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Full-Text Articles in Biochemical and Biomolecular Engineering
Spatiotemporal Metabolic Modeling Of Pseudomonas Aeruginosa Biofilm Expansion, Robert Sourk
Spatiotemporal Metabolic Modeling Of Pseudomonas Aeruginosa Biofilm Expansion, Robert Sourk
Masters Theses
Spatiotemporal metabolic modeling of microbial metabolism is a step closer to achieving higher dimensionalities in numerical studies (in silico) of biofilm maturation. Dynamic Flux Balance Analysis (DFBA) is an advanced modeling technique because this method incorporates Genome Scale Metabolic Modeling (GSMM) to compute the biomass growth rate and metabolite fluxes. Biofilm thickness is pertinent because this variable of biofilm maturation can be measured in a laboratory (in vitro). Pseudomonas aeruginosa (P. aeruginosa) is the model bacterium used in this computational model based on previous research conducted by Dr. Michael Henson, available GSMMs, and the societal significance of patients suffering from …
Metabolic Modeling Of Bacterial Co-Cultures For Co-To-Butyrate Conversion In Bubble Column Bioreactors, Naresh Kandlapalli
Metabolic Modeling Of Bacterial Co-Cultures For Co-To-Butyrate Conversion In Bubble Column Bioreactors, Naresh Kandlapalli
Masters Theses
One of the most promising routes to renewable liquid fuels and chemicals is the fermentation of waste carbon by specialized microbes. Commercial development of gas fermentation technology is underway but many fundamental research problems must be addressed to further advance the technology towards economic competitiveness. This thesis addresses the important problem of developing integrated metabolic and transport models that predict gas fermentation performance in industrially relevant bubble column reactors. The computational models describe the conversion of CO-rich waste streams including synthesis gas to the platform chemical butyrate. The proposed modeling approach involves combining genome-scale reconstructions of bacterial species metabolism with …
Metabolic Modeling Of Gas Fermentation For Renewable Fuel And Chemical Production, Xiangan Li
Metabolic Modeling Of Gas Fermentation For Renewable Fuel And Chemical Production, Xiangan Li
Doctoral Dissertations
Gas fermentation has emerged as a technologically and economically attractive option for producing renewable fuels and chemicals from carbon monoxide (CO) rich waste streams. As compared to traditional catalyst technologies, microbial systems have several advantages including operation near ambient temperature and pressure, high conversion efficiencies, robustness to gas impurities and high product yields that have motivated both fundamental research and commercial development. While microbial production of high-value products from waste gases is challenging because wild-type strains capable of gas consumption tend to synthesize these products at low yields, strategy like metabolically engineering the gas fermenting acetogens have been studied to …