Chemical Engineering Commons^™

Effects Of Monoclonal Anti-Abeta Antibodies On The Amyloid Beta Peptide Fibrillogenesis And Their Involvement In The Clearance Of Alzheimer's Disease Plaques, Jeffy Pilar Jimenez

USF Tampa Graduate Theses and Dissertations

Alzheimer’s disease (AD) is the most common cause of senile dementia worldwide. AD is a neurodegenerative disorder characterized by the loss of memory and language skill, collapse of the cognitive function, and distortion of social behavior. As of today, the onset mechanisms of AD and cure are unknown; however, three hallmarks are commonly encountered: extra and intracellular accumulation of amyloid beta (A!) peptide plaques, formation of intracellular neurofibrillary tangles, and inevitable neuronal death. Hypothetically, a possible scenario provoking or involved in the onset of AD is a cascade effect that starts with an imbalance in the production and clearance of …

Pegylation Of Niosomes, John A. Elliott

USF Tampa Graduate Theses and Dissertations

The research presented in this dissertation describes the creation and characterization of a novel antibody-vesicle conjugate modified with polyethylene glycol (PEG) that possesses enhanced binding to and uptake by inflammation-activated endothelial cells with improved storage stability and longer shelf-life and potential reduction in immunogenic potential compared to previous designs.

Targeted drug delivery provides an effective means of delivering therapeutic concentrations of a drug to the site or organ of action. The drug is delivered using a niosome, a vesicle with an aqueous core and a bilayer membrane composed of non-ionic surfactants and cholesterol. Antibodies that recognize specific cell antigens are …

Thermodynamic Model And The Controlling Variables Of Phosphate Lattice Loss, Mohammad Abutayeh

USF Tampa Graduate Theses and Dissertations

A thermodynamic model was developed based upon five equilibrium reactions to predict the limits of distribution of phosphates between the liquid and the solid phases in a reactor used to extract phosphoric acid from phosphate rock. A computer code was generated to carry out different simulations of the model using several inputs of temperatures and liquid phase sulfuric acid contents. Ideal Solution, Debye-Hückel, and Robinson-Guggenheim-Bates electrolyte activity coefficient models were employed alternately in each simulation to complete the thermodynamic model and the outputs were compared to one another.

Experimental data of equilibrium constants were regressed to adjust the values of …