft Switching Capability, Sajad Ghabeli Sani, Mohamad Reza Banaei, Seyed Hossein Hosseini May 2023

Analysis And Implementation Of A New High-Buck Dc-Dc Converter With Interleaved Output Inductors And Soft Switching Capability, Sajad Ghabeli Sani, Mohamad Reza Banaei, Seyed Hossein Hosseini

Turkish Journal of Electrical Engineering and Computer Sciences

This paper proposes an innovative structure for DC-DC converters with high buck gain by using a lower number of elements. The converter provides highly efficient output power and an extended output voltage range. In addition, the distribution of output current between two inductors and the soft-switching capability of the power switches have made the converter suitable for applications that require high output current. All power switches accomplish the ZVZCS (zero-voltage and zero-current switching) condition with the aid of a small auxiliary inductor (Lx), which charges and discharges parallel capacitors of main switches to provide soft-switching conditions. Thus, the switching losses …


Integration Of Neural Network And Distance Relay To Improve The Fault Localization On Transmission Lines, Linh Tran May 2023

Integration Of Neural Network And Distance Relay To Improve The Fault Localization On Transmission Lines, Linh Tran

Turkish Journal of Electrical Engineering and Computer Sciences

Power transmission lines are integral and very important components of power systems. Because of the length of these lines and the complexity of the power grids, the lines may encounter various incidents such as lightning strike, shortage, and breakage. When an incident or a fault occurs, a fast process of identification, localization, and isolation of the fault is desired. An accurate fault localization would have a great impact in reducing the restoration time of the system. One of the most popular solutions for fault detection and localization is the distance relays using the impedance-based algorithms. However, these relays are still …


Deep Learning-Based Turkish Spelling Error Detection With A Multi-Class False Positive Reduction Model, Burak Aytan, Cemal Okan Şakar May 2023

Deep Learning-Based Turkish Spelling Error Detection With A Multi-Class False Positive Reduction Model, Burak Aytan, Cemal Okan Şakar

Turkish Journal of Electrical Engineering and Computer Sciences

Spell checking and correction is an important step in the text normalization process. These tasks are more challenging in agglutinative languages such as Turkish since many words can be derived from the root word by combining many suffixes. In this study, we propose a two-step deep learning-based model for misspelled word detection in the Turkish language. A false positive reduction model is integrated into the system to reduce the false positive predictions originating from the use of foreign words and abbreviations that are commonly used in Internet sharing platforms. For this purpose, we create a multi-class dataset by developing a …


Breath Analysis For Detection Of Lung Cancer With Hybrid Sensor-Based Electronic Nose, Ümi̇t Özsandikcioğlu, Ayten Atasoy May 2023

Breath Analysis For Detection Of Lung Cancer With Hybrid Sensor-Based Electronic Nose, Ümi̇t Özsandikcioğlu, Ayten Atasoy

Turkish Journal of Electrical Engineering and Computer Sciences

Lung cancer has the highest death rates among all types of cancer worldwide. Detection of lung cancer in its early stages significantly increases the survival rate. In this study, the aim is to improve the lung cancer detection performance of electronic noses (e-noses) with breath analysis by using two different types of gas sensor-based e-nose. The developed e-nose system consists of 14 quartz crystal microbalance (QCM) sensors and 8 metal oxide semiconductor (MOS) sensors. Breath samples were collected from a total of 100 volunteers, including 60 patients with lung cancer, 20 healthy nonsmokers, and 20 healthy smokers, and were classified …


An Analytical Solution Of Fractional Order Pi Controller Design For Stable/Unstable/Integrating Processes With Time Delay, Erdal Çökmez, İbrahi̇m Kaya May 2023

An Analytical Solution Of Fractional Order Pi Controller Design For Stable/Unstable/Integrating Processes With Time Delay, Erdal Çökmez, İbrahi̇m Kaya

Turkish Journal of Electrical Engineering and Computer Sciences

This paper aims to put forward an analytical solution for tuning parameters of a fractional order PI (FOPI) controller for stable, unstable, and integrating processes with time delay. Following this purpose, the analytical weighted geometrical center (AWGC) method has been extended to the design of fractional order PI controllers. To apply AWGC, the stability equations of the closed-loop system are written in terms of process and fractional order PI controller parameters. With the proposed method, the centroid can be calculated analytically, and the controller parameters can be easily calculated without the need of repetitive drawings of the stability boundary regions. …


An Efficient Deep Learning Architecture For Turkish Lira Recognition And Counterfeit Detection, Burak İyi̇kesi̇ci̇, Ergun Erçelebi̇ May 2023

An Efficient Deep Learning Architecture For Turkish Lira Recognition And Counterfeit Detection, Burak İyi̇kesi̇ci̇, Ergun Erçelebi̇

Turkish Journal of Electrical Engineering and Computer Sciences

Banknote counterfeiting is a common practice worldwide. Due to the recent developments in technology, banknote imitation has become easier than before. There are different kinds of algorithms developed for the detection of counterfeit banknotes for different countries in the literature. The earlier algorithms utilized classical image processing techniques where the implementations of machine learning and deep learning algorithms appeared with the developments in the artificial intelligence field as well as the computer hardware. In this study, a novel convolutional neural networks-based deep learning algorithm has been developed that detects counterfeit Turkish Lira banknotes and their denominations using the banknote images …


Unbiased Federated Learning In Energy Harvesting Error-Prone Channels, Zeynep Çakir, Eli̇f Tuğçe Ceran Arslan May 2023

Unbiased Federated Learning In Energy Harvesting Error-Prone Channels, Zeynep Çakir, Eli̇f Tuğçe Ceran Arslan

Turkish Journal of Electrical Engineering and Computer Sciences

Federated learning (FL) is a communication-efficient and privacy-preserving learning technique for collaborative training of machine learning models on vast amounts of data produced and stored locally on the distributed users. This paper investigates unbiased FL methods that achieve a similar convergence as state-of-the-art methods in scenarios with various constraints like an error-prone channel or intermittent energy availability. For this purpose, we propose FL algorithms that jointly design unbiased user scheduling and gradient weighting according to each user's distinct energy and channel profile. In addition, we exploit a prevalent metric called the age of information (AoI), which quantifies the staleness of …


Quadratic Programming Based Partitioning For Block Cimmino With Correct Value Representation, Zuhal Taş, Fahreddi̇n Şükrü Torun May 2023

Quadratic Programming Based Partitioning For Block Cimmino With Correct Value Representation, Zuhal Taş, Fahreddi̇n Şükrü Torun

Turkish Journal of Electrical Engineering and Computer Sciences

The block Cimmino method is successfully used for the parallel solution of large linear systems of equations due to its amenability to parallel processing. Since the convergence rate of block Cimmino depends on the orthogonality between the row blocks, advanced partitioning methods are used for faster convergence. In this work, we propose a new partitioning method that is superior to the state-of-the-art partitioning method, GRIP, in several ways. Firstly, our proposed method exploits the Mongoose partitioning library which can outperform the state-of-the-art methods by combining the advantages of classical combinatoric methods and continuous quadratic programming formulations. Secondly, the proposed method …


More Wifi For Everyone: Increasing Spectral Efficiency In Wifi6 Networks Using A Distributed Obss/Pd Mechanism, Ali̇ Karakoç, Hüseyi̇n Bi̇rkan Yilmaz, Mehmet Şükrü Kuran May 2023

More Wifi For Everyone: Increasing Spectral Efficiency In Wifi6 Networks Using A Distributed Obss/Pd Mechanism, Ali̇ Karakoç, Hüseyi̇n Bi̇rkan Yilmaz, Mehmet Şükrü Kuran

Turkish Journal of Electrical Engineering and Computer Sciences

In this paper, we propose a distributed algorithm that determines effective Overlapping Basic Service Set/Preamble Detection (OBSS/PD) threshold levels in each WiFi6 device to maximize the total throughput by increasing the spectral efficiency. Within WiFi6 standard, OBSS/PD mechanism is introduced to increase the overall efficiency of WiFi networks by tuning the receiver sensitivity as well as the transmission power. In a nutshell, the proposed algorithm, RACEBOT, tunes the hearing (i.e. reception) and speaking (i.e. transmission) parameters of each WiFi device individually for the betterment of the WiFi experience of all WiFi networks in a neighborhood. WiFi experience is not only …


Power Amplifier Based On Composite Injection-Voltaic Transistors, Nodira Batirdjanovna Alimova Apr 2023

Power Amplifier Based On Composite Injection-Voltaic Transistors, Nodira Batirdjanovna Alimova

Chemical Technology, Control and Management

The problem of high-current radio engineering devices is related to the fact that the use of high-power transistors and other semiconductor devices is limited by such a phenomenon as a secondary breakdown, in which there is a sharp decrease in the voltage on the device with simultaneous internal current lacing, and the device fails. To solve the problem of secondary breakdown, schemes have been proposed that operate stably at reverse voltage values 4-5 times higher than usual and at power dissipation 2-3 times higher than the maximum allowable power for an individual device. The problem is proposed to be solved …


Methods And Algorithms For Monitoring And Prediction Of Various Fire Hazardous Situations, Mizaakbar Xakkulmirzayevich Hudayberdiyev, Oybek Zokirovich Koraboshev Apr 2023

Methods And Algorithms For Monitoring And Prediction Of Various Fire Hazardous Situations, Mizaakbar Xakkulmirzayevich Hudayberdiyev, Oybek Zokirovich Koraboshev

Chemical Technology, Control and Management

This article analyzes emergency situations arising from natural disasters (fires, explosions, earthquakes, floods, landslides, etc.) and man-made accidents. The event in which the values of fire risks in the area decrease uniformly and at the same time the amount of fire risks is minimal is considered optimal. Models, methods, and logistic regression algorithm have been used to predict fire hazard situations and identify potential fire safety measures.


A Study Of Iot-Optimized Low Power Asset Tracking With Cloud-Enabled Lorawan, Fatima Salman Apr 2023

A Study Of Iot-Optimized Low Power Asset Tracking With Cloud-Enabled Lorawan, Fatima Salman

Symposium of Student Scholars

The world of technology is expanding very quickly today, including technologies like cloud-based asset monitoring, but this makes it difficult to keep up with this technology's development and many other things. It is possible to monitor and manage your assets remotely with a cloud-based system thanks to its many features. The lifecycle of any commodity, including inventory, machinery, vehicles, and real estate, can be tracked using this kind of cloud-based system. Wide-area networks can be used to send data with the aid of low-power wide-area network (LPWAN) technologies like LoRa, SigFox, and NB-IoT. This project will examine traditional, cloud-based, LPWAN-based …


Region-Specified Inverse Design Of Absorption And Scattering In Nanoparticles By Using Machine Learning, Alex Vallone, Nooshin M. Estakhri, Nasim Mohammadi Estrakhri Apr 2023

Region-Specified Inverse Design Of Absorption And Scattering In Nanoparticles By Using Machine Learning, Alex Vallone, Nooshin M. Estakhri, Nasim Mohammadi Estrakhri

Engineering Faculty Articles and Research

Machine learning provides a promising platform for both forward modeling and the inverse design of photonic structures. Relying on a data-driven approach, machine learning is especially appealing for situations when it is not feasible to derive an analytical solution for a complex problem. There has been a great amount of recent interest in constructing machine learning models suitable for different electromagnetic problems. In this work, we adapt a region-specified design approach for the inverse design of multilayered nanoparticles. Given the high computational cost of dataset generation for electromagnetic problems, we specifically investigate the case of a small training dataset, enhanced …


Gpu Utilization: Predictive Sarimax Time Series Analysis, Dorothy Dorie Parry Apr 2023

Gpu Utilization: Predictive Sarimax Time Series Analysis, Dorothy Dorie Parry

Modeling, Simulation and Visualization Student Capstone Conference

This work explores collecting performance metrics and leveraging the output for prediction on a memory-intensive parallel image classification algorithm - Inception v3 (or "Inception3"). Experimental results were collected by nvidia-smi on a computational node DGX-1, equipped with eight Tesla V100 Graphic Processing Units (GPUs). Time series analysis was performed on the GPU utilization data taken, for multiple runs, of Inception3’s image classification algorithm (see Figure 1). The time series model applied was Seasonal Autoregressive Integrated Moving Average Exogenous (SARIMAX).


Automatic Generation Of Virtual Work Guide For Complex Procedures: A Case, Shan Liu, Yuzhong Shen Apr 2023

Automatic Generation Of Virtual Work Guide For Complex Procedures: A Case, Shan Liu, Yuzhong Shen

Modeling, Simulation and Visualization Student Capstone Conference

Practical work guides for complex procedures are significant and highly affect the efficiency and accuracy of on-site users. This paper presents a technique to generate virtual work guides automatically for complex procedures. Firstly, the procedure information is extracted from the electronic manual in PDF format. And then, the extracted procedure steps are mapped to the virtual model parts in preparation for animation between adjacent steps. Next, smooth animations of the procedure are generated based on a 3D natural cubic spline curve to improve the spatial ability of the work guide. In addition, each step's annotation is automatically adjusted to improve …


Implementation Of Static Rfid Landmarks In Slam For Planogram Compliance, Brennan L. Drake Apr 2023

Implementation Of Static Rfid Landmarks In Slam For Planogram Compliance, Brennan L. Drake

Honors College Theses

Autonomous robotic systems are becoming increasingly prevalent in everyday life and exhibit robust solutions in a wide range of applications. They face many obstacles with the foremost of which being SLAM, or Simultaneous Localization and Mapping, that encompasses both creation of the map of an unknown environment and localization of the robot in said environment. In this experiment, researchers propose the use of RFID tags in a semi-dynamic commercial environment to provide concrete landmarks for localization and mapping in pursuit of increased locational certainty. With this obtained, the ultimate goal of the research is to construct a robotics platform for …


Network Economics-Based Crowdsourcing In Online Social Networks, Natasha S. Kubiak Apr 2023

Network Economics-Based Crowdsourcing In Online Social Networks, Natasha S. Kubiak

Electrical and Computer Engineering ETDs

This thesis addresses the challenge of user recruitment by various competing marketing agencies (MAs) in Online Social Networks. A labor economics approach, following the principles of contract theory, is devised to enable MAs to reveal the potential of each participating user to contribute a personalized level of quality and quantity of information to the crowdsourcing process. The MAs objective is to maximize their personal benefit, i.e., total utility obtained, given its budget. The latter optimization problem is formulated as a Generalized Colonel Blotto (GCB) game among the MAs, where each MA aims at incentivizing each user to report its information. …


Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki Apr 2023

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …


Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki Apr 2023

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …