Biochemical and Biomolecular Engineering Commons^™

Real-Time Monitoring Of Cell Death Progress Using Capacitance Spectroscopy, Suyang Wu

Electronic Theses and Dissertations

Biologics, including the monoclonal antibody (mAb), has experienced rapid development in the last decade. However, the price of biologics is often prohibitively high because of the low process efficiency. Delaying the inevitable cell death improves the productivity of upstream bioprocessing, whose success relies on monitoring the cell death onset that indicates the timing for preventive actions.

This study proposes to develop a real-time monitoring model that quantifies the dying cell percentage in lab-scale bioreactors using capacitance spectroscopy. The capacitance spectroscopy contains cell death-related information due to various physical properties changes during the cell death process, e.g., cytoplasmic conductivity change. The …

Study Level Recovery Processes Of Thorium And Several Rare Earth Elements From Monazite Ore, Makayla Hyde, Jaclyn Choate

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Monazite ore is composed of several minerals including several rare earth element (REE) and thorium phosphates. Many past research projects have looked at the extraction of REE from monazite ore but have discarded the thorium phosphate compound as waste. Since thorium could be a possible fuel for state-of-the-art future nuclear reactors, this research focuses on a way to recover thorium from the monazite ore. The overall purpose of this research is to develop a conceptual recovery process that recovers thorium dioxide from monazite ore. In some parts of the world where uranium sources are limited; then, thorium could be used …

Development Of An Integrated Salt Cartridge-Reverse Electrodialysis (Red) Device To Increase Electrolyte Concentrations Of Human Blood Flow To Power Biomedical Devices, Caroline Campbell

Chemical Engineering Undergraduate Honors Theses

Emerging technologies in nanotechnology and biomedical sciences have led to an increase in biomedical implantable devices including cardiac pacemakers, artificial organs, drug pumps, and sensors. These devices require continuous stable and reliable power to operate, which creates the demand for the need to find a safe, reliable, and stable power source. A promising avenue for a power source for these devices is a miniaturized reverse electrodialysis (RED) biopower cell design that utilizes the salinity differences between bloodstreams that flow inside the human body. Initial results of the RED system demonstrate that higher gradient salinity differences between streams lead to a …