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Drug delivery

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Articles 61 - 65 of 65

Full-Text Articles in Chemical Engineering

High-Frequency Ultrasound Drug Delivery And Cavitation, Mario Alfonso Diaz Jan 2007

High-Frequency Ultrasound Drug Delivery And Cavitation, Mario Alfonso Diaz

Theses and Dissertations

The viability of a drug delivery system which encapsulates chemotherapeutic drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release by ultrasound application was investigated at an applied frequency of 500 kHz. The investigation also included elucidating the mechanism of drug release at 70 kHz, a frequency which had previously been shown to induce drug release. A fluorescence detection chamber was used to measure in vitro drug release from both Pluronic and stabilized micelles and a hydrophone was used to monitor bubble activity during the experiments. A threshold for release between 0.35 and 0.40 in mechanical index was …

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Characterization Of Polyethylene Glycol Hydrogels For Biomedical Applications, Anushree Datta Jan 2007

Characterization Of Polyethylene Glycol Hydrogels For Biomedical Applications, Anushree Datta

LSU Master's Theses

Polyethylene glycol is one of the most widely used synthetic materials for biomedical applications. Its biocompatibility, flexibility, and 'stealth' properties make it ideal for use in drug delivery applications. The main objective of this paper is to characterize the structural and mass transfer properties of polyethylene glycol hydrogels for applications in drug delivery and biological immobilization. Swelling behavior of the gels was studied to determine the mesh size, and other significant structural parameters of the gel. For accurate design of drug delivery device, along with network design, mathematical modeling of release profiles was performed. The study of PEG hydrogels was …

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The Role Of Cavitation In Acoustically Activated Drug Delivery, Mario A. Diaz, Ghaleb A. Husseini, William G. Pitt, Eric S. Richardson, Douglas A. Christensen Oct 2005

The Role Of Cavitation In Acoustically Activated Drug Delivery, Mario A. Diaz, Ghaleb A. Husseini, William G. Pitt, Eric S. Richardson, Douglas A. Christensen

Faculty Publications

The triblock copolymer, Pluronic P105, has been found to be an ideal ultrasonically activated drug delivery vehicle because it forms micelles with hydrophobic polypropylene oxide cores that sequester hydrophobic drugs (Fig. 1). These micelles release their contents upon the application of low frequency ultrasound [1]such that drugs can be released specifically at the ultrasonicated region (Fig. 2). Such ultrasonically controlled release has been effective against cancer cells in vitro [2] and in vivo [3]. This poster presents our results showing that collapse cavitation is associated with drug release. Cavitation is generally divided into two types of behavior. Stable cavitation is …

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Stable Polymer Micelle Systems As Anti-Cancer Drug Delivery Carriers, Yi Zeng Jun 2005

Stable Polymer Micelle Systems As Anti-Cancer Drug Delivery Carriers, Yi Zeng

Theses and Dissertations

Several temporarily stable polymer micelle systems that might be used as ultrasonic-activated drug delivery carriers were synthesized and investigated. These polymeric micelle systems were Plurogel®, Tetronic®, poly(ethylene oxide)-b-poly(N-isopropylacrylamide) and poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-lactaten). In previous work in our lab, Pruitt et al. developed a stabilized drug carrier named Plurogel® [5, 6]. Unfortunately, the rate of the successful Plurogel® synthesis was only about 30% by simply following Pruitt's process. In this work, this rate was improved to 60% by combining the process of adding 0.15 M NaCl and/or 10 µl/ml n-butanol and by preheating the solution before polymerization. Tetronics® were proved not …

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Mechanism Of Targeted Chemotherapeutic Delivery Using Ultrasound, Thaidra A. Gaufin, Byron K. Murray, Seiga Ohmine, Kim L. O'Neill, William G. Pitt, Briant S. Stringham Jan 2005

Mechanism Of Targeted Chemotherapeutic Delivery Using Ultrasound, Thaidra A. Gaufin, Byron K. Murray, Seiga Ohmine, Kim L. O'Neill, William G. Pitt, Briant S. Stringham

Faculty Publications

Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The advantages of focused delivery to select tissues are manifold, but the exact mechanisms are largely unknown and need clarification to optimize delivery. The present study further defined the role of collapse cavitation in US-induced permeabilization of cell membranes and subsequent drug or gene uptake by the cell. Cavitation, defined as the collapse of micro-bubbles, produces high shear stresses and shock waves that may transiently puncture cell membranes and has been suggested as the cause of increased permeability. The hypothesis that collapsing bubbles permeabilize …

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