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Biochemical and Biomolecular Engineering Commons™
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Full-Text Articles in Biochemical and Biomolecular Engineering
Finite Element Modelling And Exergy Analysis Of A Solar Thermal Hollow Fiber Vacuum Membrane Distillation System, Benjamin Shuldes
Finite Element Modelling And Exergy Analysis Of A Solar Thermal Hollow Fiber Vacuum Membrane Distillation System, Benjamin Shuldes
Department of Chemical and Biomolecular Engineering: Theses and Student Research
A finite element model was developed to investigate the performance of a vacuum membrane distillation module under various operating conditions and membrane parameters. Porosity, tortuosity, pore diameter, membrane thickness, and fiber length were varied along with feed temperature, velocity, and flow configuration. In all cases, boundary layer polarization phenomena were seen to inhibit the performance of the module. At certain conditions, for a 7.5 cm fiber, the reduction in permeate flux from 65 LMH (Liter/m2/h) at the inlet to below 45 LMH at the outlet of the fibers was observed. In most cases, salt concentration polarization was the …
Metabolic Modeling And Omics-Integrative Analysis Of Single And Multi-Organism Systems: Discovery And Redesign, Mohammad Mazharul Islam
Metabolic Modeling And Omics-Integrative Analysis Of Single And Multi-Organism Systems: Discovery And Redesign, Mohammad Mazharul Islam
Department of Chemical and Biomolecular Engineering: Theses and Student Research
Computations and modeling have emerged as indispensable tools that drive the process of understanding, discovery, and redesign of biological systems. With the accelerating pace of genome sequencing and annotation information generation, the development of computational pipelines for the rapid reconstruction of high-quality genome-scale metabolic networks has received significant attention. These models provide a rich tapestry for computational tools to quantitatively assess the metabolic phenotypes for various systems-level studies and to develop engineering interventions at the DNA, RNA, or enzymatic level by careful tuning in the biophysical modeling frameworks. in silico genome-scale metabolic modeling algorithms based on the concept of optimization, …
Creation And Application Of Various Tools For The Reconstruction, Curation, And Analysis Of Genome-Scale Models Of Metabolism, Wheaton L. Schroeder
Creation And Application Of Various Tools For The Reconstruction, Curation, And Analysis Of Genome-Scale Models Of Metabolism, Wheaton L. Schroeder
Department of Chemical and Biomolecular Engineering: Theses and Student Research
Systems biology uses mathematics tools, modeling, and analysis for holistic understanding and design of biological systems, allowing the investigation of metabolism and the generation of actionable hypotheses based on model analyses. Detailed here are several systems biology tools for model reconstruction, curation, analysis, and application through synthetic biology. The first, OptFill, is a holistic (whole model) and conservative (minimizing change) tool to aid in genome-scale model (GSM) reconstructions by filling metabolic gaps caused by lack of system knowledge. This is accomplished through Mixed Integer Linear Programming (MILP), one step of which may also be independently used as an additional curation …