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Optical Probing Of Gastrocnemius In Patients With Peripheral Artery Disease Characterizes Myopathic Biochemical Alterations And Correlates With Stage Of Disease, Ryan A. Becker, Kim Cluff, Nithyanandhi Duraisamy, Hootan Mehraein, Hussam Farhoud, Tracie Collins, George P. Casale, Iraklis I. Pipinos, Jeyamkondan Subbiah

Department of Biological Systems Engineering: Papers and Publications

Peripheral artery disease (PAD) is a condition caused by atherosclerotic blockages in the arteries supplying the lower limbs and is characterized by ischemia of the leg, progressive myopathy, and increased risk of limb loss. The affected leg muscles undergo significant changes of their biochemistry and metabolism including variations in the levels of many key proteins, lipids, and nucleotides. The mechanisms behind these changes are poorly understood. The objective of this study was to correlate the severity of the PAD disease stage and associated hemodynamic limitation (determined by the ankle brachial index, ABI) in the legs of the patients with alterations …