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High‐ And Low‐Molecular‐Weight Chitosan Act As Adjuvants During Single‐Dose Influenza A Virus Protein Vaccination Through Distinct Mechanisms, Anna T. Lampe, Eric Farris, Deborah M. Brown, Angela K. Pannier

Biological Systems Engineering: Papers and Publications

The investigation of new adjuvants is essential for the development of efficacious vaccines. Chitosan (CS), a derivative of chitin, has been shown to act as an adjuvant, improving vaccine‐induced immune responses. However, the effect of CS molecular weight (MW) on this adjuvanticity has not been investigated, despite MW having been shown to impact CS biological properties. Here, two MW variants of CS were in- vestigated for their ability to enhance vaccine‐elicited immune responses in vitro and in vivo, using a single‐dose influenza A virus (IAV) protein vaccine model. Both low‐ molecular‐weight (LMW) and high‐molecular‐weight (HMW) CS‐induced interferon regulatory factor pathway …