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Biochemical and Biomolecular Engineering Commons™
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Full-Text Articles in Biochemical and Biomolecular Engineering
Protein Release Study Using Heparin Modified Methacrylamide Chitosan Hydrogels, Dakotah G. Cox
Protein Release Study Using Heparin Modified Methacrylamide Chitosan Hydrogels, Dakotah G. Cox
Williams Honors College, Honors Research Projects
This study was performed to improve the release of proteins from hydrogels in order to increase their effectiveness in treating spinal cord injuries. Heparin, which has the ability to bind to proteins and slow their release, underwent methacrylation, was added to prepared methacrylamide chitosan (MAC) solutions with a model protein (SDF-1α) and photopolymerized to create MAC-heparin hydrogels. Varying weight percentages of methacrylated heparin were tested in order to determine the optimal amount needed to improve the release profile. The pure MAC hydrogels and gels with 10 wt% heparin had a rapid release of the SDF-1α (>23% and >29%, respectively, …
The Effect Of Drying On The Release Of Small Hydrophilic Molecular Drugs From Polyelectrolyte Complex Beads, Dounsavanh Letdara
The Effect Of Drying On The Release Of Small Hydrophilic Molecular Drugs From Polyelectrolyte Complex Beads, Dounsavanh Letdara
Williams Honors College, Honors Research Projects
The effects of bead composition and dryness on the release rate of small molecules, like a drug or dye, from polyelectrolyte complex (PEC) beads were studied. Release studies were performed on dried and not dried beads prepared using different PEC to drug ratios. The beads were dried for two hours, which allowed them to reach a constant weight. The beads were loaded with a dye, so their release could be detected through the visible light regime. A plate reader was used to determine the absorbance of a sample, and then the amount of dye released was determined. The data presented …