Biochemical and Biomolecular Engineering Commons^™

Ultrafiltration Membrane Process For Pyrogen Removal In The Preparation Of Water For Injection (Wfi), Thet N. Soe

Inquiry: The University of Arkansas Undergraduate Research Journal

An artificial kidney process based on ultrafiltration (called hemodiafiltration) more effectively removes blood toxins, particularly those of higher molecular weight, than conventional dialysis. In hemodiafiltration, replacement liquid must be added directly to the patient's blood to replace liquid filtered out of the blood in the ultrafiltration cartridge. This replacement liquid is made up of' "water for injection" (WFI) and other components such as salts and glucose. WFI is produced either by distillation or reverse osmosis and has a cost of $1.00 per liter. A patient with kidney problems would require three hemodiafiltration treatments per week, each requiring 70-80 liters of …