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Full-Text Articles in Biochemical and Biomolecular Engineering
Model Validation And Transition To Turbulence In Orbiting Culture Dishes., Jonathan Michael D. Thomas
Model Validation And Transition To Turbulence In Orbiting Culture Dishes., Jonathan Michael D. Thomas
Electronic Theses and Dissertations
Wall shear stress (WSS) is commonly accepted as the primary influence affecting characteristics of anchored endothelial cells when subjected to fluid flow. Orbital shakers are commonly used to study cellular responses due to their ease of use, ability to run several experiments simultaneously, and since they exert physiologically relevant oscillatory shear. These studies require comprehensive resolution of WSS, however the fluid dynamics inside orbiting culture dishes has not yet been well described since the flow is complex and difficult to quantify analytically. A computational fluid dynamics (CFD) model of flow in an orbiting dish has been developed that yields detailed …
Calcium Alginate Microbead Production Via An Air Assisted Shearing Process, Ryan Loftus
Calcium Alginate Microbead Production Via An Air Assisted Shearing Process, Ryan Loftus
Williams Honors College, Honors Research Projects
The purpose of this project was to model the size of calcium alginate microbeads produced by extruding a solution of 1.5 wt.% alginate from a syringe and needle with air shear generated from a pneumatic line flowing in an annular tube around the extrusion needle. The air shear would create microdroplets that would fall into a solution of 2 wt.% calcium chloride in water, crosslinking the droplets into beads. These microbeads can be used in drug dispersion applications or in encapsulation of cells throughout the body due to their biocompatibility. The goal was to create uniform beads that ranged from …