Chemical Engineering Commons^™

Polyhexamethylene Biguanide Release By Chitosan-Heparin Nanoparticles, Jacob Ress

Williams Honors College, Honors Research Projects

Chitosan and heparin were used to synthesize nanoparticles using polyelectrolyte complexation. The optimal mixing ratio was determined to be 1:4 by studying the particle characteristics of zeta potential and dynamic light scattering of the ratios 1:2, 1:3, 1:4, 1:5 and 1:6 (chitosan: heparin). The particles were loaded with the antibiotic polyhexamethylene biguanide (PHMB) and the release was measured over 335 hours using the dialysis membrane incubation method and detected via ultraviolet-visible (UV-Vis) spectroscopy. Around 80% of the encapsulated PHMB was released over the measured period. The goal of this part of the study was to determine the drug release behavior …

Understanding Early Amyloid-Ss Aggregation To Engineer Polyacid-Functionalized Nanoparticles As An Inhibitor Design Platform, Nicholas Vander Munnik

Theses and Dissertations

Alzheimer’s disease (AD) is characterized by the presence of amyloid-ß (Aß) protein aggregates in the brains of those afflicted. This protein aggregates via a complex pathway to progress from monomers to soluble oligomers and ultimately insoluble fibrils. Due to the dynamic nature of aggregation, it has proven exceedingly difficult to determine the precise interactions that lead to the formation of transient oligomers. A statistical thermodynamic model has been developed to elucidate these interactions. Aß was simulated using fully-atomistic replica exchange molecular dynamics. We use an ensemble of 5 × 105 configurations taken from these simulations as input for a self-consistent …

New Wellbore-Integrity Classification For Gas Migration Problems And New Cement Formulations Using Graphene Nano Platelets To Prevent Gas Migration Through Cement, Mohammed Mousa M. Alkhamis

Masters Theses

"Gas migration, one of the primary problems related to the integrity of oil wells, is caused by cement failures. Gas migration can result in costly well repairs and may endanger personal, equipment, and result in severe operational difficulties and environmental issues. The ultimate objectives of this research were to provide a comprehensive review of the problem and to provide a solution to the problem using Graphene Nano Platelets (GNPs).

An intensive review was performed to understand the cement failures. The reasons behind these failures were analyzed and classified with respect to their locations in the wellbore. Recommendations and potential solutions …

Enhancement Of Heat Transfer Coefficient Using Nanofluids For Multi-Stage Flash Desalination (Msf) Plant, Nasser Zouli

Doctoral Dissertations

“The enhancement of thermal conductivity and local heat transfer coefficient, under laminar and turbulent flow regimes, of water-based spherical Al₂O₃, CuO, and Fe₂O₃ nanofluids have been experimentally investigated for the improvement of the thermal desalination processes using a newly developed sophisticated noninvasive heat transfer coefficient probe that is flush mounted on the inner wall surface of the test section. The nanoparticles have been selected because of their superior thermal conductivity and low cost, as well as the magnetic characteristic of Fe₂O₃ nanoparticle since a magnet can collect it and reuse. …

Green Synthesis Of Copper Oxide Nanoparticles In Aqueous Medium As A Potential Efficient Catalyst For Catalysis Applications, Hany A. Elazab Dr

Chemical Engineering

In this research, we have developed a reliable green method for the synthesis of copper oxide nanoparticles as a potential efficient catalyst for several catalysis applications. In our experimental approach, microwave-assisted synthesis technique was used in order to perform chemical reduction of copper salt using hydrazine hydrate as a strong reducing agent. The prepared catalyst was characterized using various techniques showing the formation of well dispersed copper oxide nanoparticles. The synthesized Copper oxide catalyst shows many advantages including the use of environmentally benign solvent systems,

Assessment Of Nanocomposites Vs. Amorphous Solid Dispersions For Dissolution Enhancement Of Bcs Class Ii Drugs, Meng Li

Dissertations

Nanoparticle-based formulations (nanocomposites) and amorphous solid dispersions, shortly ASDs, are two major pharmaceutical formulation platforms used for the bioavailability enhancement of poorly water-soluble drugs. While they both have several advantages-disadvantages, a scientific comparative assessment of their drug release performance and dissolution mechanisms at different drug doses is not available. With the goal of addressing this issue, the dissertation aims to achieve three major objectives: (1) develop a processing-formulation understanding of wet media milling process for fast-efficient production of drug nanoparticles in stable nanosuspension form, (2) elucidate the impact of various classes dispersants on drug release rate and mechanisms during the …

Novel Synthesis Of Cigs Nanoparticles For Scalable, Benign Inks For Solution Processed Solar Cells, Jacob Fields, Ryan Ellis, Rakesh Agrawal

The Summer Undergraduate Research Fellowship (SURF) Symposium

One potential production route to high efficiency, low cost, photovoltaics (PVs) which was explored is Copper Indium Gallium Sulfide (CIGS) nanocrystal inks for solution processed PVs. A common CIGS nanocrystal ink synthesis utilizes ligands—molecules attached to the particle surface—for colloidal stability, size control, and shape control. It is desirable to devise a novel synthesis which will incorporate a ligand that allows suspensions in more benign solvents than current methods—a desirable characteristic for large scale production. In order to develop the aforementioned synthesis of CIGS nanoparticles, an optimization study of synthesis parameters was performed. Selection of an appropriate solvent, and sulfur …

Carbon Removal And Optoelectronic Property Tuning In Copper Arsenic Sulfide Thin Films Through Ligand Exchange And Alloying, Louis R. Schroeder, Scott Mcclary, Rakesh Agrawal

The Summer Undergraduate Research Fellowship (SURF) Symposium

Solution processed thin film solar cells are attractive alternatives to conventional energy sources due to low waste generation, flexibility in substrate choice, and scalability. The novel semiconductor Cu3AsS4 in the enargite phase has a near ideal band gap of 1.4 eV and has earth abundant constituent elements; yet single-junction solar cells have yielded low efficiencies due to a secondary carbonaceous phase present, among other issues. This carbonaceous phase may be eliminated by exchanging the carbonaceous ligands with molecular metal chalcogenides. To characterize the ligand exchanged particles, UV-Vis-NIR spectroscopy, Raman spectroscopy, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, and …

Enhancement Of Heat Transfer Coefficient Using Fe₂O₃-Water Nanofluids, Nasser Zouli, S. A. M. Mohammed, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this work, we developed a local heat transfer probe that can measure the heat transfer coefficient to study the effect of the nanofluid with various concentrations and size of nanoparticles on the local heat transfer coefficient in a developed separate effect experimental setup.Water with iron (III) oxide (Fe₂O₃) nanoparticles were used as the nanofluids flowing through the test section. The nanoparticle sizes of the Fe₂O₃ were varying between 20 and 40nm. The concentrations for the different nanoparticle sizes were ranged between 0 and 0.09 % in volume fractions. The results show that use of aqueous Fe₂O₃ nanoparticles can significantly …

Design Of 3d Macroporous Inverse Opal Tio2 Binary And Ternary Composites Sensitized With Gold Nanoparticles And Cds Quantum Dots For Photocatalysis, Daniel A. Corella

Master of Science in Chemical Sciences Theses

Materials composed of titanium (IV) oxide (TiO₂) have received enormous scientific interest due to titania’s abundance, non-toxicity, and photocatalytic proficiency, however its large band gap limits its applicability under ambient conditions. Various attempts have been made to incorporate titania into composite systems to sensitize it for activity under a broader range of wavelengths. One such method includes utilizing narrow band gap semiconductors to form an electron transfer process analogous to photosynthesis referred to as a Z-scheme. Z-scheme systems can catalyze the decomposition of aqueous pollutants via generation of reactive oxygen species after input of sunlight. This work reports …

Titanium Nanoparticles Synthesized Via Hydrothermal Reaction, Kyle W. Hodge

Williams Honors College, Honors Research Projects

The main goal of this project was to determine if increasing the time and temperature of a hydrothermally reacted titanium nanotube would increase the size of the nanotubes. Five experiments were conducted while varying the time and temperature of the reaction: 120°C for 24 hours, 120°C for 48 hours, 150°C for 24 hours, 180°C for 24 hours, and 180°C for 48 hours. Following the synthesis of all of these samples x-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) analyses were performed. The XRD analysis revealed anatase titanium nanoparticles formed in the 120°C and 150°C samples, this could …

Green Synthesis Of Copper Oxide Nanoparticles In Aqueous Medium As A Potential Efficient Catalyst For Catalysis Applications, Waad Mohsen, M. A. Sadek, Hany A. Elazab

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this research, we have developed a reliable green method for the synthesis of copper oxide nanoparticles as a potential efficient catalyst for several catalysis applications. In our experimental approach, microwave-assisted synthesis technique was used in order to perform chemical reduction of copper salt using hydrazine hydrate as a strong reducing agent. The prepared catalyst was characterized using various techniques showing the formation of well dispersed copper oxide nanoparticles. The synthesized Copper oxide catalyst shows many advantages including the use of environmentally benign solvent systems, green synthetic approach, and mild reaction conditions.

Soot Oxidation By Oh: Theory Development, Model, And Experimental Validation, Hossein Ghiassi, David Lignell, Joann S. Lighty

Faculty Publications

Soot oxidation by OH has been represented by an equation developed by Neoh that includes the efficiency of OH radicals to react, the collision efficiency. The focus of this study is the theoretical development of the collision efficiency, enabling a more accurate prediction of soot oxidation where OH is the principle oxidizer. In addition to the traditional parameters, such as OH concentration and temperature, this approach aims to improve the prediction of soot oxidation by considering the fraction of the active area as well as the size of the soot particle and aggregate. The fraction of the active area was …

Electrochemical Fabrication Of Energetic Thin Films, Jonathan J. Coleman

Chemical and Biological Engineering ETDs

Current thermal battery heat sources suffer from slow reaction propagation rates and require extreme care when handling to protect from inadvertent ignition sources. Nanostructured intermetallic heat sources are strong candidates for improved heat sources as they have high enthalpy of reaction, are highly conductive before and after firing and are completely gasless reactions. Current fabrication methods of these heat sources rely on a PVD multistep layering process that is time and capital intensive, and cost prohibiting to their use. The composition and nanostructuring these films require can be provided with electrochemical codeposition, where the two components (aluminum and nickel) are …

Recent Progresses In Molybdenum-Based Electrocatalysts For The Hydrogen Evolution Reaction, Ze-Xing Wu, Jie Wang, Jun-Po Guo, Jing Zhu, De-Li Wang

Journal of Electrochemistry

Electrochemical catalytic production of hydrogen has been considered as a promising and sustainable strategy for clean and renewable energy technologies. Molybdenum-based non noble metal catalysts for the hydrogen evolution reaction have attracted extensive attention due to its effective catalytic performance. In this review, the recent progresses in molybdenum-carbide, phosphide, nitride and sulfide electrocatalysts are presented. In addition, the strategies to improve the catalytic performance are analyzed and the prospects for the future development trends are expected.

Engineering Gold Nanoparticles And Their Use To Control Nucleation, Pedram Jahanian

Wayne State University Dissertations

This study focuses on fabrication of hybrid nanostructures using gold nanoparticles (AuNP) as seeds and partially oxidized potassium tetracyanoplatinate, known as Krogmann’s salt (KCP), and later this method will be employed to manufacture a prototype sensor for detecting different vapors. Nanocrystals are synthesized using electrochemical method with the aim to have more control over the size and shape of the charge transfer salt based on the seed mediated nucleation method. AuNP seeds are prepared on highly ordered pyrolytic graphite (HOPG) substrate by the electrocrystallization method. An aqueous solution of 0.05 to 1 mM Hydrogen tetrachloroaurate (HAuCl4) with 0.1 mM (Potassium …

Synthesis And Characterization Of Curcumin Polymer For Application In Radiation Induced Lung Damage, Mark C. Bailey

Theses and Dissertations--Chemical and Materials Engineering

Radiotherapy is used as a primary treatment for many cancers, including lung cancer. Although radiotherapy has proven to be an effective cancer treatment, its use is heavily limited due to the peripheral toxicity to healthy tissue. In this work, the antioxidant, curcumin, was tested as a radioprotectant to reduce radiation damage to healthy cells. Curcumin has been limited in use due to its poor bioavailability. In order to avoid problems associated with free curcumin delivery, curcumin poly(beta-amino ester) (CPBAE) was synthesized.

The first study investigated the in vitro radioprotection effect of curcumin in HUVEC dosed with gamma radiation. Cells treated …

Bioresponsive Polymer Coating On Nanoparticles, Tunyaboon Laemthong

Masters Theses

"Nanotechnology incorporated with molecular biology became a promising way to treat cancer. The size of nanoparticles enables them to overcome the side effects noticed in cancer treatment like chemotherapy and surgery. Various types and shapes of nanoparticles have been synthesized and used in drug delivery to tumor sites. However, one of problems of using these nanoparticles is the aggregation after injecting them into human body due to flow rate of bloodstream. The coagulation and aggregation will result in clogging blood vessel and lower therapeutic efficacy.

In this thesis, a solution to the aggregation problem was proposed, which is coating biopolymer …

Bioactive Poly(Beta-Amino Ester) Biomaterials For Treatment Of Infection And Oxidative Stress, Andrew L. Lakes

Theses and Dissertations--Chemical and Materials Engineering

Polymers have deep roots as drug delivery tools, and are widely used in clinical to private settings. Currently, however, numerous traditional therapies exist which may be improved through use of polymeric biomaterials. Through our work with infectious and oxidative stress disease prevention and treatment, we aimed to develop application driven, enhanced therapies utilizing new classes of polymers synthesized in-house. Applying biodegradable poly(β-amino ester) (PBAE) polymers, covalent-addition of bioactive substrates to these PBAEs avoided certain pitfalls of free-loaded and non-degradable drug delivery systems. Further, through variation of polymer ingredients and conditions, we were able to tune degradation rates, release profiles, cellular …

Dissolution Of Chalcogens In Amine Thiol Solvents For Use In Nanoparticles, Gaurav A. Mittal, Caleb K. Miskin, Rakesh Agrawal

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lead chalcogenide quantum dots have been shown to be ideal materials for solar cells due to their tunable band gap. Developing a dissolution procedure for chalcogens will help lower the production cost of the solar cells produced by the associated nanoparticles. Dissolution was performed in both aqueous and nonaqueous solutions. Precursors for sulfur and selnium were dissolved in both the aqueous solution of ammonium thioglycolate and ammonium hydroxide and in combinations of amines and thiols. Precursors for tellurium were dissolved in ethylenediamine and different thiols. Lead telluride forms larger microparticles that can be suitable for thermoelectric devices. The optimum solutions …

Carbon Dioxide Sequestration To Form Calcium Carbonate Nanoparticles, Krista E. Stump, Michael T. Harris

The Summer Undergraduate Research Fellowship (SURF) Symposium

The emission of carbon dioxide caused by burning fossil fuels is one of the leading sources of global warming. Reducing the amount of CO₂ released into the atmosphere through carbon sequestration can mitigate this problem. One method of carbon sequestration is the use of a carbon dioxide scrubber. Once captured, CO₂ can be used to create a valuable chemical commodity such as calcium carbonate nanoparticles. To create CaCO₃ particles in the 50-100 nanometer range, a chemical additive is necessary to limit particle size. The study used a laboratory scale carbon dioxide scrubber to react CO₂ with …

The Electroreduction Of Carbon Dioxide On Porous Copper Nanoparticles, Monica Alisa Padilla

Chemical and Biological Engineering ETDs

Copper nanoparticles of porous, controlled structure were synthesized using the sacrificial support method (SSM). The precursor weight percent (wt%) of copper (Cu) and fumed silica (EH-5) was varied to determine the optimum ratio for this material. The precursors were reduced at i) 350°C in a 7% H2 atmosphere and ii) at 250°C in a 100% H2 atmosphere. The specific surface areas of the nanoparticles was measured by Brunauer-Emmett-Teller N2 absorption. The morphologies and widths of the nanoparticles were confirmed by imaging the nanoparticles by scanning electron microscopy (SEM). The bulk composition of the nanoparticles was determined by X-ray diffraction (XRD). …

Engineering Of Lipid Nanoparticles For Advanced Drug Deilvery Applications, Stephen L. Hayward

Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research

‘Nanomedicine’, the application of nanotechnology principles to the field of medicine, has stimulated the development of nano-platforms for next generation drug delivery. By exploiting nanoscale properties of materials to selectively alter intrinsic characteristics of therapeutics, researchers have improved the efficacy and pharmacokinetic profiles for a variety of drug types. Despite preliminary commercial and clinical success, there still remains a need to develop an improved delivery platform that can provide high cargo entrapment, efficient intracellular delivery, evasion of intracellular degradation pathways, and provide cell population specific targeting.

In this study we engineered a nanocarrier system composed of a core bilayer structure …

Creation Of An Annotated Library On Fda Approved Nanomedicines, Marley R. Hodson, Tanin Izadi, Nastassja Lewinski Ph.D, Bridget T. Mcinnes Ph.D

UROP Posters

Nanomedicine is a type of nanotechnology used in the medical field to limit the dosage amount and target drug delivery to specific cells. Nanomedicines that are approved and used tend to be extremely successful; however despite over a decade of research, only a limited number of nanomedicines have advanced for clinical use. A possible reason for the numerous nanomedicine failures is lack of easily accessible information and research on previous nanomedicines. In this project, we have compiled nanomedicine labeling information from the Drugs@FDA website. We have extracted phrases/sentences from labels relating to keywords on nanomaterial properties and drug profile characteristics. …

Inhalable Nanocomposites And Anticancer Agents For Cancer Therapy, Nathanael A. Stocke

Theses and Dissertations--Chemical and Materials Engineering

Cancer is designated as the leading cause of mortality worldwide and lung cancer is responsible for nearly 30% of all cancer related deaths. Over the last few decades mortality rates have only marginally increased and rates of recurrence remain high. These factors, among others, suggest the need for more innovative treatment modalities in lung cancer therapy. Targeted pulmonary delivery is well established for treating pulmonary diseases such as asthma and provides a promising platform for lung cancer therapy. Increasing local deposition of anticancer agents (ACAs) and reducing systemic exposure of these toxic moieties could lead to better therapeutic outcomes and …

Optimization Of Polydopamine Coatings, Helen C. Terrill Ms.

Williams Honors College, Honors Research Projects

Polydopamine coatings were fabricated onto the surfaces of glass slides, silicon wafers, and Teflon pieces. A method to change surface properties was optimized, providing a new way of using substrates by means of make-over surface properties. The technology has a wide range of potential approaches including high performance coatings and biomedical surfaces. The experiments can be conducted with various types of surface modifications to make surfaces hydrophilic, hydrophobic, conductive, or magnetic. The changes of film thickness and surface energy as functions of incubation time were quantified by means of ellipsometry, profilometry, and contact angle measurements. The use of primer polydopamine …

The Kinetics Of A Palladium Precursor – Tobacco Mosaic Virus Reaction, Adi Banerjee, Mayo Adigun, Michael T. Harris

The Summer Undergraduate Research Fellowship (SURF) Symposium

There have been numerous developments in the field of production of metallic nanoparticles using biotemplates such as the Tobacco Mosaic Virus (TMV). Past research has looked at the conditions required to maximise nanoparticle formation. This study of the kinetics of a nanomaterial synthesis reaction using a biotemplate would elucidate the understanding of the controlled growth of nanoparticles, which can be applied in the fabrication of photocatalysts, electrical nanocircuits and solar cells. This study specifically focuses on the reaction between a palladium precursor and the TMV without an external reducing agent, where the palladium ion concentration is measured over time using …

Stability Of Aqueous Dispersions Of Titanium Dioxide Against Sedimentation And Aggregation, Guanrong Bai, Xilan Zhu, Elias I. Franses, David S. Corti, Yung-Jih Yang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Particles of titanium dioxide (TiO₂) are widely used as white pigments in paints and inks, due to their brightness and high refractive index. Yet, with TiO₂ having a high density (4.2 g/cm³), particles with typical sizes of 300 nm sediment rapidly even before significant agglomeration can occur. Thus, increasing the stability of TiO2 dispersions against sedimentation as well as aggregation is important. We studied the effect of sodium dodecyl sulfate (SDS), a commonly used dispersant, on the stability of aqueous dispersions of TiO₂ with weight fractions from 0.01 to 40. The sedimentation time of …

Investigation Of Stabilization Mechanisms For Colloidal Suspension Using Nanoparticles., Qingwen He

Electronic Theses and Dissertations

Over the past decade, charged nanoparticles have been found to enhance the stability of colloidal suspensions. One promising explanation of this stabilization mechanism is “Nanoparticle Haloing”- the formation of a non-adsorbing nanoparticle layer surrounding neutral colloids that would induce an effective electrostatic repulsion between them. The objective of this work was to investigate the effect of additional charged nanoparticles on the interaction between neural colloids in nanoparticle-regulated complex fluids. Firstly, colloidal probe Atomic Force Microscopy (CP-AFM) is used to directly measure the interaction force in such system with nanoparticle volume fractions varying from 10-6 to 10-2. It is found that …

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual examination of suspicious regions …